Mdm2 promotes the rapid degradation of p53
DOI 10.1038/387296a0
Cited by (1,057)
Items 401–500 of 1,057
- Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1Hye‐Kyung Na, Young‐Joon Surh · 2013 · Free Radical Biology and Medicine
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- The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activityPoyurovsky, Masha V, Priest, Christina, Kentsis, Alex, Borden, Katherine LB, Pan, Zhen‐Qiang, Pavletich, Nikola, Prives, Carol · 2007 · The EMBO Journal
- p53 Signaling and Cell Cycle CheckpointsZoe A. Stewart, Jennifer A. Pietenpol · 2001 · Chemical Research in Toxicology
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- New therapeutic strategies to treat human cancers expressing mutant p53 proteinsGiovanni Blandino, Silvia Di Agostino · 2018 · Journal of Experimental & Clinical Cancer Research
- 5-Fluorouracil Activation of p53 Involves an MDM2-Ribosomal Protein InteractionXiao‐Xin Sun, Mu‐Shui Dai, Hua Lu · 2007 · Journal of Biological Chemistry
- Tyrosine phosphorylation of Mdm2 by c‐Abl: implications for p53 regulationZehavit Goldberg, Ronit Vogt Sionov, Michael Berger, Yaara Zwang, Ruth Perets, Richard A. Van Etten, Moshe Oren, Yoichi Taya, Ygal Haupt · 2002 · The EMBO Journal
- Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target SequenceAlberto Inga, Francesca Storici, Thomas A. Darden, Michael A. Resnick · 2002 · Molecular and Cellular Biology
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- Putative role of hepatitis B virus X protein in hepatocarcinogenesis: Effects on apoptosis, DNA repair, mitogen‐activated protein kinase and JAK/STAT pathwaysPatrick B. Arbuthnot, Alexio Capovilla, Michael Charles Kew · 2000 · Journal of Gastroenterology and Hepatology
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- Mutant p53: it’s not all one and the sameMargaret C. Kennedy, Scott W. Lowe · 2022 · Cell Death and Differentiation
- Signaling angiogenesis via p42/p44 MAP kinase and hypoxiaEdurne Berra, Julie Milanini, Darren E. Richard, Maude Le Gall, Francesc Viñals, Emmanuel Gothié, Danièle Roux, Gilles Pagès, Jacques Pouysségur · 2000 · Biochemical Pharmacology
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- High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?Tim Crook, John Malcolm Nicholls, Louise A. Brooks, Jenny O’Nions, Martin J. Allday · 2000 · Oncogene
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- Mdm2: The Ups and DownsTamar Juven‐Gershon, Moshe Oren · 1999 · Molecular Medicine
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- Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosisJuan Antonio Bernal, Rosa Luna, Águeda G. Espina, Iciar Lazaro‐Trueba, Francisco Ramos‐Morales, Francisco Romero, Carmen Arias, Augusto Silva, Marı́a Tortolero, José A. Pintor‐Toro · 2002 · Nature Genetics
- Regulation of Mdm2-Directed Degradation by the C Terminus of p53Michael H.G. Kubbutat, Robert L. Ludwig, Margaret A. Ashcroft, Karen H. Vousden · 1998 · Molecular and Cellular Biology
- miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stressXiao, Jiening, Lin, Huixian, Luo, Xiaobin, Luo, Xiaoyan, Wang, Zhiguo · 2011 · The EMBO Journal
- mdmx is a negative regulator of p53 activity in vivo.Rick A. Finch, Dorit B. Donoviel, David Potter, Min Shi, Amy Fan, D D Freed, Ching-Yun Wang, Brian Zambrowicz, Ramiro Ramírez‐Solis, Arthur Sands et al. · 2002 · PubMed
- Mutations in serines 15 and 20 of human p53 impair its apoptotic activityTamar Unger, Ronit Vogt Sionov, Eli Moallem, Carole Yee, Peter M. Howley, Moshe Oren, Ygal Haupt · 1999 · Oncogene
- Loss of p53 and centrosome hyperamplificationPheruza Tarapore, Kenji Fukasawa · 2002 · Oncogene
- E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.T F Kowalik, James V. DeGregori, Gustavo W. Leone, Laszlo Jakoi, Joseph Roy Nevins · 1998 · PubMed
