Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

Mack, David H.; Vartikar, Jai; Pipas, James M.; Laimins, Laimonis A.

doi:10.1038/363281a0

Cited by 322Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

Mack, David H., Vartikar, Jai, Pipas, James M., Laimins, Laimonis A.·1993·Nature

DOI 10.1038/363281a0

Open this paper in CoChat — free account

Abstract

The p53 protein is apparently central to the development of human cancers because both alleles are often found to be mutated in different tumour types. In addition, wild-type p53 can inhibit transformation by viral and cellular oncogenes in vitro, so p53 has been classified as a tumour suppressor. Investigations of the normal function of p53 have indicated that at least one of its functions could involve the activation of gene expression through the binding of specific DNA-regulatory sequences. Also, overexpression of p53 can mediate growth arrest and repress transcription from a variety of promoters. We demonstrate here both in vivo and in vitro that expression of wild-type p53 specifically represses the activity of promoters whose initiation is dependent on the presence of a TATA box. Promoters whose accurate transcription is directed by a pyrimidine-rich initiator element, however, are immune to the effects of p53. Furthermore, we observe that repression is mediated by an interaction of p53 with basal transcription factor(s). Thus, p53 appears to repress the activity of certain promoters through direct communication with TATA box-dependent basal transcription machinery.

Integrity signals

Registry

Crossref · 10.1038/363281a0

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

p53 was first reported to bind to coactivators including TATA-box binding protein, NF-Y, and Sp1, and to interfere with their transactivator function.
“In 1993, p53 was first reported to bind to coactivators, including the TATA-box binding protein,73, 74 the CCAAT-box binding factor (NF-Y)75 and specificity protein 1 (Sp1) that binds to GC-boxes,76 and to interfere with their transactivator function.”
From Census and evaluation of p53 target genes (2017) · cites this paper as [73]

p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018 · see citing works
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,673 · see citing works
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761 · see citing works
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987 · see citing works
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
Baker, S. J., Markowitz, S. D., Fearon, E. R., Willson, J. K. V., & Vogelstein, B. (1990) · Science · doi:10.1126/science.2144057 · Cited by 1,742 · see citing works
Mechanism of transcriptional activation by Sp1: Evidence for coactivators
Pugh, B. F., & Tjian, R. (1990) · Cell · doi:10.1016/0092-8674(90)90683-6 · Cited by 1,031 · see citing works
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells
Maltzman, W., & Czyzyk, L. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.9.1689 · Cited by 893 · see citing works
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Scheffner, M., Münger, K., Byrne, J. C., & Howley, P. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5523 · Cited by 850 · see citing works
Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53
Chin, K., Ueda, K., Pastan, I. H., & Gottesman, M. M. (1992) · Science · doi:10.1126/science.1346476 · Cited by 726 · see citing works
Transcription from a TATA-less promoter requires a multisubunit TFIID complex.Preprint
Pugh, B. F., & Tjian, R. (1991) · Genes & Development · doi:10.1101/gad.5.11.1935 · Cited by 613 · see citing works
Wild-type p53 activates transcription in vitro
Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R., & Prives, C. (1992) · Nature · doi:10.1038/358083a0 · Cited by 579 · see citing works
Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.Preprint
Martinez, J., Georgoff, I., Martinez, J., & Levine, A. J. (1991) · Genes & Development · doi:10.1101/gad.5.2.151 · Cited by 528 · see citing works
Wild-type p53 binds to the TATA-binding protein and represses transcription.
Seto, E., Usheva, A., Zambetti, G. P., Momand, J. A., Horikoshi, N., Weinmann, R. S., Levine, A. J., & Shenk, T. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12028 · Cited by 504 · see citing works
Wild-type p53 can down-modulate the activity of various promoters.
Ginsberg, D., Mechta‐Grigoriou, F., Yaniv, M., & Oren, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.9979 · Cited by 434 · see citing works
Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription
Inostroza, A., Mermelstein, F. H., Ha, I., Lane, W. S., & Reinberg, D. (1992) · Cell · doi:10.1016/0092-8674(92)90172-9 · Cited by 377 · see citing works
Family of proteins that interact with TFIID and regulate promoter activity
Meisterernst, M., & Roeder, R. G. (1991) · Cell · doi:10.1016/0092-8674(91)90530-c · Cited by 320 · see citing works
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.Preprint
Zambetti, G. P., Bargonetti, J., Walker, K. K., Prives, C. L., & Levine, A. J. (1992) · Genes & Development · doi:10.1101/gad.6.7.1143 · Cited by 311 · see citing works
Activation of class II gene transcription by regulatory factors is potentiated by a novel activity.
Meisterernst, M., Roy, A., Lieu, H. M., & Roeder, R. (1991) · Cell · doi:10.1016/0092-8674(91)90443-3 · Cited by 281 · see citing works
Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53‐mediated repression of transcription.
Lechner, M. S., Mack, D. H., Finicle, A. B., Crook, T., Vousden, K. H., & Laimins, L. A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05375.x · Cited by 272 · see citing works
Self-citation
OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts
Westin, G., Gerster, T., Müller, M. M., Schaffner, G., & Schaffner, W. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.17.6787 · Cited by 248 · see citing works
Purification of PCNA as a nucleotide excision repair protein
Nichols, A. F., & Sancar, A. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.10.2441 · Cited by 224 · see citing works
Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription.
O'Shea-Greenfield, A., & Smale, S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48443-8 · Cited by 190 · see citing works
Promoter specificity of basal transcription factors
Parvin, J. D., Timmers, H. T. M., & Sharp, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90084-p · Cited by 133 · see citing works
The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site
Morris, G. F., & Mathews, M. B. (1991) · Journal of Virology · doi:10.1128/jvi.65.12.6397-6406.1991 · Cited by 72 · see citing works

Flagged first, then by citations

Sorted by citations

WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321 · see citing works
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,338 · see citing works
Tumor spectrum analysis in p53-mutant mice
Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051 · see citing works
Regulation of the G2/M transition by p53
Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,553 · see citing works
Control of apoptosis by p53
Fridman, J. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1207116 · Cited by 1,401 · see citing works
Clinical Implications of the p53 Tumor-Suppressor Gene
Harris, C. C., & Hollstein, M. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310283291807 · Cited by 1,317 · see citing works
Life, death, and the pursuit of apoptosis.Preprint
White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,300 · see citing works
The RNA Polymerase II Core Promoter
Smale, S. T., & Kadonaga, J. T. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161520 · Cited by 1,138 · see citing works
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes
Caelles, C., Helmberg, A., & Karin, M. (1994) · Nature · doi:10.1038/370220a0 · Cited by 843 · see citing works
Identification of a p53-dependent negative response element in the bcl-2 gene.
Miyashita, T., Harigai, M., Hanada, M., & Reed, J. C. (1994) · PubMed · Cited by 746 · see citing works
Two Polymorphic Variants of Wild-Type p53 Differ Biochemically and Biologically
Thomas, M., Kalita, A., Labrecque, S., Pim, D., Banks, L., & Matlashewski, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1092 · Cited by 700 · see citing works
Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies
Harris, C. C. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.20.1442 · Cited by 682 · see citing works
Twenty years of p53 research: structural and functional aspects of the p53 protein
May, P., & May, E. (1999) · Oncogene · doi:10.1038/sj.onc.1203285 · Cited by 663 · see citing works
Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint
Zhao, R., Gish, K., Murphy, M. E., Yin, Y., Notterman, D. A., Hoffman, W. H., Tom, E., Mack, D. H., & Levine, A. J. (2000) · Genes & Development · doi:10.1101/gad.14.8.981 · Cited by 631 · see citing works
Self-citation
Induction of apoptosis in HeLa cells by trans-activation-deficient p53.Preprint
Haupt, Y., Rowan, S., Shaulian, E., Vousden, K. H., & Oren, M. (1995) · Genes & Development · doi:10.1101/gad.9.17.2170 · Cited by 547 · see citing works
Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes
Smale, S. T. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(96)00206-0 · Cited by 540 · see citing works
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.Preprint
Wagner, A. J., Kokontis, J. M., & Hay, N. (1994) · Genes & Development · doi:10.1101/gad.8.23.2817 · Cited by 540 · see citing works
p53 in growth control and neoplasia
Gottlieb, T. M., & Oren, M. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(95)00019-c · Cited by 481 · see citing works
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.
Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Spillare, E. A., Weinberg, W. C., Felley‐Bosco, E., Wang, X. W., Geller, D. A., Tzeng, E., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2442 · Cited by 463 · see citing works
Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
Dumaz, N., & Meek, D. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.7002 · Cited by 455 · see citing works
p53 regulates a G 2 checkpoint through cyclin B1
Innocente, S. A., Abrahamson, J., Cogswell, J. P., & Lee, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2147 · Cited by 435 · see citing works
Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes.
Hussain, S. P., & Harris, C. C. (1998) · PubMed · Cited by 409 · see citing works
Sequence-specific transcriptional activation is essential for growth suppression by p53.
Pietenpol, J. A., Tokino, T., Thiagalingam, S., El‐Deiry, W. S., Kinzler, K. W., & Vogelstein, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.1998 · Cited by 406 · see citing works
DNA topoisomerase I is involved in both repression and activation of transcription
Merino, A., Madden, K., Lane, W. A. S., Champoux, J., & Reinberg, D. (1993) · Nature · doi:10.1038/365227a0 · Cited by 380 · see citing works
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.
Werner, H., Karnieli, E., Rauscher, F. J., & LeRoith, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8318 · Cited by 370 · see citing works
Inhibition of Cyclooxygenase-2 Gene Expression by p53
Subbaramaiah, K., Altorki, N. K., Chung, W. J., MESTRE, J. R., Sampat, A., & Dannenberg, A. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10911 · Cited by 350 · see citing works
The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53
Robertson, K. D., & Jones, P. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6457 · Cited by 352 · see citing works
Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.
O'Connor, P. M., Jackman, J., Jondle, D., Bhatia, K. G., MAGRATH, I. T., & Kohn, K. W. (1993) · PubMed · Cited by 306 · see citing works
The requirement for the p53 proline‐rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression
Venot, C., Maratrat, M., Dureuil, C., Conseiller, E., Bracco, L. P., & Debussche, L. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4668 · Cited by 292 · see citing works
Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53
Zhai, W., & Comai, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5930-5938.2000 · Cited by 289 · see citing works
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.Preprint
Yew, P. R., Liu, X., & Berk, A. J. (1994) · Genes & Development · doi:10.1101/gad.8.2.190 · Cited by 282 · see citing works
Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
Komarova, E. A., Chernov, M. V., Franks, R., Wang, K., Armin, G., Zelnick, C. R., Chin, D. M., Bacus, S. S., Stark, G. R., & Gudkov, A. V. (1997) · The EMBO Journal · doi:10.1093/emboj/16.6.1391 · Cited by 272 · see citing works
p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1
Milne, D., Campbell, L. E., Campbell, D. G., & Meek, D. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5511 · Cited by 257 · see citing works
Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation
Truant, R., Antunović, J., Greenblatt, J., Prives, C. L., & Cromlish, J. A. (1995) · Journal of Virology · doi:10.1128/jvi.69.3.1851-1859.1995 · Cited by 256 · see citing works
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.Preprint
Maheswaran, S., Englert, C., Bennett, P., Heinrich, G., & Haber, D. A. (1995) · Genes & Development · doi:10.1101/gad.9.17.2143 · Cited by 246 · see citing works
p53 domains: identification and characterization of two autonomous DNA-binding regions.Preprint
Wang, Y., Reed, M. J., Wang, P., Stenger, J. E., Mayr, G. A., Anderson, M. E., Schwedes, J. F., & Tegtmeyer, P. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2575 · Cited by 239 · see citing works
Transcriptional activation by p53 correlates with suppression of growth but not transformation
Crook, T. J. (1994) · Cell · doi:10.1016/0092-8674(94)90071-x · Cited by 233 · see citing works
Core promoters: active contributors to combinatorial gene regulation: Figure 1.Preprint
Smale, S. T. (2001) · Genes & Development · doi:10.1101/gad.937701 · Cited by 233 · see citing works
Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression.
Zhang, L., Yu, D., Hu, M., Xiong, S., Lang, A., Ellis, L. M., & Pollock, R. E. (2000) · PubMed · Cited by 230 · see citing works
Negative regulation of bcl-2 expression by p53 in hematopoietic cells
Wu, Y.-L., Mehew, J. W., Heckman, C. A., Arcinas, M., & Boxer, L. M. (2001) · Oncogene · doi:10.1038/sj.onc.1204067 · Cited by 221 · see citing works
Wild-type p53 negatively regulates the expression of a microtubule-associated protein.Preprint
Murphy, M. E., Hinman, A. M., & Levine, A. J. (1996) · Genes & Development · doi:10.1101/gad.10.23.2971 · Cited by 221 · see citing works
p53 Activation in Adipocytes of Obese Mice
Yahagi, N., Shimano, H., Matsuzaka, T., Najima, Y., Sekiya, M., Nakagawa, Y., Ide, T., Tomita, S., Okazaki, H., Tamura, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302364200 · Cited by 220 · see citing works
Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene
Chen, J., Lin, J., & Levine, A. J. (1995) · Molecular Medicine · doi:10.1007/bf03401562 · Cited by 214 · see citing works
Tumor suppressor genes
Hinds, P. W., & Weinberg, R. A. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90102-3 · Cited by 207 · see citing works
p53 Signaling and Cell Cycle Checkpoints
Stewart, Z. A., & Pietenpol, J. A. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000199t · Cited by 200 · see citing works
Transcriptional repression mediated by the p53 tumour suppressor
Ho, J., & Benchimol, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401191 · Cited by 200 · see citing works
Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma.
Pal, S., Datta, K., & Mukhopadhyay, D. (2001) · PubMed · Cited by 197 · see citing works
Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases
Takenaka, I. M., Morin, F., Seizinger, B. R., & Kley, N. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5405 · Cited by 197 · see citing works
Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein
Sabbatini, P., Chiou, S., Rao, L., & White, E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.1060 · Cited by 191 · see citing works
p53 is a general repressor of RNA polymerase III transcription
Cairns, C. A., & White, R. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3112 · Cited by 190 · see citing works
The p53 gene and its role in human brain tumors
Bögler, O., Huang, H., Kleihues, P., & Cavenee, W. K. (1995) · Glia · doi:10.1002/glia.440150311 · Cited by 188 · see citing works
Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest
Ryan, K. M., & Vousden, K. H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3692 · Cited by 184 · see citing works
Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression
Horikoshi, N., Usheva, A., Chen, J., Levine, A. J., Weinmann, R. S., & Shenk, T. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.227 · Cited by 182 · see citing works
Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis
Drane, P., Bravard, A., Bouvard, V., & May, E. (2001) · Oncogene · doi:10.1038/sj.onc.1204101 · Cited by 180 · see citing works
TATA‐binding protein‐associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA‐less class II promoter.
Martinez, E., Chiang, C.-M., Ge, H., & Roeder, R. G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06610.x · Cited by 175 · see citing works
Functional interactions between p53 and the TFIIH complex are affected by tumour‐associated mutations.
Léveillard, T., Anděra, L., Bissonnette, N., Schaeffer, L., Bracco, L. P., Egly, J., & Wasylyk, B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00506.x · Cited by 173 · see citing works
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
Ossovskaya, V., Mazo, I. A., Chernov, M. V., Chernova, O. B., Strezoska, Ž., Kondratov, R. V., Stark, G. R., Chumakov, P. M., & Gudkov, A. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10309 · Cited by 170 · see citing works
The tumour suppressor protein p53 can repress transcription of cyclin B
Krause, K. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.22.4410 · Cited by 170 · see citing works
Transcriptional Repression by Msx-1 Does Not Require Homeodomain DNA-Binding Sites
Catron, K. M., Zhang, H., Marshall, S. C., Inostroza, J. A., Wilson, J. M., & Abate, C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.861 · Cited by 167 · see citing works
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer
Hussain, S. P., & Harris, C. C. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s1383-5742(99)00028-9 · Cited by 162 · see citing works
The transcription factor p53: Not a repressor, solely an activator.
Fischer, M., Steiner, L., & Engeland, K. (2014) · Cell Cycle · doi:10.4161/15384101.2014.949083 · Cited by 153 · see citing works
Regulation of ES cell differentiation by functional and conformational modulation of p53
Sabapathy, K., Klemm, M., Jaenisch, R., & Wagner, E. F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6217 · Cited by 159 · see citing works
Hormonal Regulation of Human Corticotropin-Releasing Hormone Gene Expression: Implications for the Stress Response and Immune/Inflammatory Reaction
Vamvakopoulos, N. C., & Chrousos, G. P. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-4-409 · Cited by 158 · see citing works
p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor
Yun, J., Chae, H., Choy, H. E., Chung, J., Yoo, H., Han, M.-H., & Shin, D. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29677 · Cited by 155 · see citing works
p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1
Ohlsson, C., Kley, N., Werner, H., & LeRoith, D. (1998) · Endocrinology · doi:10.1210/endo.139.3.5832 · Cited by 157 · see citing works
Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.
Milne, D., Campbell, D. G., Caudwell, F. B., & Meek, D. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37101-6 · Cited by 154 · see citing works
Inhibition of DNA Topoisomerase IIα Gene Expression by the p53 Tumor Suppressor
Wang, Q., Zambetti, G. P., & Suttle, D. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.389 · Cited by 149 · see citing works
Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.
Webster, N. J. G., Resnik, J. L., Reichart, D. B., Strauss, B. E., Haas, M., & Seely, B. L. (1996) · PubMed · Cited by 150 · see citing works
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.
Shen, Y. H., & Shenk, T. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8940 · Cited by 148 · see citing works
The p53 tumor suppressor gene in breast cancer
Elledge, R. M., & Allred, D. C. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00666204 · Cited by 147 · see citing works
Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53
Kunz, C., Pebler, S., Otte, J., & von der Ahe, D. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.18.3710 · Cited by 144 · see citing works
Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.
Ueba, T., Nosaka, T., Takahashi, J. A., Shibata, F., Florkiewicz, R. Z., Vogelstein, B., Oda, Y., Kikuchi, H., & Hatanaka, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9009 · Cited by 142 · see citing works
Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells.
Chung, T., Lee, Y., Ko, J., & Kim, C. (2003) · PubMed · Cited by 137 · see citing works
A novel cytostatic process enhances the productivity of Chinese hamster ovary cells
Fussenegger, M., Mazur, X., & Bailey, J. E. (1997) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19970920)55:6 · Cited by 136 · see citing works
Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells.
Pani, G., Bedogni, B., Anzevino, R., Colavitti, R., Palazzotti, B., Borrello, S., & Galeotti, T. (2000) · PubMed · Cited by 134 · see citing works
Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB and Myc/Max
Kirch, H.-C., Flaswinkel, S., Rumpf, H., Brockmann, D., & Esche, H. (1999) · Oncogene · doi:10.1038/sj.onc.1202626 · Cited by 135 · see citing works
Prognostic and predictive value of p53 and p21 in breast cancer
Elledge, R. M., & Allred, D. C. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006163101948 · Cited by 132 · see citing works
Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.
Morris, G. F., Bischoff, J. R., & Mathews, M. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.895 · Cited by 130 · see citing works
p53 oligomerization and DNA looping are linked with transcriptional activation.
Stenger, J. E., Tegtmeyer, P., Mayr, G. A., Reed, M. J., Wang, Y., Wang, P., Hough, P. V. C., & Mastrangelo, I. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06947.x · Cited by 131 · see citing works
A temperature‐sensitive mutant of human p53.
Zhang, W., Guo, X. Y., Hu, G., Liu, W. B., Shay, J. W., & Deisseroth, A. B. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06543.x · Cited by 127 · see citing works
Unliganded Thyroid Hormone Receptor α Can Target TATA-Binding Protein for Transcriptional Repression
Fondell, J. D., Brunel, F., Hisatake, K., & Roeder, R. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.281 · Cited by 126 · see citing works
Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.
Li, C. J., Wang, C., Friedman, D. J., & Pardee, A. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5461 · Cited by 124 · see citing works
Tyrosinase Gene Expression is Regulated by p53
Khlgatian, M. K., Hadshiew, I., Asawanonda, P., Yaar, M., Eller, M. S., Gilchrest, B. A., Fujita, M., & Norris, D. A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01667.x · Cited by 122 · see citing works
Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression
Nozaki, M., Tada, M., Kobayashi, H., Zhang, C. L., Sawamura, Y., Abe, H., Ishii, N., & Meir, E. G. V. (1999) · Neuro-Oncology · doi:10.1093/neuonc/1.2.124 · Cited by 126 · see citing works
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.Preprint
Godley, L. A., Kopp, J. B., Eckhaus, M., Paglino, J. J., Owens, J., & VARMUS, H. E. (1996) · Genes & Development · doi:10.1101/gad.10.7.836 · Cited by 119 · see citing works
Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter
Shivakumar, C. V., Brown, D. R., Deb, S., & Deb, S. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6785 · Cited by 120 · see citing works
Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus.
Eichbaum, Q. G., Iyer, R., Raveh, D., Mathieu, C., & Ezekowitz, R. A. B. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.6.1985 · Cited by 119 · see citing works
Aberrant p53 Expression Correlates With Expression of Vascular Endothelial Growth Factor mRNA and Interleukin-8 mRNA and Neoangiogenesis in Non-Small-Cell Lung Cancer
Yuan, A., Yu, C.-J., Luh, K.-T., Kuo, S.-H., Lee, Y.-C., & Yang, P.-C. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.4.900 · Cited by 126 · see citing works
Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens
Hussain, S. P., & Harris, C. C. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00015-6 · Cited by 120 · see citing works
p53: A Cell Cycle Regulator Activated by DNA Damage
Selivanova, G., & Wiman, K. G. (1995) · Advances in cancer research · doi:10.1016/s0065-230x(08)60253-5 · Cited by 118 · see citing works
Transactivation of the Human p53 Tumor Suppressor Gene by c-Myc/Max Contributes to Elevated Mutant p53 Expression in Some Tumors
Roy, B., Beamon, J., Bálint, É., & Reisman, D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7805 · Cited by 118 · see citing works
Adenovirus and cell cycle control
Ben-Israel, H. (2002) · Frontiers in bioscience · doi:10.2741/ben · Cited by 115 · see citing works
Promoter elements in Drosophila melanogaster revealed by sequence analysis.
Arkhipova, I. R. (1995) · Genetics · doi:10.1093/genetics/139.3.1359 · Cited by 117 · see citing works
Cyclo-oxygenase-1 and -2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance
Shibata, M., Kodani, I., Osaki, M., Araki, K., Adachi, H., Ryoke, K., & Ito, H. (2005) · Oral Oncology · doi:10.1016/j.oraloncology.2004.09.009 · Cited by 116 · see citing works
Core Promoter Specificities of the Sp1 and VP16 Transcriptional Activation Domains
Emami, K. H., Navarre, W. W., & Smale, S. T. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.5906 · Cited by 115 · see citing works
Differential Regulation of the Overlapping Kaposi's Sarcoma-Associated Herpesvirus vGCR (orf74) and LANA (orf73) Promoters
Jeong, J. H., Papin, J. F., & Dittmer, D. P. (2001) · Journal of Virology · doi:10.1128/jvi.75.4.1798-1807.2001 · Cited by 114 · see citing works
p53 Inhibits RNA Polymerase III-Directed Transcription in a Promoter-Dependent Manner
Chesnokov, I. N., Chu, W.-M., Botchan, M. R., & Schmid, C. W. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.7084 · Cited by 114 · see citing works
p130/E2F4 Binds to and Represses the cdc2 Promoter in Response to p53
Taylor, W. R., Schönthal, A. H., Galante, J., & Stark, G. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005101200 · Cited by 110 · see citing works
Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
Leung, W. K., To, K., Ng, Y.-P., Lee, T.-L., Lau, J. Y. W., Chan, F. K. L., Ng, E. K. W., Chung, S., & Sung, J. J. �. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1607 · Cited by 109 · see citing works

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein
Farmer, G. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4281 · Cited by 74 · see citing works
Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.
Ragimov, N., Krauskopf, A., Navot, N., Rotter, V., Oren, M., & Aloni, Y. (1993) · PubMed · Cited by 159 · see citing works
Wild-type p53 binds to the TATA-binding protein and represses transcription.
Seto, E., Usheva, A., Zambetti, G. P., Momand, J. A., Horikoshi, N., Weinmann, R. S., Levine, A. J., & Shenk, T. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12028 · Cited by 504 · see citing works
Transcriptional Repression by the p53 Tumor Suppressor Protein
Zilfou, J. T., & Murphy, M. E. (2005) · Springer eBooks · doi:10.1007/0-387-30127-5_4 · Cited by 1 · see citing works
Wild-type p53 activates transcription in vitro
Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R., & Prives, C. (1992) · Nature · doi:10.1038/358083a0 · Cited by 579 · see citing works

Authors: Mack, D. H., Vartikar, J., Pipas, J. M., & Laimins, L. A.
Affiliations: University of Chicago (US)
University of Pittsburgh (US)
Howard Hughes Medical Institute (US)
ORCID: Pipas, James M.
Laimins, Laimonis A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-05
Volume: 363
Issue: 6426
Pages: 281-283
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/363281a0
OpenAlex: W1969881374
Cited by: 322
References: 24
Citations by year: 2022: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2014: 2 · 2013: 2 · 2012: 2
FWCI: 21.03
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: p53, transcriptional repression, TATA box, initiator element, basal transcription factors, promoter activity, tumour suppressor, transcriptional regulation, growth arrest
MeSH terms: Animals, Cell Line, Globins, HeLa Cells, Humans, Promoter Regions, Genetic, Rabbits, Simian virus 40, Transcription, Genetic, Transfection, Tumor Suppressor Protein p53, TATA Box, 3T3 Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks