Cited by 429Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerPlanarian Biology and Electrostimulation

The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.

The establishment of spemann's organizer and patterning of the vertebrate embryo

Open access

De Robertis, E. M., Larraín, J., Oelgeschläger, M., Wessely, O.·2000·Nature Reviews Genetics

DOI 10.1038/35042039PMC PMC2291143

Open this paper in CoChat — free account

Abstract

Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.

Integrity signals

Registry

Crossref · 10.1038/35042039

Cites

115 of 115 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Wnt signaling and cancer
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
Zimmerman, L. B., Jesús-Escobar, J. M. D., & Harland, R. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80133-6 · Cited by 1,639
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
Smith, W. C., & Harland, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90316-5 · Cited by 1,184
Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4
Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127
Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
Sasai, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90068-x · Cited by 1,122
The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation
Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907

Flagged first, then by citations

Show all 115 references

Sorted by citations

Items 201–300 of 428

Terminal addition in a cellular world
Torday, J. S., & Miller, W. B. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.12.003 · Cited by 26
Reassembling gastrulation
Schauer, A., & Heisenberg, C. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.12.014 · Cited by 25
Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer
Reid, C. D., Zhang, Y., Sheets, M. D., & Kessler, D. S. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.05.018 · Cited by 25
Intracellular Communication among Morphogen Signaling Pathways during Vertebrate Body Plan Formation
Takebayashi‐Suzuki, K., & Suzuki, A. (2020) · Genes · doi:10.3390/genes11030341 · Cited by 24
Acupuncture and moxibustion reduces neuronal edema in Alzheimer′s disease rats
Sun, G., Zhou, H., Kong, L.-H., Du, Y., Shen, F., Wang, S., Chen, B., & Zeng, X. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.133148 · Cited by 24
Cutting, pasting and painting: experimental embryology and neural development
Schoenwolf, G. C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097549 · Cited by 24
BMP antagonism by Spemann's organizer regulates rostral–caudal fate of mesoderm
Lane, M. C., Davidson, L. A., & Sheets, M. D. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.012 · Cited by 24
Heterochrony as Diachronically Modified Cell-Cell Interactions
Torday, J. S. (2016) · Biology · doi:10.3390/biology5010004 · Cited by 23
Neural stemness unifies cell tumorigenicity and pluripotent differentiation potential
Zhang, M., Liu, Y., Shi, L., Fang, L., Xu, L., & Cao, Y. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102106 · Cited by 23
Boundaries and Functional Domains in the Animal/Vegetal Axis of Xenopus Gastrula Mesoderm
Kumano, G., Ezal, C., & Smith, W. C. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0341 · Cited by 23
Mechanisms of Development
ten Donkelaar, H. J. (2006) · Springer eBooks · doi:10.1007/3-540-34659-7_2 · Cited by 22
Self-regulation of the head-inducing properties of the Spemann organizer
Inui, M., Montagner, M., Ben‐Zvi, D., Martello, G., Soligo, S., Manfrin, A., Aragona, M., Enzo, E., Zacchigna, L., Zanconato, F., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203000109 · Cited by 22
BMPs Regulate msx Gene Expression in the Dorsal Neuroectoderm of Drosophila and Vertebrates by Distinct Mechanisms
Esteves, F. F., Springhorn, A., Kague, É., Taylor, E., Pyrowolakis, G., Fisher, S., & Bier, E. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004625 · Cited by 22
