The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Abstract
Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception. Cilia are membrane-bound microtubule-based structures and in C. elegans are only found at the dendritic endings of sensory neurons. Here we show that mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Our findings imply that sensory perception regulates the lifespan of this animal, and suggest that in nature, its lifespan may be regulated by environmental cues.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In worms, a number of different mutations that disrupt the function of sensory neurons extend lifespan (90).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [90]
Citations
Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Self-citationKimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501
Self-citationSignals from the reproductive system regulate the lifespan of C. elegans
Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,014
Self-citationMutant sensory cilia in the nematode Caenorhabditis elegans
Perkins, L. A., Hedgecock, E. M., Thomson, J. N., & Culotti, J. G. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90314-3 · Cited by 907
Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898
The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature
Golden, J. W., & Riddle, D. L. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90201-x · Cited by 602
Genes that regulate both development and longevity in Caenorhabditis elegans.
Larsen, P. L., Albert, P. S., & Riddle, D. L. (1995) · Genetics · doi:10.1093/genetics/139.4.1567 · Cited by 584
Interacting genes in nematode dauer larva formation
Riddle, D. L., Swanson, M. M., & Albert, P. S. (1981) · Nature · doi:10.1038/290668a0 · Cited by 518
Structure and Function of Cyclic Nucleotide-Gated Channels
Zagotta, W. N., & Siegelbaum, S. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001315 · Cited by 501
Dorman, J. B., Albinder, B., Shroyer, T., & Kenyon, C. J. (1995) · Genetics · doi:10.1093/genetics/141.4.1399 · Cited by 458
Self-citationKomatsu, H., Mori, I., Rhee, J.-S., Akaike, N., & Ohshima, Y. (1996) · Neuron · doi:10.1016/s0896-6273(00)80202-0 · Cited by 445
Coburn, C. M., & Bargmann, C. I. (1996) · Neuron · doi:10.1016/s0896-6273(00)80201-9 · Cited by 441
Paradis, S., Ailion, M., Toker, A., Thomas, J. H., & Ruvkun, G. (1999) · Genes & Development · doi:10.1101/gad.13.11.1438 · Cited by 431
Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span
Apfeld, J., & Kenyon, C. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81751-1 · Cited by 379
Self-citationGenetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
Vowels, J. J., & Thomas, J. H. (1992) · Genetics · doi:10.1093/genetics/130.1.105 · Cited by 354
Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans
Avery, L., & Horvitz, H. R. (1989) · Neuron · doi:10.1016/0896-6273(89)90206-7 · Cited by 349
Collet, J., Spike, C. A., Lundquist, E. A., Shaw, J. E., & Herman, R. K. (1998) · Genetics · doi:10.1093/genetics/148.1.187 · Cited by 241
Sensory control of dauer larva formation in Caenorhabditis elegans
Albert, P. S., Brown, S. J., & Riddle, D. L. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980305 · Cited by 202
Neurosecretory control of aging in Caenorhabditis elegans
Ailion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W., & Thomas, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7394 · Cited by 121
Exclusive Expression of Kinesin Gene in Chemosnsory Neurons Open to the External Environment
Tabish, M., Siddiqui, Z. K., Nishikawa, K., & Siddiqui, S. S. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.0146 · Cited by 120
Komatsu, H., Jin, Y., L’Étoile, N. D., Mori, I., Bargmann, C. I., Akaike, N., & Ohshima, Y. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01111-7 · Cited by 115
Coburn, C. M., Mori, I., Ohshima, Y., & Bargmann, C. I. (1998) · Development · doi:10.1242/dev.125.2.249 · Cited by 108
Sensory activity affects sensory axon development in C. elegans
Peckol, E. L., Zallen, J. A., Yarrow, J. C., & Bargmann, C. I. (1999) · Development · doi:10.1242/dev.126.9.1891 · Cited by 91
Research works printed but not linked: 1
- Lawless,J. F. Models and Methods for Lifetime Data (Wiley, New York, 1982).
Cited by
Sorted by citations
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Self-citationGenetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337
Self-citationNeural mechanisms of ageing and cognitive decline
Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
Metadata
- Authors
- Apfeld, J., & Kenyon, C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kenyon, Cynthia
- Venue
- Nature
- Published
- 1999-12
- Volume
- 402
- Issue
- 6763
- Pages
- 804-809
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1587592813
- Cited by
- 573
- References
- 26
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 27 · 2023: 14 · 2022: 20 · 2021: 27 · 2020: 15 · 2019: 30 · 2018: 13 · 2017: 25 · 2016: 21 · 2015: 24 · 2014: 15 · 2013: 22 · 2012: 23
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- lifespan regulation, sensory perception, sensory cilia, sensory neurons, sensory transduction, ciliary defects, Caenorhabditis elegans, environmental cues, aging
- MeSH terms
- Animals, Cilia, Germ Cells, Larva, Longevity, Mutation, Neurons, Afferent, Receptor, Insulin, Sensory Deprivation, Transcription Factors, Helminth Proteins, Caenorhabditis elegans, Genes, Helminth, Caenorhabditis elegans Proteins, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
