Mdm2 promotes the rapid degradation of p53

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Items 801–900 of 1,058

1. Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
   Jiang‐Jiang Qin, Xin Li, Courtney Hunt, Wei Wang, Hui Wang, Ruiwen Zhang · 2018 · Genes & Diseases
2. Protein Degradation and the Pathologic Basis of Disease
   John W. Hanna, Ángel Guerra-Moreno, Jessie Ang, Yagmur Micoogullari · 2018 · American Journal Of Pathology
3. Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism
   Xin Yu, Adam R. Blanden, Sumana Narayanan, Lalithapriya Jayakumar, David J. Lubin, David J. Augeri, S. David Kimball, Stewart N. Loh, Darren R. Carpizo · 2014 · Oncotarget
4. Genetic and epigenetic alterations as hallmarks of the intricate road to cancer
   Marcella Macaluso, Marco Giorgio Paggi, Antonio Giordano · 2003 · Oncogene
5. Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation
   Lorenzo Montanaro, Maria Calienni, Sara Bertoni, Laura Rocchi, Pasquale Sansone, Gianluca Storci, Donatella Santini, Claudio Ceccarelli, Mario Taffurelli, Domenica Carnicelli et al. · 2010 · Cancer Research
6. West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus
   Mi-Ran Yang, Sung Ryul Lee, Wonkyung Oh, Eun‐Woo Lee, Jung‐Yong Yeh, Jin‐Ju Nah, Yi-Seok Joo, Jaekyoon Shin, Han‐Woong Lee, Suhkneung Pyo et al. · 2007 · Cellular Microbiology
7. The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms
   Amy Mauser, Shinichi Saito, Ettore Appella, Carl W. Anderson, William T. Seaman, Shannon C. Kenney · 2002 · Journal of Virology
8. The death substrate Gas2 binds m‐calpain and increases susceptibility to p53‐dependent apoptosis
   Roberta Benetti, Giannino Del Sal, Martín Monte, Gabriela Paroni, Claudio Brancolini, Claudio Schneider · 2001 · The EMBO Journal
9. Prognostic Value of p53 Genetic Changes in Colorectal Cancer
   Ulf Kressner, Mats Inganäs, Sara Byding, Ingrid Blikstad, Lars Påhlman, Bengt L. G. Glimelius, Gudrun E. Lindmark · 1999 · Journal of Clinical Oncology
10. Activation of p53 by oncogenes.
    Scott W. Lowe · 1999 · Endocrine Related Cancer
11. Functional interplay between MDM2, p63/p73 and mutant p53
    Maren Stindt, Patricia A. J. Muller, R Ludwig, Sebastian Kehrloesser, Volker Dötsch, Karen H. Vousden · 2014 · Oncogene
12. Grb10/Nedd4‐mediated multiubiquitination of the insulin‐like growth factor receptor regulates receptor internalization
    Giada Monamì, Velia Emiliozzi, Andrea Morrione · 2008 · Journal of Cellular Physiology
13. Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor Protein
    Willem den Besten, Mei-Ling Kuo, Richard Thomas Williams, Charles J. Sherr · 2005 · Cell Cycle
14. P53 activity is essential for normal development in Xenopus
    John B. Wallingford, Daniel W. Seufert, Valerie Christine Virta, Peter D. Vize · 1997 · Current Biology
15. Identification of Three Functions of the Adenovirus E4orf6 Protein That Mediate p53 Degradation by the E4orf6-E1B55K Complex
    Emmanuelle Querido, Megan R. Morrison, Huan Chu Pham Dang, Sarah W.-L. Thirlwell, Dominique Boivin, Philip E. Branton · 2001 · Journal of Virology
16. Role of two upstream open reading frames in the translational control of oncogene mdm2
    Cheryl Y. Brown, Gregory J. Mize, Mario Javier Pineda, Donna L. George, David Morris · 1999 · Oncogene
17. ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization
    Chandrashekhar K. Korgaonkar, Lili Zhao, Modestos Modestou, Dawn E. Quelle · 2002 · Molecular and Cellular Biology
18. Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes
    Penny G. Ard, Chandrima Chatterjee, Sudeesha Kunjibettu, Leon R. Adside, Lisa E. Gralinski, Steven B. McMahon · 2002 · Molecular and Cellular Biology
19. Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC–p53 protein interactions
    Yuan Shen, Shanshan Liu, Jiao Jie Fan, Ying‐Hua Jin, Baolei Tian, Xiaofei Zheng, Hanjiang Fu · 2017 · EMBO Reports
20. Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope
    Atif Zafar, Wei Wang, Gang Liu, Wa Xian, Frank McKeon, Jia Zhou, Ruiwen Zhang · 2020 · Cancer Letters
21. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
    Qi Zhang, Shelya X. Zeng, Yu Zhang, Yi-Wei Zhang, Derong Ding, Qi-Zhuang Ye, Samy O. Meroueh, Hua Lu · 2012 · EMBO Molecular Medicine
22. Mitochondrial Ribosomal Protein L41 Suppresses Cell Growth in Association with p53 and p27Kip1
    Young A. Yoo, Mi Jin Kim, Jong Kuk Park, Young Min Chung, Jong Hyeok Lee, Sung-Gil Chi, Jun Suk Kim, Young Do Yoo · 2005 · Molecular and Cellular Biology
23. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway
    Zonghan Dai, Robert C. Quackenbush, Kevin Dale Courtney, Matthew Grove, David Cortez, Gary W. Reuther, Ann Marie Pendergast · 1998 · Genes & Development
24. Live and Let Die – Regulation of Villous Trophoblast Apoptosis in Normal and Abnormal Pregnancies
    Alexander E. P. Heazell, Ian P. Crocker · 2008 · Placenta
25. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.
    Monika Phelps, Matthew Darley, John N Primrose, Jeremy P. Blaydes · 2003 · PubMed
26. Mdm2 overexpression and p14ARF inactivation are two mutually exclusive events in primary human lung tumors
    Béatrice Eymin, Sylvie Gazzéri, Christian Brambilla, Elisabeth M. Brambilla · 2002 · Oncogene
27. Inhibition of p53 degradation by Mdm2 acetylation
    Xinjiang Wang, Jan Taplick, Naama Geva, Moshe Oren · 2004 · FEBS Letters
28. Proteasomal Inhibition Attenuates Transcriptional Activity of Hypoxia-Inducible Factor 1 (HIF-1) via Specific Effect on the HIF-1α C-Terminal Activation Domain
    Kaluz, Stefan, Kaluzová, Milota, Stanbridge, Eric J. · 2006 · Molecular and Cellular Biology
29. Overexpression of Insulin-Like Growth Factor-1 Attenuates the Myocyte Renin-Angiotensin System in Transgenic Mice
    Annarosa Leri, Yu Liu, Xiaowei Wang, Jan Kajstura, Ashwani Malhotra, Leonard G. Meggs, Piero Anversa · 1999 · Circulation Research
30. Identification of ribosomal protein S25 (RPS25)–MDM2–p53 regulatory feedback loop
    Xinyuan Zhang, Wenjing Wang, Hui Wang, M-H Wang, Wenrong Xu, R Zhang · 2012 · Oncogene
31. Zinc Finger Proteins in Neuro-Related Diseases Progression
    Siyuan Bu, Yihan Lv, Yusheng Liu, Sen Qiao, Hongmei Wang · 2021 · Frontiers in Neuroscience
32. Critical Role of Cysteine Residue 81 of Macrophage Migration Inhibitory Factor (MIF) in MIF-induced Inhibition of p53 Activity
    Haiyoung Jung, Hyun‐A Seong, Hyunjung Ha · 2008 · Journal of Biological Chemistry
33. A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
    Lasse Weinmann, Jörg Wischhusen, Mark J. Demma, Ulrike Naumann, Patrick Roth, Bimalendu Dasmahapatra, Michael Weller · 2008 · Cell Death and Differentiation
34. Negative cross‐talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells
    Sagar Sengupta, Jean‐Luc Vonesch, Caroline Waltzinger, Hong Zheng, Bohdan Wasylyk · 2000 · The EMBO Journal
35. Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma
    Y. Kamiya · 2002 · Carcinogenesis
36. Hypoxia Enhances Metastatic Efficiency by Up-Regulating Mdm2 in KHT Cells and Increasing Resistance to Apoptosis
    Li Zhang, Richard Peter Hill · 2004 · Cancer Research
37. Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis
    Kazushi Inoue, Renren Wen, Jerold E. Rehg, Masashi Adachi, John L. Cleveland, Martine F. Roussel, Charles J. Sherr · 2000 · Genes & Development
38. Synoviolin, protein folding and the maintenance of joint homeostasis
    Naoko Yagishita, Satoshi Yamasaki, Kusuki Nishioka, Toshihiro Nakajima · 2008 · Nature Clinical Practice Rheumatology
39. Depletion of the Nucleolar Protein Nucleostemin Causes G1 Cell Cycle Arrest via the p53 Pathway
    Hanhui Ma, Thoru Pederson · 2007 · Molecular Biology of the Cell
40. Regulatory Roles for Long ncRNA and mRNA
    Armen Karapetyan, Coen Buiting, Renske A. Kuiper, Marcel W. Coolen · 2013 · Cancers
41. Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation
    Xinjiang Wang, Amir Zalcenstein, Moshe Oren · 2003 · Cell Death and Differentiation
42. MdmX Is a RING Finger Ubiquitin Ligase Capable of Synergistically Enhancing Mdm2 Ubiquitination
    James Charles Badciong, Arthur L. Haas · 2002 · Journal of Biological Chemistry
43. Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis
    J M R Lambert, Ali Moshfegh, Pierre L. Hainaut, Klas G. Wiman, Vladimir J.N. Bykov · 2009 · Oncogene
44. Nedd4-2 Phosphorylation Induces Serum and Glucocorticoid-regulated Kinase (SGK) Ubiquitination and Degradation
    Ruifeng Zhou, Peter M. Snyder · 2004 · Journal of Biological Chemistry
45. Anti-hepatocyte growth factor antibody inhibits hepatocyte proliferation during liver regeneration
    Andrew W. Burr, Kieran Toole, Claire Chapman, Julie E. Hines, Alastair D. Burt · 1998 · The Journal of Pathology
46. The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil
    Wěi Li, Carol H. Thompson, Yvonne E. Cossart, Christopher J. O’Brien, Edward Braddon McNeil, Richard A. Scolyer, Barbara R. Rose · 2003 · Head & Neck
47. Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
    Zhihong Lai, Tao Yang, Young B. Kim, Thais M. Sielecki, Melody A. Diamond, Peter R. Strack, Mark Rolfe, Maureen Caligiuri, Pamela A. Benfield, Kurt R. Auger et al. · 2002 · Proceedings of the National Academy of Sciences
48. p53 Biological Network: At the Crossroads of the Cellular-Stress Response Pathway and Molecular Carcinogenesis
    S. Perwez Hussain, Cutis C. Harris · 2006 · Journal of Nippon Medical School
49. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms.
    Hui Wang, Li Nan, Dong Soo Yu, Sudhir Agrawal, Ruiwen Zhang · 2001 · PubMed
50. ZBP-89 Promotes Growth Arrest through Stabilization of p53
    Longchuan Bai, Juanita L. Merchant · 2001 · Molecular and Cellular Biology
51. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas
    Kazushi Inoue, Frédérique Zindy, David H. Randle, Jerold E. Rehg, Charles J. Sherr · 2001 · Genes & Development
52. Therapeutic targeting of cancer cell cycle using proteasome inhibitors
    Namrata Rastogi, Durga Prasad Mishra · 2012 · Cell Division
53. Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells
    Emarndeena Haji Cheteh, Victoria Sarne, Sophia Ceder, Julie Bianchi, Martin Augsten, Helene Rundqvist, Lars Egevad, Arne Östman, Klas G. Wiman · 2020 · Cell Death Discovery
54. USP7 - a crucial regulator of cancer hallmarks
    Gouranga Saha, Srija Roy, Malini Basu, Mrinal K. Ghosh · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
55. Regulation of p53 - insights into a complex process
    Karen A. Boehme, Christine Blattner · 2009 · Critical Reviews in Biochemistry and Molecular Biology
56. Characterization of Human Constitutive Photomorphogenesis Protein 1, a RING Finger Ubiquitin Ligase That Interacts with Jun Transcription Factors and Modulates Their Transcriptional Activity
    Elisabetta Bianchi, Simona Denti, Raffaella Catena, Grazisa Rossetti, Simona Polo, Sona Gasparian, Stella Putignano, Lars Rogge, Ruggero Pardi · 2003 · Journal of Biological Chemistry
57. Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells
    Lauréline Roger, Laurent Jullien, Véronique Gire, Pierre Roux · 2010 · Journal of Cell Science
58. An Aqueous Extract of Fagonia cretica Induces DNA Damage, Cell Cycle Arrest and Apoptosis in Breast Cancer Cells via FOXO3a and p53 Expression
    Matthew Lam, Amtul Razzaq Carmichael, Helen R. Griffiths · 2012 · PLoS ONE
59. Definition of the p53 Functional Domains Necessary for Inducing Apoptosis
    Jianhui Zhu, Shunzhen Zhang, Jieyuan Jiang, Xinbin Chen · 2000 · Journal of Biological Chemistry
60. Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions
    Paul D. Smith, Susan Crossland, Gillian A. Parker, Peter Osin, Louise A. Brooks, Joanne Waller, Elizabeth Philp, Mark R Crompton, Barry A. Gusterson, Martin J. Allday et al. · 1999 · Oncogene
61. Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class�I histone deacetylases
    Sanjay Gupta · 2012 · International Journal of Oncology
62. Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression
    Jianxia Wei, Mengna Li, Changning Xue, Shipeng Chen, Lemei Zheng, Hongyu Deng, Faqing Tang, Guiyuan Li, Wei Xiong, Zhaoyang Zeng et al. · 2023 · Journal of Experimental & Clinical Cancer Research
63. Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes
    Maralee McVean, Hengyi Xiao, Ken‐ichi Isobe, Jill C. Pelling · 2000 · Carcinogenesis
64. Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells
    Ute Fischer, Sabine Steffens, Susanne Frank, Nikolai G. Rainov, Klaus Schulze‐Osthoff, Christof Maria Kramm · 2004 · Oncogene
65. The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine
    J. Malíková, Adéla Zdařilová, Alice Hlobílková, Jitka Ulrichová A · 2006 · Cell Biology and Toxicology
66. c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53
    Ronit Vogt Sionov, Eli Moallem, Michael Berger, Anat Kazaz, Offer Gerlitz, Yinon Ben‐Neriah, Moshe Oren, Ygal Haupt · 1999 · Journal of Biological Chemistry
67. Mutation of Mouse p53 Ser23 and the Response to DNA Damage
    Wu, Zhiqun, Earle, John, Saito, Shin'ichi, Anderson, Carl W., Appella, Ettore, Xu, Yang · 2002 · Molecular and Cellular Biology
68. MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice
    Shrikant R. Mulay, Dana Thomasová, Mi Ryu, Hans‐Joachim Anders · 2012 · Kidney International
69. LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation
    Kaixuan Zeng, Xiaoxiang Chen, Xiuxiu Hu, Xiangxiang Liu, Tao Xu, Huiling Sun, Yuqin Pan, Bangshun He, Shukui Wang · 2018 · Oncogene
70. Accumulation of protein O‐GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O‐GlcNAc metabolism
    Kan Liu, Andrew J. Paterson, Fengxue Zhang, Joanne McAndrew, Ken‐ichiro Fukuchi, James Michael Wyss, Ling Peng, Yong Hu, Jeffrey E. Kudlow · 2004 · Journal of Neurochemistry
71. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
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72. Targeting Ubiquitination for Cancer Therapies
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73. Radiation-Induced p53 and p21WAF–1/CIP1 Expression in the Murine Intestinal Epithelium
    James W. Wilson, David Mark Pritchard, John A. Hickman, Christopher S. Potten · 1998 · American Journal Of Pathology
74. Escape of p53 protein from E6‐mediated degradation in HeLa cells after cisplatin therapy
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75. Myc-Mediated Proliferation and Lymphomagenesis, but Not Apoptosis, Are Compromised by E2f1 Loss
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76. Alterations of the p16-pRb Pathway and the Chromosome Locus 9p21–22 in Non-Small-Cell Lung Carcinomas
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77. Single-nucleotide Polymorphisms in the p53 Signaling Pathway
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78. The Role of the Apoptotic Machinery in Tumor Suppression
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79. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity
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80. The Cell Cycle-regulated Protein Human GTSE-1 Controls DNA Damage-induced Apoptosis by Affecting p53 Function
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81. Regulation of transcription factors by protein degradation
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82. Interplay between Ribosomal Protein S27a and MDM2 Protein in p53 Activation in Response to Ribosomal Stress
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83. Analysis of the degradation function of Mdm2.
    Michael H.G. Kubbutat, R Ludwig, Arnold J. Levine, Karen H. Vousden · 1999 · PubMed
84. Monitoring and Signaling of Radiation-Induced Damage in Mammalian Cells
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85. Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay
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86. Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression
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87. Critical Role of VCP/p97 in the Pathogenesis and Progression of Non-Small Cell Lung Carcinoma
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88. TRIM24 Is a p53-Induced E3-Ubiquitin Ligase That Undergoes ATM-Mediated Phosphorylation and Autodegradation during DNA Damage
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89. Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
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90. MDM2 Enhances the Function of Estrogen Receptor α in Human Breast Cancer Cells
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91. A Role for p53 in Maintaining and Establishing the Quiescence Growth Arrest in Human Cells
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92. MSL2 Promotes Mdm2-independent Cytoplasmic Localization of p53
    Jan-Philipp Kruse, Wei Jun Gu · 2008 · Journal of Biological Chemistry
93. Differential Regulation of Estrogen Receptor α Turnover and Transactivation by Mdm2 and Stress-Inducing Agents
    Vanessa Duong, Nathalie Boulle, Sylvain Daujat, Jérôme Chauvet, Sandrine Bonnet, Henry Neel, Vincent Cavaillès · 2007 · Cancer Research
94. PTEN Regulates Mdm2 Expression through the P1 Promoter
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95. Regulation of p53 Localization and Activity by Ubc13
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96. The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association
    Yoichi Nagata, Tadashi Anan, Tetsuo Yoshida, Tamio Mizukami, Yoichi Taya, Toshiyoshi Fujiwara, Hirohisa Kato, Hideyuki Saya, Mitsuyoshi Nakao · 1999 · Oncogene
97. p53-Mediated Regulation of Proliferating Cell Nuclear Antigen Expression in Cells Exposed to Ionizing Radiation
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98. Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response
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99. Preeclampsia Is Associated with Alterations in the p53-Pathway in Villous Trophoblast
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100. How To Design a Successful p53–MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures
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