Cited by 1,789Bone Metabolism and DiseasesOsteomyelitis and Bone Disorders ResearchPhagocytosis and Immune Regulation

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, Hisahiro, Hayashi, Shin-Ichi, Kunisada, Takahiro, Ogawa, Minetaro, Nishikawa, Satomi, Okamura, Hitoshi, Sudo, Tetsuo, Shultz, Leonard D., Nishikawa, Shin-Ichi·1990·Nature

DOI 10.1038/345442a0

Open this paper in CoChat — free account

Abstract

Mice homozygous for the recessive mutation osteopetrosis (op) on chromosome 3 have a restricted capacity for bone remodelling, and are severely deficient in mature macrophages and osteoclasts. Both cell populations originate from a common haemopoietic progenitor. As op/op mice are not cured by transplants of normal bone marrow cells, the defects in op/op mice may be associated with an abnormal haematopoietic microenvironment rather than with an intrinsic defect in haematopoietic progenitors. To investigate the molecular and biochemical basis of the defects caused by the op mutation, we established primary fibroblast cell lines from op/op mice and tested the ability of these cell lines to support the proliferation of macrophage progenitors. We show that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels. This defect in M-CSF production and the recent mapping of the Csfm structural gene near op on chromosome 3 suggest that op is a mutation within the Csfm gene itself. We have sequenced Csfm complementary DNA prepared from op/op fibroblasts and found a single base pair insertion in the coding region of the Csfm gene that generates a stop codon 21 base pairs downstream. Thus, the op mutation is within the Csfm coding region and we conclude that the pathological changes in this mutant result from the absence of M-CSF.

Integrity signals

Registry

Crossref · 10.1038/345442a0

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
Metcalf, D. (1989) · Nature · doi:10.1038/339027a0 · Cited by 1,023
CSF‐1—A mononuclear phagocyte lineage‐specific hemopoietic growth factor
Stanley, E. R., Guilbert, L. J., Tushinski, R. J., & Bartelmez, S. H. (1983) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240210206 · Cited by 516
Apparent role of the macrophage growth factor, CSF-1, in placental development
Pollard, J. W., Bartocci, A., Arceci, R. J., Orlofsky, A., Ladner, M. B., & Stanley, E. R. (1987) · Nature · doi:10.1038/330484a0 · Cited by 482
Osteopetrosis, a New Recessive Skeletal Mutation on Chromosome 12 of the Mouse
Marks, S. C., & LANE, P. W. (1976) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a108657 · Cited by 304
Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation.
Wiktor-Jędrzejczak, W., Ahmed, A. A., Szczylik, C. A., & Skelly, R. R. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.5.1516 · Cited by 293
B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.
Ogawa, M., Nishikawa, S.-I., Ikuta, K., Yamamura, F., Naito, M., Takahashi, K., & Nishikawa, S.-I. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02949.x · Cited by 281
Self-citation
Human CSF‐1: gene structure and alternative splicing of mRNA precursors.
Ladner, M. B., Martin, G. A., Noble, J. A., Nikoloff, D. M., Tal, R., Kawasaki, E. S., & White, T. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02561.x · Cited by 228
The Molecular Control of Blood Cell Development
Sachs, L. (1987) · Science · doi:10.1126/science.3317831 · Cited by 221
Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis
Regenstreif, L. J., & Rossant, J. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90319-9 · Cited by 181

