Mdm2 promotes the rapid degradation of p53

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Items 1,001–1,057 of 1,057

1. Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201
   Jeay, Sébastien, Ferretti, Stéphane, Holzer, Philipp, Fuchs, Jeanette, Chapeau, Emilie A., Wartmann, Markus, Sterker, Dario, Romanet, Vincent, Murakami, Masato, Kerr, Grainne et al. · 2018 · Cancer Research
2. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment
   Gu, Lubing, Zhang, Hailong, Liu, Tao, Zhou, Sheng, Du, Yuhong, Xiong, Jing, Yi, Sha, Qu, Cheng-Kui, Fu, Haian, Zhou, Muxiang · 2016 · Cancer Cell
3. Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors
   Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D., Beck, Hilary P., Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L., Huang, Xin et al. · 2013 · Journal of Medicinal Chemistry
4. Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
   Xiong, Shunbin, Pant, Vinod, Suh, Young-Ah, Van Pelt, Carolyn S., Wang, Yongxing, Valentin-Vega, Yasmine A., Post, Sean M., Lozano, Guillermina · 2010 · Cancer Research
5. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
   Chang, Alex Chia Yu, Ong, Sang-Ging, LaGory, Edward L., Kraft, Peggy E., Giaccia, Amato J., Wu, Joseph C., Blau, Helen M. · 2016 · Proceedings of the National Academy of Sciences
6. The Mdm network and its regulation of p53 activities: a rheostat of cancer risk
   Eischen, Christine M., Lozano, Guillermina · 2014 · Human Mutation
7. Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed‐backbone antisense oligonucleotides: In vitro and in vivo activities and mechanisms
   Wang, Hui, Yu, Dong, Agrawal, Sudhir, Zhang, Ruiwen · 2003 · The Prostate
8. Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway
   Lee, Hye-Ra, Toth, Zsolt, Shin, Young C., Lee, Jong-Soo, Chang, Heesoon, Gu, Wei, Oh, Tae-Kwang, Kim, Myung Hee, Jung, Jae U. · 2009 · Journal of Virology
9. First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer models
   Pairawan, Seyed, Zhao, Ming, Yuca, Erkan, Annis, Allen, Evans, Kurt, Sutton, David, Carvajal, Luis, Ren, Jian-Guo, Santiago, Solimar, Guerlavais, Vincent et al. · 2021 · Breast Cancer Research
10. A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma
    Yi, Hanjie, Yan, Xianglei, Luo, Qiuyun, Yuan, Luping, Li, Baoxia, Pan, Wentao, Zhang, Lin, Chen, Haibo, Wang, Jing, Zhang, Yubin et al. · 2018 · Journal of Experimental & Clinical Cancer Research
11. Nutlin-3a Is a Potential Therapeutic for Ewing Sarcoma
    Pishas, Kathleen I., Al-Ejeh, Fares, Zinonos, Irene, Kumar, Raman, Evdokiou, Andreas, Brown, Michael P., Callen, David F., Neilsen, Paul M. · 2011 · Clinical Cancer Research
12. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death
    Boesten, L S M, Zadelaar, S M, De Clercq, S, Francoz, S, van Nieuwkoop, A, Biessen, E A L, Hofmann, F, Feil, S, Feil, R, Jochemsen, A G et al. · 2006 · Cell Death & Differentiation
13. Blockade of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase and Murine Double Minute Synergistically Induces Apoptosis in Acute Myeloid Leukemia via BH3-Only Proteins Puma and Bim
    Zhang, Weiguo, Konopleva, Marina, Burks, Jared K., Dywer, Karen C., Schober, Wendy D., Yang, Jer-Yen, McQueen, Teresa J., Hung, Mien-Chie, Andreeff, Michael · 2010 · Cancer Research
14. Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway
    Bang, Scott, Kaur, Sandeep, Kurokawa, Manabu · 2019 · International Journal of Molecular Sciences
15. The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase
    Sanduja, Sandhya, Kaza, Vimala, Dixon, Dan A. · 2009 · Aging
16. Absence of p16 INK4a and truncation of ARF tumor suppressors in chickens
    Kim, Soo-Hyun, Mitchell, Michael, Fujii, Hideta, Llanos, Susana, Peters, Gordon · 2003 · Proceedings of the National Academy of Sciences
17. MDMX inhibits the p300/CBP-mediated acetylation of p53
    Sabbatini, Peter, McCormick, Frank · 2002 · DNA and Cell Biology
18. MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells
    Wang, Bo, Fang, Liming, Zhao, Hui, Xiang, Tong, Wang, Dechun · 2012 · Acta Biochimica et Biophysica Sinica
19. The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival
    Valentin-Vega, Y A, Okano, H, Lozano, G · 2008 · Cell Death & Differentiation
20. A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens
    Bouhaddou, Mehdi, Barrette, Anne Marie, Stern, Alan D., Koch, Rick J., DiStefano, Matthew S., Riesel, Eric A., Santos, Luis C., Tan, Annie L., Mertz, Alex E., Birtwistle, Marc R. · 2018 · PLOS Computational Biology
21. MdmX Promotes Bipolar Mitosis To Suppress Transformation and Tumorigenesis in p53-Deficient Cells and Mice
    Matijasevic, Zdenka, Steinman, Heather A., Hoover, Kathleen, Jones, Stephen N. · 2008 · Molecular and Cellular Biology
22. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation.
