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The chemical repertoire of natural ribozymes
Abstract
Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity--they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth.
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“Today, RNA serves as the sole genetic molecule in many viruses, and the number of reactions catalyzed by RNA enzymes (“ribozymes”) is ever increasing (Doudna and Cech, 2002; Chen et al., 2007).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Doudna and Cech, 2002
In the citing paper
“Today, RNA serves as the sole genetic molecule in many viruses, and the number of reactions catalyzed by RNA enzymes (“ribozymes”) is ever increasing (Doudna and Cech, 2002; Chen et al., 2007).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Doudna and Cech, 2002
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Metadata
- Authors
- Doudna, J. A., & Cech, T. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature
- Published
- 2002-07
- Volume
- 418
- Issue
- 6894
- Pages
- 222-228
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1980410097
- Cited by
- 745
- References
- 99
- Citations by year
- 2026: 28 · 2025: 21 · 2024: 25 · 2023: 14 · 2022: 23 · 2021: 24 · 2020: 24 · 2019: 29 · 2018: 15 · 2017: 29 · 2016: 17 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- ribozymes, RNA catalysis, RNA chemistry, origin of life, RNA evolution, phosphodiester bond cleavage
- MeSH terms
- Animals, Catalysis, Endoribonucleases, Humans, Introns, Models, Molecular, Nucleic Acid Conformation, Ribonucleoproteins, RNA Splicing, Substrate Specificity, RNA, Catalytic, Ribonuclease P
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