Cited by 1,158Genomics and Chromatin DynamicsBacterial Genetics and BiotechnologyGene Regulatory Network Analysis

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Transcriptional activation by recruitment

Ptashne, Mark, Gann, Alexander·1997·Nature

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Abstract

The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.

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How eukaryotic transcriptional activators work
Ptashne, M. (1988) · Nature · doi:10.1038/335683a0 · Cited by 1,828
Self-citation
MECHANISM AND CONTROL OF TRANSCRIPTION INITIATION IN PROKARYOTES
McClure, W. R. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.001131 · Cited by 1,014
Mechanism of transcriptional activation by Sp1: Evidence for coactivators
Pugh, B. F., & Tjian, R. (1990) · Cell · doi:10.1016/0092-8674(90)90683-6 · Cited by 978
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast
Hope, I. A., & Struhl, K. (1986) · Cell · doi:10.1016/0092-8674(86)90070-x · Cited by 918
Deletion analysis of GAL4 defines two transcriptional activating segments
Ma, J., & Ptashne, M. (1987) · Cell · doi:10.1016/0092-8674(87)90081-x · Cited by 887
Self-citation
A Third Recognition Element in Bacterial Promoters: DNA Binding by the α Subunit of RNA Polymerase
Ross, W., Gosink, K. K., Salomon, J., Igarashi, K., Zou, C., Ishihama, A., Severinov, K., & Gourse, R. L. (1993) · Science · doi:10.1126/science.8248780 · Cited by 789
BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID)
Burley, S. K., & Roeder, R. G. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.004005 · Cited by 734
RSC, an Essential, Abundant Chromatin-Remodeling Complex
Cairns, B. R., Lorch, Y., Li, Y., Zhang, M., Lacomis, L., Erdjument‐Bromage, H., Tempst, P., Du, J., Laurent, B. C., & Kornberg, R. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81820-6 · Cited by 667
Mechanism of Protein Access to Specific DNA Sequences in Chromatin: A Dynamic Equilibrium Model for Gene Regulation
Polach, K. J., & Widom, J. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0606 · Cited by 657
Negative effect of the transcriptional activator GAL4
Gill, G., & Ptashne, M. (1988) · Nature · doi:10.1038/334721a0 · Cited by 648
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Ptashne, M. A Genetic Switch: Phage Lambda and Higher Organisms (Cell and Blackwell Scientific, Cambridge, MA, 1992).
Hawley, D. K. & McClure, W. R. Mechanism of activation of transcription initiation from the lambda-PRM promoter. J. Mol. Biol. 157, 493–525 (1982). · DOI

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Falahzadeh, K., Shahhoseini, M., & Afsharian, P. (2016) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2016.4316 · Cited by 1

Authors: Ptashne, M., & Gann, A.
Affiliations: Harvard University (US)
Lancaster University (GB)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-04
Volume: 386
Issue: 6625
Pages: 569-577
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/386569a0
OpenAlex: W2087950896
Cited by: 1,158
References: 103
Citations by year: 2026: 5 · 2025: 20 · 2024: 29 · 2023: 13 · 2022: 22 · 2021: 32 · 2020: 20 · 2019: 22 · 2018: 21 · 2017: 15 · 2016: 34 · 2015: 18 · 2014: 35 · 2013: 27 · 2012: 43
FWCI: 8.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: transcriptional activation, recruitment model, activators, transcription machinery, histones, gene expression regulation, bacterial transcription
MeSH terms: Transcriptional Activation, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Fungal

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Transcriptional activation by recruitment

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