Cited by 1,158Genomics and Chromatin DynamicsBacterial Genetics and BiotechnologyGene Regulatory Network Analysis

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

Transcriptional activation by recruitment

Ptashne, Mark, Gann, Alexander·1997·Nature

Open this paper in CoChat — free account

Abstract

The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.

Integrity signals

Registry

Crossref · 10.1038/386569a0

Cites

103 of 103 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

How eukaryotic transcriptional activators work
Ptashne, M. (1988) · Nature · doi:10.1038/335683a0 · Cited by 1,828
Self-citation
MECHANISM AND CONTROL OF TRANSCRIPTION INITIATION IN PROKARYOTES
McClure, W. R. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.001131 · Cited by 1,014
Mechanism of transcriptional activation by Sp1: Evidence for coactivators
Pugh, B. F., & Tjian, R. (1990) · Cell · doi:10.1016/0092-8674(90)90683-6 · Cited by 978
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast
Hope, I. A., & Struhl, K. (1986) · Cell · doi:10.1016/0092-8674(86)90070-x · Cited by 918
Deletion analysis of GAL4 defines two transcriptional activating segments
Ma, J., & Ptashne, M. (1987) · Cell · doi:10.1016/0092-8674(87)90081-x · Cited by 887
Self-citation
A Third Recognition Element in Bacterial Promoters: DNA Binding by the α Subunit of RNA Polymerase
Ross, W., Gosink, K. K., Salomon, J., Igarashi, K., Zou, C., Ishihama, A., Severinov, K., & Gourse, R. L. (1993) · Science · doi:10.1126/science.8248780 · Cited by 789
BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID)
Burley, S. K., & Roeder, R. G. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.004005 · Cited by 734
RSC, an Essential, Abundant Chromatin-Remodeling Complex
Cairns, B. R., Lorch, Y., Li, Y., Zhang, M., Lacomis, L., Erdjument‐Bromage, H., Tempst, P., Du, J., Laurent, B. C., & Kornberg, R. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81820-6 · Cited by 667
Mechanism of Protein Access to Specific DNA Sequences in Chromatin: A Dynamic Equilibrium Model for Gene Regulation
Polach, K. J., & Widom, J. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0606 · Cited by 657
Negative effect of the transcriptional activator GAL4
Gill, G., & Ptashne, M. (1988) · Nature · doi:10.1038/334721a0 · Cited by 648
Self-citation

Flagged first, then by citations

Show all 103 references

Research works printed but not linked: 2

Ptashne, M. A Genetic Switch: Phage Lambda and Higher Organisms (Cell and Blackwell Scientific, Cambridge, MA, 1992).
Hawley, D. K. & McClure, W. R. Mechanism of activation of transcription initiation from the lambda-PRM promoter. J. Mol. Biol. 157, 493–525 (1982). · DOI

Sorted by citations

Items 801–900 of 1,000

αα-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes
Theisen, F. F., Salladini, E., Davidsen, R., Rasmussen, C. J., Staby, L., Kragelund, B. B., & Skriver, K. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101963 · Cited by 14
Transcription Activation by Escherichia coli Rob at Class II Promoters: Protein–Protein Interactions between Rob's N-Terminal Domain and the σ70 Subunit of RNA Polymerase
Taliaferro, L. P., Keen, E. F., Sanchez-Alberola, N., & Wolf, R. E. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.03.019 · Cited by 14
Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of MagnitudePreprint
Mazzocca, M., Narducci, D. N., Grosse‐Holz, S., Matthias, J., & Hansen, A. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.10.653248 · Cited by 14
A general method for chemogenetic control of peptide function
Shen, J., Geng, L., Li, X., Emery, C., Kroning, K. E., Shingles, G., Lee, K. L., Heyden, M., Li, P., & Wang, W. (2022) · Nature Methods · doi:10.1038/s41592-022-01697-8 · Cited by 13
High throughput methods to study protein-protein interactions during host-pathogen interactions
Chandrasekharan, G., & Unnikrishnan, M. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151393 · Cited by 13
Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors
Mindel, V., Brodsky, S., Yung, H., Manadre, W., & Barkai, N. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae718 · Cited by 15
An RNA-based transcription activator derived from an inhibitory aptamer
Wang, S., Shepard, J. R. E., & Shi, H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1227 · Cited by 13
Structure of Rot, a global regulator of virulence genes inStaphylococcus aureus
Zhu, Y., Fan, X., Zhang, X., Jiang, X., Niu, L., Teng, M., & Li, X. (2014) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s1399004714015326 · Cited by 13
Precise Regulation of Gene Expression Dynamics Favors Complex Promoter Architectures
Müller, D., & Stelling, J. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000279 · Cited by 13
Distance and Helical Phase Dependence of Synergistic Transcription Activation in cis-Regulatory Module
Huang, Q., Gong, C., Li, J., Zhu, Z., Chen, Y., Wang, J., & Hua, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031198 · Cited by 13
Piecing together more efficient gene expression
Somia, N. V., Kafri, T., & Verma, I. M. (1999) · Nature Biotechnology · doi:10.1038/6962 · Cited by 13
Dynamical Analysis on Gene Activity in the Presence of Repressors and an Interfering Promoter
Nakanishi, H., Mitarai, N., & Sneppen, K. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.132894 · Cited by 13
Regions of GAL4 critical for binding to a promoter in vivo revealed by a visual DNA‐binding analysis
Mizutani, A., & Tanaka, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg220 · Cited by 13
Dissection of a surface‐exposed portion of the cAMP–CRP complex that mediates transcription activation and repression
Meibom, K. L., Søgaard‐Andersen, L., Mironov, A. S., & Valentin‐Hansen, P. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01362.x · Cited by 13
A T9G Mutation in the Prototype TATA-Box TCACTATATATAG Determines Nucleosome Formation and Synergy with Upstream Activator Sequences in Plant Promoters
Ranjan, A., Ansari, S. A., Srivastava, R., Mantri, S. S., Asif, M. H., Sawant, S. V., & Tuli, R. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.148064 · Cited by 13
Structure-Based Design of a Potent Artificial Transactivation Domain Based on p53
Langlois, C., Gatto, A. D., Arseneault, G., Lafrance‐Vanasse, J., Simone, M. D., Morse, T., de Paola, I., Lussier-Price, M., Legault, P., Pedone, C., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja208999e · Cited by 13
Transactivation activity of the human cytomegalovirus IE2 protein occurs at steps subsequent to TATA box-binding protein recruitment
Kim, S., Hong, Y., Jeang, K., & Kim, S. (2000) · Microbiology · doi:10.1099/0022-1317-81-1-37 · Cited by 13
An Arabidopsis 14‐3‐3 protein can act as a transcriptional activator in yeast
Wang, J., Goodman, H. M., & Zhang, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01739-6 · Cited by 13
Activation of the Gal1 Gene of Yeast by Pairs of 'Non-Classical' Activators
Cheng, J. X., Gandolfi, M., & Ptashne, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.025 · Cited by 13
Self-citation
Intramolecular interaction of yeast TFIIB in transcription control
Zhang, D. Y., Dorsey, M. J., Voth, W. P., Carson, D. J., Zeng, X., Stillman, D. J., & Ma, J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.9.1913 · Cited by 13
Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells
Zhao, Y., Liu, L., Hassett, R., & Siepel, A. C. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad843 · Cited by 13
Transitions for Regulating Early Transcription
Michel, M., & Cramer, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.050 · Cited by 12
In vivo interactions of the Acanthamoeba TBP gene promoter
Chen, L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh297 · Cited by 12
Structure of the p53/RNA polymerase II assembly
Liou, S.-H., Singh, S. K., Singer, R. H., Coleman, R. A., & Liu, W.-L. (2021) · Communications Biology · doi:10.1038/s42003-021-01934-4 · Cited by 12
Chemically Regulated Transcription Factors Reveal the Persistence of Repressor-resistant Transcription after Disrupting Activator Function
Biggar, S. R., & Crabtree, G. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002991200 · Cited by 12
GAGA Factor-dependent Transcription and Establishment of DNase Hypersensitivity Are Independent and Unrelated Events in Vivo
Pile, L. A., & Cartwright, I. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1398 · Cited by 12
Chromatin Remodeling and Transcription
Hirose, S. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022220 · Cited by 12
Nuclear Matrix Attachment Regions Confer Long-range Function upon the Immunoglobulin EnhancerPreprint
Fernández, L. Á., Winkler, M., Forrester, W. C., Jenuwein, T., & Grosschedl, R. (1998) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1998.63.515 · Cited by 12
Carboxy‐terminal region of the yeast heat shock factor contains two domains that make transcription independent of the TFIIH protein kinase
Sakurai, H., Hashikawa, N., Imazu, H., & Fukasawa, T. (2003) · Genes to Cells · doi:10.1046/j.1356-9597.2003.00689.x · Cited by 12
Density transitions in the regulation of transcription
Navalkar, A., Eppert, M., Sabari, B. R., & Mittag, T. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.01.009 · Cited by 11
Using synthetic biology to make cells tomorrow's test tubes
García, H. G., Brewster, R. C., & Phillips, R. (2016) · Integrative Biology · doi:10.1039/c6ib00006a · Cited by 11
WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation
Yang, S.-D., Sun, G.-H., Wu, P., Chen, C., Kuang, Y.-J., Liu, L., Zheng, Z., He, Y.-C., Gu, Q., Lu, T., et al. (2021) · bioRxiv · doi:10.1084/jem.20211688 · Cited by 9
Bioinformatic Evaluation of Transcriptional Regulation of WNT Pathway Genes with reference to Diabetic Nephropathy
McKay, G. J., Kavanagh, D. H., Crean, J. K. G., & Maxwell, A. P. (2015) · Journal of Diabetes Research · doi:10.1155/2016/7684038 · Cited by 10
Identification of a Positive Transcription Regulatory Element within the Coding Region of the nifLA Operon in Azotobacter vinelandii
Mitra, R., Das, H. K., & Dixit, A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.7.3716-3724.2005 · Cited by 11
Contributions to gene activation by multiple functions of Bicoid
Xiuguang, M. A., Dong, Y. U. A. N., Scarborough, T., & Ma, J. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3380447 · Cited by 11
Epigenetic control: slow and global, nimble and local: Figure 1.Preprint
Cheng, C. S., Johnson, T., & Hoffmann, A. (2008) · Genes & Development · doi:10.1101/gad.1677008 · Cited by 11
Transcriptome Informatics
Chen, L., & Wong, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.20204-5 · Cited by 14
Boosting transcriptional activities by employing repeated activation domains in transcription factors
He, C., Liang, Y., Chen, R., Shen, Y., Li, R., Sun, T., Du, X., Ni, X., Shang, J., He, Y., et al. (2024) · The Plant Cell · doi:10.1093/plcell/koae315 · Cited by 10
Single-molecule analysis of transcription activation: dynamics of SAGA coactivator recruitment
Jeon, J., Friedman, L. J., Zhou, D. J., Seo, H. D., Adeleke, O. A., Graham, B., Patteson, E. F., Gelles, J., & Buratowski, S. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01451-y · Cited by 10
Gene activation guided by nascent RNA-bound transcription factors
Liang, Y., Xu, H., Cheng, T., Fu, Y., Huang, H.-W., Qian, W., Wang, J., Zhou, Y., Qian, P., Yin, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35041-7 · Cited by 11
The early function of cortisol in liver during Aeromonas hydrophila infection: Dynamics of the transcriptome and accessible chromatin landscapes
Jiang, H., Sun, M., Zhao, Y., Liu, G., Zhong, L., Xue, H., Chen, X., Zheng, Y., & Wang, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.989075 · Cited by 10
The complex Tup1‐Cyc8 bridges transcription factor ClrB and putative histone methyltransferase LaeA to activate the expression of cellulolytic genes
Zhang, X., Hu, Y., Liu, G., Liu, M., Li, Z., Zhao, J., Song, X., Zhong, Y., Qu, Y., Wang, L., et al. (2022) · Molecular Microbiology · doi:10.1111/mmi.14885 · Cited by 10
On the kinetic design of transcription.
Höfer, T., & Rasch, M. J. (2005) · PubMed · Cited by 10
The multiple roles of CRP at the complex acs promoter depend on activation region 2 and IHF
Sclavi, B., Beatty, C. M., Thach, D. S., Fredericks, C. E., Buckle, M., & Wolfe, A. J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05797.x · Cited by 10
Transcriptional regulation via TF-modifying enzymes: an integrative model-based analysis
Everett, L. J., Jensen, S. T., & Hannenhalli, S. S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr172 · Cited by 10
Regulation of chromatin structure during thymic T cell development
Winandy, S. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20391 · Cited by 10
Imposing Specificity by Localization: Mechanism and Evolvability
Ptashne, M., & Gann, A. A. F. (2002) · Natural computing series · doi:10.1007/978-3-642-55606-7_9 · Cited by 10
Self-citation
Mutations That Increase Acidity Enhance the Transcriptional Activity of the Glutamine-rich Activation Domain in Stage-specific Activator Protein
Benuck, M. L., Li, Z., & Childs, G. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25419 · Cited by 10
Identification and functional characterization of JrbZIP40 in walnut reveals its role in salt and drought stress tolerance in transgenic Arabidopsis seedlings
Wei, J., Jiao, C., Li, X.-Y., Li, X., Zhang, X., Wang, Y., Song, Y., Yang, K., Liu, Y., Zhang, J., et al. (2025) · BMC Plant Biology · doi:10.1186/s12870-025-06928-6 · Cited by 9
σ70 and PhoB activator
Canals, A., Blanco, A. G., & Coll, M. (2012) · Transcription · doi:10.4161/trns.20444 · Cited by 9
Action at distance along the DNA: A random jump model on enhancer action
Murugan, R. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.06.003 · Cited by 9
ImprintedZac1in neural stem cells
Daniel, G. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i2.300 · Cited by 10
Linking Core Promoter Classes to Circadian Transcription
Westermark, P. O. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006231 · Cited by 10
Serial analysis of binding elements for human transcription factors
Chen, J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.237 · Cited by 9
DNA wrapping in transcription initiation by RNA polymerase II
Coulombe, B. (1999) · Biochemistry and Cell Biology · doi:10.1139/o99-028 · Cited by 9
High-Mobility-Group A-Like CarD Binds to a DNA Site Optimized for Affinity and Position and to RNA Polymerase To Regulate a Light-Inducible Promoter in Myxococcus xanthus
García‐Heras, F., Abellón‐Ruiz, J., Murillo, F. J., Padmanabhan, S., & Arnanz, M. E. (2012) · Journal of Bacteriology · doi:10.1128/jb.01766-12 · Cited by 9
Dynamic Behavior of the RNA Polymerase II and the Ubiquitin Proteasome System During the Neuronal DNA Damage Response to Ionizing Radiation
Casafont, Í., Palanca, A., Lafarga, V., Mata-Garrido, J., Berciano, M. T., & Lafarga, M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9565-8 · Cited by 10
Role of transcription factor-mediated nucleosome disassembly in PHO5 gene expression
Kharerin, H., Bhat, P. J., Marko, J. F., & Padinhateeri, R. (2016) · Scientific Reports · doi:10.1038/srep20319 · Cited by 9
Nuclear Factors That Regulate Erythropoiesis
Blobel, G. A., & Weiss, M. J. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596582.008 · Cited by 9
Predictive Models of Gene Regulation
Das, D., & Zhang, M. Q. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-390-5_5
B-Cell Coactivator OBF-1 Exhibits Unusual Transcriptional Properties and Functions in a DNA-Bound Oct-1-Dependent Fashion
Krapp, A., & Strubin, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4247 · Cited by 9
Carboxy-terminally truncated form of a coactivator UTF1 stimulates transcription from a variety of gene promoters through the TATA Box.
