Cited by 1,789Bone Metabolism and DiseasesOsteomyelitis and Bone Disorders ResearchPhagocytosis and Immune Regulation

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, Hisahiro, Hayashi, Shin-Ichi, Kunisada, Takahiro, Ogawa, Minetaro, Nishikawa, Satomi, Okamura, Hitoshi, Sudo, Tetsuo, Shultz, Leonard D., Nishikawa, Shin-Ichi·1990·Nature

DOI 10.1038/345442a0

Open this paper in CoChat — free account

Abstract

Mice homozygous for the recessive mutation osteopetrosis (op) on chromosome 3 have a restricted capacity for bone remodelling, and are severely deficient in mature macrophages and osteoclasts. Both cell populations originate from a common haemopoietic progenitor. As op/op mice are not cured by transplants of normal bone marrow cells, the defects in op/op mice may be associated with an abnormal haematopoietic microenvironment rather than with an intrinsic defect in haematopoietic progenitors. To investigate the molecular and biochemical basis of the defects caused by the op mutation, we established primary fibroblast cell lines from op/op mice and tested the ability of these cell lines to support the proliferation of macrophage progenitors. We show that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels. This defect in M-CSF production and the recent mapping of the Csfm structural gene near op on chromosome 3 suggest that op is a mutation within the Csfm gene itself. We have sequenced Csfm complementary DNA prepared from op/op fibroblasts and found a single base pair insertion in the coding region of the Csfm gene that generates a stop codon 21 base pairs downstream. Thus, the op mutation is within the Csfm coding region and we conclude that the pathological changes in this mutant result from the absence of M-CSF.

Integrity signals

Registry

Crossref · 10.1038/345442a0

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
Metcalf, D. (1989) · Nature · doi:10.1038/339027a0 · Cited by 1,023
CSF‐1—A mononuclear phagocyte lineage‐specific hemopoietic growth factor
Stanley, E. R., Guilbert, L. J., Tushinski, R. J., & Bartelmez, S. H. (1983) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240210206 · Cited by 516
Apparent role of the macrophage growth factor, CSF-1, in placental development
Pollard, J. W., Bartocci, A., Arceci, R. J., Orlofsky, A., Ladner, M. B., & Stanley, E. R. (1987) · Nature · doi:10.1038/330484a0 · Cited by 482
Osteopetrosis, a New Recessive Skeletal Mutation on Chromosome 12 of the Mouse
Marks, S. C., & LANE, P. W. (1976) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a108657 · Cited by 304
Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation.
Wiktor-Jędrzejczak, W., Ahmed, A. A., Szczylik, C. A., & Skelly, R. R. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.5.1516 · Cited by 293
B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.
Ogawa, M., Nishikawa, S.-I., Ikuta, K., Yamamura, F., Naito, M., Takahashi, K., & Nishikawa, S.-I. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02949.x · Cited by 281
Self-citation
Human CSF‐1: gene structure and alternative splicing of mRNA precursors.
Ladner, M. B., Martin, G. A., Noble, J. A., Nikoloff, D. M., Tal, R., Kawasaki, E. S., & White, T. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02561.x · Cited by 228
The Molecular Control of Blood Cell Development
Sachs, L. (1987) · Science · doi:10.1126/science.3317831 · Cited by 221
Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis
Regenstreif, L. J., & Rossant, J. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90319-9 · Cited by 181

