The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Abstract
Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception. Cilia are membrane-bound microtubule-based structures and in C. elegans are only found at the dendritic endings of sensory neurons. Here we show that mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Our findings imply that sensory perception regulates the lifespan of this animal, and suggest that in nature, its lifespan may be regulated by environmental cues.
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“In worms, a number of different mutations that disrupt the function of sensory neurons extend lifespan (90).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [90]
Citations
Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
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A C. elegans mutant that lives twice as long as wild type
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Self-citationSignals from the reproductive system regulate the lifespan of C. elegans
Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,014
Self-citationMutant sensory cilia in the nematode Caenorhabditis elegans
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Research works printed but not linked: 1
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Sorted by citations
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Self-citationGenetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337
Self-citationNeural mechanisms of ageing and cognitive decline
Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
Metadata
- Authors
- Apfeld, J., & Kenyon, C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kenyon, Cynthia
- Venue
- Nature
- Published
- 1999-12
- Volume
- 402
- Issue
- 6763
- Pages
- 804-809
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1587592813
- Cited by
- 573
- References
- 26
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 27 · 2023: 14 · 2022: 20 · 2021: 27 · 2020: 15 · 2019: 30 · 2018: 13 · 2017: 25 · 2016: 21 · 2015: 24 · 2014: 15 · 2013: 22 · 2012: 23
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- lifespan regulation, sensory perception, sensory cilia, sensory neurons, sensory transduction, ciliary defects, Caenorhabditis elegans, environmental cues, aging
- MeSH terms
- Animals, Cilia, Germ Cells, Larva, Longevity, Mutation, Neurons, Afferent, Receptor, Insulin, Sensory Deprivation, Transcription Factors, Helminth Proteins, Caenorhabditis elegans, Genes, Helminth, Caenorhabditis elegans Proteins, Forkhead Transcription Factors
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