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Cited by 559

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

Caceres, Alfredo, Kosik, Kenneth S.·1990·Nature
DOI 10.1038/343461a0
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Abstract

Neurons in culture can have fundamentally distinct morphologies which permit their cytological identification and the recognition of their neurites as axons or dendrites. Microtubules may have a role in determining morphology by the selective stabilization of spatially distinct microtubule subsets. The plasticity of a neurite correlates inversely with the stability of its component microtubules: microtubules in growth cones are very dynamic, and in initial neurites there is continuous incorporation of labelled subunits, whereas in mature neurites, microtubules are highly stabilized. The binding of microtubule-associated proteins to the microtubules very probably contributes to this stability. Cerebellar neurons in dissociated culture initially extend exploratory neurites and, after a relatively constant interval, become polarized. Polarity becomes evident when a single neurite exceeds the others in length. These stable neurites cease to undergo the retractions and extensions characteristic of initial neurites and assume many features of axons and dendrites. We have now studied the role of the neuronal microtubule-associate protein tau in neurite polarization by selectively inhibiting tau expression by the addition of antisense oligonucleotides to the culture media. Although the extension of initial exploratory neurites occurred normally, neurite asymmetry was inhibited by the failure to elaborate an axon.

Overview

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Registry

Crossref · 10.1038/343461a0

Cites

1 of 1 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 1 references

Research works printed but not linked: 14

  1. Okabe, S. & Hirokawa, N. J. Cell Biol. 107, 651–664 (1988). · DOI
  2. Horio, T. & Hotani, H. Nature 321, 605–607 (1986). · DOI
  3. Mitchison, T. & Kirschner, M. Neuron 1, 761–772 (1988). · DOI
  4. Ferreira, A., Busciglio, J. & Caceres A. Devl Bran Res. 34, 9–31 (1987). · DOI
  5. Kosik, K. S. et al. Neuron 1, 817–825 (1988). · DOI
  6. Goslin, K. & Banker, G. J. Cell Biol. 108, 1507–1516 (1989). · DOI
  7. Drubin, D. G. & Kirschner, M. W. J. Cell Biol. 103, 2739–2746 (1986). · DOI · Paper page
  8. Ferreira, A., Busciglio, J. & Caceres, A. Devl Brain Res. 49, 215–228 (1989). · DOI
  9. Kowall, N. W. & Kosik, K. S. Ann. Neurol. 12, 639–643 (1987). · DOI
  10. Jahn, R., Schiebler, W. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 81, 1684–1687 (1984). · DOI
  11. Kosik, K. S., Orecchio, L. D., Bakalis, S., Duffy, L. & Neve, R. L. J. Neurochem. 51, 587–598 (1988). · DOI
  12. Tabor, S. in Current Protocols in Molecular Biology Vol. 1 (eds Ausubel, F. B. et al.) 3.10.4–3.10.5 (Wiley, New York, 1989).
  13. Chorey, J. in Current Protocols in Molecular Biology Vol. 1 (eds Ausubel, F. B. et al.) 2.7.1–2.7.5 (Wiley, New York, 1989).
  14. Loke, S. L. et al. Proc. natn. Acad. Sci. U.S.A. 86, 3474–3478 (1989). · DOI

Cited by

Metadata

Authors
Caceres, A., & Kosik, K. S.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1990-02
Volume
343
Issue
6257
Pages
461-463
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/343461a0
Cited by
559
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.