    Jung, Yong-Sam, Qian, Yingjuan, Chen, Xinbin · 2012 · DNA Repair
23. Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.
    Sarkari, Feroz, La Delfa, Anthony, Arrowsmith, Cheryl H., Frappier, Lori, Sheng, Yi, Saridakis, Vivian · 2010 · Journal of Molecular Biology
24. A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy
    Huang, Xiaoping, Zhang, Ying, Tang, Yaqiong, Butler, Napoleon, Kim, Jungeun, Guessous, Fadila, Schiff, David, Mandell, James, Abounader, Roger · 2013 · Neoplasia
25. Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage
    Joseph, Troy W., Zaika, Alex, Moll, Ute M. · 2003 · The FASEB Journal
26. Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.
    Wei, Xi, Wu, Shaofang, Song, Tanjing, Chen, Lihong, Gao, Ming, Borcherds, Wade, Daughdrill, Gary W., Chen, Jiandong · 2016 · Proceedings of the National Academy of Sciences
27. Role of Mdm4 in drug sensitivity of breast cancer cells
    Lam, S, Lodder, K, Teunisse, A F A S, Rabelink, M J W E, Schutte, M, Jochemsen, A G · 2010 · Oncogene
28. Modulation of the expression of p16INK4aand p14ARFby hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence
    Zhu, Deguang, Xu, Gang, Ghandhi, Shanaz, Hubbard, Karen · 2002 · Journal of Cellular Physiology
29. SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than TP53 Mutation Status
    Fujihara, Kenji M., Corrales Benitez, Mariana, Cabalag, Carlos S., Zhang, Bonnie Z., Ko, Hyun S., Liu, David S., Simpson, Kaylene J., Haupt, Ygal, Lipton, Lara, Haupt, Sue et al. · 2021 · Molecular Cancer Therapeutics
30. MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9
    Chen, Xiaofeng, Qiu, Jinrong, Yang, Dapeng, Lu, Jianlei, Yan, Caiyun, Zha, Xiaoming, Yin, Yongmei · 2013 · PLoS ONE
31. PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells
    Sheng, Caibin, Mendler, Isabella-Hilda, Rieke, Sara, Snyder, Petra, Jentsch, Marcel, Friedrich, Dhana, Drossel, Barbara, Loewer, Alexander · 2019 · Cell Reports
32. Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization
    Gama, V, Gomez, J A, Mayo, L D, Jackson, M W, Danielpour, D, Song, K, Haas, A L, Laughlin, M J, Matsuyama, S · 2009 · Cell Death & Differentiation
33. Comparisons of tumor suppressor p53, p21, and p16 gene therapy effects on glioblastoma tumorigenicity in situ
    Wang, Tzu-Jou, Huang, Ming-Shyan, Hong, Chi-Yuan, Tse, Victor, Silverberg, Gerald D., Hsiao, Michael · 2001 · Biochemical and Biophysical Research Communications
34. Small-molecule correctors and stabilizers to target p53
    Fallatah, Maryam M.J., Law, Fiona V., Chow, Warren A., Kaiser, Peter · 2023 · Trends in Pharmacological Sciences
35. Small molecules that bind the Mdm2 RING stabilize and activate p53
    Roxburgh, P., Hock, A. K., Dickens, M. P., Mezna, M., Fischer, P. M., Vousden, K. H. · 2012 · Carcinogenesis
36. Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model
    Tonsing-Carter, Eva, Bailey, Barbara J., Saadatzadeh, M. Reza, Ding, Jixin, Wang, Haiyan, Sinn, Anthony L., Peterman, Kacie M., Spragins, Tiaishia K., Silver, Jayne M., Sprouse, Alyssa A. et al. · 2015 · Molecular Cancer Therapeutics
37. SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle
    Lu, Ya-Fei, Xu, Xiao-Peng, Lu, Xiao-Peng, Zhu, Qian, Liu, Ge, Bao, Yan-Tao, Wen, He, Li, Ying-Lu, Gu, Wei, Zhu, Wei-Guo · 2020 · Oncogene
38. MdmX inhibits Smad transactivation
    Kadakia, Madhavi, Brown, Thomas L, McGorry, Molly M, Berberich, Steven J · 2002 · Oncogene
39. Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R
    Mitchell, Jonathan K., Midkiff, Bentley R., Israelow, Benjamin, Evans, Matthew J., Lanford, Robert E., Walker, Christopher M., Lemon, Stanley M., McGivern, David R. · 2017 · mBio
40. Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
    Charoenpattarapreeda, Jiraborrirak, Tan, Yaw Sing, Iegre, Jessica, Walsh, Stephen J., Fowler, Elaine, Eapen, Rohan S., Wu, Yuteng, Sore, Hannah F., Verma, Chandra S., Itzhaki, Laura et al. · 2019 · Chemical Communications
41. Design and linkage optimization of ursane-thalidomide-based PROTACs and identification of their targeted-degradation properties to MDM2 protein
    Qi, Zhiwen, Yang, Guliang, Deng, Tao, Wang, Jianmin, Zhou, Hao, Popov, Sergey A., Shults, Elvira E., Wang, Chengzhang · 2021 · Bioorganic Chemistry
42. p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death
    Baudot, Alice D., Crighton, Diane, O'Prey, Jim, Somers, Joanna, Sierra Gonzalez, Pablo, Ryan, Kevin M. · 2016 · Cell Cycle
43. BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models
    Hao, Xiaoguang, Bahia, Ravinder K, Cseh, Orsolya, Bozek, Danielle A, Blake, Sophia, Rinnenthal, Jörg, Weyer-Czernilofsky, Ulrike, Rudolph, Dorothea, Artee Luchman, H · 2023 · Neuro-Oncology
44. Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation In Vivo
    De Clercq, Sarah, Gembarska, Agnieszka, Denecker, Geertrui, Maetens, Marion, Naessens, Michael, Haigh, Katharina, Haigh, Jody J., Marine, Jean-Christophe · 2010 · Molecular and Cellular Biology
45. MdmX regulates transformation and chromosomal stability in p53-deficient cells
    Matijasevic, Zdenka, Krzywicka-Racka, Anna, Sluder, Greenfield, Jones, Stephen N. · 2008 · Cell Cycle
46. Essential Role of Phospholipase Cγ2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis
    Wen, Renren, Chen, Yuhong, Bai, Li, Fu, Guoping, Schuman, James, Dai, Xuezhi, Zeng, Hu, Yang, Chunying, Stephan, Robert P., Cleveland, John L. et al. · 2006 · Molecular and Cellular Biology
47. Stimulation of human DNA polymerase epsilon by MDM2
    Asahara, H. · 2003 · Nucleic Acids Research
48. The roles of MDM2 and MDMX phosphorylation in stress signaling to p53
    Chen, J. · 2012 · Genes & Cancer
49. CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop
    Wei, Zhao, Guo, Haiyang, Liu, Zhaojian, Zhang, Xiyu, Liu, Qiao, Qian, Yanyan, Gong, Yaoqin, Shao, Changshun · 2015 · Free Radical Biology and Medicine
50. Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
    Tang, Jun, Agrawal, Trisha, Cheng, Qian, Qu, Like, Brewer, Michael D., Chen, Jiandong, Yang, Xiaolu · 2013 · PLoS ONE
51. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities
    Valentin-Vega, Yasmine A., Box, Neil, Terzian, Tamara, Lozano, Guillermina · 2009 · Differentiation
52. Affinity-based screening of MDM2/MDMX–p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors
    Noguchi, Taro, Oishi, Shinya, Honda, Kaori, Kondoh, Yasumitsu, Saito, Tamio, Kubo, Tatsuhiko, Kaneda, Masato, Ohno, Hiroaki, Osada, Hiroyuki, Fujii, Nobutaka · 2013 · Bioorganic & Medicinal Chemistry Letters
53. The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation
    Cheng, Qian, Chen, Jiandong · 2011 · Cell Cycle
54. Discovery and characterization of brigimadlin, a novel and highly potent MDM2-p53 antagonist suitable for intermittent dose schedules
    Gollner, Andreas, Rudolph, Dorothea, Weyer-Czernilofsky, Ulrike, Baumgartinger, Rosa, Jung, Peter, Weinstabl, Harald, Ramharter, Jürgen, Grempler, Rolf, Quant, Jens, Rinnenthal, Jörg et al. · 2024 · Molecular Cancer Therapeutics
55. What do we need to know and understand about p53 to improve its clinical value?
    Salomao, Norman, Karakostis, Konstantinos, Hupp, Ted, Vollrath, Friz, Vojtesek, Borivoj, Fahraeus, Robin · 2021 · The Journal of Pathology
56. Interleukin-1α associates with the tumor suppressor p53 following DNA damage
    Novak, J., Zamostna, B., Vopalensky, V., Buryskova, M., Burysek, L., Doleckova, D., Pospisek, M. · 2020 · Scientific Reports
57. Cellular senescence and cancer
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