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Cited by 5,092Cannabis and Cannabinoid ResearchReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Molecular characterization of a peripheral receptor for cannabinoids

Munro, Sean, Thomas, Kerrie L., Abu-Shaar, Muna·1993·Nature
DOI 10.1038/365061a0
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Abstract

The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen.

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Crossref · 10.1038/365061a0

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Citations

Cites

Show all 30 references

Research works printed but not linked: 8

  1. Dewey, W. L. Pharmac. Rev. 38, 151–178 (1986).
  2. Hollister, L. E. Pharmac. Rev. 38, 1–20 (1986).
  3. Razdan, R. K. Pharmac. Rev. 38, 75–149 (1986).
  4. Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. & Howlett, A. C. Molec. Pharmacol. 34, 605–613 (1988).
  5. Martin, B. R. Pharmac. Rev. 38, 45–74 (1986).
  6. Reichman, M., Nen, W. & Hokin, L. E. Molec. Pharmac. 40, 547–555 (1991).
  7. Munson, A. E. & Fehr, K. O. in Adverse Health and Behavioral Consequences of Cannabis Use (eds Fehr, K. O. & Kalant H.) 257–353 (Addiction Research Foundation, Toronto, 1983).
  8. Robinson, A. P., White, T. M. & Mason, D. W. Immunology 57, 239–247 (1986).

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Metadata

Authors
Munro, S., Thomas, K. L., & Abu-Shaar, M.
Affiliations
MRC Laboratory of Molecular Biology (GB)
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1993-09
Volume
365
Issue
6441
Pages
61-65
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/365061a0
OpenAlex
W2056188558
Cited by
5,092
References
30
Citations by year
2026: 76 · 2025: 119 · 2024: 165 · 2023: 172 · 2022: 198 · 2021: 244 · 2020: 212 · 2019: 184 · 2018: 169 · 2017: 188 · 2016: 182 · 2015: 175 · 2014: 188 · 2013: 201 · 2012: 202
FWCI
39.25
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
cannabinoid receptors, delta-9-tetrahydrocannabinol, peripheral cannabinoid receptors, macrophages, receptor cloning, G protein-coupled receptors, immunosuppression, anti-inflammatory activity
MeSH terms
Amides, Amino Acid Sequence, Animals, Arachidonic Acids, Base Sequence, Brain, Cannabinoids, Cloning, Molecular, DNA, Fatty Acids, Unsaturated, Humans, Macrophages, Molecular Sequence Data, Morpholines, Naphthalenes, Receptors, Drug, RNA, Spleen, Tumor Cells, Cultured, Receptors, Cannabinoid, Benzoxazines, Rats, Polyunsaturated Alkamides, Endocannabinoids

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