Flagged first, then by citations

Show all 19 references

Research works printed but not linked: 1

Saiki, R. K. et al. Science 239, 487–491 (1988). · DOI · Paper page

Sorted by citations

Items 201–300 of 1,001

CSF‐1 Controls Cerebellar Microglia and Is Required for Motor Function and Social Interaction
Kana, V., Desland, F. A., Casanova-Acebes, M., Ayata, P., Badimon, A., Nabel, E., Yamamuro, K., Sneeboer, M., Tan, I.-L., Flanigan, M. E., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182037 · Cited by 220
Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
Gouon-Evans, V., Lin, E. Y., & Pollard, J. W. (2002) · Breast Cancer Research · doi:10.1186/bcr441 · Cited by 217
Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands
HOROWITZ, M., Xi, Y., WILSON, K., & Kacena, M. A. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00030-7 · Cited by 215
Physiologic root resorption in primary teeth: molecular and histological events
Harokopakis-Hajishengallis, E. (2007) · Journal of Oral Science · doi:10.2334/josnusd.49.1 · Cited by 214
Immunologic basis of transplant-associated arteriosclerosis.
Shi, C., Lee, W. S., He, Q., Zhang, D., Fletcher, D. L., Newell, J. B., & Haber, E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4051 · Cited by 213
Insight into the microphthalmia gene
Moore, K. J. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89143-x · Cited by 213
Origin and functional heterogeneity of non‐lymphoid tissue dendritic cells in mice
Helft, J., Ginhoux, F., Bogunovic, M., & Mérad, M. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00885.x · Cited by 224
Interaction between osteoblast and osteoclast: impact in bone disease.
Phan, T. C. A., Xu, J., & Zheng, M. (2004) · PubMed · doi:10.14670/hh-19.1325 · Cited by 213
Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor α–transgenic mice
Li, P., Schwarz, E. M., O’Keefe, R. J., Ma, L., Looney, R. J., Ritchlin, C. T., Boyce, B. F., & Xing, L. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11419 · Cited by 208
Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis
Segawa, M., Fukada, S., Yamamoto, Y., Yahagi, H., Kanematsu, M., SATO, M., Ito, T., Uezumi, A., HAYASHI, S., & Miyagoe‐Suzuki, Y. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.08.008 · Cited by 221
Self-citation
The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants
Scimeca, J., Franchi, A. J., Trojani, C., Parrinello, H., Grosgeorge, J., Robert, C., Jaillon, O., Poirier, C., Gaudray, P., & Carle, G. F. (2000) · Bone · doi:10.1016/s8756-3282(99)00278-1 · Cited by 204
CTLA-4 directly inhibits osteoclast formation
Axmann, R., Herman, S., Zaiss, M. M., Franz, S., Polzer, K., Zwerina, J., i, M. H., Smolen, J. S., & Schett, G. A. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080713 · Cited by 201
Biology of the TRANCE axis
Walsh, M. C., & Choi, Y. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00027-3 · Cited by 201
Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis
Söderström, K., Stein, E. A., Colmenero, P., Purath, U., Müller‐Ladner, U., de Matos, C. T., Tarner, I. H., Robinson, W. H., & Engleman, E. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000546107 · Cited by 206
Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer
Sevenich, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00697 · Cited by 206
Osteoclasts, Master Sculptors of Bone
Novack, D. V., & O’Brien, C. A. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-040919 · Cited by 208
Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1.
Srivastava, S., Weitzmann, M. N., Kimble, R. B., Rizzo, M., Zahner, M., Milbrandt, J., Ross, F. P., & Pacifici, R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4561 · Cited by 197
Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes
Akagawa, K., Takasuka, N., Nozaki, Y., Komuro, I., Azuma, M., Ueda, M., Naito, M., & Takahashi, K. (1996) · Blood · doi:10.1182/blood.v88.10.4029.bloodjournal88104029 · Cited by 196