Flagged first, then by citations

Show all 19 references

Research works printed but not linked: 1

Saiki, R. K. et al. Science 239, 487–491 (1988). · DOI · Paper page

Sorted by citations

Items 701–800 of 1,001

Detection of transcripts and binding sites for colony-stimulating factor-1 during bone development
Hofstetter, W., Wetterwald, A., Cecchini, M. G., Mueller, C., & Felix, R. (1995) · Bone · doi:10.1016/s8756-3282(95)00163-8 · Cited by 51
Lymphohematopoietic development from embryonic stem cells in vitro
Nakano, T. (1995) · Seminars in Immunology · doi:10.1016/1044-5323(95)90047-0 · Cited by 51
Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying
Cipriani, G., Gibbons, S. J., Verhulst, P.-J., Choi, K. M., Eisenman, S. T., Hein, S. S., Ordog, T., Linden, D. R., Szurszewski, J. H., & Farrugia, G. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.09.001 · Cited by 50
VEGF and M-CSF levels in periodontal tissue during tooth movement
Kaku, M., Motokawa, M., Tohma, Y., Tsuka, N., Koseki, H., Sunagawa, H., Hernandes, R. A. M., Ohtani, J., Fujita, T., Kawata, T., et al. (2008) · Biomedical Research · doi:10.2220/biomedres.29.181 · Cited by 50
Osteoclastic activity induces osteomodulin expression in osteoblasts
Ninomiya, K., Miyamoto, T. K., Imai, J., Fujita, N., Suzuki, T., Iwasaki, R., Yagi, M., Watanabe, S., Toyama, Y., & Suda, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.193 · Cited by 52
Signal Transduction Pathways Regulating Hematopoietic Differentiation
Smithgall, T. E. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01346-2 · Cited by 50
Carbonic anhydrase II is an AP‐1 target gene in osteoclasts
David, J. ‐., Rincón, M., Neff, L., Horne, W. C., & Baron, R. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1099 · Cited by 50
Cytokines in Hematopoiesis
Alexander, W. S. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043013 · Cited by 50
c-Src Control of Chloride Channel Support for Osteoclast HCl Transport and Bone Resorption
Edwards, J. C., Cohen, C., Xu, W., & Schlesinger, P. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605865200 · Cited by 50
Development and maintenance of the brain’s immune toolkit: microglia and non-parenchymal brain macrophages
Lopez‐Atalaya, J. P., Askew, K. E., Sierra, A., & Gomez‐Nicola, D. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22545 · Cited by 49
Functional Human Antigen-Specific T Cells Produced In Vitro Using Retroviral T Cell Receptor Transfer into Hematopoietic Progenitors
van Lent, A. U., Nagasawa, M., van Loenen, M. M., Schotte, R., Schumacher, T. N., Heemskerk, M. H. M., Spits, H., & Legrand, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.4959 · Cited by 49
Hematopoietic Stem Cell Niches and Signals Controlling Immune Cell Development and Maintenance of Immunological Memory
Miao, R., Lim, V., Kothapalli, N., Ma, Y., Fossati, J., Zehentmeier, S., Sun, R., & Pereira, J. P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.600127 · Cited by 52
Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice
Tagaya, H., Kunisada, T., Yamazaki, H., Yamane, T., Tokuhisa, T., Wagner, E. F., Sudo, T., Shultz, L. D., & Hayashi, S. (2000) · Blood · doi:10.1182/blood.v95.11.3363 · Cited by 49
Self-citation
The origins of osteoclasts
Horowitz, M. C., & Lorenzo, J. (2004) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000127825.05580.eb · Cited by 49
1,25(OH)2-vitamin D3 affects the subcellular distribution of protein kinase C isoenzymes in rat duodenum: Influence of aging
Balogh, G., Boland, R., & de Boland, A. R. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20001215)79:4 · Cited by 17
Dental Abnormalities Associated with Failure of Tooth Eruption in src Knockout and op/op Mice
Tiffee, J., Xing, L., Nilsson, S. K., & Boyce, B. F. (1999) · Calcified Tissue International · doi:10.1007/s002239900657 · Cited by 49
The Role of BMP Signaling in Osteoclast Regulation
Heubel, B. P., & Nohe, A. (2021) · Journal of Developmental Biology · doi:10.3390/jdb9030024 · Cited by 49
Current perspectives of residual ridge resorption: Pathological activation of oral barrier osteoclasts
Kondo, T., Kanayama, K., Egusa, H., & Nishimura, I. (2022) · Journal of Prosthodontic Research · doi:10.2186/jpr.jpr_d_21_00333 · Cited by 49
