Mdm2 promotes the rapid degradation of p53

Cited by (1,058)

Items 101–200 of 1,058

1. Nucleo‐cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
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2. E1A signaling to p53 involves the p19ARFtumor suppressor
   Elisa de Stanchina, Mila E. McCurrach, Frédérique Zindy, Sheau-Yann Shieh, Gerardo Ferbeyre, Andrew V. Samuelson, Carol L. Prives, Martine F. Roussel, Charles J. Sherr, Scott W. Lowe · 1998 · Genes & Development
3. The cellular response to p53: the decision between life and death
   Ronit Vogt Sionov, Ygal Haupt · 1999 · Oncogene
4. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
   Thomas G. Hofmann, Andreas Möller, Hüseyin Sirma, Hanswalter Zentgraf, Yoichi Taya, Wulf Dröge, Hans Will, Michael Lienhard Schmitz · 2001 · Nature Cell Biology
5. p53 signaling in cancer progression and therapy
   Hany E. S. Marei, Asmaa A. Al Thani, Nahla M. Afifi, Anwarul Hasan, Thomas Caceci, Giacomo Pozzoli, Andrea Morrione, Antonio Giordano, Carlo Cenciarelli · 2021 · Cancer Cell International
6. Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
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7. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.
   Chehab, Nabil H., Malikzay, Asra, Stavridi, Elena S., Halazonetis, Thanos D. · 1999 · Proceedings of the National Academy of Sciences
8. Signaling to p53: ribosomal proteins find their way
   Zhang, Yanping, Lu, Hua · 2009 · Cancer Cell
9. The expanding universe of p53 targets
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10. Functions of the MDM2 oncoprotein
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11. Stochastic modelling for quantitative description of heterogeneous biological systems
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12. Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity
    Xirodimas, Dimitris P, Saville, Mark K, Bourdon, Jean-Christophe, Hay, Ronald T, Lane, David P · 2004 · Cell
13. Rescuing the function of mutant p53
    Alex N. Bullock, Alan Roy Fersht · 2001 · Nature reviews. Cancer
14. Regulation of the p53 Tumor Suppressor Protein
    Moshe Oren · 1999 · Journal of Biological Chemistry
15. Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
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16. Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway
    Yanping Zhang, Gabrielle White Wolf, Krishna Bhat, Aiwen Jin, Theresa Allio, William Burkhart, Yue Xiong · 2003 · Molecular and Cellular Biology
17. Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
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18. The Ubiquitin-Proteasome Pathway and Its Role in Cancer
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19. ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor
    Delin Chen, Ning Kon, Muyang Li, Wenzhu Zhang, Jun Qin, Wei Jun Gu · 2005 · Cell
20. P19 ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
    Weikang Tao, Arnold J. Levine · 1999 · Proceedings of the National Academy of Sciences
21. The INK4A/ARF locus and its two gene products.
    Sharpless, Norman E, DePinho, Ronald A · 1999 · Current Opinion in Genetics & Development
22. Inhibition of MDM2-mediated p53 Ubiquitination and Degradation by Ribosomal Protein L5
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23. MDM2 inhibitors for cancer therapy
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24. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis
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25. MEKK1/JNK signaling stabilizes and activates p53
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26. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
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27. twist is a potential oncogene that inhibits apoptosis
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28. Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6
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29. Evaluation of the use of therapeutic peptides for cancer treatment
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30. Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1
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31. The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor
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32. Acetylation of p53 inhibits its ubiquitination by Mdm2
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33. Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition
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34. Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
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35. LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity
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36. Non-histone protein methylation as a regulator of cellular signalling and function
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37. p53 and its mutants in tumor cell migration and invasion
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38. Prognostic and Predictive Gene Signature for Adjuvant Chemotherapy in Resected Non–Small-Cell Lung Cancer
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39. Angiogenesis and Cardiac Hypertrophy
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40. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
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41. Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300
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42. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
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43. Regulation of p53 function and stability by phosphorylation.
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44. Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
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45. Strategies for Targeting Protein–Protein Interactions With Synthetic Agents
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46. The role of iron in cell cycle progression and the proliferation of neoplastic cells
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47. The ubiquitin‐proteasome pathway and proteasome inhibitors
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48. Regulating tumor suppressor genes: post-translational modifications
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49. E3 ubiquitin ligases: styles, structures and functions
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50. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage
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51. Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage
    Batchelor, Eric, Mock, Caroline S., Bhan, Irun, Loewer, Alexander, Lahav, Galit · 2008 · Molecular Cell
52. Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
    Alex N. Bullock, Julia Henckel, Alan Roy Fersht · 2000 · Oncogene
53. Drugging the undruggables: exploring the ubiquitin system for drug development
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54. Structure and acetyl-lysine recognition of the bromodomain
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55. ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53
    Damu Tang, Dongcheng Wu, Atsushi Hirao, Jill M. Lahti, Lieqi Liu, Brie Mazza, Vincent J. Kidd, Tak W. Mak, Alistair John Ingram · 2002 · Journal of Biological Chemistry
56. Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity
    Sabrina Strano, Eliana Rosa Munarriz, Mario Rossi, Luisa Castagnoli, Yosef Shaul, Ada Sacchi, Moshe Oren, Marius Sudol, Gianni Cesareni, Giovanni Blandino · 2001 · Journal of Biological Chemistry
57. p53-Dependent apoptosis pathways
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58. RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
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59. The MDM2-p53 pathway revisited
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60. Regulation of p53 stability
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61. p300/MDM2 complexes participate in MDM2-mediated p53 degradation
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62. Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
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63. Thermodynamic stability of wild-type and mutant p53 core domain
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64. c-Jun and p53 Activity Is Modulated by SUMO-1 Modification
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65. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
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66. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.
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67. The proteasomal system
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68. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
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69. NUMB controls p53 tumour suppressor activity
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70. MDM2, an introduction.
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71. Nucleolus: the fascinating nuclear body
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72. Molecular targeting therapies for neuroblastoma: Progress and challenges
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73. Translating p53 into the clinic
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74. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
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75. The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells
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76. A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation
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77. A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73
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78. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
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79. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
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80. Sex differences in cancer mechanisms
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81. Zebrafish as a Model Organism for the Identification and Characterization of Drugs and Genes Affecting p53 Signaling
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82. The spatial and temporal organization of ubiquitin networks
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83. Targeting the MDM2-p53 Interaction for Cancer Therapy
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84. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
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85. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
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86. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
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87. The MDM2 RING-finger domain is required to promote p53 nuclear export
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88. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
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89. Mdm2-mediated ubiquitylation: p53 and beyond
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90. Opposing Effects of Ras on p53
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91. The inherent instability of mutant p53 is alleviated by Mdm2 or p16 INK4a loss
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92. Stress Signals Utilize Multiple Pathways To Stabilize p53
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93. Deadly encounter: ubiquitin meets apoptosis
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94. Inhibition of HDM2 and Activation of p53 by Ribosomal Protein L23
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95. p53-independent functions of the p19ARF tumor suppressor
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96. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
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97. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
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98. The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53
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99. PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy
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100. TheArabidopsisAux/IAA Protein Family Has Diversified in Degradation and Auxin Responsiveness
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