17β-Estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α.
Saika, M., Inoue, D., Kido, S., & Matsumoto, T. (2001) · Endocrinology · doi:10.1210/endo.142.6.8220 · Cited by 194
Delayed hematopoietic development in osteopetrotic (op/op) mice.
Begg, S. K., Radley, J., Pollard, J. W., Chisholm, O., Stanley, E. R., & Bertoncello, I. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.1.237 · Cited by 194
Lipopolysaccharide Promotes the Survival of Osteoclasts Via Toll-Like Receptor 4, but Cytokine Production of Osteoclasts in Response to Lipopolysaccharide Is Different from That of Macrophages
Itoh, K., Udagawa, N., Kobayashi, K., Suda, K., Li, X., Takami, M., Okahashi, N., Nishihara, T., & Takahashi, N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3688 · Cited by 193
The Interplay between the Bone and the Immune System
Mori, G., D’Amelio, P., Faccio, R., & Brunetti, G. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/720504 · Cited by 196
Bone loss: Factors that regulate osteoclast differentiation - an update
Roux, S., & Orcel, P. (2000) · Arthritis Research & Therapy · doi:10.1186/ar127 · Cited by 193
Structure and Development of the Skeleton
Marks, S. C., & Odgren, P. R. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50103-7 · Cited by 194
The Potential of Probiotics as a Therapy for Osteoporosis
Collins, F. L., Rios‐Arce, N. D., Schepper, J. D., Parameswaran, N., & McCabe, L. R. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0015-2016 · Cited by 194
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer
Lin, W., Xu, D., Austin, C. D., Caplazi, P., Senger, K., Sun, Y., Jeet, S., Young, J., Delarosa, D., Suto, E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02019 · Cited by 192
Antigen Markers of Macrophage Differentiation in Murine Tissues
Gordon, S., Lawson, L. J., Rabinowitz, S. S., Crocker, P. R., Morris, L., & Perry, V. H. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77377-8_1 · Cited by 187
Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling
Riddle, R. C., Khatri, R., Schipani, E., & Clemens, T. L. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0477-9 · Cited by 186
Breast cancer bone metastases: pathogenesis and therapeutic targets
Brook, N., Brook, E., Dharmarajan, A., Dass, C. R., & Chan, A. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.01.003 · Cited by 194
Development and heterogeneity of macrophages and their related cells through their differentiation pathways
Takahashi, K., Naito, M., & Takeya, M. (1996) · Pathology International · doi:10.1111/j.1440-1827.1996.tb03641.x · Cited by 186
Roles of stromal cell RANKL, OPG, and M‐CSF expression in biphasic TGF‐β regulation of osteoclast differentiation
Karst, M., Gorny, G., Galvin, R. J. S., & Oursler, M. J. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20036 · Cited by 184
A RANKL–PKCβ–TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclastsPreprint
Ferron, M., Settembre, C., Shimazu, J., Lacombe, J., Kato, S., Rawlings, D. J., Ballabio, A., & Karsenty, G. (2013) · Genes & Development · doi:10.1101/gad.213827.113 · Cited by 187
Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice
Bergmann, C., Hoefer, I. E., Meder, B., Roth, H., van Royen, N., Breit, S. M., Jost, M. M., Aharinejad, S., Hartmann, S., & Buschmann, I. R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0206087 · Cited by 181
Colony stimulating factor 1 is required for mammary gland development during pregnancy.
Pollard, J. W., & Hennighausen, L. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9312 · Cited by 180
Green tea and bone metabolism
Shen, C., Yeh, J. K., Cao, J., & Wang, J.-S. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.06.008 · Cited by 181
Ontogeny and Functional Specialization of Dendritic Cells in Human and Mouse
Haniffa, M. A., Collin, M. P., & Ginhoux, F. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00001-6 · Cited by 199
Role of cytokines in the regulation of bone resorption
Roodman, G. D. (1993) · Calcified Tissue International · doi:10.1007/bf01673412 · Cited by 177
The Role of Estrogen Receptors and Androgen Receptors in Sex Steroid Regulation of B Lymphopoiesis
Smithson, G. M., Couse, J. F., Lubahn, D. B., Korach, K. S., & Kincade, P. W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.27 · Cited by 176
Role of colony-stimulating factors in osteoclast development
Takahashi, N., Udagawa, N., Akatsu, T., Tanaka, H., 塩野目, 学., & Suda, T. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060912 · Cited by 176
RANKL as the master regulator of osteoclast differentiation
Takayanagi, H. (2021) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01191-1 · Cited by 175
Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-β1-dependent cells
Hemmi, H., Yoshino, M., Yamazaki, H., Naito, M., Iyoda, T., Omatsu, Y., Shimoyama, S., Letterio, J. J., Nakabayashi, T., Tagaya, H., et al. (2001) · International Immunology · doi:10.1093/intimm/13.5.695 · Cited by 175
Self-citation
The Role of Receptor Activator of Nuclear Factor- B Ligand and Osteoprotegerin in the Pathogenesis and Treatment of Metabolic Bone Diseases
Hofbauer, L. C., & Heufelder, A. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6702 · Cited by 178
MITF and PU.1 Recruit p38 MAPK and NFATc1 to Target Genes during Osteoclast Differentiation
Sharma, S. M., Bronisz, A., Hu, R., Patel, K., Mansky, K. C., Sif, S., & Ostrowski, M. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609723200 · Cited by 174
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages
Voehringer, D., van Rooijen, N., & Locksley, R. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1106686 · Cited by 173
Molecular regulation of osteoclast activity
Bruzzaniti, A., & Baron, R. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9009-x · Cited by 181
Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity
Martin, T. J., & Ng, K. W. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240560312 · Cited by 176
Journal of Bone and Mineral Research
Mundy, G. R. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650081315 · Cited by 173
The molecular mechanism behind bone remodelling: a review
Proff, P., & Römer, P. (2009) · Clinical Oral Investigations · doi:10.1007/s00784-009-0268-2 · Cited by 183
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
Hashimoto, D., Chow, A. T., Greter, M., Saenger, Y. M., Kwan, W.-H., Leboeuf, M., Ginhoux, F., Ochando, J., Kunisaki, Y., van Rooijen, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101709 · Cited by 173
Maintaining homeostatic control of periodontal bone tissue
Hathaway‐Schrader, J. D., & Novince, C. M. (2021) · Periodontology 2000 · doi:10.1111/prd.12368 · Cited by 174
Receptor-type Protein-tyrosine Phosphatase ζ Is a Functional Receptor for Interleukin-34
Nandi, S., Cioce, M., Yeung, Y.-G., Nieves, E., Tesfa, L., Lin, H., Hsu, A. W., Halenbeck, R., Cheng, H.-Y., Gökhan, Ş., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442731 · Cited by 170
Insulin cell mass is altered in Csf1 op /Csf1 op macrophage-deficient mice
Banaei-Bouchareb, L., Gouon–Evans, V., Samara‐Boustani, D., Castellotti, M. C., Czernichow, P., Pollard, J. W., & Polak, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103591 · Cited by 176
Suppression of Osteoprotegerin Expression by Prostaglandin E2 Is Crucially Involved in Lipopolysaccharide-Induced Osteoclast Formation
Suda, K., Udagawa, N., Sato, N., Takami, M., Itoh, K., Woo, J., Takahashi, N., & Nagai, K. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2504 · Cited by 171
Pathogenesis of Paget Disease of Bone
Ralston, S. H., & Layfield, R. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9599-0 · Cited by 170
Demystifying the development of dendritic cell subtypes, a little
Naik, S. H. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.28 · Cited by 173
Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages
Naito, M., Umeda, S., Yamamoto, T., Moriyama, H., Umezu, H., Hasegawa, G., Usuda, H., Shultz, L. D., & Takahashi, K. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.2.133 · Cited by 169
Self-citation
Inhibition of Posttraumatic Microglial Proliferation in a Genetic Model of Macrophage Colony‐Stimulating Factor Deficiency in the Mouse
Raivich, G., Moreno-Flores, M. T., Möller, J. C., & Kreutzberg, G. W. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00552.x · Cited by 170
Linkage of M-CSF Signaling to Mitf, TFE3, and the Osteoclast Defect in Mitfmi/mi Mice
Weilbaecher, K. N., Motyckova, G., Huber, W. E., Takemoto, C. M., Hemesath, T. J., Xu, Y., Hershey, C. L., Dowland, N., Wells, A. G., & Fisher, D. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00360-4 · Cited by 169
Inhibition of Hormone and Cytokine-stimulated Osteoclastogenesis and Bone Resorption by Interleukin-4 and Interleukin-13 Is Associated with Increased Osteoprotegerin and Decreased RANKL and RANK in a STAT6-dependent Pathway
Palmqvist, P., Lundberg, P., Persson, E., Johansson, A., Lundgren, I., Lie, A., Conaway, H. H., & Lerner, U. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510160200 · Cited by 167
Modulation of Growth Factor/Cytokine Synthesis and Signaling by 1α,25-Dihydroxyvitamin D3: Implications in Cell Growth and Differentiation
Gürlek, A., Pittelkow, M. R., & Kumar, R. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0044 · Cited by 167
Osteotropic cancers: From primary tumor to bone
Buijs, J. T., & van der Pluijm, G. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.044 · Cited by 175
Recent advances in osteoclast biology and pathological bone resorption.
Blair, H. C., & Athanasou, N. A. (2004) · PubMed · doi:10.14670/hh-19.189 · Cited by 169
Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus.
Harrington, M. A., Konicek, B. W., Song, A., Xia, X., Fredericks, W. J., & Rauscher, F. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36920-0 · Cited by 167
Identification of cell cycle–arrested quiescent osteoclast precursors in vivo
Mizoguchi, T., Muto, A., Udagawa, N., Arai, A., Yamashita, T., Hosoya, A., Ninomiya, T., Nakamura, H., Yamamoto, Y., Kinugawa, S., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806139 · Cited by 166
Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives
Terkawi, M. A., Matsumae, G., Shimizu, T., Takahashi, D., Kadoya, K., & Iwasaki, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031786 · Cited by 174
Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis.
Fujikawa, Y., Sabokbar, A., Neale, S. D., & Athanasou, N. A. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.11.816 · Cited by 165
Control of RANKL gene expression
O’Brien, C. A. (2009) · Bone · doi:10.1016/j.bone.2009.08.050 · Cited by 170
Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor.
Naito, M., Hayashi, S., Yoshida, H., Nishikawa, S., Shultz, L. D., & Takahashi, K. (1991) · PubMed Central · Cited by 163
Self-citation
Induction of Osteoclast Differentiation by Runx2 through Receptor Activator of Nuclear Factor-κB Ligand (RANKL) and Osteoprotegerin Regulation and Partial Rescue of Osteoclastogenesis in Runx2–/– Mice by RANKL Transgene
Enomoto, H., Shiojiri, S., Hoshi, K., Furuichi, T., Fukuyama, R., Yoshida, C. A., Kanatani, N., Nakamura, R. M., Mizuno, A., Zanma, A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302457200 · Cited by 163
Fenton Reaction Is Primarily Involved in a Mechanism of (−)-Epigallocatechin-3-gallate to Induce Osteoclastic Cell Death
Nakagawa, H., Wachi, M., Woo, J., Kato, M., Kasai, S., Takahashi, F., Lee, I.-S., & Nagai, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6622 · Cited by 161
Efficient differentiation and function of human macrophages in humanized CSF-1 mice
Rathinam, C., Poueymirou, W. T., Rojas, J., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Rongvaux, A., Eynon, E. E., Manz, M. G., & Flavell, R. A. (2011) · Blood · doi:10.1182/blood-2010-12-326926 · Cited by 160
Osteoimmunology: Interactions of the Immune and Skeletal Systems
Rho, J., Takami, M., & Choi, Y. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)12997-9 · Cited by 159
Minireview: Transcriptional Regulation in Development of Bone
Kobayashi, T., & Kronenberg, H. M. (2004) · Endocrinology · doi:10.1210/en.2004-1343 · Cited by 164
Mice Lacking Both Granulocyte Colony-Stimulating Factor (CSF) and Granulocyte-Macrophage CSF Have Impaired Reproductive Capacity, Perturbed Neonatal Granulopoiesis, Lung Disease, Amyloidosis, and Reduced Long-Term Survival
Seymour, J. F., Lieschke, G. J., Grail, D., Quilici, C., HODGSON, G. S., & Dunn, A. R. (1997) · Blood · doi:10.1182/blood.v90.8.3037 · Cited by 156
Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor
Chiţu, V., & Stanley, E. R. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.10.004 · Cited by 163
In vitro and ex vivo models of adipocytes
Dufau, J., Shen, J. X., Couchet, M., Barbosa, T. D. C., Mejhert, N., Massier, L., Griseti, E., Mouisel, É., Amri, E., Lauschke, V. M., et al. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00519.2020 · Cited by 169
Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation
Kim, K., Cho, M., Lee, S., Oh, H.-J., Kang, C.-M., Ju, J. H., Min, S., Cho, Y. G., Park, S., & Kim, H. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.03.004 · Cited by 155
The Critical Role of IL-34 in Osteoclastogenesis
Chen, Z. J., Büki, K. G., Vääräniemi, J., Gu, G., & Väänänen, H. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018689 · Cited by 158
NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation
Crotti, T. N., Flannery, M. R., Walsh, N. C., Fleming, J. D., Goldring, S. R., & McHugh, K. P. (2006) · Gene · doi:10.1016/j.gene.2005.12.012 · Cited by 157
Deficiency of Osteoclasts in Osteopetrotic Mice Is Due to a Defect in the Local Microenvironment Provided by Osteoblastic Cells*
Takahashi, N., Udagawa, N., Akatsu, T., Tanaka, H., Isogai, Y., & Suda, T. (1991) · Endocrinology · doi:10.1210/endo-128-4-1792 · Cited by 154
Secretory Granule Proteases in Rat Mast Cells. Cloning of 10 Different Serine Proteases and a Carboxypeptidase A from Various Rat Mast Cell Populations
Lützelschwab, C. M., Pejler, G., Aveskogh, M., & Hellman, L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.1.13 · Cited by 153
Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development
Pawson, T. J., & Bernstein, A. (1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90276-c · Cited by 153
Bone marrow transplantation for autosomal recessive osteopetrosis A report from the Working Party on Inborn Errors of the European Bone Marrow Transplantation Group
Gerritsen, E. J. A., Vossen, J. M. J. J., Fasth, A. L., Friedrich, W., Morgan, G., Padmos, A., Vellodi, A., Porras, Ó., O’Meara, A., Porta, F., et al. (1994) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)82004-9 · Cited by 151
Origins and functions of phagocytes in the embryo
Lichanska, A. M., & Hume, D. A. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00157-0 · Cited by 155
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization
Miyamoto, K., Yoshida, S., Kawasumi, M., Hashimoto, K., Kimura, T., Sato, Y., Kobayashi, T., Miyauchi, Y., Hoshi, H., Iwasaki, R., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101890 · Cited by 155
Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line
Mackie, P. S., Fisher, J. L., Zhou, H., & Choong, P. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1679 · Cited by 149
Osteoblasts induce Ca 2+ oscillation-independent NFATc1 activation during osteoclastogenesis
Kuroda, Y., Hisatsune, C., Nakamura, T., Matsuo, K., & Mikoshiba, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800642105 · Cited by 148
The Skin-Resident Immune Network
Tay, S. S., Roediger, B., Tong, P. L., Tikoo, S., & Weninger, W. (2014) · Current Dermatology Reports · doi:10.1007/s13671-013-0063-9 · Cited by 147
Macrophages and CSF-1
Jones, C. V., & Ricardo, S. D. (2013) · Organogenesis · doi:10.4161/org.25676 · Cited by 152
Macrophages: important accessory cells for reproductive function
Cohen, P. E., Nishimura, K., Zhu, L., & Pollard, J. W. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.765 · Cited by 147
N ew M olecules in the T umor N ecrosis F actor L igand and R eceptor S uperfamilies with I mportance for P hysiological and P athological B one R esorption
Lerner, U. H. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500202 · Cited by 147
Cells of Bone
Takahashi, N., Udagawa, N., Takami, M., & Suda, T. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1/50109-8 · Cited by 151
The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans
Welm, A. L., Sneddon, J. B., Taylor, C., Nuyten, D. S. A., van de Vijver, M. J., Hasegawa, B. H., & Bishop, J. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702095104 · Cited by 146
Increased Serum Enzyme Levels Associated with Kupffer Cell Reduction with No Signs of Hepatic or Skeletal Muscle Injury
Radi, Z. A., Koza‐Taylor, P., Bell, R. R., Obert, L., Runnels, H. A., BEEBE, J. S., Lawton, M. P., & Sadis, S. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.029 · Cited by 145
Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis
Hwang, S.-J., Choi, B., Kang, S.-S., Chang, J.-H., Kim, Y., Chung, Y., Sohn, D. H., So, M. W., Lee, C., Robinson, W. H., et al. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3693 · Cited by 149
The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors
Hirayama, F., Lyman, S., Clark, S., & Ogawa, M. (1995) · Blood · doi:10.1182/blood.v85.7.1762.bloodjournal8571762 · Cited by 144
Self-citation
Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition
Prada, C. E., Jousma, E., Rizvi, T. A., Wu, J., Dunn, R. S., Mayes, D. A., Cancelas, J. A., Dombi, E., Kim, M., West, B. L., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1056-7 · Cited by 143
Absence of Colony Stimulating Factor-1 in Osteopetrotic (csfmop/csfmop) Mice Disrupts Estrous Cycles and Ovulation1
Cohen, P. E., Zhu, L., & Pollard, J. W. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.1.110 · Cited by 143
Incomplete restoration of colony-stimulating factor 1 (CSF-1) function in CSF-1–deficient Csf1op/Csf1op mice by transgenic expression of cell surface CSF-1
Dai, X.-M., Zong, X.-H., Sylvestre, V. T., & Stanley, E. R. (2003) · Blood · doi:10.1182/blood-2003-08-2739 · Cited by 144
Immunologically Relevant Cells in the Uterus1
Hunt, J. S. (1994) · Biology of Reproduction · doi:10.1095/biolreprod50.3.461 · Cited by 143

Authors: Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I.
Affiliations: Kumamoto University (JP)
Jackson Laboratory (US)
ORCID: Yoshida, Hisahiro
Kunisada, Takahiro
Ogawa, Minetaro
Shultz, Leonard D.
Nishikawa, Shin-Ichi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1990-05
Volume: 345
Issue: 6274
Pages: 442-444
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/345442a0
OpenAlex: W2041138285
Cited by: 1,789
References: 19
Citations by year: 2026: 10 · 2025: 20 · 2024: 14 · 2023: 24 · 2022: 46 · 2021: 27 · 2020: 38 · 2019: 44 · 2018: 25 · 2017: 56 · 2016: 39 · 2015: 45 · 2014: 56 · 2013: 63 · 2012: 63
FWCI: 18.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: osteopetrosis, macrophage colony-stimulating factor, mouse chromosome 3, macrophage deficiency, bone remodeling, stop codon, gene mapping
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Colony-Stimulating Factors, Genes, Mice, Mutant Strains, Molecular Sequence Data, Osteopetrosis, RNA, Messenger, Polymerase Chain Reaction, Macrophage Colony-Stimulating Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks