Cited by 9,757Lipid Membrane Structure and BehaviorCaveolin-1 and cellular processesSphingolipid Metabolism and Signaling

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Functional rafts in cell membranes

Simons, Kai, Ikonen, Elina·1997·Nature

DOI 10.1038/42408

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Abstract

A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.

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Authors: Simons, K., & Ikonen, E.
Affiliations: European Molecular Biology Laboratory (DE)
ORCID: Simons, Kai
Ikonen, Elina
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-06
Volume: 387
Issue: 6633
Pages: 569-572
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/42408
OpenAlex: W2121936687
Cited by: 9,757
References: 68
Citations by year: 2026: 168 · 2025: 188 · 2024: 208 · 2023: 223 · 2022: 240 · 2021: 263 · 2020: 293 · 2019: 274 · 2018: 278 · 2017: 289 · 2016: 312 · 2015: 344 · 2014: 343 · 2013: 347 · 2012: 388
FWCI: 18.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords: lipid rafts, cell membrane structure, sphingolipids, cholesterol, lipid clustering, membrane fluidity, signal transduction, membrane trafficking
MeSH terms: Animals, Biological Transport, Cell Membrane, Cholesterol, Detergents, Golgi Apparatus, Humans, Membrane Lipids, Membrane Proteins, Solubility, Sphingolipids, Signal Transduction

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Functional rafts in cell membranes

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