Mdm2 promotes the rapid degradation of p53

Cited by (1,058)

Items 501–600 of 1,058

1. p53 Regulation of G ₂ Checkpoint Is Retinoblastoma Protein Dependent
   Flatt, Patricia M., Tang, Luo Jia, Scatena, Caroline D., Szak, Suzanne T., Pietenpol, Jennifer A. · 2000 · Molecular and Cellular Biology
2. Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
   Gire, Veronique, Wynford-Thomas, David · 1998 · Molecular and Cellular Biology
3. Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo
   Saville, Mark K., Sparks, Alison, Xirodimas, Dimitris P., Wardrop, Julie, Stevenson, Lauren F., Bourdon, Jean-Christophe, Woods, Yvonne L., Lane, David P. · 2004 · Journal of Biological Chemistry
4. Cotranscriptional exon skipping in the genotoxic stress response
   Martin Dutertre, Gabriel Sanchez, Marie‐Cécile De Cian, Jérôme Barbier, Étienne Dardenne, Lise Gratadou, Gwendal Dujardin, Catherine Le Jossic-Corcos, Laurent Corcos, Didier Auboeuf · 2010 · Nature Structural & Molecular Biology
5. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
   Eun‐Woo Lee, Min-Sik Lee, Suzanne Camus, Jaewang Ghim, Mi Ran Yang, Wonkyung Oh, Nam‐Chul Ha, David Philip Lane, Jaewhan Song · 2009 · The EMBO Journal
6. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53
   Rehan Khan, Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Mir Tahir, Muneeb U. Rehman, Farrah Diebaa Rashid Ali, Sarwat Sultana · 2011 · Toxicology and Applied Pharmacology
7. Pifithrin-α protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice
   Xuwan Liu, Chu Chang Chua, Jinping Gao, Zhongyi Chen, Cathy Landy, Ronald C. Hamdy, Balvin H.L. Chua · 2004 · American Journal of Physiology-Heart and Circulatory Physiology
8. DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
   Xiaoqiao Yue, Chenjun Bai, Dafei Xie, Teng Ma, Ping‐Kun Zhou · 2020 · Frontiers in Genetics
9. Transcription, apoptosis and p53: catch-22
   Martin Schüler, Douglas R. Green · 2005 · Trends in Genetics
10. MicroRNA-9 Reveals Regional Diversity of Neural Progenitors along the Anterior-Posterior Axis
    Boyan Bonev, Angela Oliveira Pisco, Nancy Papalopulu · 2011 · Developmental Cell
11. Regulation of ES cell differentiation by functional and conformational modulation of p53
    Kanaga Sabapathy, Martina Klemm, Rudolf Jaenisch, Erwin F. Wagner · 1997 · The EMBO Journal
12. Long Noncoding RNAs Regulate Cell Growth, Proliferation, and Apoptosis
    Jingqiu Li, Haihua Tian, Jie Yang, Zhaohui Gong · 2016 · DNA and Cell Biology
13. Regulating the Regulators: Control of Protein Ubiquitination and Ubiquitin-like Modifications by Extracellular Stimuli
    Min Gao, Michael Karin · 2005 · Molecular Cell
14. Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
    Lihong Chen, Sudhir Agrawal, Wenqiang Zhou, Ruiwen Zhang, Jiandong Chen · 1998 · Proceedings of the National Academy of Sciences
15. A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
    Limin Li, Jian Liao, Jürgen Ruland, Tak W. Mak, Stanley N. Cohen · 2001 · Proceedings of the National Academy of Sciences
16. Ser18 and 23 phosphorylation is required for p53‐dependent apoptosis and tumor suppression
    Chao, Connie, Herr, Deron, Chun, Jerold, Xu, Yang · 2006 · The EMBO Journal
17. Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy?
    Steven Pennock, Luis J. Haddock, Dean Eliott, Shizuo Mukai, Andrius Kazlauskas · 2014 · Progress in Retinal and Eye Research
18. Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression
    Beverly, Levi J., Felsher, Dean W., Capobianco, Anthony J. · 2005 · Cancer Research
19. Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
    Slađana Bursać, Maja Cokarić Brdovčak, Giulio Donati, Siniša Volarević · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
20. Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity
    Brigitte A. Wevers, Tanja M. Kaptein, Esther Willems, Bart Theelen, Teun Boekhout, Teunis B. H. Geijtenbeek, Sonja I. Gringhuis · 2014 · Cell Host & Microbe
21. The F Box Protein Dsg1/Mdm30 Is a Transcriptional Coactivator that Stimulates Gal4 Turnover and Cotranscriptional mRNA Processing
    Masafumi Muratani, Charles K.-H. Kung, Kevan M. Shokat, William P. Tansey · 2005 · Cell
22. Estrogen Receptor-Dependent Proteasomal Degradation of the Glucocorticoid Receptor Is Coupled to an Increase in Mdm2 Protein Expression
    Harriet Karimi Kinyamu, Trevor Archer · 2003 · Molecular and Cellular Biology
23. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
    Xiong, Shunbin, Van Pelt, Carolyn S., Elizondo-Fraire, Ana C., Liu, Geng, Lozano, Guillermina · 2006 · Proceedings of the National Academy of Sciences
24. Mechanisms of p53 degradation
    Chuck C.‐K. Chao · 2014 · Clinica Chimica Acta
25. Genetic polymorphisms in cell cycle regulatory genesMDM2 andTP53 are associated with susceptibility to lung cancer
    Xuemei Zhang, Xiaoping Miao, Yongli Guo, Wen Tan, Yifeng Zhou, Tong Sun, Yonggang Wang, Dongxin Lin · 2005 · Human Mutation
26. Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop
    Trudy G. Oliver, Etienne Meylan, Gregory P. Chang, Wen Xue, James R. Burke, Timothy J. Humpton, Diana Hubbard, Arjun J. Bhutkar, Tyler Jacks · 2011 · Molecular Cell
27. p53 is balancing development, differentiation and de-differentiation to assure cancer prevention
    Alina Molchadsky, Noa Rivlin, Ran Brosh, Varda Rotter, Rachel Sarig · 2010 · Carcinogenesis
28. Proteasome system of protein degradation and processing
    Alexey V. Sorokin, E. R. Kim, Lev P. Ovchinnikov · 2009 · Biochemistry (Moscow)
29. Hsp90: an emerging target for breast cancer therapy
    Jason Beliakoff, Luke J. Whitesell · 2004 · Anti-Cancer Drugs
30. The ubiquitin–proteasome system in cardiac dysfunction
    Giulia Mearini, Saskia Schlossarek, Monte S. Willis, Lucie Carrier · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
31. A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer
    Xiangya Ding, Xuemei Jia, Cong Wang, Jingyun Xu, Shou‐Jiang Gao, Chun Lu · 2018 · Cell Death and Differentiation
32. Should mutant TP53 be targeted for cancer therapy?
    Zilu Wang, Andreas Strasser, Gemma L. Kelly · 2022 · Cell Death and Differentiation
33. MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice
    Kelvin Ka-lok Wu, Xiaofan Xu, Manyin Wu, Xiaomu Li, Moinul Hoque, Gloria Hoi‐Yee Li, Qizhou Lian, Kekao Long, Tongxi Zhou, Hai‐long Piao et al. · 2024 · Nature Communications
34. Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain
    Sridevi Yadavilli, Lindsey D. Mayo, Maureen Higgins, Sonia Laı́n, Vijay K. Hegde, Walter A. Deutsch · 2009 · DNA repair
35. Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin
    Peter Tsvetkov, Gad Asher, Veronica Reiss, Yosef Shaul, Leo Sachs, Joseph Lotem · 2005 · Proceedings of the National Academy of Sciences
36. Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein
    Dawid Walerych, Grzegorz Kudla, Małgorzata Gutkowska, Bartosz Wawrzynów, Lin Muller, Frank W. King, Aleksandra Helwak, Joanna Boros, Maciej Żylicz, Maciej Żylicz · 2004 · Journal of Biological Chemistry
37. Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice
    Sluss, Hayla K., Armata, Heather, Gallant, Judy, Jones, Stephen N. · 2004 · Molecular and Cellular Biology
38. Proteasome activator PA28γ regulates p53 by enhancing its MDM2‐mediated degradation
    Zhuo Zhang, Ruiwen Zhang · 2008 · The EMBO Journal
39. gadd153/Chop10 , a Potential Target Gene of the Transcriptional Repressor ATF3
    Curt D. Wolfgang, Benjamin P.C. Chen, Jennifer L. Martindale, Nikki J. Holbrook, Tsonwin Hai · 1997 · Molecular and Cellular Biology
40. Promoter specificity and stability control of the p53-related protein p73
    Chang‐Woo Lee, Nicholas Barrie La Thangue · 1999 · Oncogene
41. USP4 inhibits p53 through deubiquitinating and stabilizing ARF‐BP1
    Xinna Zhang, Franklin G. Berger, Jianhua Yang, Xiongbin Lu · 2011 · The EMBO Journal
42. Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
    Ian Robert Hardcastle, Junfeng Liu, Eric Valeur, Anna F. Watson, Shafiq Uddin Ahmed, Timothy J. Blackburn, Karim Bennaceur, W. Clegg, Catherine J. Drummond, Jane Endicott et al. · 2011 · Journal of Medicinal Chemistry
43. Cancer-Associated Mutations in the MDM2 Zinc Finger Domain Disrupt Ribosomal Protein Interaction and Attenuate MDM2-Induced p53 Degradation
    Mikael S. Lindström, Aiwen Jin, Chad Deisenroth, Gabrielle White Wolf, Yanping Zhang · 2006 · Molecular and Cellular Biology
44. Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury
    Atsuhiko T. Naito, Sho Okada, Tohru Minamino, Koji Iwanaga, Mei-Lan Liu, Tomokazu S. Sumida, Seitaro Nomura, Naruhiko Sahara, Tatsuya Mizoroki, Akihiko Takashima et al. · 2010 · Circulation Research
45. Tumor suppressor p53: regulation and function
    Kumaravel Somasundaram · 2000 · Frontiers in bioscience
46. 20S Proteasomal Degradation of Ornithine Decarboxylase Is Regulated by NQO1
    Gad Asher, Zippi Bercovich, Peter Tsvetkov, Yosef Shaul, Chaim Kahana · 2005 · Molecular Cell
47. mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.
    Young‐Chae Chang, Yong Soo Lee, Tazuko Tejima, Ken‐ichiro Tanaka, Satoshi Ōmura, Nicholas H. Heintz, Youji Mitsui, Junji Magae · 1998 · PubMed
48. DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation
    Blattner, Christine, Tobiasch, Edda, Litfen, Margarethe, Rahmsdorf, Hans J, Herrlich, Peter · 1999 · Oncogene
49. p53 and metabolism: from mechanism to therapeutics
    Fernando Moreira Simabuco, Mirian Galliote Morale, Isadora Carolina Betim Pavan, Ana Paula Morelli, Fernando Riback Silva, Rodrigo Esaki Tamura · 2018 · Oncotarget
50. Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?
    Subhasree Ashok Nag, X. Zhang, Kalkunte S. Srivenugopal, M.-H. Wang, W. Wang, Ruifeng Zhang · 2014 · Current Medicinal Chemistry
51. Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation
    Aimo Kannt, Ivan Đikić · 2021 · Cell chemical biology
52. Cancer signaling, cell/gene therapy, diagnosis and role of nanobiomaterials
    Gvozden Luka Rosic · 2024 · Advances in Biology & Earth Sciences
53. Association of breast cancer outcome with status of p53 and MDM2 SNP309.
    B. Boersma, Tiffany M. Howe, J. Goodman, H. Yfantis, Dong H. Lee, S. Chanock, S. Ambs · 2006 · Journal of the National Cancer Institute
54. The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation
    Syed Feroj Ahmed, Satamita Deb, Indranil Paul, Anirban Chatterjee, Tapashi Mandal, Uttara Chatterjee, Mrinal K. Ghosh · 2012 · Journal of Biological Chemistry
55. The Dark Side of EGFP: Defective Polyubiquitination
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56. The C terminus of p53 binds the N-terminal domain of MDM2
    Masha V. Poyurovsky, Chen Katz, Oleg Laptenko, Rachel Beckerman, Maria Lokshin, Jinwoo Ahn, In‐Ja L. Byeon, Ronen Gabizon, Melissa Mattia, Andrew Zupnick et al. · 2010 · Nature Structural & Molecular Biology
57. HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation
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58. Splitting p63
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59. The tumor suppressorsInk4candp53collaborate independently withPatchedto suppress medulloblastoma formation
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60. p53 accumulates but is functionally impaired when DNA synthesis is blocked
    Gottifredi, Vanesa, Shieh, Sheau-Yann, Taya, Yoichi, Prives, Carol · 2001 · Proceedings of the National Academy of Sciences
61. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
    Grier, Jason D., Xiong, Shunbin, Elizondo-Fraire, Ana C., Parant, John M., Lozano, Guillermina · 2006 · Molecular and Cellular Biology
62. Interaction of viral oncoproteins with cellular target molecules: infection with high‐risk vs low‐risk human papillomaviruses
    David Pim, Lawrence Banks · 2010 · Apmis
63. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis
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64. Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction
    John G. Allen, Matthew P. Bourbeau, G. Erich Wohlhieter, Michael D. Bartberger, Klaus Michelsen, Randall W. Hungate, Robert C. Gadwood, Rick D. Gaston, Bruce Evans, Larry W. Mann et al. · 2009 · Journal of Medicinal Chemistry
65. Reactive Oxygen Species and Human Inflammatory Periodontal Diseases
    Cenk Fatih Çanakçı, Y. Cicek, V. Canakci · 2005 · Biochemistry (Moscow)
66. From the Cover: p53 accumulates but is functionally impaired when DNA synthesis is blocked
    Vanesa Gottifredi, Sheau-Yann Shieh, Yoichi Taya, Carol Prives · 2001 · Proceedings of the National Academy of Sciences
67. Strategies for manipulating the p53 pathway in the treatment of human cancer
    Ted R. Hupp, David Philip Lane, Kathryn L. Ball · 2000 · Biochemical Journal
68. NUMB-ing down cancer by more than just a NOTCH
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69. Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists
    Hong Shen, Carl G. Maki · 2011 · Current Pharmaceutical Design
70. SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
    Jin Ming Dai, Zhi Yan Wang, Dao Chun Sun, Ru Xian Lin, Sheng Qi Wang · 2006 · Journal of Cellular Physiology
71. Phosphorylation of Human p53 at Serine 46 Determines Promoter Selection and whether Apoptosis Is Attenuated or Amplified
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72. Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP
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73. NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?
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74. TP53 mutations in epithelial ovarian cancer
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75. Molecular aetiology and pathogenesis of basal cell carcinoma
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76. P53: An ubiquitous target of anticancer drugs
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77. Inflammation, carcinogenesis and cancer
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78. Induction of <i>ARF</i> tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1
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79. STAT1 and pathogens, not a friendly relationship
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80. JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation
    Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li et al. · 2014 · PLoS Biology
81. MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future
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82. Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions
    Chong V. Li, Marzena Pazgier, Changqing Li, Weirong Yuan, Min Liu, Gang Wei, Weiyue Lu, Wuyuan Lu · 2010 · Journal of Molecular Biology
83. Tip60 is targeted to proteasome‐mediated degradation by Mdm2 and accumulates after UV irradiation
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84. Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53
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85. Hdmx Stabilizes Mdm2 and p53
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86. Hypophosphorylation of Mdm2 Augments p53 Stability
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87. Molecular mechanisms of photocarcinogenesis
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88. E2F-1 induced apoptosis
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89. Identification of p53 regulators by genome-wide functional analysis
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90. Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer
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91. Stabilization of p53 by CP-31398 Inhibits Ubiquitination without Altering Phosphorylation at Serine 15 or 20 or MDM2 Binding
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92. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation.
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93. Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation
    Cynthia A. Pise-Masison, Renaud Mahieux, Hua Jiang, Margaret A. Ashcroft, Michael F. Radonovich, Janet F. Duvall, Claire Guillerm, John N Brady · 2000 · Molecular and Cellular Biology
94. Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
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95. Revisiting TP 53 Mutations and Immunohistochemistry—A Comparative Study in 157 Diffuse Gliomas
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96. The role of the ubiquitin/proteasome system in cellular responses to radiation
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97. The loss of mdm2 induces p53 mediated apoptosis
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98. Untitled work
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99. MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death
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100. What we could do now: molecular pathology of bladder cancer
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