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Cyr61, a Member of CCN Family, Is a Tumor Suppressor in Non-Small Cell Lung Cancer

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B-MYB Is Required for Recovery from the DNA Damage–Induced G2 Checkpoint in p53 Mutant Cells

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Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients

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Rb/E2F4 and Smad2/3 link survivin to TGF-β-induced apoptosis and tumor progression

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DNA Damage Promotes Histone Deacetylase 4 Nuclear Localization and Repression of G2/M Promoters, via p53 C-terminal Lysines

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5‐ D emethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G 2/M cell cycle arrest and apoptosis

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Wild-type p53 and p73 negatively regulate expression of proliferation related genes

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E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress

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Cdc2: A monopotent or pluripotent CDK?

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p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers

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Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53

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Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei

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E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma

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One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor

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Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression

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Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation

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Inhibitory Effects of Metabolites of 5-Demethylnobiletin on Human Nonsmall Cell Lung Cancer Cells

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A role for p53 in terminal epithelial cell differentiation

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The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression

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PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma

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Transcriptional Repression of Taurine Transporter Gene (TauT) by p53 in Renal Cells

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The Epithelial Cell Transforming Sequence 2, a Guanine Nucleotide Exchange Factor for Rho GTPases, Is Repressed by p53 via Protein Methyltransferases and Is Required for G1-S Transition

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Coordination of Repair, Checkpoint, and Cell Death Responses to DNA Damage

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The human 1‐8D gene (IFITM2) is a novel p53 independent pro‐apoptotic gene

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A Role for the Fanconi Anemia C Protein in Maintaining the DNA Damage-induced G2 Checkpoint

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The chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites

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p53 Inactivation Upregulates p73 Expression through E2F-1 Mediated Transcription

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A role for p53 in terminal epithelial cell differentiation

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E2 Ubiquitin-conjugating Enzyme, UBE2C Gene, Is Reciprocally Regulated by Wild-type and Gain-of-Function Mutant p53

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Ca 2+ /calmodulin‐dependent protein kinase II‐γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling

Saddouk, F. Z., Sun, L., Liu, Y. F., Jiang, M., Singer, D. V., Backs, J., Riper, D. A. V., Ginnan, R. G., Schwarz, J. J., & Singer, H. A. (2015) · The FASEB Journal · doi:10.1096/fj.15-279158 · Cited by 33 · see citing works

Studies on radiation-induced apoptosis in G 0 human lymphocytes

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Transcriptional control of the proliferation cluster by the tumor suppressor p53

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Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells

Wong, S. H. K., Shih, R. S. M., Schoene, N. W., & Lei, K. Y. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00061.2008 · Cited by 30 · see citing works

Improving the selectivity of cancer treatments by interfering with cell response pathways

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p53-Mediated Growth Suppression in Response to Nutlin-3 in Cyclin D1–Transformed Cells Occurs Independently of p21

Kan, C. E., Patton, J. T., Stark, G. R., & Jackson, M. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0259 · Cited by 26 · see citing works

Role of p21 in SP600125-induced cell cycle arrest, endoreduplication, and apoptosis

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Context is key: Understanding the regulation, functional control, and activities of the p53 tumour suppressor

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Exit from Arsenite-Induced Mitotic Arrest Is p53 Dependent

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X‐irradiated human lymphocytes with unstable aberrations and their preferential elimination by p53/survivin‐dependent apoptosis

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Regulation of p53-dependent transcription

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Interplay between HMGA and TP53 in cell cycle control along tumor progression

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Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2–M arrest in A549 cells

Ikeda, M., Okamoto, I., Tamura, K., Satoh, T., Yonesaka, K., Fukuoka, M., & Nakagawa, K. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.08.005 · Cited by 15 · see citing works

p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.

Brusa, G., Benvenuti, M., Mazzacurati, L., Mancini, M., Pattacini, L., Martinelli, G., Barbieri, E., Greenberger, J. S., Baccarani, M., & Santucci, M. A. (2003) · PubMed · Cited by 14 · see citing works

Functional Analysis of CDK Inhibitor p21WAF1

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G2-phase arrest through p21(WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells.

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P130 and its truncated form mediate p53-induced cell cycle arrest inRb−/− Saos2 cells

Gao, C.-F., Ren, S., Wang, J., Zhang, S.-L., Jin, F., Nakajima, T., Ikeda, M., & Tsuchida, N. (2002) · Oncogene · doi:10.1038/sj.onc.1205933 · Cited by 12 · see citing works

A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities

Rakotopare, J., Lejour, V., Duval, C. J., Eldawra, E., Escoffier, H., & Toledo, F. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050376 · Cited by 14 · see citing works

Nitric Oxide Down-regulates Polo-like Kinase 1 through a Proximal Promoter Cell Cycle Gene Homology Region

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ZNF500 abolishes breast cancer proliferation and sensitizes chemotherapy by stabilizing P53 via competing with MDM2

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Targeting the Cell Cycle to Kill Cancer Cells

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DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p34cdc2: Role of p53

Mukherjee, J. J., & Kumar, S. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.05.009 · Cited by 8 · see citing works

Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients

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Identification and Mechanistic Studies of a Cell Cycle Regulator JP18 from a Library of Synthetic Indole Terpenoid Mimics

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A role for p53 in terminal epithelial cell differentiation

Saifudeen, Z. R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200213972 · Cited by 7 · see citing works

Characterization of the CDP-like/CTAS-1 binding site in the okadaic acid response element (OARE) of the human CDK1(p34cdc2) promoter.

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2‐Chloroethyl‐3‐sarcosinamide‐1‐nitrosourea (SarCNU) inhibits prostate carcinoma cell growth via p53‐dependent and p53‐independent pathways

Huynh, H. T., Nguyen, T., Panasci, L., & Do, P. (2004) · Cancer · doi:10.1002/cncr.20670 · Cited by 5 · see citing works

Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response

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Transactivation of Human cdc2 Promoter by Adenovirus E1A

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SarCNU‐induced G2/M arrest in hepatoma cells is mediated by a p53‐independent phosphorylation of cdc‐2 at Tyr15

Hung, H., Chow, P. K. H., Soo, K. C., Panasci, L. C., & Hung, N. T. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20336 · Cited by 2 · see citing works

Research progress on cell cycle arrest in dermal fibroblasts

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RNA-Seq Uncovers Association of Endocrine-Disrupting Chemicals with Hub Genes and Transcription Factors in Aggressive Prostate Cancer

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Treatment-Induced Tumor Cell Senescence and Its Consequences

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Vaccinia virus modulates the host cell cycle to promote infection

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NRF1 Transcriptomic Signatures Contribute to the Pathogenesis of the Most Aggressive Brain Cancer - Glioblastoma

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G2 Phase Cell Cycle Regulation by E2F4 Following Genotoxic Stress

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Signaling in natural killer cells: SHIP, 2B4 and the Kinome

Wahle, J. A. (2007) · Digital Commons - University of South Florida (University of South Florida)

The Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans Activates p53-dependent DNA Damage Checkpoint Pathways in Normal Human Fibroblasts

Morisaki, H., Kurihara, K., Haseba, Y., Takahashi, M., & Igarashi, T. (2005) · Shōwa Shigakkai zasshi/Showa Shigakkai zasshi · doi:10.11516/dentalmedres1981.25.161

The Dual Specificity Phosphatase Cdc25C is a Direct Target for Transcriptional Repression by the Tumor Suppressor p53

Clair, S. S., & Manfredi, J. J. (2006) · Cell Cycle · doi:10.4161/cc.5.7.2628 · Cited by 39 · see citing works

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

Benson, E. K., Mungamuri, S. K., Attie, O., Kracikova, M., Sachidanandam, R., Manfredi, J. J., & Aaronson, S. A. (2013) · Oncogene · doi:10.1038/onc.2013.378 · Cited by 95 · see citing works

p53 can repress transcription of cell cycle genes through a p21^WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

Quaas, M., Müller, G. A., & Engeland, K. (2012) · Cell Cycle · doi:10.4161/cc.22917 · Cited by 107 · see citing works

p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor

Yun, J., Chae, H., Choy, H. E., Chung, J., Yoo, H., Han, M.-H., & Shin, D. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29677 · Cited by 155 · see citing works

Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex

Fischer, M., Quaas, M., Nickel, A., & Engeland, K. (2015) · Oncotarget · doi:10.18632/oncotarget.6356 · Cited by 59 · see citing works