The polychaete-to-clitellate transition: An EvoDevo perspective
Kuo, D. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.01.016 · Cited by 23
XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination
Onai, T., Matsuo‐Takasaki, M., Inomata, H., Aramaki, T., Matsumura, M., Yakura, R., Sasai, N., & Sasai, Y. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601684 · Cited by 22
Epigenetic control of embryonic renal cell differentiation by L1 retrotransposon
Ramos, K. S., Montoya-Durango, D. E., Teneng, I., Nañez, A., & Stribinskis, V. (2011) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20786 · Cited by 22
Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the BMP signaling pathway
Zhao, H., Cao, Y., & Grunz, H. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00069-1 · Cited by 22
Conservation and Diversification of an Ancestral Chordate Gene Regulatory Network for Dorsoventral Patterning
Kozmiková, I., Smolikova, J., Vlček, Č., & Kozmík, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014650 · Cited by 21
miRNAs and morphogen gradients
Inui, M., Montagner, M., & Piccolo, S. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.11.013 · Cited by 21
Tbx2 regulates anterior neural specification by repressing FGF signaling pathway
Cho, G.-S., Park, D., Choi, S., & Han, J. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.020 · Cited by 21
Expression of Transposable Elements in Neural Tissues during Xenopus Development
Faunes, F., Sánchez, N., Moreno, M., Olivares, G. H., Lee‐Liu, D., Almonacid, L. I., Slater, A. W., Norambuena, T., Taft, R. J., Mattick, J. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022569 · Cited by 20
Self-citation
Coordinated regulation of the dorsal‐ventral and anterior‐posterior patterning of Xenopus embryos by the BTB / POZ zinc finger protein Zbtb14
Takebayashi‐Suzuki, K., Konishi, H., Miyamoto, T., Nagata, T., Uchida, M., & Suzuki, A. (2018) · Development Growth & Differentiation · doi:10.1111/dgd.12431 · Cited by 20
Cloning of noggin gene from hydra and analysis of its functional conservation using Xenopus laevis embryos
Chandramore, K., Ito, Y., Takahashi, S., Asashima, M., & Ghaskadbi, S. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00412.x · Cited by 20
Mechanistic insights from the LHX1‐driven molecular network in building the embryonic head
McMahon, R., Sibbritt, T., Salehin, N., Osteil, P., & Tam, P. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12609 · Cited by 20
Mechanisms of Development
ten Donkelaar, H. J., & Fritzsch, B. (2023) · Springer eBooks · doi:10.1007/978-3-031-26098-8_2 · Cited by 20
Kruppel‐like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning
Gao, Y. H., Cao, Q., Lü, L., Zhang, X., Zhang, Z., Dong, X., Jia, W., & Cao, Y. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24310 · Cited by 20
Groucho corepressor proteins regulate otic vesicle outgrowth
Bajoghli, B., Aghaallaei, N., & Czerny, T. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20398 · Cited by 21
Recent advances in neural development
Kiecker, C. M., & Lumsden, A. (2009) · F1000 Biology Reports · doi:10.3410/b1-1 · Cited by 20
Morphogenic machines evolve more rapidly than the signals that pattern them: lessons from amphibians
Shook, D. R., & Keller, R. E. (2007) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21204 · Cited by 20
Hydra, a candidate for an alternative model in environmental genomics
Yum, S., Woo, S., Lee, A., Won, H., & Kim, J. (2014) · Molecular & Cellular Toxicology · doi:10.1007/s13273-014-0038-3 · Cited by 19
Hemichordata
Kaul-Strehlow, S., & Röttinger, É. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1856-6_2 · Cited by 19
WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Proliferation during Planarian Regeneration
Pascual-Carreras, E., Sureda-Gómez, M., Barrull-Mascaró, R., Jordà, N., Gelabert, M., Coronel-Córdoba, P., Saló, E., & Adell, T. (2021) · Genes · doi:10.3390/genes12010101 · Cited by 17
The second polar body contributes to the fate asymmetry in the mouse embryo
Jin, H., Yang, H. N., Wang, H., Li, J. X. H., Shen, W., Zhang, L., Chen, L., Jia, S., Yuan, P., Chen, H., et al. (2022) · National Science Review · doi:10.1093/nsr/nwac003 · Cited by 18
A p38 MAPK–CREB pathway functions to pattern mesoderm in Xenopus
Keren, A., Keren‐Politansky, A., & Bengal, E. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.07.010 · Cited by 18
Klf4 is required for germ-layer differentiation and body axis patterning duringXenopusembryogenesis
Cao, Q., Zhang, X., Lü, L., Yang, L., Gao, J., Gao, Y. H., Ma, H., & Cao, Y. (2012) · Development · doi:10.1242/dev.082024 · Cited by 17
Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia
He, A. B.-L., Yang, N., Man, C. H., Ng, N. K. L., Cher, C. Y., Leung, H. C., Kan, L. L. H., Cheng, B. Y.-L., Lam, S. S. Y., Wang, M. L., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201910895 · Cited by 17
Osteogenic Growth Factors and Cytokines and Their Role in Bone Repair
Gerstenfeld, L. C., Edgar, C. M., Kakar, S., Jacobsen, K. A., & Einhorn, T. A. (2007) · Springer eBooks · doi:10.1007/978-1-84628-366-6_2 · Cited by 17
Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation
Halder, D., Park, J. H., Choi, M., Chai, J. C., Lee, Y. S., Mandal, C., Jung, K. H., & Chai, Y. G. (2013) · Journal of Applied Toxicology · doi:10.1002/jat.2832 · Cited by 16
hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation
Oren, A., Toporik, A., Biton, S., Almogy, N., Eshel, D., Bernstein, J., Savitsky, K., & Rotman, G. (2004) · Gene · doi:10.1016/j.gene.2004.01.029 · Cited by 16
Normal Function of Myf5 During Gastrulation Is Required for Pharyngeal Arch Cartilage Development in Zebrafish Embryos
Lin, C., Lee, H., Chen, H., Hsieh, C.-C., & Tsai, H. (2013) · Zebrafish · doi:10.1089/zeb.2013.0903 · Cited by 16
Totipotency, cell differentiation and reprogramming in humans
Hansis, C. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60644-x · Cited by 16
Siamois functions in the early blastula to induce Spemann's organiser
Kodjabachian, L., & Lemaire, P. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00484-1 · Cited by 16
Lysosomal degradation of the maternal dorsal determinant Hwa safeguards dorsal body axis formation
Zhu, X., Wang, P., Wei, J., Li, Y., Zhai, J., Zheng, T., & Tao, Q. (2021) · EMBO Reports · doi:10.15252/embr.202153185 · Cited by 15
The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling
Wang, F., Hu, W., Xian, J., Ohnuma, S., & Brenton, J. D. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.11.010 · Cited by 15
The Xenopus homologue of Down syndrome critical region protein 6 drives dorsoanterior gene expression and embryonic axis formation by antagonising polycomb group proteins
Li, H., Grifone, R., Saquet, A., Carron, C., & Shi, D. (2013) · Development · doi:10.1242/dev.098319 · Cited by 15
Acquisition of the dorsal structures in chordate amphioxus
Morov, A. R., Ukizintambara, T., Sabirov, R. M., & Yasui, K. (2016) · Open Biology · doi:10.1098/rsob.160062 · Cited by 17
JmjC Domain-containing Protein 6 (Jmjd6) Derepresses the Transcriptional Repressor Transcription Factor 7-like 1 (Tcf7l1) and Is Required for Body Axis Patterning during Xenopus Embryogenesis
Zhang, X., Gao, Y. H., Lü, L., Zhang, Z., Gan, S., Xu, L., Lei, A., & Cao, Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646554 · Cited by 15
The serpin PN1 is a feedback regulator of FGF signaling in germ layer and primary axis formation
Acosta, H., Iliev, D., Grahn, T. H. M., Gouignard, N., Maccarana, M., Griesbach, J., Herzmann, S., Sagha, M., Climent, M., & Pera, E. M. (2015) · Development · doi:10.1242/dev.113886 · Cited by 15
Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo
Pera, E. M., Hou, S., Strate, I., Wessely, O., & Robertis, E. M. D. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052003ep · Cited by 15
Self-citation
The role and limits of a gradient based explanation of morphogenesis: a theoretical consideration
