Cited by 1,789Bone Metabolism and DiseasesOsteomyelitis and Bone Disorders ResearchPhagocytosis and Immune Regulation

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, Hisahiro, Hayashi, Shin-Ichi, Kunisada, Takahiro, Ogawa, Minetaro, Nishikawa, Satomi, Okamura, Hitoshi, Sudo, Tetsuo, Shultz, Leonard D., Nishikawa, Shin-Ichi·1990·Nature

DOI 10.1038/345442a0

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Abstract

Mice homozygous for the recessive mutation osteopetrosis (op) on chromosome 3 have a restricted capacity for bone remodelling, and are severely deficient in mature macrophages and osteoclasts. Both cell populations originate from a common haemopoietic progenitor. As op/op mice are not cured by transplants of normal bone marrow cells, the defects in op/op mice may be associated with an abnormal haematopoietic microenvironment rather than with an intrinsic defect in haematopoietic progenitors. To investigate the molecular and biochemical basis of the defects caused by the op mutation, we established primary fibroblast cell lines from op/op mice and tested the ability of these cell lines to support the proliferation of macrophage progenitors. We show that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels. This defect in M-CSF production and the recent mapping of the Csfm structural gene near op on chromosome 3 suggest that op is a mutation within the Csfm gene itself. We have sequenced Csfm complementary DNA prepared from op/op fibroblasts and found a single base pair insertion in the coding region of the Csfm gene that generates a stop codon 21 base pairs downstream. Thus, the op mutation is within the Csfm coding region and we conclude that the pathological changes in this mutant result from the absence of M-CSF.

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Authors: Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I.
Affiliations: Kumamoto University (JP)
Jackson Laboratory (US)
ORCID: Yoshida, Hisahiro
Kunisada, Takahiro
Ogawa, Minetaro
Shultz, Leonard D.
Nishikawa, Shin-Ichi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1990-05
Volume: 345
Issue: 6274
Pages: 442-444
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/345442a0
OpenAlex: W2041138285
Cited by: 1,789
References: 19
Citations by year: 2026: 10 · 2025: 20 · 2024: 14 · 2023: 24 · 2022: 46 · 2021: 27 · 2020: 38 · 2019: 44 · 2018: 25 · 2017: 56 · 2016: 39 · 2015: 45 · 2014: 56 · 2013: 63 · 2012: 63
FWCI: 18.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: osteopetrosis, macrophage colony-stimulating factor, mouse chromosome 3, macrophage deficiency, bone remodeling, stop codon, gene mapping
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Colony-Stimulating Factors, Genes, Mice, Mutant Strains, Molecular Sequence Data, Osteopetrosis, RNA, Messenger, Polymerase Chain Reaction, Macrophage Colony-Stimulating Factor, Mice

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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