Temporal dynamics of immune-stromal cell interactions in fracture healing
Capobianco, C. A., Hankenson, K. D., & Knights, A. J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1352819 · Cited by 52
γ-Glutamyltranspeptidase Stimulates Receptor Activator of Nuclear Factor-κB Ligand Expression Independent of Its Enzymatic Activity and Serves as a Pathological Bone-resorbing Factor
Niida, S., Kawahara, M., Ishizuka, Y., Ikeda, Y., Kondo, T., Hibi, T., Suzuki, Y., Ikeda, K., & Taniguchi, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311905200 · Cited by 48
Sbds is required for Rac2-mediated monocyte migration and signaling downstream of RANK during osteoclastogenesis
Leung, R., Cuddy, K., Wang, Y., Rommens, J. M., & Glogauer, M. (2010) · Blood · doi:10.1182/blood-2010-05-282574 · Cited by 49
VEGF, FLT3 ligand, PlGF and HGF can substitute for M-CSF to induce human osteoclast formation: implications for giant cell tumour pathobiology
Taylor, R. M., Kashima, T. G., Knowles, H. J., & Athanasou, N. A. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.108 · Cited by 48
Cell Surface Colony-Stimulating Factor 1 Can Be Cleaved by TNF-α Converting Enzyme or Endocytosed in a Clathrin-Dependent Manner
Horiuchi, K., Miyamoto, T. K., Takaishi, H., Hakozaki, A., Kosaki, N., Miyauchi, Y., Furukawa, M., Takito, J., Kaneko, H., Matsuzaki, K., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6715 · Cited by 48
Expression Patterns of Matrix Metalloproteinases and Vascular Endothelial Growth Factor During Epiphyseal Ossification
Álvarez, J., Costales, L., Serra, R. A., Balbı́n, M., & López, J. M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050204 · Cited by 48
Progressive increase in bone mass and development of odontomas in aging osteopetrotic c-src-deficient mice
Amling, M., Neff, L., Priemel, M., Schilling, A. F., Rueger, J. M., & Baron, R. (2000) · Bone · doi:10.1016/s8756-3282(00)00373-2 · Cited by 48
Alterations in Differentiation and Behavior of Monocytic Phagocytes in Transgenic Mice that Express Dominant Suppressors of ras Signaling
Jin, D. I., Jameson, S. B., Reddy, M. A., Schenkman, D., & Ostrowski, M. C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.693 · Cited by 47
Liver Regeneration is Impaired in Macrophage Colony Stimulating Factor Deficient Mice After Partial Hepatectomy: The Role of M-CSF-Induced Macrophages
Amemiya, H., Kono, H., & Fujii, H. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.08.008 · Cited by 47
Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements
Mediero, A., Pérez‐Aso, M., & Cronstein, B. N. (2014) · The FASEB Journal · doi:10.1096/fj.14-255703 · Cited by 48
Contribution of colony-stimulating factor 1 to neuropathic pain
Yu, X., Basbaum, A. I., & Guan, Z. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000883 · Cited by 47
Disturbed tooth eruption in osteopetrotic (op/op) mice: histopathogenesis of tooth malformation and odontomas
Ida‐Yonemochi, H., Noda, T., Shimokawa, H., & Saku, T. (2002) · Journal of Oral Pathology and Medicine · doi:10.1034/j.1600-0714.2002.00087.x · Cited by 47
Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts
Chen, Z. P., & Chen, K. Y. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199703)170:3 · Cited by 23
Self-citation
Hepatocyte growth factor is involved in formation of osteoclast‐like cells mediated by clonal stromal cells (MC3T3‐G2/PA6)
Sato, T., Hakeda, Y., Yamaguchi, Y., Mano, H., Tezuka, K., Matsumoto, K., Nakamura, T., Mori, Y., Yoshizawa, K., Sumitani, K., et al. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041640124 · Cited by 47
Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.
Berkowitz, E. A., Seroogy, K. B., Schroeder, J. A., Russell, W. E., Evans, E. P., Riedel, R. F., Phillips, H. K., Harrison, C. A., Lee, D. C., & Luetteke, N. (1996) · PubMed · Cited by 47
Osteoclast Progenitors Reside in the Peroxisome Proliferator-Activated Receptor γ-Expressing Bone Marrow Cell Population
Wei, W., Zeve, D., Wang, X., Du, Y., Tang, W., Dechow, P. C., Graff, J. M., & Wan, Y. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05979-11 · Cited by 46
Osteoblast Role in Rheumatic Diseases