- Comparative study of the p53-mdm2 and p53-MDMX interfacesBöttger, Volker, Böttger, Angelika, Garcia-Echeverria, Carlos, Ramos, Yolande FM, van der Eb, Alex J, Jochemsen, Aart G, Lane, David P · 1999 · Oncogene
- Mdmx as an essential regulator of p53 activityJean‐Christophe Marine, Aart G. Jochemsen · 2005 · Biochemical and Biophysical Research Communications
- UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.Yoshiaki Okamoto, Toshinori Ozaki, Kou Miyazaki, Mineyoshi Aoyama, Masaru Miyazaki, Akira Nakagawara · 2003 · PubMed
- p53 regulation by ubiquitinBrooks, Christopher L., Gu, Wei · 2011 · FEBS Letters
- Targeting protein–protein interactions: Lessons from p53/MDM2Justin K. Murray, Samuel H. Gellman · 2007 · Biopolymers
- 20S proteasomes and protein degradation “by default”Gad Asher, Nina Bacher Reuven, Yosef Shaul · 2006 · BioEssays
- Deubiquitinating enzymes—the importance of driving in reverse along the ubiquitin–proteasome pathwaySimon S. Wing · 2003 · The International Journal of Biochemistry & Cell Biology
- A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoterVanessa Brès, Rosemary Kiernan, Laetitia K. Linares, C. Chable-Bessia, Olga Plechakova, Céline Tréand, S. Emiliani, J. Peloponese, K. Jeang, O. Coux et al. · 2003 · Nature Cell Biology
- The p53 tumour suppressor geneRobert JC Steele, Alastair Mark Thompson, Peter A. Hall, David Philip Lane · 1998 · British journal of surgery
- Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle ArrestKevin M. Ryan, Karen H. Vousden · 1998 · Molecular and Cellular Biology
- p53 regulates Period2 expression and the circadian clockTakao Miki, Tomoko Matsumoto, Zhaoyang Zhao, Cheng Chi Lee · 2013 · Nature Communications
- Inhibition of MDM2 by hsp90 Contributes to Mutant p53 StabilizationYanhua Peng, Lihong Chen, Changgong Li, Wenge Lu, Jiandong Chen · 2001 · Journal of Biological Chemistry
- Regulation of p53 stability and activity in response to genotoxic stressMichael S. Colman, Cynthia A. Afshari, J. Carl Barrett · 2000 · Mutation Research/Reviews in Mutation Research
- Quinone Reductases Multitasking in the Metabolic WorldDavid Ross · 2004 · Drug Metabolism Reviews
- Methylation Silencing and Mutations of the p14ARF and p16INK4a Genes in Colon CancerNathalie Hirt‐Burri, Phillip H. Shaw, Hanifa Bouzourène, Isabelle Sordat, Bernard Sordat, M Gillet, Daniel F. Schorderet, Fred T. Bosman, Pascal Chaubert · 2001 · Laboratory Investigation
- Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.Taija M. Kiviharju, Philip S. Lecane, Robert G. Sellers, Donna M. Peehl · 2002 · PubMed
- Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang et al. · 2011 · Nature Medicine
- Regulating the p53 system through ubiquitinationYili Yang, Chou-Chi H. Li, Allan M. Weissman · 2004 · Oncogene
- Cutaneous Photobiology. The Melanocyte vs. the Sun: Who Will Win the Final Round?Ana Luisa Kadekaro, Renny J. Kavanagh, Kazumasa Wakamatsu, Shosuke Ito, Michelle A. Pipitone, ZALFA A. ABDEL‐MALEK · 2003 · Pigment Cell Research
- Kinetics of p53 Binding to Promoter Sites In VivoSuzanne T. Szak, Deborah J. Mays, Jennifer A. Pietenpol · 2001 · Molecular and Cellular Biology
- The Arabidopsis elch mutant reveals functions of an ESCRT component in cytokinesisChristoph Spitzer, Swen Schellmann, Aneta D. Sabovljević, Mojgan Shahriari, Channa Keshavaiah, Nicole Bechtold, Michel Herzog, Stefan Müller, Franz‐Georg Hanisch, Martin Hülskamp · 2006 · Development
- The ubiquitin system, disease, and drug discoveryMatthew D. Petroski · 2008 · BMC Biochemistry
- Circ0008399 Interaction with WTAP Promotes Assembly and Activity of the m6A Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder CancerWenjie Wei, Jiayin Sun, Hui Zhang, Xingyuan Xiao, Chao Huang, Liang Wang, He Zhong, Yangkai Jiang, Xiaoping Zhang, Guosong Jiang · 2021 · Cancer Research
- Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitinationHideaki Oda, Sushant Kumar, Peter M. Howley · 1999 · Proceedings of the National Academy of Sciences
- p53 regulation by post-translational modification and nuclear retention in response to diverse stressesGretchen S. Jimenez, Shireen H Khan, Jayne M. Stommel, Geoffrey M. Wahl · 1999 · Oncogene
- Control of p53 ubiquitination and nuclear export by MDM2 and ARF.Yanping Zhang, Yue Xiong · 2001 · PubMed
- Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 PromoterTakahito Nakagawa, Masato Takahashi, Toshinori Ozaki, Kenichi Watanabe, Satoru Todo, Hiroyuki Mizuguchi, Takao Hayakawa, Akira Nakagawara · 2002 · Molecular and Cellular Biology
- Ribosomal protein S14 unties the MDM2–p53 loop upon ribosomal stressXiang Yu Zhou, Qin Hao, Jingling Liao, Q Zhang, Hua Lu · 2012 · Oncogene
- Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer TherapiesLindsey N. Micel, John J. Tentler, Peter G. Smith, Gail S. Eckhardt · 2013 · Journal of Clinical Oncology
- Tumor suppressor genesKay F. Macleod · 2000 · Current Opinion in Genetics & Development
- Sustained oscillations and time delays in gene expression of protein Hes1Mogens H. Jensen, Kim Sneppen, Guido Tiana · 2003 · FEBS Letters
- p53 Activation by Small Molecules: Application in OncologyLyubomir T. Vassilev · 2005 · Journal of Medicinal Chemistry
- MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced ApoptosisCinzia Rinaldo, Andrea Prodosmo, Francesca Mancini, Stefano Iacovelli, Ada Sacchi, Fabiola Moretti, Silvia Soddu · 2007 · Molecular Cell
- DNA damage and oxidant stress activate p53 through differential upstream signaling pathwaysTao Shi, Daan M. K. van Soest, Paulien E. Polderman, Boudewijn M.T. Burgering, Tobias B. Dansen · 2021 · Free Radical Biology and Medicine
- The role of p53-target genes in human cancerTakashi Tokino, Yusuke Nakamura · 2000 · Critical Reviews in Oncology/Hematology
- Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2Mu‐Shui Dai, Xiao‐Xin Sun, Hua Lu · 2008 · Molecular and Cellular Biology
- The role of p53 in neuronal cell deathRichard S. Morrison, Y Kinoshita · 2000 · Cell Death and Differentiation
- p21/p53, Cellular Growth Control and Genomic IntegrityWafik S. El‐Deiry · 1998 · Current topics in microbiology and immunology
- TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53Zhicheng Zhou, Zhongzhong Ji, You Wang, Jian Li, Hui Cao, Helen He Zhu, Wei‐Qiang Gao · 2014 · Gastroenterology
- Senescence Regulation by the p53 Protein FamilyYingjuan Qian, Xinbin Chen · 2012 · Methods in molecular biology
- p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human MacrophagesJulie M. Lowe, Daniel Menéndez, Pierre R. Bushel, Maria Shatz, Erin L. Kirk, Melissa A. Troester, Stavros Garantziotis, Michael B. Fessler, Michael A. Resnick · 2014 · Cancer Research
- Genotoxic and non-genotoxic pathways of p53 inductionOlivier Pluquet, Pierre L. Hainaut · 2001 · Cancer Letters
- The Transactivation Domains of the p53 ProteinNitin Raj, Laura Donatella Attardi · 2016 · Cold Spring Harbor Perspectives in Medicine
- Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86Catharina Beskow, Jurate Skikuniene, Åsa Holgersson, Bo R Nilsson, Rolf Lewensohn, Lena Kanter, Kristina Viktorsson · 2009 · British Journal of Cancer
- Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivoXirodimas, Dimitris, Saville, Mark K, Edling, Charlotte, Lane, David P, Laín, Sonia · 2001 · Oncogene
- p53 from complexity to simplicity: mutant p53 stabilization, gain‐of‐function, and dominant‐negative effectMikhail V. Blagosklonny · 2000 · The FASEB Journal
- The relationship between the nucleolus and cancer: Current evidence and emerging paradigmsInes Oršolić, Deana Jurada, Nick Pullen, Moshe Oren, Aristides G. Eliopoulos, Siniša Volarević · 2015 · Seminars in Cancer Biology
- Inspiration from the mirror: D-amino acid containing peptides in biomedical approachesZhaoqianqi Feng, Bing Xu · 2016 · BioMolecular Concepts
- p38 Kinase Regulates Nitric Oxide-induced Apoptosis of Articular Chondrocytes by Accumulating p53 via NFκB-dependent Transcription and Stabilization by Serine 15 PhosphorylationSong Ja Kim, Sang‐Gu Hwang, Deug Y. Shin, Shin‐Sung Kang, Jang‐Soo Chun · 2002 · Journal of Biological Chemistry
- Frequent Methylation Silencing of p15INK4b(MTS2) and p16INK4a (MTS1) in B-Cell and T-Cell LymphomasAudrey Sylvia Baur, Phil Shaw, Nathalie Hirt‐Burri, Françoise Delacrétaz, Fred T. Bosman, Pascal Chaubert · 1999 · Blood
- The role of ubiquitin modification in the regulation of p53Hock, Andreas K., Vousden, Karen H. · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe MoleculesAhmet Bakan, Neysa Nevins, Ami S. Lakdawala, İvet Bahar · 2012 · Journal of Chemical Theory and Computation
- ATM-Mediated Phosphorylations Inhibit Mdmx/Mdm2 Stabilization by HAUSP in Favor of p53 ActivationErik Meulmeester, Yaron Pereg, Yosef Shiloh, Aart G. Jochemsen · 2005 · Cell Cycle
- Limiting the power of p53 through the ubiquitin proteasome pathwayVinod Pant, Guillermina Lozano · 2014 · Genes & Development
- LiposarcomaAimee Marie Crago, Mark Andrew Dickson · 2016 · Surgical Oncology Clinics of North America
- Reactivation of p53 gene by MDM2 inhibitors: A novel therapy for cancer treatmentAmit Gupta, Karan Shah, Manisha J. Oza, Tapan Behl · 2018 · Biomedicine & Pharmacotherapy
- Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme IsomerizationZhihong Lai, Katherine V. Ferry, Melody A. Diamond, Kevin E. Wee, Young B. Kim, Jianhong Ma, Tao Yang, Pamela A. Benfield, Robert A. Copeland, Kurt R. Auger · 2001 · Journal of Biological Chemistry
- Redox signalling and transition metals in the control of the p53 pathwayCatherine Méplan, Marie‐Jeanne Richard, Pierre L. Hainaut · 2000 · Biochemical Pharmacology
- The Haemophilus ducreyi Cytolethal Distending Toxin Induces Cell Cycle Arrest and Apoptosis via the DNA Damage Checkpoint PathwaysXimena Cortes-Bratti, Christina Karlsson, Teresa Lagergård, Monica Thelestam, Teresa Frisan · 2001 · Journal of Biological Chemistry
- Hdmx modulates the outcome of p53 activation in human tumor cellsWade, Mark, Wong, Ee Tsin, Tang, Mengjia, Stommel, Jayne M., Wahl, Geoffrey M. · 2006 · Journal of Biological Chemistry
- Inactivation of the p53-homologue p73 by the mdm2-oncoproteinDobbelstein, Matthias, Wienzek, Sandra, König, Claudia, Roth, Judith · 1999 · Oncogene
- Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling ComplexSeth A. Ettenberg, Alessandra Magnifico, Mauricio A. Cuello, Marion M. Nau, Yaffa Rubinstein, Yosef Yarden, Allan M. Weissman, Stan Lipkowitz · 2001 · Journal of Biological Chemistry
- The role of DNA damage responses in p53 biologyDaniel Speidel · 2015 · Archives of Toxicology
- Reactive Oxygen Species Induced p53 Activation: DNA Damage, Redox Signaling, or Both?Tao Shi, Tobias B. Dansen · 2020 · Antioxidants and Redox Signaling
- Life and death decisions by E2F-1L A Bell, Kevin M. Ryan · 2003 · Cell Death and Differentiation
- Fluctuations in p53 Signaling Allow Escape from Cell-Cycle ArrestReyes, José, Chen, Jia-Yun, Stewart-Ornstein, Jacob, Karhohs, Kyle W., Mock, Caroline S., Lahav, Galit · 2018 · Molecular Cell
- Malin Decreases Glycogen Accumulation by Promoting the Degradation of Protein Targeting to Glycogen (PTG)Carolyn A. Worby, Matthew S. Gentry, Jack E. Dixon · 2007 · Journal of Biological Chemistry
- Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?Simin Qi, Gang Cheng, Xiangdong Cheng, Zhiyuan Xu, Beihua Xu, Weidong Zhang, Jiang‐Jiang Qin · 2020 · Frontiers in Cell and Developmental Biology
- Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle CheckpointJennifer T. Thomas, Laimonis A. Laimins · 1998 · Journal of Virology