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Functional rafts in cell membranes
Abstract
A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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“VLCFAs increase membrane stiffness, thereby decreasing fluidity, and they are likely critical for proper myelin function [191,213,214,217], myelination [218], myelin maintenance [207,213,215], and neuron polarity during CNS development [219].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [217]
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Grassmé, H., Jekle, A., Riehle, A., Schwarz, H., Berger, J., Sandhoff, K., Kolesnick, R., & Gulbins, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101207200 · Cited by 637
Cholesterol Sensing, Trafficking, and Esterification
Chang, T., Chang, C. C. Y., Ohgami, N., & Yamauchi, Y. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104656 · Cited by 643
Metadata
- Authors
- Simons, K., & Ikonen, E.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Venue
- Nature
- Published
- 1997-06
- Volume
- 387
- Issue
- 6633
- Pages
- 569-572
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2121936687
- Cited by
- 9,757
- References
- 68
- Citations by year
- 2026: 168 · 2025: 188 · 2024: 208 · 2023: 223 · 2022: 240 · 2021: 263 · 2020: 293 · 2019: 274 · 2018: 278 · 2017: 289 · 2016: 312 · 2015: 344 · 2014: 343 · 2013: 347 · 2012: 388
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- lipid rafts, cell membrane structure, sphingolipids, cholesterol, lipid clustering, membrane fluidity, signal transduction, membrane trafficking
- MeSH terms
- Animals, Biological Transport, Cell Membrane, Cholesterol, Detergents, Golgi Apparatus, Humans, Membrane Lipids, Membrane Proteins, Solubility, Sphingolipids, Signal Transduction
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