Corrado, A., Maruotti, N., & Cantatore, F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061272 · Cited by 41
Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases
Gao, W., Jian-Xin, L. I. U., Liu, M., Yao, Y.-D., Liu, Z., Liu, L., He, H., & Zhou, H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105563 · Cited by 47
The increased in vitro osteoclastogenesis in patients with rheumatoid arthritis is due to increased percentage of precursors and decreased apoptosis — The In Vitro Osteoclast Differentiation in Arthritis (IODA) study
Durand, M., Boire, G., Komarova, S. V., Dixon, S. J., Sims, S. M., Harrison, R. E., Nabavi, N., Maria, O. M., Manolson, M. F., Mizianty, M. J., et al. (2010) · Bone · doi:10.1016/j.bone.2010.10.167 · Cited by 46
Op/op mice defective in production of functional colony-stimulating factor-1 lack macrophages in muscularis externa of the small intestine
Mikkelsen, H. B., & Thuneberg, L. (1999) · Cell and Tissue Research · doi:10.1007/s004410051254 · Cited by 46
The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development
Popoff, S. N., & Marks, S. C. (1995) · Bone · doi:10.1016/8756-3282(95)00347-4 · Cited by 46
Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis
Yin, Z., Gong, G., Liu, X., & Yin, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1274679 · Cited by 45
An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation
Hohenhaus, D. M., Schaale, K., Cao, K. L., Seow, V., Iyer, A., Fairlie, D. P., & Sweet, M. J. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.07.001 · Cited by 45
Involvement of FcR in signal transduction of osteoclast-associated receptor (OSCAR)
Ishikawa, S. (2004) · International Immunology · doi:10.1093/intimm/dxh103 · Cited by 45
Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF in Humanized Mice
Li, Y., Chen, Q., Zheng, D., Yin, L., Chionh, Y. H., Wong, L. H., Tan, S. Q., Tan, T. C., Chan, J. K. Y., Alonso, S., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300742 · Cited by 45
Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia
Polk, A., Lu, Y., Wang, T., Seymour, E. K., Bailey, N. G., Singer, J. W., Boonstra, P. S., Lim, M. S., Malek, S. N., & Wilcox, R. A. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3099 · Cited by 47
S1P-S1PR1 Signaling: the “Sphinx” in Osteoimmunology
Xiao, L., Zhou, Y., Friis, T., Beagley, K. W., & Xiao, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01409 · Cited by 47
The Bone Morphogenetic Protein Pathway: The Osteoclastic Perspective
Lademann, F., Hofbauer, L. C., & Rauner, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.586031 · Cited by 45
Concerted Action of Smad and CREB-binding Protein Regulates Bone Morphogenetic Protein-2-stimulated Osteoblastic Colony-stimulating Factor-1 Expression
Ghosh‐Choudhury, N., Singha, P. K., Woodruff, K. A., Clair, P. S., Bsoul, S., Werner, S. L., & Choudhury, G. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511071200 · Cited by 45
The RANK/RANKL/osteoprotegerin system in rheumatoid arthritis: New insights from animal models
Neumann, E., Gay, S., & Müller‐Ladner, U. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21361 · Cited by 45
Kupffer cells required for high affinity peptide-induced deletion, not retention, of activated CD8+ T cells by mouse liver
Kuniyasu, Y., Marfani, S. M., Inayat, I., Sheikh, S. Z., & Mehal, W. Z. (2004) · Hepatology · doi:10.1002/hep.20153 · Cited by 45
Mechanisms modulating inflammatory osteolysis: A review with insights into therapeutic targets
Shi, W., & Siegal, G. P. (2008) · Pathology - Research and Practice · doi:10.1016/j.prp.2008.07.002 · Cited by 47
The cytokine stew and innate resistance to L. monocytogenes
Mocci, S., Dalrymple, S. A., Nishinakamura, R., & Murray, R. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00996.x · Cited by 45
Distinct in vivo functions of two macrophage subpopulations as evidenced by studies using macrophage‐deficient op/op mouse
Wiktor-Jędrzejczak, W., Szperl, M., Urbanowska, E., & Ansari, A. A. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220743 · Cited by 45
Reassignment of the human CSF1 gene to chromosome 1p13-p21
Morris, S. W., Valentine, M., Shapiro, D., Sublett, J., Deaven, L., Foust, J. T., Roberts, W., Cerretti, D., & Look, A. T. (1991) · Blood · doi:10.1182/blood.v78.8.2013.2013 · Cited by 45
Stem Cell Membrane‐Encapsulated Zeolitic Imidazolate Framework‐8: A Targeted Nano‐Platform for Osteogenic Differentiation
Ren, N., Liang, N., Dong, M., Feng, Z., Meng, L., Sun, C., Wang, A., Yu, X., Wang, W., Xie, J., et al. (2022) · Small · doi:10.1002/smll.202202485 · Cited by 44
Microglia – the brain’s busy bees
Cronk, J. C., & Kipnis, J. (2013) · F1000Prime Reports · doi:10.12703/p5-53 · Cited by 49
Rodent Osteoclast Cultures
Orriss, I. R., & Arnett, T. R. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-415-5_8 · Cited by 44
Macrophage Colony Stimulating Factor Derived from CD4+ T Cells Contributes to Control of a Blood-Borne Infection
Fontana, M. F., de Melo, G. L., Anidi, C. M., Hamburger, R., Kim, C. Y., Lee, S. Y., Pham, J., & Kim, C. C. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006046 · Cited by 44
Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment
Győri, D., Chessa, T. A. M., Hawkins, P. T., & Stephens, L. (2017) · Cancers · doi:10.3390/cancers9030024 · Cited by 45
Fibronectins containing extradomain A or B enhance osteoblast differentiation via distinct integrins
Sens, C., Huck, K., Pettera, S., Uebel, S. F. W., Wabnitz, G. H., Moser, M., & Nakchbandi, I. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.739987 · Cited by 47
Ascorbic acid promotes osteoclastogenesis from embryonic stem cells
Tsuneto, M., Yamazaki, H., Yoshino, M., Yamada, T., & Hayashi, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.016 · Cited by 44
Self-citation
Effects of macrophage‐colony‐stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor
Sasaki, A., Yokoo, H., Naito, M., Kaizu, C., Shultz, L. D., & Nakazato, Y. (2000) · Neuropathology · doi:10.1046/j.1440-1789.2000.00286.x · Cited by 37
Self-citation
Influence of RANKL inhibition on immune system in the treatment of bone diseases
Fouque-Aubert, A., & Chapurlat, R. D. (2007) · Joint Bone Spine · doi:10.1016/j.jbspin.2007.05.004 · Cited by 45
Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-γ, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
Horowitz, M., & Lorenzo, J. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50155-4 · Cited by 60
The role of nutrients, peptide growth factors and co-culture cells in development of preimplantation embryos in vitro
Kane, M. T., Carney, E. W., & Ellington, J. E. (1992) · Theriogenology · doi:10.1016/0093-691x(92)90237-l · Cited by 44
Immunophenotypic and ultrastructural heterogeneity of macrophage differentiation in bone marrow and fetal hematopoiesis of mouse in vitro and in vivo
Morioka, Y., Naito, M., Sato, T., & Takahashi, K. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.5.642 · Cited by 44
Dysosteosclerosis presents as an “Osteoclast-Poor” form of osteopetrosis: Comprehensive investigation of a 3-year-old girl and literature review
Whyte, M. P., Wenkert, D., McAlister, W. H., Novack, D. V., Nenninger, A. R., Zhang, X., Huskey, M., & Mumm, S. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.131 · Cited by 43
Emerging Roles of Osteoclasts in the Modulation of Bone Microenvironment and Immune Suppression in Multiple Myeloma
Mansour, A., Wakkach, A., & Blin‐Wakkach, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00954 · Cited by 44
Activin A receptor type 1–mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway
Omi, M., Kaartinen, V., & Mishina, Y. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009521 · Cited by 43
Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1/2 pathway
Lu, X., Su, N. Y., Yang, J., Huang, W., Li, C., Zhao, L., He, Q., Du, X., Shen, Y., Chen, B., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.123 · Cited by 44
Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Inhibits Tumor Necrosis Factor (TNF)-α-induced Osteoclast Differentiation by Down-regulation of Expression of TNF Receptors 1 and 2
Yogesha, S. D., Khapli, S. M., & Wani, M. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410828200 · Cited by 44
Colony Stimulating Factor-1–Induced Osteoclast Spreading Depends on Substrate and Requires the Vitronectin Receptor and the c-src Proto-Oncogene
Teti, A. M., Taranta, A., Migliaccio, S., Degiorgi, A., Santandrea, E., Villanova, I., Faraggiana, T., Chellaiah, M., & Hruska, K. A. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.1.50 · Cited by 43
Mechanisms of Osteoclast Dysfunction in Human Osteopetrosis: Abnormal Osteoclastogenesis and Lack of Osteoclast-Specific Adhesion Structures
Teti, A. M., Migliaccio, S., Taranta, A., Bernardini, S., Rossi, G., Luciani, M., Iacobini, M., Felice, L. D., Boldrini, R., Bosman, C., et al. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.12.2107 · Cited by 43
Osteoprotegerin and Osteoprotegerin-Ligand Balance: a New Paradigm in Bone Metabolism Providing New Therapeutic Targets
Lories, R. J. U., & Luyten, F. P. (2001) · Clinical Rheumatology · doi:10.1007/s100670170095 · Cited by 43
Human osteosarcoma-derived cell lines produce soluble factor(s) that induces differentiation of blood monocytes to osteoclast-like cells
Miyamoto, N., Higuchi, Y., Mori, K., Ito, M., Tsurudome, M., Nishio, M., Yamada, H., Sudo, A., Kato, K., Uchida, A., et al. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00134-5 · Cited by 43
Effects of Cyclic Tensile Forces on the Expression of Vascular Endothelial Growth Factor (VEGF) and Macrophage-colony-stimulating Factor (M-CSF) in Murine Osteoblastic MC3T3-E1 Cells
Motokawa, M., Kaku, M., Tohma, Y., Kawata, T., Fujita, T., Kohno, S., Tsutsui, K., Ohtani, J., Tenjo, K., Shigekawa, M., et al. (2005) · Journal of Dental Research · doi:10.1177/154405910508400505 · Cited by 42
Reduced Macrophage-Dependent Inflammation Improves Endothelin-1–Induced Vascular Injury
Javeshghani, D., Barhoumi, T., Idris-Khodja, N., Paradis, P., & Schiffrin, E. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01298 · Cited by 43
Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c‐Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice
Park, S., Kim, J., Cheon, Y., Baek, J. M., Ahn, S., Yoon, K., Lee, M. S., & Oh, J. (2016) · Phytotherapy Research · doi:10.1002/ptr.5565 · Cited by 44
Interface Oral Health Science 2014
Takahashi, N., Sasaki, K., & Suzuki, O. (2014) · Springer eBooks · doi:10.1007/978-4-431-55192-8 · Cited by 43
IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization
Ségaliny, A. I., Brion, R., Brulin, B., Maillasson, M., Charrier, C., Télétchéa, S., & Heymann, D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.029 · Cited by 45
Lipopolysaccharide from Prevotella nigrescens stimulates osteoclastogenesis in cocultures of bone marrow mononuclear cells and primary osteoblasts.
Chung, Y., Chang, E.-J., Kim, S.-J., Kim, H., Kim, H., Lee, S., & Ko, J. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00876.x · Cited by 49
CSF-1 Receptor-Dependent Colon Development, Homeostasis and Inflammatory Stress Response
Huynh, D., Yildiz, D. A., Malaterre, J., Chan, C. K., Dai, X.-M., Bertoncello, I., Stanley, E. R., & Ramsay, R. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056951 · Cited by 42
Fas Death Receptor Signaling Represses Monocyte Numbers and Macrophage Activation In Vivo
Brown, N. J., Hutcheson, J., Bickel, E., Scatizzi, J. C., Albee, L. D., Haines, G. K., Eslick, J., Bradley, K., Taricone, E., & Perlman, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7584 · Cited by 42
Macrophage Colony Stimulating-Factor Transcripts Are Differentially Regulated in Rat Bone-Marrow by Gender Hormones
Lea, C. K., Sarma, U., & Flanagan, A. M. (1999) · Endocrinology · doi:10.1210/endo.140.1.6451 · Cited by 42
Alcohol, Cytokines, and Estrogen in the Control of Bone Remodeling
Kimble, R. B. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03780.x · Cited by 42
Reciprocal osteoblastic and osteoclastic modulation in co-cultured MG63 osteosarcoma cells and human osteoclast precursors
Costa‐Rodrigues, J., Fernandes, A. C., & Fernandes, M. H. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23295 · Cited by 41
Osteocytes Produce Interferon-β as a Negative Regulator of Osteoclastogenesis
Hayashida, C., Ito, J., Nakayachi, M., Okayasu, M., Ohyama, Y., Hakeda, Y., & Sato, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.523811 · Cited by 41
