Mdm2 promotes the rapid degradation of p53

Cited by (1,057)

Items 401–500 of 1,057

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    Le Li, Youxiang Mao, Lina Zhao, Lijia Li, Jinjun Wu, Mengjia Zhao, Wenjing Du, Yu Li, Peng Jiang · 2019 · Nature
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    Poyurovsky, Masha V, Priest, Christina, Kentsis, Alex, Borden, Katherine LB, Pan, Zhen‐Qiang, Pavletich, Nikola, Prives, Carol · 2007 · The EMBO Journal
  4. p53 Signaling and Cell Cycle Checkpoints
    Zoe A. Stewart, Jennifer A. Pietenpol · 2001 · Chemical Research in Toxicology
  5. MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation
    Wei Fu, Qiuping Ma, Lei Chen, Pengfei Li, Mu Zhang, Sivapriya Ramamoorthy, Zafar Nawaz, Tsukasa Shimojima, Hengbin Wang, Yonghua Yang et al. · 2009 · Journal of Biological Chemistry
  6. New therapeutic strategies to treat human cancers expressing mutant p53 proteins
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  7. 5-Fluorouracil Activation of p53 Involves an MDM2-Ribosomal Protein Interaction
    Xiao‐Xin Sun, Mu‐Shui Dai, Hua Lu · 2007 · Journal of Biological Chemistry
  8. Tyrosine phosphorylation of Mdm2 by c‐Abl: implications for p53 regulation
    Zehavit Goldberg, Ronit Vogt Sionov, Michael Berger, Yaara Zwang, Ruth Perets, Richard A. Van Etten, Moshe Oren, Yoichi Taya, Ygal Haupt · 2002 · The EMBO Journal
  9. Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence
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  10. Cancer Risk and the ATM Gene: a Continuing Debate
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    Gretchen S. Jimenez, Monica Nistér, Jayne M. Stommel, Michelle Beeche, Erin A. Barcarse, Xiao-Qun Zhang, Stephen O’Gorman, Geoffrey M. Wahl · 2000 · Nature Genetics
  18. Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
    Xiao‐Xin Sun, Kishore B. Challagundla, Mu‐Shui Dai · 2011 · The EMBO Journal
  19. Alternative and aberrant splicing of MDM2 mRNA in human cancer
    Frank Bartel, Helge W. Taubert, Linda C. Harris · 2002 · Cancer Cell
  20. High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?
    Tim Crook, John Malcolm Nicholls, Louise A. Brooks, Jenny O’Nions, Martin J. Allday · 2000 · Oncogene
  21. Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53
    Rajeev Rajendra, Diptee Malegaonkar, Pooja Pungaliya, Henderson Marshall, Zeshaan A. Rasheed, James E. Brownell, Leroy F. Liu, Stuart G. Lutzker, Ahamed Saleem, Eric H. Rubin · 2004 · Journal of Biological Chemistry
  22. MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
    Eric Kobet, Xiaoya Zeng, Yong Zhu, David Keller, Hua Lu · 2000 · Proceedings of the National Academy of Sciences
  23. Mdm2: The Ups and Downs
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  25. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis
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  27. miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress
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  29. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity
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  33. Mdmx as an essential regulator of p53 activity
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  39. A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter
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  41. Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest
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  42. p53 regulates Period2 expression and the circadian clock
    Takao Miki, Tomoko Matsumoto, Zhaoyang Zhao, Cheng Chi Lee · 2013 · Nature Communications
  43. Inhibition of MDM2 by hsp90 Contributes to Mutant p53 Stabilization
    Yanhua Peng, Lihong Chen, Changgong Li, Wenge Lu, Jiandong Chen · 2001 · Journal of Biological Chemistry
  44. Regulation of p53 stability and activity in response to genotoxic stress
    Michael S. Colman, Cynthia A. Afshari, J. Carl Barrett · 2000 · Mutation Research/Reviews in Mutation Research
  45. Quinone Reductases Multitasking in the Metabolic World
    David Ross · 2004 · Drug Metabolism Reviews
  46. Methylation Silencing and Mutations of the p14ARF and p16INK4a Genes in Colon Cancer
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  47. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.
    Taija M. Kiviharju, Philip S. Lecane, Robert G. Sellers, Donna M. Peehl · 2002 · PubMed
  48. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
    Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang et al. · 2011 · Nature Medicine
  49. Regulating the p53 system through ubiquitination
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  50. Cutaneous Photobiology. The Melanocyte vs. the Sun: Who Will Win the Final Round?
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  51. Kinetics of p53 Binding to Promoter Sites In Vivo
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  52. The Arabidopsis elch mutant reveals functions of an ESCRT component in cytokinesis
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  54. Circ0008399 Interaction with WTAP Promotes Assembly and Activity of the m6A Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder Cancer
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  55. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
    Hideaki Oda, Sushant Kumar, Peter M. Howley · 1999 · Proceedings of the National Academy of Sciences
  56. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses
    Gretchen S. Jimenez, Shireen H Khan, Jayne M. Stommel, Geoffrey M. Wahl · 1999 · Oncogene
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    Yanping Zhang, Yue Xiong · 2001 · PubMed
  58. Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter
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  59. Ribosomal protein S14 unties the MDM2–p53 loop upon ribosomal stress
    Xiang Yu Zhou, Qin Hao, Jingling Liao, Q Zhang, Hua Lu · 2012 · Oncogene
  60. Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies
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  63. p53 Activation by Small Molecules: Application in Oncology
    Lyubomir T. Vassilev · 2005 · Journal of Medicinal Chemistry
  64. MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
    Cinzia Rinaldo, Andrea Prodosmo, Francesca Mancini, Stefano Iacovelli, Ada Sacchi, Fabiola Moretti, Silvia Soddu · 2007 · Molecular Cell
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  66. The role of p53-target genes in human cancer
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  67. Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2
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  70. TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53
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  71. Senescence Regulation by the p53 Protein Family
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