The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Functional rafts in cell membranes
Abstract
A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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“VLCFAs increase membrane stiffness, thereby decreasing fluidity, and they are likely critical for proper myelin function [191,213,214,217], myelination [218], myelin maintenance [207,213,215], and neuron polarity during CNS development [219].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [217]
Citations
Cites
The Fluid Mosaic Model of the Structure of Cell Membranes
Singer, S. J., & Nicolson, G. L. (1972) · Science · doi:10.1126/science.175.4023.720 · Cited by 9,158
Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921
Lipid sorting in epithelial cells
Simons, K., & Gerrit van, M. E. E. R. (1988) · Biochemistry · doi:10.1021/bi00417a001 · Cited by 1,373
Self-citationProtein Sorting by Transport Vesicles
Rothman, J. E., & Wieland, F. (1996) · Science · doi:10.1126/science.272.5259.227 · Cited by 1,156
Morphogenesis of the Polarized Epithelial Cell Phenotype
Rodriguez-Boulan, E. J., & Nelson, W. J. (1989) · Science · doi:10.1126/science.2672330 · Cited by 1,085
Song, K. S., Li, S. C., Okamoto, T., Quilliam, L. A., Sargiacomo, M., & Lisanti, M. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9690 · Cited by 1,000
Sargiacomo, M., Sudol, M., Tang, Z., & Lisanti, M. P. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.4.789 · Cited by 947
Schnitzer, J. E., Oh, P., Pinney, E., & Allard, J. F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1217 · Cited by 928
VIP21/caveolin is a cholesterol-binding protein.
Murata, M., Peränen, J., Schreiner, R., Wieland, F., Kurzchalia, T. V., & Simons, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10339 · Cited by 899
Self-citationvan Helvoort, A., Smith, A. J., Sprong, H., Fritzsche, I., Schinkel, A. H., Borst, P., & Gerrit van, M. E. E. R. (1996) · Cell · doi:10.1016/s0092-8674(00)81370-7 · Cited by 854
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Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Self-citationLipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
Self-citationLiquid phase condensation in cell physiology and disease
Shin, Y., & Brangwynne, C. P. (2017) · Science · doi:10.1126/science.aaf4382 · Cited by 4,143
“lipid, and various membrane-associated proteins (172).”
Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains
Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R. M. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350122 · Cited by 3,923
Metadata
- Authors
- Simons, K., & Ikonen, E.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Venue
- Nature
- Published
- 1997-06
- Volume
- 387
- Issue
- 6633
- Pages
- 569-572
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2121936687
- Cited by
- 9,757
- References
- 68
- Citations by year
- 2026: 168 · 2025: 188 · 2024: 208 · 2023: 223 · 2022: 240 · 2021: 263 · 2020: 293 · 2019: 274 · 2018: 278 · 2017: 289 · 2016: 312 · 2015: 344 · 2014: 343 · 2013: 347 · 2012: 388
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- lipid rafts, cell membrane structure, sphingolipids, cholesterol, lipid clustering, membrane fluidity, signal transduction, membrane trafficking
- MeSH terms
- Animals, Biological Transport, Cell Membrane, Cholesterol, Detergents, Golgi Apparatus, Humans, Membrane Lipids, Membrane Proteins, Solubility, Sphingolipids, Signal Transduction
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