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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Abstract
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.
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“Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum [373], that results in hyperlocomoter behaviors [373,374] and also deficits in PPI [375,376].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
In the citing paper
“DAT knockout mice show an overall increased level of DA transmission, resulting in increased DA tone, hypermotoric activity, and overall increased movement [373].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
Citations
Cites
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Ehringer, H., & Hornykiewicz, O. (1960) · Journal of Molecular Medicine · doi:10.1007/bf01485901 · Cited by 1,875
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Neurotransmitter Transporters: Recent Progress
Amara, S., & Kuhar, M. J. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.000445 · Cited by 1,088
Role of Transmitter Uptake Mechanisms in Synaptic Neurotransmission
Iversen, L. L. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07066.x · Cited by 776
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
Baik, J., Picetti, R., Saiardi, A., Thiriet, G., Dierich, A., Depaulis, A., LeMeur, M., & Borrelli, E. (1995) · Nature · doi:10.1038/377424a0 · Cited by 651
The dopamine transporter: immunochemical characterization and localization in brain
Ciliax, B. J., Heilman, C. J., Demchyshyn, L. L., Pristupa, Z. B., Ince, E., Hersch, S. M., Niznik, H. B., & Levey, A. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01714.1995 · Cited by 589
Molecular characterization of the dopamine transporter.
Giros, B., & Caron, M. (1993) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90029-j · Cited by 582
Self-citationPositive and Negative Schizophrenic Symptoms and the Role of Dopamine
Crow, T. J. (1980) · The British Journal of Psychiatry · doi:10.1192/s0007125000071919 · Cited by 563
Xu, M., Moratalla, R., Gold, L. H., Hiroi, N., Koob, G. F., Graybiel, A. M., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90557-6 · Cited by 481
Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor gene.
Moine, C. L., Normand, E., & Bloch, B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4205 · Cited by 472
Dopamine receptor gene expression by enkephalin neurons in rat forebrain.
Moine, C. L., Normand, E., Guitteny, A. F., Fouqué, B., Teoule, R., & Bloch, B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.230 · Cited by 470
Zhou, Q., Quaife, C. J., & Palmiter, R. D. (1995) · Nature · doi:10.1038/374640a0 · Cited by 445
Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model.
Fischer, J. F., & Cho, A. K. (1979) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31549-1 · Cited by 443
Kitayama, S., Shimada, S., Xu, H., Markham, L., Donovan, D. M., & Uhl, G. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7782 · Cited by 396
Principles of voltammetry and microelectrode surface states
Kawagoe, K. T., Zimmerman, J. B., & Wightman, R. M. (1993) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(93)90094-8 · Cited by 394
Self-citationRaiteri, M., Cerrito, F., Cervoni, A. M., & Levi, G. (1979) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31548-x · Cited by 383
Cloning and functional characterization of a cocaine‐sensitive dopamine transporter
Bruno Giros, A., Mestikawy, S. E., Bertrand, L., & Caron, M. G. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81406-x · Cited by 368
Self-citationAltered striatal function in a mutant mouse lacking D1A dopamine receptors.
Drago, J., Gerfen, C. R., Lachowicz, J. E., Steiner, H., Hollon, T. R., Love, P. E., Ooi, G. T., Grinberg, A., Lee, E. J. K., & Huang, S.-P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12564 · Cited by 343
Control of dopamine extracellular concentration in rat striatum by impulse flow and uptake
Wightman, R. M., & Zimmerman, J. B. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90015-g · Cited by 328
Self-citationBruno Giros, A., Wang, Y. M., Suter, S. E., McLeskey, S. B., Pifl, C., & Caron, M. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33961-3 · Cited by 322
Self-citationBuck, K. J., & Amara, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12584 · Cited by 243
Dopamine uptake: A review of progress in the last decade
Horn, A. S. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90033-d · Cited by 230
Koller, B. H., & Smithies, O. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8932 · Cited by 216
Fluoxetine, a selective inhibitor of serotonin uptake
Fuller, R. W., Wong, D. T., & Robertson, D. W. (1991) · Medicinal Research Reviews · doi:10.1002/med.2610110103 · Cited by 197
Jones, S. R., Garris, P. A., Kilts, C. D., & Wightman, R. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062581.x · Cited by 184
Self-citationPifl, C., Giros, B., & Caron, M. G. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04246.1993 · Cited by 175
Self-citationDynamic Observation of Dopamine Autoreceptor Effects in Rat Striatal Slices
Kennedy, R. T., Jones, S. R., & Wightman, R. M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09391.x · Cited by 166
Self-citationParker, E. M., & Cubeddu, L. X. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24956-4 · Cited by 133
Dopamine transporter mRNA expression is intense in rat midbrain neurons and modest outside midbrain
Cerruti, C., Walther, D. M., Kuhar, M. J., & Uhl, G. R. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90187-t · Cited by 119
Jaber, M., Cador, M., Dumartin, B., Normand, E., Stinus, L., & Bloch, B. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00537-f · Cited by 108
Self-citationMolecular, Functional and Biochemical Characteristics of the Dopamine Transporter
Hitri, A., Hurd, Y. L., Wyatt, R. J., & Deutsch, S. I. (1994) · Clinical Neuropharmacology · doi:10.1097/00002826-199402000-00001 · Cited by 94
Jacocks, H. M., & Cox, B. M. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10759-3 · Cited by 84
Dopamine Transporter mRNA in Neurons of the Rat Hypothalamus
Meister, B., & Elde, R. (2008) · Neuroendocrinology · doi:10.1159/000126568 · Cited by 57
The effects of cocaine on maternal behaviors in the rat
Zimmerberg, B., & Gray, M. S. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90287-c · Cited by 49
Baumann, M. H., & Rothman, R. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)90792-l · Cited by 24
Tison, F., Normand, E., & Bloch, B. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90837-0 · Cited by 16
Research works printed but not linked: 11
- Barker, E. L., Kimmel, H. L. & Blakely, R. D. Molec. Pharmac. 46, 799–807 (1994).
- Wise, R. A. & Bozarth, M. A. Psychiat. Med. 3, 445–460 (1985).
- Fisher, J. F. & Cho, A. K. J. Pharmac. exp. Ther. 208, 203–209 (1979).
- Eshelman, A. Y., Henningsen, R. A., Neve, K. A. & Janowsky, A. J. Molec. Pharmac. 45, 312–316 (1994).
- Byck, R. & VanDyke, C. NIDA Monogr. 13, 97–118 (1977).
- Chiodo, L. A. Neurochem. Int. 26, 815–845 (1992).
- Raiteri, M., Cerrito, F., Cervoni, A. M. & Levi, G. J. Pharmac. exp. Ther. 208, 195–202 (1979).
- Wall, S. C., Gu, H. & Rudnick, G. Molec. Pharmac. 47, 544–550 (1995).
- Parker, E. M. & Cubeddu, L. X. J. Pharmac. exp. Ther. 237, 179–192 (1986).
- Jacocks, H. M. & Cox, B. M. J. Pharmac. exp. Ther. 262, 356–364 (1992).
- Graham, J. H., Maher, J. R. & Robinson, S. E. J. Pharmac. exp. Ther. 174, 707–717 (1995).
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Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633
Self-citationThe physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
Metadata
- Authors
- Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of North Carolina at Chapel Hill (US)
- Venue
- Nature
- Published
- 1996-02
- Volume
- 379
- Issue
- 6566
- Pages
- 606-612
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2014793858
- Cited by
- 2,476
- References
- 41
- Citations by year
- 2026: 34 · 2025: 39 · 2024: 32 · 2023: 61 · 2022: 52 · 2021: 62 · 2020: 47 · 2019: 54 · 2018: 62 · 2017: 67 · 2016: 58 · 2015: 74 · 2014: 93 · 2013: 73 · 2012: 97
- FWCI
- 43.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopamine transporter, hyperlocomotion, cocaine, amphetamine, psychostimulants, dopamine, neurotransmitter levels, locomotor activity, dopamine release, dopamine uptake
- MeSH terms
- Amphetamine, Animals, Carrier Proteins, Cell Line, Cocaine, Dopamine, Dynorphins, Enkephalins, Female, Gene Expression Regulation, Locomotion, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Protein Precursors, Mice, Knockout, Gene Targeting, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice, Rats
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