The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
Abstract
The inositol 1,4,5-trisphosphate (InsP3) receptor acts as an InsP3-gated Ca2+ release channel in a variety of cell types. Type 1 InsP3 receptor (IP3R1) is the major neuronal member of the IP3R family in the central nervous system, predominantly enriched in cerebellar Purkinje cells but also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. Here we report that most IP3R1-deficient mice generated by gene targeting die in utero, and born animals have severe ataxia and tonic or tonic-clonic seizures and die by the weaning period. An electroencephalogram showed that they suffer from epilepsy, indicating that IP3R1 is essential for proper brain function. However, observation by light microscope of the haematoxylin-eosin staining of the brain and peripheral tissues of IP3R1-deficient mice showed no abnormality, and the unique electrophysiological properties of the cerebellar Purkinje cells of IP3R1-deficient mice were not severely impaired.
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“we identified four dURVs in schizophrenia cases (and none in controls) in XLID gene KDM5C, an H3K4 methylation eraser gene44, 11 dURVs in cases (and 2 in controls) in DD gene KDM5B, another H3K4 methylation eraser gene45, and 11 dURVs in cases (and 3 in controls) in DD gene ITPR1, which encodes an inositol triphosphate receptor46 (Supplementary Tables 2 and 3).”
From Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia (2016) · cites this paper as [46]
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Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
The Cerebellum as a Neuronal Machine
Eccles, J. C., Ito, M., & Szentágothai, J. (1967) · Springer eBooks · doi:10.1007/978-3-662-13147-3 · Cited by 3,229
Genetic variants and strains of the laboratory mouse
(1990) · Choice Reviews Online · doi:10.5860/choice.28-1324 · Cited by 1,492
Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.
Llinas, R. H., & Sugimori, M. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013357 · Cited by 1,061
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400
Furuichi, T., Yoshikawa, S., Miyawaki, A., Wada, K., Maeda, N., & Mikoshiba, K. (1989) · Nature · doi:10.1038/342032a0 · Cited by 1,041
Self-citationDeficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90205-4 · Cited by 930
Aiba, A. (1994) · Cell · doi:10.1016/0092-8674(94)90204-6 · Cited by 614
Synaptic‐ and agonist‐induced excitatory currents of Purkinje cells in rat cerebellar slices.
Llano, I., Marty, A., Armstrong, C. M., & Konnerth, A. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018465 · Cited by 488
Synaptic currents in cerebellar Purkinje cells.
Konnerth, A., Llano, I., & Armstrong, C. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2662 · Cited by 424
Takeshima, H., lino, M., Takekura, H., Nishi, M., Kuno, J., Minowa, O., Takano, H., & Noda, T. (1994) · Nature · doi:10.1038/369556a0 · Cited by 390
Self-citationGenetic Variants and Strains of the Laboratory Mouse
Winter, R. (1990) · Journal of Medical Genetics · doi:10.1136/jmg.27.5.343-b · Cited by 312
Maeda, N., Niinobe, M., & Mikoshiba, K. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08080.x · Cited by 286
Yagi, T., Ikawa, Y., Yoshida, K., Shigetani, Y., Takeda, N., Mabuchi, I., Yamamoto, T., & Aizawa, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9918 · Cited by 238
Furuichi, T., Simon‐Chazottes, D., Fujino, I., Yamada, N., Hasegawa, M. L., Miyawaki, A., Yoshikawa, S., Jl, G., & Mikoshiba, K. (1993) · PubMed · Cited by 200
Self-citationFuruichi, T., Kohda, K., Miyawaki, A., & Mikoshiba, K. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90089-2 · Cited by 194
Self-citationInositol 1,4,5-trisphosphate receptor
Mikoshiba, K. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90069-v · Cited by 175
SMEDT, H. D., Missiaen, L., Parys, J. B., Bootman, M. D., Mertens, L., Bosch, L. V. D., & Casteels, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31861-6 · Cited by 171
Crépel, F., & Penit-Soria, J. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp015993 · Cited by 158
Maeda, N., Niinobe, M., Nakahira, K., & Mikoshiba, K. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01151.x · Cited by 144
Maeda, N., Niinobe, M., Inoue, Y., & Mikoshiba, K. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90297-2 · Cited by 144
Yagisawa, H., Hirata, M., Kanematsu, T., Watanabe, Y., OZAKI, S., Sakuma, K., Tanaka, H., Yabuta, N., Kamata, H., & Hirata, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32143-9 · Cited by 142
Miyawaki, A., Furuichi, T., Maeda, N., & Mikoshiba, K. (1990) · Neuron · doi:10.1016/0896-6273(90)90029-f · Cited by 138
Self-citationNakanishi, S., Maeda, N., & Mikoshiba, K. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-07-02075.1991 · Cited by 124
Nakade, S., Maeda, N., & Mikoshiba, K. (1991) · Biochemical Journal · doi:10.1042/bj2770125 · Cited by 95
Yamamoto‐Hino, M., Miyawaki, A., Kawano, H., Sugiyama, T., Furuichi, T., Hasegawa, M., & Mikoshiba, K. (1995) · Neuroreport · doi:10.1097/00001756-199501000-00012 · Cited by 41
Self-citationNagata, E., Tanaka, K., Gomi, S., Mihara, B., Shirai, T., Nogawa, S., Nozaki, H., Mikoshiba, K., & Fukuuchi, Y. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90418-9 · Cited by 22
Self-citationBarrick, S., Lee, H., Meyers, S., Caterina, M. J., Zeidel, M. L., Chopra, B., de Groat, W., Kanai, A., & Birder, L. A. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.02.007 · Cited by 14
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Self-citationInositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., & Shibuya, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9349 · Cited by 1,086
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Metadata
- Authors
- Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., Miyawaki, A., Furuichi, Y., Okano, H., Mikoshiba, S. K., & Noda, T.
- Affiliations
- Japanese Foundation For Cancer Research (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Keio University (JP)
- University of Tsukuba (JP)
- RIKEN (JP)
- ORCID
- Venue
- Nature
- Published
- 1996-01
- Volume
- 379
- Issue
- 6561
- Pages
- 168-171
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2066261176
- Cited by
- 485
- References
- 27
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 12 · 2020: 16 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 18 · 2015: 10 · 2014: 18 · 2013: 17 · 2012: 21
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- IP3 receptor, IP3R1, ataxia, epileptic seizures, Purkinje cells, neuronal calcium signaling, developmental lethality, tonic-clonic seizures
- MeSH terms
- Animals, Ataxia, Base Sequence, Brain, Cell Line, Electroencephalography, Epilepsy, Fetal Death, Molecular Sequence Data, Mutation, Purkinje Cells, Calcium Channels, Inositol 1,4,5-Trisphosphate, DNA Primers, Receptors, Cytoplasmic and Nuclear, Gene Targeting, Mice, Inositol 1,4,5-Trisphosphate Receptors
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