A ERK/RSK‐mediated negative feedback loop regulates M‐CSF–evoked PI3K/AKT activation in macrophages
Wang, L., Iorio, C., Yan, K., Yang, H. H., Takeshita, S., Kang, S., Neel, B. G., & Yang, W. (2017) · The FASEB Journal · doi:10.1096/fj.201700672rr · Cited by 42
Osteogenic Effect of tsRNA-10277-Loaded Exosome Derived from Bone Mesenchymal Stem Cells on Steroid-Induced Osteonecrosis of the Femoral Head
Fang, S., He, T., Jiang, J., Li, Y., & Chen, P. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s258024 · Cited by 41
Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis
Adamopoulos, I. E., Xia, Z., Lau, Y. S., & Athanasou, N. A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.076 · Cited by 41
Osteoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony-stimulating factor production
Takami, M., Woo, J., & Nagai, K. (1999) · Cell and Tissue Research · doi:10.1007/s004419900092 · Cited by 41
Osteoclasts, mononuclear phagocytes, and c-Fos: new insight into osteoimmunology
Matsuo, K., & Ray, N. (2004) · The Keio Journal of Medicine · doi:10.2302/kjm.53.78 · Cited by 42
The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation
Mancini, A., Koch, A., Whetton, A. D., & Tamura, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207841 · Cited by 41
Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat
Dobbins, D. E., Sood, R. B., Hashiramoto, A., Hansen, C. T., Wilder, R. L., & Remmers, E. F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00598-3 · Cited by 41
Study of the Nonresorptive Phenotype of Osteoclast-like Cells from Patients with Malignant Osteopetrosis: A New Approach to Investigating Pathogenesis
Flanagan, A. M., Śarmā, U., Steward, C. G., Vellodi, A., & Horton, M. A. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.2.352 · Cited by 41
The role of macrophage colony-stimulating factor in hepatic glucan-induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony-stimulating factor.
Takahashi, K., Naito, M., Umeda, S., & Shultz, L. D. (1994) · PubMed Central · Cited by 41
Self-citation
Isolation of a murine osteoclast colony-stimulating factor.
Lee, M. Y., Eyre, D. R., & Osborne, W. R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8500 · Cited by 41
CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland
Dwyer, A. R., & Pixley, F. J. (2014) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-014-9320-1 · Cited by 40
Tetracyclines Convert the Osteoclastic-Differentiation Pathway of Progenitor Cells To Produce Dendritic Cell-like Cells
Kinugawa, S., Koide, M., Kobayashi, Y., Mizoguchi, T., Ninomiya, T., Muto, A., Kawahara, I., Nakamura, M., Yasuda, H., Takahashi, N., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101174 · Cited by 42
Secretomes from mesenchymal stem cells participate in the regulation of osteoclastogenesis in vitro
Ogata, K., Katagiri, W., & Hibi, H. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1986-x · Cited by 43
Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells
Liao, C., Chen, L., Luethy, A., Kim, Y., Kani, K., MacLeod, A. R., & Gross, M. E. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0138 · Cited by 40

Authors: Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I.
Affiliations: Kumamoto University (JP)
Jackson Laboratory (US)
ORCID: Yoshida, Hisahiro
Kunisada, Takahiro
Ogawa, Minetaro
Shultz, Leonard D.
Nishikawa, Shin-Ichi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1990-05
Volume: 345
Issue: 6274
Pages: 442-444
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/345442a0
OpenAlex: W2041138285
Cited by: 1,789
References: 19
Citations by year: 2026: 10 · 2025: 20 · 2024: 14 · 2023: 24 · 2022: 46 · 2021: 27 · 2020: 38 · 2019: 44 · 2018: 25 · 2017: 56 · 2016: 39 · 2015: 45 · 2014: 56 · 2013: 63 · 2012: 63
FWCI: 18.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: osteopetrosis, macrophage colony-stimulating factor, mouse chromosome 3, macrophage deficiency, bone remodeling, stop codon, gene mapping
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Colony-Stimulating Factors, Genes, Mice, Mutant Strains, Molecular Sequence Data, Osteopetrosis, RNA, Messenger, Polymerase Chain Reaction, Macrophage Colony-Stimulating Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks