Cited by 5,092Cannabis and Cannabinoid ResearchReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology

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Molecular characterization of a peripheral receptor for cannabinoids

Munro, Sean, Thomas, Kerrie L., Abu-Shaar, Muna·1993·Nature

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Abstract

The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen.

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Authors: Munro, S., Thomas, K. L., & Abu-Shaar, M.
Affiliations: MRC Laboratory of Molecular Biology (GB)
ORCID: Munro, Sean
Thomas, Kerrie L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-09
Volume: 365
Issue: 6441
Pages: 61-65
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/365061a0
OpenAlex: W2056188558
Cited by: 5,092
References: 30
Citations by year: 2026: 76 · 2025: 119 · 2024: 165 · 2023: 172 · 2022: 198 · 2021: 244 · 2020: 212 · 2019: 184 · 2018: 169 · 2017: 188 · 2016: 182 · 2015: 175 · 2014: 188 · 2013: 201 · 2012: 202
FWCI: 39.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: cannabinoid receptors, delta-9-tetrahydrocannabinol, peripheral cannabinoid receptors, macrophages, receptor cloning, G protein-coupled receptors, immunosuppression, anti-inflammatory activity
MeSH terms: Amides, Amino Acid Sequence, Animals, Arachidonic Acids, Base Sequence, Brain, Cannabinoids, Cloning, Molecular, DNA, Fatty Acids, Unsaturated, Humans, Macrophages, Molecular Sequence Data, Morpholines, Naphthalenes, Receptors, Drug, RNA, Spleen, Tumor Cells, Cultured, Receptors, Cannabinoid, Benzoxazines, Rats, Polyunsaturated Alkamides, Endocannabinoids

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Molecular characterization of a peripheral receptor for cannabinoids

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