Cited by 1,789Bone Metabolism and DiseasesOsteomyelitis and Bone Disorders ResearchPhagocytosis and Immune Regulation

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, Hisahiro, Hayashi, Shin-Ichi, Kunisada, Takahiro, Ogawa, Minetaro, Nishikawa, Satomi, Okamura, Hitoshi, Sudo, Tetsuo, Shultz, Leonard D., Nishikawa, Shin-Ichi·1990·Nature

DOI 10.1038/345442a0

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Abstract

Mice homozygous for the recessive mutation osteopetrosis (op) on chromosome 3 have a restricted capacity for bone remodelling, and are severely deficient in mature macrophages and osteoclasts. Both cell populations originate from a common haemopoietic progenitor. As op/op mice are not cured by transplants of normal bone marrow cells, the defects in op/op mice may be associated with an abnormal haematopoietic microenvironment rather than with an intrinsic defect in haematopoietic progenitors. To investigate the molecular and biochemical basis of the defects caused by the op mutation, we established primary fibroblast cell lines from op/op mice and tested the ability of these cell lines to support the proliferation of macrophage progenitors. We show that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels. This defect in M-CSF production and the recent mapping of the Csfm structural gene near op on chromosome 3 suggest that op is a mutation within the Csfm gene itself. We have sequenced Csfm complementary DNA prepared from op/op fibroblasts and found a single base pair insertion in the coding region of the Csfm gene that generates a stop codon 21 base pairs downstream. Thus, the op mutation is within the Csfm coding region and we conclude that the pathological changes in this mutant result from the absence of M-CSF.

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Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
Metcalf, D. (1989) · Nature · doi:10.1038/339027a0 · Cited by 1,023
CSF‐1—A mononuclear phagocyte lineage‐specific hemopoietic growth factor
Stanley, E. R., Guilbert, L. J., Tushinski, R. J., & Bartelmez, S. H. (1983) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240210206 · Cited by 516
Apparent role of the macrophage growth factor, CSF-1, in placental development
Pollard, J. W., Bartocci, A., Arceci, R. J., Orlofsky, A., Ladner, M. B., & Stanley, E. R. (1987) · Nature · doi:10.1038/330484a0 · Cited by 482
Osteopetrosis, a New Recessive Skeletal Mutation on Chromosome 12 of the Mouse
Marks, S. C., & LANE, P. W. (1976) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a108657 · Cited by 304
Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation.
Wiktor-Jędrzejczak, W., Ahmed, A. A., Szczylik, C. A., & Skelly, R. R. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.5.1516 · Cited by 293
B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.
Ogawa, M., Nishikawa, S.-I., Ikuta, K., Yamamura, F., Naito, M., Takahashi, K., & Nishikawa, S.-I. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02949.x · Cited by 281
Self-citation
Human CSF‐1: gene structure and alternative splicing of mRNA precursors.
Ladner, M. B., Martin, G. A., Noble, J. A., Nikoloff, D. M., Tal, R., Kawasaki, E. S., & White, T. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02561.x · Cited by 228
The Molecular Control of Blood Cell Development
Sachs, L. (1987) · Science · doi:10.1126/science.3317831 · Cited by 221
Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis
Regenstreif, L. J., & Rossant, J. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90319-9 · Cited by 181

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Saiki, R. K. et al. Science 239, 487–491 (1988). · DOI · Paper page

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Groh, J., Weis, J., Zieger, H. L., Stanley, E. R., Heuer, H., & Martini, R. (2011) · Brain · doi:10.1093/brain/awr283 · Cited by 83
α-Lipoic Acid Inhibits Inflammatory Bone Resorption by Suppressing Prostaglandin E2 Synthesis
Ha, H., Lee, J.-H., Kim, H., Kim, H., Kwak, H. B., Lee, S., Kim, H., & Lee, Z. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.111 · Cited by 82
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Yamane, T., Kunisada, T., Yamazaki, H., Era, T., Nakano, T., & Hayashi, S.-I. (1997) · Blood · doi:10.1182/blood.v90.9.3516 · Cited by 82
Self-citation
Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia
Hinoi, E., Ochi, H., Takarada, T., Nakatani, E., Iezaki, T., Nakajima, H., Fujita, H., Takahata, Y., Hidano, S., Kobayashi, T., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1538 · Cited by 84
Expression and regulation of the tumour necrosis factor-alpha gene in the female reproductive tract
Hunt, J. (1993) · Reproduction Fertility and Development · doi:10.1071/rd9930141 · Cited by 81
Transient recruitment of osteoclasts and expression of their function in osteopetrotic (op/op) mice by a single injection of macrophage colony-stimulating factor
Kodama, H., Yamasaki, A., Abe, M., Niida, S., Hakeda, Y., & Kawashima, H. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080107 · Cited by 81
Membrane Molecules as Differentiation Antigens of Murine Macrophages
McKnight, A. J., & Gordon, S. (1998) · Advances in immunology · doi:10.1016/s0065-2776(08)60562-3 · Cited by 81
Building the Next Generation of Humanized Hemato-Lymphoid System Mice
Martinov, T., McKenna, K. M., Tan, W. H., Collins, E. J., Kehret, A. R., Linton, J. D., Olsen, T. M., Shobaki, N., & Rongvaux, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643852 · Cited by 81
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Colucci, S. C., Taraboletti, G., Primo, L., Viale, A., Roca, C., Valdembri, D., Geuna, M., Pagano, M., Grano, M., Pogrel, M. A., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051019 · Cited by 81
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Tamura, A., Hirai, H., Yokota, A., Kamio, N., Sato, A., Shoji, T., Kashiwagi, T., Torikoshi, Y., Miura, Y., Tenen, D. G., et al. (2017) · Blood · doi:10.1182/blood-2017-03-772962 · Cited by 84
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Hodge, J. M., Kirkland, M. A., Aitken, C. J., Waugh, C. M., Myers, D. E., Lopez, C. M., Adams, B. E. L., & Nicholson, G. C. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301232 · Cited by 80
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de Villiers, W. J. S., Smith, J. D., Miyata, M., Dansky, H. M., Darley, E., & Gordon, S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.4.631 · Cited by 80
Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation.
Mauro, L. J., Olmsted‐Davis, E. A., Skrobacz, B. M., Mourey, R. J., Davis, A. R., & Dixon, J. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43864-1 · Cited by 79
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Yamashita, T. (2012) · World Journal of Orthopedics · doi:10.5312/wjo.v3.i11.175 · Cited by 82
Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis
Yang, S.-Y., Wu, B., Mayton, L., Mukherjee, P., Robbins, P. D., Evans, C. H., & Wooley, P. H. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302192 · Cited by 79
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Douglass, T. G., Driggers, L., Zhang, J. G., Hoa, N. T., Delgado, C., Williams, C. C., Dan, Q., Sanchez, R., Jeffes, E. W. B., Wepsic, H. T., et al. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.04.016 · Cited by 81
Role of cytokines in bone resorption
Mundy, G. R. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240530405 · Cited by 79
Methionine down‐regulates TLR 4/ MyD 88/ NF ‐κ B signalling in osteoclast precursors to reduce bone loss during osteoporosis
Vijayan, V., Khandelwal, M., Manglani, K., Gupta, S., & Surolia, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12434 · Cited by 78
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Umeda, S., Beamer, W. G., Takagi, K., Naito, M., Hayashi, S.-I., Yonemitsu, H., Yi, T., & Shultz, L. D. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65116-4 · Cited by 78
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Santangelo, S., Gamelli, R. L., & Shankar, R. (2001) · Annals of Surgery · doi:10.1097/00000658-200101000-00015 · Cited by 78