Tsikolia, N. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052053nt · Cited by 15
Systematic screening for genes specifically expressed in the anterior neuroectoderm during early Xenopus development
Takahashi, N., Tochimoto, N., Ohmori, S., Mamada, H., Itoh, M., Inamori, M., Shinga, J., Osada, S., & Taira, M. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052083nt · Cited by 14
The Competence of Marginal Zone Cells to Become Spemann's Organizer Is Controlled by Xcad2
Levy, V., Marom, K., Rousso, S. Z., Koutsia, N., Yelin, R., & Fainsod, A. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0705 · Cited by 15
Integrin‐α3 mediates binding of Chordin to the cell surface and promotes its endocytosis
Larraı́n, J., Brown, C. T., & Robertis, E. M. D. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor902 · Cited by 15
Self-citation
Characterization of small RNAs in Xenopus tropicalis gastrulae
Faunes, F., Almonacid, L. I., Melo, F., & Larraı́n, J. (2012) · genesis · doi:10.1002/dvg.22012 · Cited by 14
Self-citation
Phylogenetic Origins of Brain Organisers
Robertshaw, E., & Kiecker, C. M. (2012) · Scientifica · doi:10.6064/2012/475017 · Cited by 14
Evolution of cis-regulatory modules for the head organizer gene goosecoid in chordates: comparisons between Branchiostoma and Xenopus
Yasuoka, Y., Tando, Y., Kubokawa, K., & Taira, M. (2019) · Zoological Letters · doi:10.1186/s40851-019-0143-1 · Cited by 13
Cell signaling molecules in hydra: insights into evolutionarily ancient functions of signaling pathways
Ghaskadbi, S. (2020) · The International Journal of Developmental Biology · doi:10.1387/ijdb.190243sg · Cited by 14
Xenopus as a Model System for the Study of GOLPH2/GP73 Function: Xenopus golph2 Is Required for Pronephros Development
Li, L., Wen, L., Gong, Y., Mei, G., Liu, J., Chen, Y., & Peng, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038939 · Cited by 14
T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development
Bou‐Rouphael, J., & Durand, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.784998 · Cited by 13
Small proteins, big roles: The signaling protein Apela extends the complexity of developmental pathways in the early zebrafish embryo
Reichman‐Fried, M., & Raz, E. (2014) · BioEssays · doi:10.1002/bies.201400048 · Cited by 13
Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo
Li, S., Lou, X., Wang, J., Liu, B., Ma, L., Su, Z., & Ding, X. (2008) · Differentiation · doi:10.1111/j.1432-0436.2008.00269.x · Cited by 12
Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm
Vorwald, P. P., & Robertis, E. M. D. (2011) · Gene Expression Patterns · doi:10.1016/j.gep.2011.07.004 · Cited by 13
Expression of the genes siamois, engrailed-2, bmp4 and myf5 during Xenopus development in presence of the marine toxins okadaic acid and palytoxin
Franchini, A., Casarini, L., Malagoli, D., & Ottaviani, E. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2009.07.027 · Cited by 13
Cholesterol homeostasis in development: The role of Xenopus 7‐dehydrocholesterol reductase (Xdhcr7) in neural development
Tadjuidje, E., & Hollemann, T. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20860 · Cited by 13
ADMP2 is essential for primitive blood and heart development in Xenopus
Kumano, G., Ezal, C., & Smith, W. C. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.010 · Cited by 13
Extending the maternal-zygotic effect with genomic imprinting
Li, X. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq028 · Cited by 12
Sperm and mammalian polarity
Pedersen, R. A. (2001) · Nature · doi:10.1038/35054182 · Cited by 12
Spemann-Mangold organizer and mesoderm induction
Asashima, M., & Satou-Kobayashi, Y. (2024) · Cells and Development · doi:10.1016/j.cdev.2024.203903 · Cited by 12
How does the mouse get its trunk?
Dunn, N. R., & Hogan, B. L. M. (2001) · Nature Genetics · doi:10.1038/86829 · Cited by 11
Signaling crosstalk between TGFβ and Dishevelled/Par1b
Mamidi, A., Inui, M., Manfrin, A., Soligo, S., Enzo, E., Aragona, M., Cordenonsi, M., Wessely, O., Dupont, S., & Piccolo, S. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.50 · Cited by 11
Self-citation
Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes
Chen, Y., Harris, M. P., Levesque, M. P., Nüsslein‐Volhard, C., & Sonawane, M. S. (2012) · Mechanisms of Development · doi:10.1016/j.mod.2012.03.003 · Cited by 11
Alkylglycerol monooxygenase, a heterotaxy candidate gene, regulates left-right patterning via Wnt signaling
Duncan, A. R., González, D. P., Viso, F. D., Robson, A., Khokha, M. K., & Griffin, J. N. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.07.019 · Cited by 11
The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus
Zhang, F., Zhu, X., Wang, P., He, Q., Huang, H., Zheng, T., Li, Y., Jia, H., Xu, L., Zhao, H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100342118 · Cited by 13
Deletion Mutants of BMP Folding Variants Act as BMP Antagonists and Are Efficient Inhibitors for Heterotopic Ossification
Weber, F. E., Schmoekel, H. G., Oelgeschläger, M., Nickel, J., Maly, F. E., Hortschansky, P., & Grätz, K. W. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.12.2142 · Cited by 11
Self-citation
Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo
Tarbashevich, K., Ghosh, A., Das, A., Kuilya, D., Sharma, S. N., Sinha, S., & Raz, E. (2025) · Nature Communications · doi:10.1038/s41467-025-58207-5 · Cited by 10
Identification of a second Xenopus twisted gastrulation gene.
Oelgeschläger, M., Tran, U., Grubisic, K., & Robertis, E. M. D. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.15005575 · Cited by 10
Self-citation
xBtg-x regulates Wnt/β-Catenin signaling during early Xenopus development
Wessely, O., Kim, J. I., Tran, U., Fuentealba, L. C., & Robertis, E. M. D. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.03.033 · Cited by 12
Self-citation
Enhancers
Cho, K. W. Y. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.53 · Cited by 10
The Organizer and Beyond
Shilo, B. (2001) · Cell · doi:10.1016/s0092-8674(01)00429-9 · Cited by 10
Movers and shakers: evolution and development of the mesoderm
Davidson, B. (2007) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21199 · Cited by 9
Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment
Satou-Kobayashi, Y., Kim, J., Fukamizu, A., & Asashima, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-93524-x · Cited by 11
Overexpression of the secreted factor Mig30 expressed in the Spemann organizer impairs morphogenetic movements during Xenopus gastrulation
Hayata, T., Tanegashima, K., Takahashi, S., Sogame, A., & Asashima, M. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00638-4 · Cited by 9
Plasma membrane cholesterol depletion disrupts prechordal plate and affects early forebrain patterning
Reis, A. H., Coburn, K. L. A., Louza, M. P., Cerqueira, D. M., Aguiar, D. P., Silva-Cardoso, L., Mendes, F. A., de Andrade, L. R., Einicker‐Lamas, M., Atella, G. C., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.003 · Cited by 9
XIC Is Required for Siamois Activity and Dorsoanterior Development
Snider, L. D., & Tapscott, S. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5061-5072.2005 · Cited by 9
New twists on embryonic patterning
Robertis, E. M. D., & Bouwmeester, T. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve163 · Cited by 9
Comparative Metabolomics of Small Molecules Specifically Expressed in the Dorsal or Ventral Marginal Zones in Vertebrate Gastrula
Suzuki, Y., Hayasaka, R., Hasebe, M., Ikeda, S., Soga, T., Tomita, M., Hirayama, A., & Kuroda, H. (2022) · Metabolites · doi:10.3390/metabo12060566 · Cited by 8
Inductive activity of the posterior tip of planula in the marine hydroid Dynamena pumila
Kraus, Y. A. (2011) · Russian Journal of Developmental Biology · doi:10.1134/s106236041102010x · Cited by 8
Zili Antagonizes Bmp Signaling to Regulate Dorsal-Ventral Patterning during Zebrafish Early Embryogenesis