Fukushima, A., Nishimoto, M., Okuda, A., & Muramatsu, M. (1999) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.1999.0673 · Cited by 11
Enrichment of transcriptional regulatory sites in non-coding genomic region
Xue, W., Wang, J., Shen, Z., & Zhu, H. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg450 · Cited by 9
Promoter Activation by Repositioning of RNA Polymerase
Kumar, A., & Moran, C. P. (2008) · Journal of Bacteriology · doi:10.1128/jb.00096-08 · Cited by 9
Transcriptional regulators of seven yeast species: Comparative genome analysis — Review
Drobná, E., Bialková, A., & Šubík, J. (2008) · Folia Microbiologica · doi:10.1007/s12223-008-0044-8 · Cited by 9
Role of Transcription Factors in the Pathogenesis of Pituitary Adenomas: A Review
Suhardja, A. S., Kovács, K., & Rutka, J. T. (2001) · Journal of Neuro-Oncology · doi:10.1023/a:1013819827162 · Cited by 9
A TATA-Binding Protein Mutant Defective for TFIID Complex Formation In Vivo
Ranallo, R. T., Struhl, K., & Stargell, L. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.3951 · Cited by 9
Systems analysis of matrix metalloproteinase mRNA expression in skeletal tissues
Qian, L. (2002) · Frontiers in bioscience · doi:10.2741/qian · Cited by 9
Inverse PCR-Generated Internally Deleted Constructs for Direct Characterization of Promoter Regulatory Regions
Kaluz, Š., Kaluzová, M., & Pastorek, J. (1999) · BioTechniques · doi:10.2144/99263bm18 · Cited by 9
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types
Mazzocca, M., Narducci, D. N., Grosse‐Holz, S., Matthias, J., Karpova, T., & Hansen, A. S. (2026) · Nature Structural & Molecular Biology · doi:10.1038/s41594-026-01807-6 · Cited by 25
Double Stranded DNA Binding Stapled Peptides: An Emerging Tool for Transcriptional Regulation
Paquette, A. R., & Boddy, C. N. C. (2023) · ChemBioChem · doi:10.1002/cbic.202300594 · Cited by 9
Comprendre la biologie moléculaire
Laudenbach, V., Mantz, J., & Desmonts, J.-M. (1999) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/s0750-7658(00)88453-1 · Cited by 8
Role of Far Upstream Repressor Elements Controlling Proto-Ha-ras Gene Transcription
Chakraborty, A. K., & Hodgson, C. P. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9711 · Cited by 8
Model of gene transcription including the return of a RNA polymerase to the beginning of a transcriptional cycle
Zhdanov, V. P. (2009) · Physical Review E · doi:10.1103/physreve.80.051925 · Cited by 9
DNA bending and looping in the transcriptional control of bacteriophage φ29
Camacho, A., & Salas, M. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00219.x · Cited by 8
Sharp DNA Bends as Landmarks of Protein-Binding Sites on Straightened DNA
Yokota, H., Fung, K., Trask, B. J., van den Engh, G., Sarıkaya, M., & Aebersold, R. H. (1999) · Analytical Chemistry · doi:10.1021/ac981370x · Cited by 8
Levels of expression of hRPB11, a core subassembly subunit of human RNA polymerase II, affect doxorubicin sensitivity and cellular differentiation
Bruno, T., Leonetti, C., Aloe, S., Iacobini, C., Floridi, A., Tondo, U. D., Punturieri, A., & Fanciulli, M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00432-3 · Cited by 8
Evolutionary conserved mechanism of transcriptional repression by even-skipped
Mckay, L. M., Carpenter, B., & Roberts, S. G. E. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.3064 · Cited by 8
A Debilitating Mutation in Transcription Factor IIE with Differential Effects on Gene Expression in Yeast
Tijerina, P., & Sayre, M. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.2.1107 · Cited by 8
Use of Artificial Activators to Define a Role for Protein-Protein and Protein-DNA Contacts in Transcriptional ActivationPreprint
Dove, S. L., & Hochschild, A. (1998) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1998.63.173 · Cited by 8
Functional analysis of a transrepressor domain in the hepatitis C virus core protein
Ray, R. B., Ghosh, A., Meyer, K., & Ray, R. (1999) · Virus Research · doi:10.1016/s0168-1702(98)00138-5 · Cited by 8
Long-range control of expression in yeast
Mannila, H., Patrikainen, A., Seppänen, J. K., & Kere, J. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.3.482 · Cited by 8
Artificial recruitment of certain Mediator components affects requirement of basal transcription factor IIE
Sakurai, H., & Fukasawa, T. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00613.x · Cited by 7
Nucleating the Assembly of Macromolecular Complexes
Peterson‐Kaufman, K. J., Carlson, C. D., Rodríguez‐Martínez, J. A., & Ansari, A. Z. (2010) · ChemBioChem · doi:10.1002/cbic.201000255 · Cited by 8
Control strategies for the timing of intracellular events
Cao, M., Qiu, B., Zhang, J., & Zhou, T. (2019) · Physical review. E · doi:10.1103/physreve.100.062401 · Cited by 7
The TATA-binding protein is not an essential target of the transcriptional activators Gal4p and Gcn4p in Saccharomyces cerevisiae
Bongards, C., Chew, B. S., & Lehming, N. (2003) · Biochemical Journal · doi:10.1042/bj20021548 · Cited by 7
Determining the Transcription Rates Yielding Steady-State Production of mRNA in the Lac Genetic Switch of Escherichia coli
Atitey, K., Loskot, P., & Rees, P. C. T. (2018) · Journal of Computational Biology · doi:10.1089/cmb.2018.0055 · Cited by 7
Universal two‐point interaction of mediator KIX with 9aaTAD activation domains
Hofrová, A., Louša, P., Kubíčková, M., Hritz, J., Otaševič, T., Repko, M., Knight, A., & Piskáček, M. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30075 · Cited by 7
Suppression analysis of positive control mutants of NifA reveals two overlapping promoters for Klebsiella pneumoniae rpoN
Grande, R., Valderrama, B., & Morett, E. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3232 · Cited by 7
Regulation of virulence gene expression in Staphylococcus aureus
Wisell, K. T. (2000) · Cited by 7
Constitutive and Regulated Promoters in Yeast: How to Design and Make Use of Promoters inS. cerevisiae
Ottoz, D. S. M., & Rudolf, F. (2018) · Wiley eBooks · doi:10.1002/9783527688104.ch6 · Cited by 7
A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discoveryPreprint
Azizoğlu, A., Brent, R., & Rudolf, F. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.12.874461 · Cited by 7
Mechanisms for DNA Interplay in Eukaryotic Transcription Factors
Muñoz, V., Goluguri, R. R., Ghosh, C., Tanielian, B., & Sadqi, M. (2025) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-071524-111008 · Cited by 8
Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding
He, Y., Tsuei, J., & Wan, Y. Y. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00105.2014 · Cited by 6
How Transcription Factors Binding Stimulates Transcriptional Bursting
Mondal, A. K., & Kolomeisky, A. B. (2024) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.4c02050 · Cited by 6
The Enigma of Transcriptional Activation Domains
Erkine, A. M., Oliveira, M., & Class, C. A. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168766 · Cited by 6
Genome-Wide Analysis of the PLATZ Gene Family in Oryza Genus: Evolution, Expression During Inflorescence Development and Stress Responses
Chen, H., Ma, X., Lv, G., Wang, Z., Wang, L., Yan, B., Shang, W., Wang, X., Ma, Z., & Zheng, W. (2025) · Agronomy · doi:10.3390/agronomy15010117 · Cited by 6
Minor Alterations in Core Promoter Element Positioning Reveal Functional Plasticity of a Bacterial Transcription Factor
Chowdhury, W. P., Satyshur, K. A., Keck, J. L., & Kiley, P. J. (2021) · mBio · doi:10.1128/mbio.02753-21 · Cited by 6
Where it all Begins: An Overview of Promoter Recognition and Open Complex Formation
Busby, S. J. W., Kolb, A., & BUC, H. C. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559982-00013 · Cited by 6
Mutations in β′ subunit of Escherichia coli RNA polymerase perturb the activator polymerase functional interaction required for promoter clearance
Swapna, G., Chakraborty, A., Kumari, V., Sen, R., & Nagaraja, V. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07636.x · Cited by 6

Authors: Ptashne, M., & Gann, A.
Affiliations: Harvard University (US)
Lancaster University (GB)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-04
Volume: 386
Issue: 6625
Pages: 569-577
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/386569a0
OpenAlex: W2087950896
Cited by: 1,158
References: 103
Citations by year: 2026: 5 · 2025: 20 · 2024: 29 · 2023: 13 · 2022: 22 · 2021: 32 · 2020: 20 · 2019: 22 · 2018: 21 · 2017: 15 · 2016: 34 · 2015: 18 · 2014: 35 · 2013: 27 · 2012: 43
FWCI: 8.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: transcriptional activation, recruitment model, activators, transcription machinery, histones, gene expression regulation, bacterial transcription
MeSH terms: Transcriptional Activation, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Fungal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transcriptional activation by recruitment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks