The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Abstract
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.
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In the citing paper
“Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum [373], that results in hyperlocomoter behaviors [373,374] and also deficits in PPI [375,376].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
In the citing paper
“DAT knockout mice show an overall increased level of DA transmission, resulting in increased DA tone, hypermotoric activity, and overall increased movement [373].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
Citations
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Cited by
Sorted by citations
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
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Self-citationThe physiology, signaling, and pharmacology of dopamine receptors
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Metadata
- Authors
- Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of North Carolina at Chapel Hill (US)
- Venue
- Nature
- Published
- 1996-02
- Volume
- 379
- Issue
- 6566
- Pages
- 606-612
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2014793858
- Cited by
- 2,476
- References
- 41
- Citations by year
- 2026: 34 · 2025: 39 · 2024: 32 · 2023: 61 · 2022: 52 · 2021: 62 · 2020: 47 · 2019: 54 · 2018: 62 · 2017: 67 · 2016: 58 · 2015: 74 · 2014: 93 · 2013: 73 · 2012: 97
- FWCI
- 43.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopamine transporter, hyperlocomotion, cocaine, amphetamine, psychostimulants, dopamine, neurotransmitter levels, locomotor activity, dopamine release, dopamine uptake
- MeSH terms
- Amphetamine, Animals, Carrier Proteins, Cell Line, Cocaine, Dopamine, Dynorphins, Enkephalins, Female, Gene Expression Regulation, Locomotion, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Protein Precursors, Mice, Knockout, Gene Targeting, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice, Rats
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