Essential role of mouse telomerase in highly proliferative organs

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Items 301–400 of 999

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  3. Variation at theTERTlocus and predisposition for cancer
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  4. A matter of death and life: the significance of germ cell death during spermatogenesis
    BLANCO‐RODRÍGUEZ · 1998 · International Journal of Andrology
  5. Telomere biology in human aging and aging syndromes
    Wolfram Klapper · 2001 · Mechanisms of Ageing and Development
  6. Organization of telomere sequences in birds: evidence for arrays of extreme length and for in vivo shortening
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  7. Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication
    Lazzerini Denchi, Eros, Celli, Giulia, de Lange, Titia · 2006 · Genes & Development
  8. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance
    Tae Ho Lee, Adrian Tun-Kyi, Rong Shi, Jormay Lim, Christina Soohoo, Greg Finn, Martin Balaštík, Lucia Pastorino, Gerburg M. Wulf, Xiao Zhen Zhou et al. · 2008 · Nature Cell Biology
  9. Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species
    Saffet Öztürk, Berna Sözen, N. Demir · 2013 · Molecular Human Reproduction
  10. Engineered telomere degradation models dyskeratosis congenita
    Dirk F. Hockemeyer, Wilhelm Palm, Richard C. Wang, Suzana S. Couto, Titia de Lange · 2008 · Genes & Development
  11. Mitochondrial-Associated Cell Death Mechanisms Are Reset to an Embryonic-Like State in Aged Donor-Derived iPS Cells Harboring Chromosomal Aberrations
    Alessandro Prigione, Amir M. Hossini, Björn Lichtner, Akdes Serin Harmancı, Beatrix Fauler, Matthias Megges, Rudi Lurz, Hans Lehrach, Evgenia Makrantonaki, Christos C. Zouboulis et al. · 2011 · PLoS ONE
  12. Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
    Christian Bär, Marı́a A. Blasco · 2016 · F1000Research
  13. Premature aging in telomerase-deficient zebrafish
    Anchelin, Monique, Alcaraz-Pérez, Francisca, Martínez, Carlos M., Bernabé-García, Manuel, Mulero, Victoriano, Cayuela, María L. · 2013 · Disease Models & Mechanisms
  14. Aging, telomeres, and atherosclerosis
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  15. Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival
    Kaida Wu, Lisa M. Orme, John D. Shaughnessy, Joth L. Jacobson, Bart Barlogie, Malcolm A.S. Moore · 2003 · Blood
  16. RecA maintains the integrity of chloroplast DNA molecules in Arabidopsis
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  17. Telomerase activity in the subventricular zone of adult mice
    Giuseppe Caporaso · 2003 · Molecular and Cellular Neuroscience
  18. Telomere dysfunction alters the chemotherapeutic profile of transformed cells
    Kee-Ho Lee, K. Lenhard Rudolph, Yeun-Jin Ju, Roger A. Greenberg, Linda A. Cannizzaro, Lynda Chin, Sarah R. Weiler, Ronald Anthony DePinho · 2001 · Proceedings of the National Academy of Sciences
  19. Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome
    Colla, Simona, Ong, Derrick Sek Tong, Ogoti, Yamini, Marchesini, Matteo, Mistry, Nipun A., Clise-Dwyer, Karen, Ang, Sonny A., Storti, Paola, Viale, Andrea, Giuliani, Nicola et al. · 2015 · Cancer Cell
  20. Shorter telomere lengths in patients with severe COVID-19 disease
    Raúl Sánchez-Vazquez, Ana Guío-Carrión, Antonio Zapatero, Paula Martínez, Marı́a A. Blasco · 2021 · Aging
  21. Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls
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  22. Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice
    González-Suárez, Eva, Geserick, Christoph, Flores, Juana M, Blasco, María A · 2005 · Oncogene
  23. Telomere Length in Fibroblasts and Blood Cells from Healthy Centenarians
    Chiara Mondello, Chariklia Petropoulou, Daniela Monti, ES GONOS, Claudio Franceschi, Fiorella Nuzzo · 1999 · Experimental Cell Research
  24. The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants
    Amy G. Clark, Amy L Rohrbaugh, Ivan G. Otterness, Virginia B. Kraus · 2002 · Matrix Biology
  25. Mice Deficient in Telomerase Activity Develop Hypertension Because of an Excess of Endothelin Production
    Gema Pérez‐Rivero, María Piedad Ruiz‐Torres, Juan V. Rivas‐Elena, Mirjana Jerkić, M. L. Díez-Marqués, José Miguel López-Novoa, Marı́a A. Blasco, Diego Rodrı́guez-Puyol · 2006 · Circulation
  26. Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In Vivo
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  31. Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment
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  38. Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice
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  39. The effect of TERC haploinsufficiency on the inheritance of telomere length
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  41. Telomerase Activity and Telomere Length in Male Germ Cells
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  42. Telomerase Mediates the Cell Survival-Promoting Actions of Brain-Derived Neurotrophic Factor and Secreted Amyloid Precursor Protein in Developing Hippocampal Neurons
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  43. Cytokine repertoire during maturation of monocytes to macrophages within spheroids of malignant and non-malignant urothelial cell lines
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  44. Longer Relative Telomere Length in Blood from Women with Sporadic and Familial Breast Cancer Compared with Healthy Controls
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  45. Increased p53 activity does not accelerate telomere‐driven ageing
    García‐Cao, Isabel, García‐Cao, Marta, Tomás‐Loba, Antonia, Martin‐Caballero, Juan, Flores, Juana M, Klatt, Peter, Blasco, María A, Serrano, Manuel · 2006 · The EMBO Reports
  46. Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles
    Lin Liu, Marı́a A. Blasco, David Lawrence Keefe · 2002 · EMBO Reports
  47. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes
    Tohru Minamino, Issei Komuro · 2008 · Nature Clinical Practice Cardiovascular Medicine
  48. Haploinsufficiency of mTR results in defects in telomere elongation
    Karen S. Hathcock, Michael T. Hemann, Kay Opperman, Margaret A. Strong, Carol W. Greider, Richard J. Hodes · 2002 · Proceedings of the National Academy of Sciences
  49. p53-Dependent and -Independent Functions of the Arf Tumor Suppressor
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  50. Pot1b Deletion and Telomerase Haploinsufficiency in Mice Initiate an ATR-Dependent DNA Damage Response and Elicit Phenotypes Resembling Dyskeratosis Congenita
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  51. Telomere length regulates ISG15 expression in human cells
    Zhenjun Lou, Jun Stephen Wei, Harold C. Riethman, Joseph A. Baur, Regina Voglauer, Jerry W. Shay, Woodring Erik Wright · 2009 · Aging
  52. Recombination in telomere-length maintenance
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  54. Impact of genetic engineering on the understanding of spermatogenesis
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  55. The reserve-capacity hypothesis: evolutionary origins and modern implications of the trade-off between tumor-suppression and tissue-repair
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  56. NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal
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  59. Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia
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  61. Short Telomeres Compromise β-Cell Signaling and Survival
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  62. Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome
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  67. Cooperation between p53 Mutation and High Telomerase Transgenic Expression in Spontaneous Cancer Development
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