The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
The establishment of spemann's organizer and patterning of the vertebrate embryo
Open accessAbstract
Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.
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“For example, overexpression of Xwnt8, Dsh, β-catenin or dominant-negative GSK3 can induce secondary axis formation.56”
From Wnt signal transduction pathways (2008) · cites this paper as [56]
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Metadata
- Authors
- De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature Reviews Genetics
- Published
- 2000-12
- Volume
- 1
- Issue
- 3
- Pages
- 171-181
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC2291143
- OpenAlex
- W1533376056
- Cited by
- 429
- References
- 115
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 16 · 2019: 7 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 18 · 2013: 9 · 2012: 18
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD021502)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Spemann's organizer, dorsal-ventral axis, embryonic patterning, cell-to-cell communication, mesoderm induction, growth factor gradients, Xenopus, zebrafish, tissue homeostasis
- MeSH terms
- Amino Acid Sequence, Animals, Glycoproteins, Molecular Sequence Data, Vertebrates, Sequence Homology, Amino Acid, Body Patterning, Intercellular Signaling Peptides and Proteins
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