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Fortin, A., Stevenson, M. M., & Gros, P. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363841 · Cited by 80
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Umeda, K., Heike, T., Yoshimoto, M., Shiota, M., Suemori, H., Luo, H., Chui, D. H. K., Torii, R., Shibuya, M., Nakatsuji, N., et al. (2004) · Development · doi:10.1242/dev.01065 · Cited by 78
Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells
Kurihara, N., Iwama, A., Tatsumi, J., Ikeda, K., & Suda, T. (1996) · Blood · doi:10.1182/blood.v87.9.3704.bloodjournal8793704 · Cited by 78
Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
Kempthorne, L., Yoon, H., Madore, C., Smith, S., Wszolek, Z. K., Rademakers, R., Kim, J., Butovsky, O., & Dickson, D. W. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00947-0 · Cited by 77
“A number of animal studies have demonstrated a role for CSF-1R in survival and development of macrophages [10, 54, 55].”
Background
Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal Motility
Cipriani, G., Gibbons, S. J., Kashyap, P., & Farrugia, G. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.01.003 · Cited by 77
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Takahashi, N., Udagawa, N., Tanaka, S., & Suda, T. (2003) · Humana Press eBooks · doi:10.1385/1-59259-366-6:129 · Cited by 77
Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2
Pekkinen, M., Terhal, P. A., Botto, L. D., Henning, P., Mäkitie, R. E., Roschger, P., Jain, A., Kol, M. A., Kjellberg, M. A., Paschalis, E. P., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126180 · Cited by 79
MouseAlx3:Anaristaless-like Homeobox Gene Expressed during Embryogenesis in Ectomesenchyme and Lateral Plate Mesoderm
ten Berge, D., Brouwer, A., Bahi, S. E., Guénet, J., Robert, B., & Meijlink, F. C. P. W. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8921 · Cited by 77
Molecular mechanisms of bone resorption
Teitelbaum, S. L., Abu‐Amer, Y., & Ross, F. P. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590102 · Cited by 77
Cell adhesion in the stromal regulation of haemopoiesis
Clark, B. R., Gallagher, J. T., & Dexter, T. M. (1992) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(11)80010-7 · Cited by 77
PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells
Henkel, G., McKercher, Sr., Yamamoto, H., Anderson, K., Oshima, R., & Maki, R. (1996) · Blood · doi:10.1182/blood.v88.8.2917.bloodjournal8882917 · Cited by 76
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Hong, M. H., Williams, H., Jin, C., & Pike, J. W. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.5.911 · Cited by 76
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Cohen, P. E., Zhu, L., Nishimura, K., & Pollard, J. W. (2002) · Endocrinology · doi:10.1210/endo.143.4.8754 · Cited by 76
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Taguchi, K., Okada, A., Kitamura, H., Yasui, T., Naiki, T., Hamamoto, S., Ando, R., Mizuno, K., Kawai, N., Tozawa, K., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013060675 · Cited by 76
Study of the cell biology and biochemistry of cherubism.
Southgate, J., Sarma, U., Townend, J., Barron, J. L., & Flanagan, A. M. (1998) · Journal of Clinical Pathology · doi:10.1136/jcp.51.11.831 · Cited by 77
The zebrafish as a model system for human disease
Ward, A. C. (2002) · Frontiers in bioscience · doi:10.2741/a814 · Cited by 76
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Novack, D. V., & Mbalaviele, G. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0011-2015 · Cited by 80
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Wang, Z. E., Myles, G. M., Brandt, C. S., Lioubin, M. N., & Rohrschneider, L. R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5348 · Cited by 75
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Zhang, X., Takakura, N., Oike, Y., Inada, T., Gale, N. W., Yancopoulos, G. D., & Suda, T. (2001) · Blood · doi:10.1182/blood.v98.4.1028 · Cited by 75
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Hul, W. V., Bollerslev, J., Gram, J., Hul, E. V., Wuyts, W. A., Bénichou, O., Vanhoenacker, F. M. H. M., & Willems, P. J. (1997) · The American Journal of Human Genetics · doi:10.1086/514844 · Cited by 74
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Zhang, L., Wang, Y., 肖凤君, Wang, S., 邢桂春, Li, Y., Yin, X., Lu, K., Wei, R., Fan, J., et al. (2014) · Cell Research · doi:10.1038/cr.2014.53 · Cited by 73
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Shuto, T., Kukita, T., Hirata, M., Jimi, E., & Koga, T. (1994) · Endocrinology · doi:10.1210/endo.134.3.8119150 · Cited by 73
