Cited by 573Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology ResearchGenetic and Kidney Cyst Diseases

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Regulation of lifespan by sensory perception in Caenorhabditis elegans

Apfeld, Javier, Kenyon, Cynthia·1999·Nature

DOI 10.1038/45544

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Abstract

Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception. Cilia are membrane-bound microtubule-based structures and in C. elegans are only found at the dendritic endings of sensory neurons. Here we show that mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Our findings imply that sensory perception regulates the lifespan of this animal, and suggest that in nature, its lifespan may be regulated by environmental cues.

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The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Self-citation
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935
daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501
Self-citation
Signals from the reproductive system regulate the lifespan of C. elegans
Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,014
Self-citation
Mutant sensory cilia in the nematode Caenorhabditis elegans
Perkins, L. A., Hedgecock, E. M., Thomson, J. N., & Culotti, J. G. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90314-3 · Cited by 907
Chlamydomonas Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in Caenorhabditis elegans Sensory Neurons
Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898
The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature
Golden, J. W., & Riddle, D. L. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90201-x · Cited by 602
Genes that regulate both development and longevity in Caenorhabditis elegans.
Larsen, P. L., Albert, P. S., & Riddle, D. L. (1995) · Genetics · doi:10.1093/genetics/139.4.1567 · Cited by 584

Show all 26 references

Research works printed but not linked: 1

Lawless,J. F. Models and Methods for Lifetime Data (Wiley, New York, 1982).

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Gendron, C. M., Kuo, T.-H., Harvanek, Z. M., Chung, B. Y., Yew, J. Y., Dierick, H. A., & Pletcher, S. D. (2013) · Science · doi:10.1126/science.1243339 · Cited by 144
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Authors: Apfeld, J., & Kenyon, C.
Affiliations: University of California, San Francisco (US)
Corresponding author: Kenyon, Cynthia
ORCID: Apfeld, Javier
Kenyon, Cynthia
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1999-12
Volume: 402
Issue: 6763
Pages: 804-809
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/45544
OpenAlex: W1587592813
Cited by: 573
References: 26
Citations by year: 2026: 17 · 2025: 17 · 2024: 27 · 2023: 14 · 2022: 20 · 2021: 27 · 2020: 15 · 2019: 30 · 2018: 13 · 2017: 25 · 2016: 21 · 2015: 24 · 2014: 15 · 2013: 22 · 2012: 23
FWCI: 5.50
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute on Aging
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: lifespan regulation, sensory perception, sensory cilia, sensory neurons, sensory transduction, ciliary defects, Caenorhabditis elegans, environmental cues, aging
MeSH terms: Animals, Cilia, Germ Cells, Larva, Longevity, Mutation, Neurons, Afferent, Receptor, Insulin, Sensory Deprivation, Transcription Factors, Helminth Proteins, Caenorhabditis elegans, Genes, Helminth, Caenorhabditis elegans Proteins, Forkhead Transcription Factors

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Regulation of lifespan by sensory perception in Caenorhabditis elegans

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