The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Lethality and centrality in protein networks
Open accessAbstract
Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeast Saccharomyces cerevisiae is affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.
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Citations
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“whereas the deletion of a random node with few connections does not influence the topology of the network [65, 66].”
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Metadata
- Authors
- Jeong, H., Mason, S. P., Barabási, A.-L., & Oltvai, Z. N.
- Venue
- Nature
- Published
- 2001-05
- Volume
- 411
- Issue
- 6833
- Pages
- 41-42
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2130790725
- Cited by
- 5,287
- References
- 3
- FWCI
- 44.73
- Type
- journal article
- Language
- en
- Open access
- green
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