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Failure of B-cell differentiation in mice lacking the transcription factor EBF

Lin, Haishan, Grosschedl, Rudolf·1995·Nature
DOI 10.1038/376263a0
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Abstract

Early B-cell factor (EBF) is a cell type-specific transcription factor that is expressed at all antigen-independent stages of B-lymphocyte differentiation and participates in the regulation of the mb-1 gene. Here we show, by targeted gene disruption in mice, that EBF is necessary for the generation of immunoglobulin-expressing B cells. EBF-deficient mice lack B cells that have rearranged their immunoglobulin D and JH gene segments, but contain B220+CD43+ progenitor cells that express germline mu and IL-7 receptor transcripts. Various non-lymphoid tissues that express EBF are apparently normal in homozygous mutant mice, including olfactory neurons in which EBF was identified as Olf-1 (refs 5, 6). Together, these data suggest that EBF plays a specific and important role in the transcriptional control of B-cell differentiation at a stage before Ig (immunoglobulin) gene rearrangement but after commitment of cells to the B-lymphoid lineage.

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Crossref · 10.1038/376263a0

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  • Developmental progression of B cells is critically dependent on activity of various transcription factors binding to promoter and enhancer elements of Ig genes.

    “In fact, gene-targeting studies indicate that the developmental progression of B cells is critically dependent on the activity of various transcription factors, which bind to promoter and enhancer elements of Ig genes (heavy and light chains), suggesting a link between the signal transduction and transcription factors during B-cell development (13-18”

    From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [16]

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Research works printed but not linked: 30

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Metadata

Authors
Lin, H., & Grosschedl, R.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1995-07
Volume
376
Issue
6537
Pages
263-267
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/376263a0
Cited by
594
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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