Uncoupling of the proliferation and differentiation signals mediated by the murine macrophage colony-stimulating factor receptor expressed in myeloid FDC-P1 cells.
Bourette, R. P., Myles, G. M., Carlberg, K., Chen, A. R., & Rohrschneider, L. R. (1995) · PubMed · Cited by 73
Macrophages in the Uterus and Placenta
Hunt, J. S., & Pollard, J. W. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77377-8_2 · Cited by 72
Macrophages in tissues and in vitro
Gordon, S., Fraser, I. P., Nath, D., Hughes, D. A., & Clarke, S. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90119-y · Cited by 75
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Shinohara, M., & Takayanagi, H. (2007) · Current Osteoporosis Reports · doi:10.1007/s11914-007-0005-1 · Cited by 72
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Nakamichi, Y., Mizoguchi, T., Arai, A., Kobayashi, Y., Sato, M., Penninger, J. M., Yasuda, H., Kato, S., DeLuca, H. F., Suda, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207361109 · Cited by 74
Innate immune regulation by STAT ‐mediated transcriptional mechanisms
Li, H. S., & Watowich, S. S. (2014) · Immunological Reviews · doi:10.1111/imr.12198 · Cited by 72
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Blin‐Wakkach, C., Wakkach, A., Sexton, P. M., Rochet, N., & Carle, G. F. (2004) · Leukemia · doi:10.1038/sj.leu.2403449 · Cited by 71
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(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70
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Tsubaki, M., Komai, M., Itoh, T., Imano, M., Sakamoto, K., Shimaoka, H., Takeda, T., Ogawa, N., Mashimo, K., Fujiwara, D., et al. (2014) · Journal of Biomedical Science · doi:10.1186/1423-0127-21-10 · Cited by 70
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Horowitz, M. C., Bothwell, A. L. M., Hesslein, D. G. T., Pflugh, D. L., & Schatz, D. G. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00328.x · Cited by 70
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Takahashi, N., Udagawa, N., Kobayashi, Y., & Suda, T. (2007) · Methods in molecular medicine · doi:10.1007/978-1-59745-401-8_18 · Cited by 71
Signalling in osteoclasts and the role of Fos/AP1 proteins
Wagner, E. F., & Matsuo, K. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.suppl_2.ii83 · Cited by 69
The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruption
Iizuka, T.-I., Cielinski, M. J., Aukerman, S. L., & Marks, S. C. (1992) · Archives of Oral Biology · doi:10.1016/0003-9969(92)90125-r · Cited by 68
Prostaglandin e2 promotes osteoclast formation in murine hematopoietic cultures through an action on hematopoietic cells
Collins, D., & Chambers, T. J. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070512 · Cited by 68
Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation
Souza, P. P. C., & Lerner, U. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01663 · Cited by 67
“Macrophages and osteoclasts share the same progenitor cells, and differentiation of both cells is affected by a loss-of-function mutation in the macrophage-colony stimulating factor (M-CSF) gene (24).”
Background
Canonical and non-canonical pathways of osteoclast formation.
Knowles, H. J., & Athanasou, N. A. (2009) · PubMed · doi:10.14670/hh-24.337 · Cited by 67
Osteoclasts—the innate immune cells of the bone
Wu, Y., Humphrey, M. B., & Nakamura, M. C. (2008) · Autoimmunity · doi:10.1080/08916930701693180 · Cited by 69
Osteoporosis with increased osteoclastogenesis in hematopoietic cell-specific STAT3-deficient mice
Zhang, Z., Welte, T., Troiano, N. W., Maher, S. E., Fu, X.-Y., & Bothwell, A. L. M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.019 · Cited by 67
Osteoblasts Provide a Suitable Microenvironment for the Action of Receptor Activator of Nuclear Factor-κB Ligand
Yamamoto, Y., Udagawa, N., Matsuura, S., Nakamichi, Y., Horiuchi, H., Hosoya, A., Nakamura, M., Ozawa, H., Takaoka, K., Penninger, J. M., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0216 · Cited by 67
Molecular basis of mouse developmental mutants.Preprint
Reith, A. D., & Bernstein, A. (1991) · Genes & Development · doi:10.1101/gad.5.7.1115 · Cited by 67
Roles of a Macrophage Receptor with Collagenous Structure(MARCO) in Host Defense and Heterogeneity of Splenic Marginal Zone Macrophages.
Ito, S., Naito, M., Kobayashi, Y., Takatsuka, H., Jiang, S. S., Usuda, H., Umezu, H., Hasegawa, G., Arakawa, M., Shultz, L. D., et al. (1999) · Archivum histologicum japonicum · doi:10.1679/aohc.62.83 · Cited by 66
Self-citation
Osteoprotegerin-Deficient Male Mice as a Model for Severe Alveolar Bone Loss: Comparison With RANKL-Overexpressing Transgenic Male Mice
Koide, M., Kobayashi, Y., Ninomiya, T., Nakamura, M., Yasuda, H., Arai, Y., Okahashi, N., Yoshinari, N., Takahashi, N., & Udagawa, N. (2013) · Endocrinology · doi:10.1210/en.2012-1928 · Cited by 67
CSF-1 signaling in macrophages: pleiotrophy through phosphotyrosine-based signaling pathways
Mouchemore, K. A., & Pixley, F. J. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.666845 · Cited by 70
Bone remodelling: A signalling system for osteoclast regulation
Filvaroff, E. H., & Derynck, R. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70434-8 · Cited by 66
Augmented Proliferation of Human Alveolar Macrophages After Allogeneic Bone Marrow Transplantation
Nakata, K., Gotoh, H., Watanabe, J., Uetake, T., Komuro, I., Yuasa, K., Watanabe, S., Ieki, R., Sakamaki, H., Akiyama, H., et al. (1999) · Blood · doi:10.1182/blood.v93.2.667 · Cited by 66
Induction of Colony-Stimulating Factor Expression followingStaphylococcusorSalmonellaInteraction with Mouse or Human Osteoblasts
Bost, K. L., Bento, J. L., Ellington, J. K., Marriott, I., & Hudson, M. C. (2000) · Infection and Immunity · doi:10.1128/iai.68.9.5075-5083.2000 · Cited by 66
CELLULAR AND MOLECULAR BIOLOGY OF THE OSTEOCLAST
Baron, R., Ravesloot, J., Neff, L., Chakraborty, M., Chatterjee, D., Lomri, A., & Horne, W. C. (1993) · Elsevier eBooks · doi:10.1016/b978-0-08-092500-4.50018-8 · Cited by 66
Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass
Inoue, K., Qin, Y., Xia, Y., Han, J., Yuan, R., Sun, J., Xu, R., Jiang, J. X., Greenblatt, M. B., & Zhao, B. (2023) · eLife · doi:10.7554/elife.82118 · Cited by 65
Colony-Stimulating Factor 1 Receptor (CSF1R) Activates AKT/mTOR Signaling and Promotes T-Cell Lymphoma Viability
Murga‐Zamalloa, C., Rolland, D. C. M., Polk, A., Wolfe, A., Dewar, H., Chowdhury, P., Önder, Ö., Dewar, R., Brown, N. A., Bailey, N. G., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1486 · Cited by 66
Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing
Fan, S., Sun, X., Su, C., Xue, Y., Song, X., & Deng, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1193765 · Cited by 65
Hematoendothelial Differentiation of Human Embryonic Stem Cells
Vodyanik, M. A., & Slukvin, I. I. (2007) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb2306s36 · Cited by 65
Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors
Levaot, N., Ottolenghi, A., Mann, M., Ram, G. G., Kam, Z., & Geiger, B. (2015) · Bone · doi:10.1016/j.bone.2015.05.021 · Cited by 68
Bone effects of vitamin D – Discrepancies between in vivo and in vitro studies
Suda, T., Takahashi, F., & Takahashi, N. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.11.011 · Cited by 66
Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cells
Amiri, F., Paradis, P., Reudelhuber, T. L., & Schiffrin, E. L. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282fc2184 · Cited by 65
Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis
Shaposhnik, Z., Wang, X., & Lusis, A. J. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m005215 · Cited by 64
Microglia in colony‐stimulating factor 1‐deficient op/op mice
Blevins, G., & FEDOROFF, S. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490400412 · Cited by 64

Authors: Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I.
Affiliations: Kumamoto University (JP)
Jackson Laboratory (US)
ORCID: Yoshida, Hisahiro
Kunisada, Takahiro
Ogawa, Minetaro
Shultz, Leonard D.
Nishikawa, Shin-Ichi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1990-05
Volume: 345
Issue: 6274
Pages: 442-444
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/345442a0
OpenAlex: W2041138285
Cited by: 1,789
References: 19
Citations by year: 2026: 10 · 2025: 20 · 2024: 14 · 2023: 24 · 2022: 46 · 2021: 27 · 2020: 38 · 2019: 44 · 2018: 25 · 2017: 56 · 2016: 39 · 2015: 45 · 2014: 56 · 2013: 63 · 2012: 63
FWCI: 18.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: osteopetrosis, macrophage colony-stimulating factor, mouse chromosome 3, macrophage deficiency, bone remodeling, stop codon, gene mapping
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Colony-Stimulating Factors, Genes, Mice, Mutant Strains, Molecular Sequence Data, Osteopetrosis, RNA, Messenger, Polymerase Chain Reaction, Macrophage Colony-Stimulating Factor, Mice

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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