Li, D., Sun, H., Deng, W., Tao, D., Liu, Y., & Ma, Y. (2011) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.28.397 · Cited by 8
Mechanisms of Development
ten Donkelaar, H. J. (2014) · Springer eBooks · doi:10.1007/978-3-642-54687-7_2 · Cited by 8
Regional Specification of the Head and Trunk–Tail Organizers of a Urodele (Cynops pyrrhogaster) Embryo Is Patterned during Gastrulation
Kanéda, T., Miyazaki, K., Kudo, R., Goto, K., Sakaguchi, K., Matsumoto, M., Todaka, S., Yoshinaga, K., & SUZUKI, A. S. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0587 · Cited by 8
Xtbx6r, a novel T-box gene expressed in the paraxial mesoderm, has anterior neural-inducing activity
Yabe, S. G., Tazumi, S., Yokoyama, J., & Uchiyama, H. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.062177sy · Cited by 8
General Aspects of Genetic Improvement (Traditional and Transgenic Methods) Aiming to Food Biofortification
Hina, A., Abbasi, A., Imtiaz, S., Haq, I. U., Hassan, A. U., & Chaudhry, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-33957-8_4 · Cited by 7
Cell lineage–guided mass spectrometry reveals increased energy metabolism and reactive oxygen species in the vertebrate organizer
Baxi, A. B., Li, J., Quach, V. M., Pade, L. R., Moody, S. A., & Nemes, P. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311625121 · Cited by 7
Goosecoid Controls Neuroectoderm Specification via Dual Circuits of Direct Repression and Indirect Stimulation in Xenopus Embryos
Umair, Z., Kumar, V., Goutam, R. S., Kumar, S., Lee, U., & Kim, J. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0055 · Cited by 7
Essential Role of RIG-I in Hematopoietic Precursor Emergence in Primitive Hematopoiesis during Zebrafish Development
Wang, Y., Nie, L., Xu, X., Shao, T., Fan, D., Lin, A., Xiang, L., & Shao, J.-Z. (2022) · ImmunoHorizons · doi:10.4049/immunohorizons.2200028 · Cited by 7
Transgenic Reporter Tools Tracing Endogenous Canonical Wnt Signaling in Xenopus
Denayer, T., Tran, H. T., & Vleminckx, K. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-469-2_24 · Cited by 7
Xom induces proteolysis of β‐catenin through GSK 3β‐mediated pathway
Wu, B., Gao, H., Le, Y., Wu, X., & Zhu, Z. (2017) · FEBS Letters · doi:10.1002/1873-3468.12949 · Cited by 7
Using ascidian embryos to study the evolution of developmental gene regulatory networks
Cone, A. C., & Zeller, R. (2005) · Canadian Journal of Zoology · doi:10.1139/z04-165 · Cited by 8
Molecular study of mouse peri‐implantation development using the in vitro culture of aggregated inner cell mass
Alarcón, V. B., & Marikawa, Y. (2003) · Molecular Reproduction and Development · doi:10.1002/mrd.20015 · Cited by 7
Induction and Differentiation of theXenopusCiliated Embryonic Epidermis
Cibois, M., Scerbo, P., Thomé, V., Pasini, A., & Kodjabachian, L. (2014) · doi:10.1002/9781118492833.ch7 · Cited by 7

Authors: De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Oelgeschläger, M.
Wessely, O.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 1
Issue: 3
Pages: 171-181
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/35042039
PMC: PMC2291143
OpenAlex: W1533376056
Cited by: 429
References: 115
Citations by year: 2026: 3 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 16 · 2019: 7 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 18 · 2013: 9 · 2012: 18
FWCI: 2.06
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD021502)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords: Spemann's organizer, dorsal-ventral axis, embryonic patterning, cell-to-cell communication, mesoderm induction, growth factor gradients, Xenopus, zebrafish, tissue homeostasis
MeSH terms: Amino Acid Sequence, Animals, Glycoproteins, Molecular Sequence Data, Vertebrates, Sequence Homology, Amino Acid, Body Patterning, Intercellular Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The establishment of spemann's organizer and patterning of the vertebrate embryo

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks