Cited by 5,092Cannabis and Cannabinoid ResearchReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology

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Molecular characterization of a peripheral receptor for cannabinoids

Munro, Sean, Thomas, Kerrie L., Abu-Shaar, Muna·1993·Nature

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Abstract

The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen.

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Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression
Collins, S. (1987) · Blood · doi:10.1182/blood.v70.5.1233.1233 · Cited by 1,189
The probable arrangement of the helices in G protein‐coupled receptors.
Baldwin, J. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05814.x · Cited by 968
Molecular cloning of a human cannabinoid receptor which is also expressed in testis
Gérard, C. M., Mollereau, C., Vassart, G., & Parmentier, M. (1991) · Biochemical Journal · doi:10.1042/bj2790129 · Cited by 698
An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2
Seed, B. (1987) · Nature · doi:10.1038/329840a0 · Cited by 674
Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry
Mailleux, P., & Vanderhaeghen, J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90409-u · Cited by 660
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.
Zhou, Q. Y., Li, C., Olah, M. E., Johnson, R. A., Stiles, G. L., & Civelli, O. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7432 · Cited by 659
ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM
Simmons, D., Makgoba, M. W., & Seed, B. (1988) · Nature · doi:10.1038/331624a0 · Cited by 616

Show all 30 references

Research works printed but not linked: 8

Dewey, W. L. Pharmac. Rev. 38, 151–178 (1986).
Hollister, L. E. Pharmac. Rev. 38, 1–20 (1986).
Razdan, R. K. Pharmac. Rev. 38, 75–149 (1986).
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. & Howlett, A. C. Molec. Pharmacol. 34, 605–613 (1988).
Martin, B. R. Pharmac. Rev. 38, 45–74 (1986).
Reichman, M., Nen, W. & Hokin, L. E. Molec. Pharmac. 40, 547–555 (1991).
Munson, A. E. & Fehr, K. O. in Adverse Health and Behavioral Consequences of Cannabis Use (eds Fehr, K. O. & Kalant H.) 257–353 (Addiction Research Foundation, Toronto, 1983).
Robinson, A. P., White, T. M. & Mason, D. W. Immunology 57, 239–247 (1986).

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Matias, I., Pochard, P., Orlando, P., Salzet, M., Pestel, J., & Marzo, V. D. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03078.x · Cited by 180
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
Preet, A., Ganju, R. K., & Groopman, J. E. (2007) · Oncogene · doi:10.1038/sj.onc.1210641 · Cited by 179
Discovery and Development of Fatty Acid Amide Hydrolase (FAAH) Inhibitors
Seierstad, M. J., & Breitenbucher, J. G. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800311k · Cited by 179
Interleukin-2 Suppression by 2-Arachidonyl Glycerol Is Mediated through Peroxisome Proliferator-Activated Receptor γ Independently of Cannabinoid Receptors 1 and 2
Rockwell, C. E., Snider, N. T., Thompson, J. T., Heuvel, J. P. V., & Kaminski, N. E. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.019117 · Cited by 179
Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes
Henry, D. J., & Chavkin, C. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11289-9 · Cited by 179
Selective activation of cannabinoid CB2 receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
Nackley, A. G., Makriyannis, A., & Hohmann, A. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00126-x · Cited by 179
Respiratory and Immunologic Consequences of Marijuana Smoking
Tashkin, D. P., Baldwin, G. C., Sarafian, T. A., Dubinett, S. M., & Roth, M. D. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb06006.x · Cited by 179
The Cannabinoid CB1 Receptor Mediates Retrograde Signals for Depolarization-Induced Suppression of Inhibition in Cerebellar Purkinje Cells
Yoshida, T., Hashimoto, K., Zimmer, A., Maejima, T., Araishi, K., & Kano, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01690.2002 · Cited by 179
Cannabinoid ligand-receptor signaling in the mouse uterus.
Das, S., Paria, B. C., Chakraborty, I., & Dey, S. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4332 · Cited by 179
Modulation and Functional Involvement of CB2 Peripheral Cannabinoid Receptors During B-Cell Differentiation
Carayon, P., Marchand, J., Dussossoy, D., Derocq, J., Jbilo, O., Bord, A., Bouaboula, M., Galiègue, S., Mondière, P., Pénarier, G., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3605 · Cited by 179
Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α
Newton, R. C., & Decicco, C. P. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980541n · Cited by 179
Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium
Kimball, E. S., Schneider, C. R., Wallace, N. H., & Hornby, P. J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00407.2005 · Cited by 178
The evolution and comparative neurobiology of endocannabinoid signalling
Elphick, M. R. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0394 · Cited by 180
Cannabinoid Mechanisms of Pain Suppression
Walker, J. M., & Hohmann, A. G. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_17 · Cited by 177
Cannabinoid analgesia
Walker, J. M., & Huang, S. M. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00252-8 · Cited by 176
Endocannabinoid signalling: has it got rhythm?
Vaughn, L. K., Denning, G., Stuhr, K. L., de Wit, H., Hill, M. N., & Hillard, C. J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00790.x · Cited by 176
PSNCBAM‐1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats
Horswill, J. G., Bali, U., Shaban, S. N., Keily, J. F., Jeevaratnam, P., Babbs, A. J., Reynet, C., & In, P. W. K. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707347 · Cited by 176
CB2 Receptor in Microglia: The Guardian of Self-Control
Komorowska‐Müller, J. A., & Schmöle, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010019 · Cited by 176
Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry
Bridges, D., Rice, A. S. C., Egertová, M., Elphick, M. R., Winter, J., & Michael, G. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00200-8 · Cited by 177
The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide
Wartmann, M., Campbell, D., Subramanian, A., BURSTEIN, S. H., & Davis, R. J. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00027-7 · Cited by 176
Stimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells
Bouaboula, M., Bourrié, B., Rinaldi, M. L., Shire, D. J., Fur, G. L., & Casellas, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.13973 · Cited by 176
Beyond THC and Endocannabinoids
Pacher, P., Kogan, N. M., & Mechoulam, R. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021441 · Cited by 175
Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors
Bauer, M., Chicca, A., Tamborrini, M., Eisen, D., Lerner, R., Lutz, B., Poetz, O., Pluschke, G., & Gertsch, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382481 · Cited by 175
The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants
Hill, M. N., Hillard, C. J., Bambico, F. R., Patel, S., Gorzalka, B. B., & Gobbi, G. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.006 · Cited by 175
Structural Basis for Human Monoglyceride Lipase Inhibition
Bertrand, T., Augé, F., Houtmann, J., Rak, A., Vallée, F., Mikol, V., Berne, P., Michot, N., Cheuret, D., Hoornaert, C., et al. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.11.060 · Cited by 176
Regulation of food intake by oleoylethanolamide
Verme, J. L., Gaetani, S., Fu, J., Oveisi, F., Burton, K. J., & Piomelli, D. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4494-0 · Cited by 174

Authors: Munro, S., Thomas, K. L., & Abu-Shaar, M.
Affiliations: MRC Laboratory of Molecular Biology (GB)
ORCID: Munro, Sean
Thomas, Kerrie L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-09
Volume: 365
Issue: 6441
Pages: 61-65
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/365061a0
OpenAlex: W2056188558
Cited by: 5,092
References: 30
Citations by year: 2026: 76 · 2025: 119 · 2024: 165 · 2023: 172 · 2022: 198 · 2021: 244 · 2020: 212 · 2019: 184 · 2018: 169 · 2017: 188 · 2016: 182 · 2015: 175 · 2014: 188 · 2013: 201 · 2012: 202
FWCI: 39.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: cannabinoid receptors, delta-9-tetrahydrocannabinol, peripheral cannabinoid receptors, macrophages, receptor cloning, G protein-coupled receptors, immunosuppression, anti-inflammatory activity
MeSH terms: Amides, Amino Acid Sequence, Animals, Arachidonic Acids, Base Sequence, Brain, Cannabinoids, Cloning, Molecular, DNA, Fatty Acids, Unsaturated, Humans, Macrophages, Molecular Sequence Data, Morpholines, Naphthalenes, Receptors, Drug, RNA, Spleen, Tumor Cells, Cultured, Receptors, Cannabinoid, Benzoxazines, Rats, Polyunsaturated Alkamides, Endocannabinoids

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Molecular characterization of a peripheral receptor for cannabinoids

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