A living system on a chip

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Spence, J., Mayhew, C., Rankin, S., Kuhar, M., Vallance, J. E., Tolle, K., Hoskins, E. E., Kalinichenko, V., Wells, S., Zorn, A., et al. (2010) · Nature · doi:10.1038/nature09691 · Cited by 1,850 · see citing works

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

Sung, J. H., Kam, C., & Shuler, M. L. (2010) · Lab on a Chip · doi:10.1039/b917763a · Cited by 485 · see citing works

Perfused multiwell plate for 3D liver tissue engineering

Domanský, K., Inman, W., Serdy, J., Dash, A., Lim, M. H. M., & Griffith, L. G. (2009) · Lab on a Chip · doi:10.1039/b913221j · Cited by 446 · see citing works

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

Sung, J. H., Yu, J., Luo, D., Shuler, M. L., & March, J. C. (2010) · Lab on a Chip · doi:10.1039/c0lc00273a · Cited by 321 · see citing works

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

Mahler, G. J., Esch, M. B., Glahn, R. P., & Shuler, M. L. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22366 · Cited by 220 · see citing works

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

Imura, Y., Sato, K., & Yoshimura, E. (2010) · Analytical Chemistry · doi:10.1021/ac100806x · Cited by 172 · see citing works

A microfluidic platform for probing small artery structure and function

Günther, A., Yasotharan, S., Vagaon, A., Lochovsky, C., Pinto, S., Yang, J., Lau, C. H., Voigtlaender‐Bolz, J., & Bolz, S. (2010) · Lab on a Chip · doi:10.1039/c004675b · Cited by 154 · see citing works

Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure

Sonntag, F., Schilling, N., Mader, K., Gruchow, M., Klotzbach, U., Lindner, G., Horland, R., Wagner, I. P., Lauster, R., Howitz, S., et al. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.02.001 · Cited by 69 · see citing works

25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409 · see citing works

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750 · see citing works

Macroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissues

Jia Liu, B., Dvir, T., Jin, L., Tsui, J. H., Qing, Q., Suo, Z., Langer, R., Kohane, D. S., Lieber, C. M., & Tian, B. (2012) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 642 · see citing works

A liver-on-a-chip platform with bioprinted hepatic spheroids

Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016) · Biofabrication · doi:10.1088/1758-5090/8/1/014101 · Cited by 615 · see citing works

Screening out irrelevant cell-based models of disease

Horvath, P., Aulner, N., Bickle, M., Davies, A. M., Nery, E. D., Ebner, D., Montoya, M. C., Östling, P., Pietiäinen, V., Price, L. S., et al. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.175 · Cited by 525 · see citing works

Cell–Material Interactions Revealed Via Material Techniques of Surface Patterning

Yao, X., Peng, R., & Ding, J. (2013) · Advanced Materials · doi:10.1002/adma.201301762 · Cited by 502 · see citing works

Revisiting lab-on-a-chip technology for drug discovery

Neužil, P., Giselbrecht, S., Länge, K., Huang, T. J., & Manz, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3799 · Cited by 490 · see citing works

Organ-on-a-chip devices advance to market

Zhang, B., & Radisic, M. (2017) · Lab on a Chip · doi:10.1039/c6lc01554a · Cited by 437 · see citing works

Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail

Pound, P., & Ritskes-Hoitinga, M. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1678-1 · Cited by 419 · see citing works

Organotypic liver culture models: meeting current challenges in toxicity testing

LeCluyse, E. L., Witek, R. P., Andersen, M. E., & Powers, M. J. (2012) · Critical Reviews in Toxicology · doi:10.3109/10408444.2012.682115 · Cited by 363 · see citing works

Biomimetic tissues on a chip for drug discovery

Ghaemmaghami, A. M., Hancock, M. J., Harrington, H., Kaji, H., & Khademhosseini, A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2011.10.029 · Cited by 359 · see citing works

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

Caddeo, S., Boffito, M., & Sartori, S. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00040 · Cited by 285 · see citing works

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

Esch, M. B., Mahler, G. J., Stokol, T., & Shuler, M. L. (2014) · Lab Chip · doi:10.1039/c4lc00371c · Cited by 281 · see citing works

Recent advances in microfluidic technologies for cell-to-cell interaction studies

Rothbauer, M., Zirath, H., & Ertl, P. (2018) · Lab on a Chip · doi:10.1039/c7lc00815e · Cited by 277 · see citing works

Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

Janjua, T. I., Cao, Y., Kleitz, F., Lindén, M., Yu, C., & Popat, A. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115115 · Cited by 260 · see citing works

Biology-inspired microphysiological systems to advance medicines for patient benefit and animal welfare

Marx, U. (2020) · ALTEX · doi:10.14573/altex.2001241 · Cited by 271 · see citing works

Biomaterial delivery of morphogens to mimic the natural healing cascade in bone

Mehta, M., Schmidt‐Bleek, K., Duda, G. N., & Mooney, D. J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.006 · Cited by 244 · see citing works

Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research

Gupta, N., Liu, J. R., Patel, B., Solomon, D. E., Vaidya, B., & Gupta, V. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10013 · Cited by 236 · see citing works

Light-assisted direct-write of 3D functional biomaterials

Hribar, K. C., Soman, P., Warner, J., Chung, P., & Chen, S. (2013) · Lab on a Chip · doi:10.1039/c3lc50634g · Cited by 231 · see citing works

Organs-on-a-chip: a new tool for drug discovery

Polini, A., Prodanov, L., Bhise, N. S., Manoharan, V., Dokmeci, M. R., & Khademhosseini, A. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.886562 · Cited by 223 · see citing works

Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro†

Pendergraft, S. S., Sadri‐Ardekani, H., Atala, A., & Bishop, C. E. (2017) · Biology of Reproduction · doi:10.1095/biolreprod.116.143446 · Cited by 219 · see citing works

Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology

Nguyen, N., Shaegh, S. A. M., Kashaninejad, N., & Phan, D. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.05.008 · Cited by 211 · see citing works

The role of the spleen in malaria

Portillo, H. A. D., Ferrer, M., Brugat, T., Jaular, L. M., Langhorne, J., & Lacerda, M. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01741.x · Cited by 202 · see citing works

A microfluidic flow-stretch chip for investigating blood vessel biomechanics

Zheng, W., Jiang, B., Wang, D., Zhang, W., Wang, Z., & Jiang, X. (2012) · Lab on a Chip · doi:10.1039/c2lc40173h · Cited by 166 · see citing works

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

Theobald, J., Ghanem, A., Wallisch, P., Banaeiyan, A. A., Andrade-Navarro, M. A., Taškova, K., Haltmeier, M., Kurtz, A., Becker, H., Reuter, S., et al. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00417 · Cited by 157 · see citing works

How multi-organ microdevices can help foster drug development

Esch, M. B., Smith, A. S. T., Prot, J. M., Oleaga, C., Hickman, J. J., & Shuler, M. L. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.003 · Cited by 154 · see citing works

Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective

van den Broek, L. J., Limandjaja, G. C., Niessen, F. B., & Gibbs, S. (2014) · Experimental Dermatology · doi:10.1111/exd.12419 · Cited by 148 · see citing works

An On-Chip Small Intestine–Liver Model for Pharmacokinetic Studies

Kimura, H., Ikeda, T., Nakayama, H., Sakai, Y., & Fujii, T. (2015) · SLAS Technology · doi:10.1177/2211068214557812 · Cited by 136 · see citing works

Organic Bioelectronics for In Vitro Systems

Pitsalidis, C., Pappa, A., Boys, A. J., Fu, Y., Moysidou, C., van Niekerk, D. C., Sáez, J., Savva, A., Iandolo, D., & Owens, R. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00539 · Cited by 137 · see citing works

Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders

Jahromi, M. A. M., Abdoli, A., Rahmanian, M., Bardania, H., Bayandori, M., Basri, S. M. M., Kalbasi, A., Aref, A. R., Karimi, M., & Hamblin, M. R. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01653-2 · Cited by 138 · see citing works

Biofabrication methods for reconstructing extracellular matrix mimetics

Aazmi, A., Zhang, D., Mazzaglia, C., Yu, M., Wang, Z., Yang, H., Huang, Y. Y. S., & Ma, L. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.08.018 · Cited by 131 · see citing works

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

Park, S., Sim, W. Y., Min, B., Yang, S. S., Khademhosseini, A., & Kaplan, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046689 · Cited by 130 · see citing works

Emerging trends in organ-on-a-chip systems for drug screening

Wang, Y., Gao, Y., Pan, Y., Zhou, D., Liu, Y., Yin, Y. B., Yang, J., Wang, Y., & Song, Y. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.02.006 · Cited by 130 · see citing works

Applications of tumor chip technology

Hachey, S. J., & Hughes, C. C. W. (2018) · Lab on a Chip · doi:10.1039/c8lc00330k · Cited by 128 · see citing works

Accelerating drug discovery via organs-on-chips

Chan, C. Y., Huang, P., Guo, F., Ding, X., Kapur, V., Mai, J. D., Yuen, P. K., & Huang, T. J. (2013) · Lab on a Chip · doi:10.1039/c3lc90115g · Cited by 125 · see citing works

μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips

Loskill, P., Marcus, S. G., Mathur, A., Reese, W. M., & Healy, K. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139587 · Cited by 123 · see citing works

Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications

Lian, N., & Li, T. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.010 · Cited by 122 · see citing works

Microfluidics-assisted in vitro drug screening and carrier production

Tsui, J. H., Lee, W.-H., Pun, S. H., Kim, J., & Kim, D. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.004 · Cited by 122 · see citing works

Respiratory microflows in the pulmonary acinus

Sznitman, J. (2012) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2012.10.028 · Cited by 121 · see citing works

A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

Chen, H. J., Miller, P. G., & Shuler, M. L. (2018) · Lab on a Chip · doi:10.1039/c8lc00111a · Cited by 118 · see citing works

Micropatterned superhydrophobic structures for the simultaneous culture of multiple cell types and the study of cell–cell communication

Efremov, A. N., Stanganello, E., Welle, A., Scholpp, S., & Levkin, P. A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.034 · Cited by 118 · see citing works

Bio-inspired porous antenna-like nanocube/nanowire heterostructure as ultra-sensitive cellular interfaces

Kong, B., Tang, J., Wu, Z., Selomulya, C., Wang, H., Wei, J., Wang, Y., Zheng, G., & Zhao, D. (2014) · NPG Asia Materials · doi:10.1038/am.2014.56 · Cited by 116 · see citing works

Organs-on-a-chip for drug discovery

Selimović, Š., Dokmeci, M. R., & Khademhosseini, A. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.06.005 · Cited by 114 · see citing works

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?

Frossi, B., Mion, F., Sibilano, R., Danelli, L., & Pucillo, C. E. M. (2018) · Immunological Reviews · doi:10.1111/imr.12636 · Cited by 111 · see citing works

Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology

Malvezzi, H., Marengo, E. B., Podgaec, S., & Piccinato, C. D. A. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02471-0 · Cited by 110 · see citing works

An Overview of Organs-on-Chips Based on Deep Learning

Li, J., Chen, J., Bai, H., Wang, H., Hao, S., Ding, Y., Peng, B., Zhang, J., Li, L., & Huang, W. (2022) · Research · doi:10.34133/2022/9869518 · Cited by 113 · see citing works

A coral-on-a-chip microfluidic platform enabling live-imaging microscopy of reef-building corals

Shapiro, O. H., Kramarsky‐Winter, E., Gavish, A. R., Stocker, R., & Vardi, A. (2016) · Nature Communications · doi:10.1038/ncomms10860 · Cited by 109 · see citing works

WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

Loskill, P., Thiagarajan, S., Tharp, K. M., Lee-Montiel, F. T., Jeeawoody, S., Reese, W. M., Zushin, P. H., Stahl, A., & Healy, K. E. (2017) · Lab on a Chip · doi:10.1039/c6lc01590e · Cited by 106 · see citing works

Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

Harink, B., Gac, S. L., Truckenmüller, R. K., van Blitterswijk, C., & Habibović, P. (2013) · Lab on a Chip · doi:10.1039/c3lc50293g · Cited by 105 · see citing works

Workshop meeting report Organs-on-Chips: human disease models

van de Stolpe, A., & den Toonder, J. M. J. (2013) · Lab on a Chip · doi:10.1039/c3lc50248a · Cited by 96 · see citing works

Formation and manipulation of cell spheroids using a density adjusted PEG/DEX aqueous two phase system

Han, C., Takayama, S., & Park, J. (2015) · Scientific Reports · doi:10.1038/srep11891 · Cited by 90 · see citing works

Microphysiological Systems: Design, Fabrication, and Applications

Wang, K., Man, K., Liu, J., Liu, Y., Chen, Q., Zhou, Y., & Yang, Y. S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01667 · Cited by 83 · see citing works

The role of microscaffold properties in controlling the collagen assembly in 3D dermis equivalent using modular tissue engineering

Imparato, G., Urciuolo, F., Casale, C., & Netti, P. A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.062 · Cited by 84 · see citing works

Gradient‐Regulated Hydrogel for Interface Tissue Engineering: Steering Simultaneous Osteo/Chondrogenesis of Stem Cells on a Chip

Shi, X., Zhou, J., Zhao, Y., Li, L., & Wu, H. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200333 · Cited by 74 · see citing works

An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass spectrometer as detector

Zhang, J., Wu, J., Li, H., Chen, Q., & Lin, J. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.01.013 · Cited by 70 · see citing works

Dry Eye Disease: Emerging Approaches to Disease Analysis and Therapy

Heidari, M., Noorizadeh, F., Wu, K. J., Inomata, T., & Mashaghi, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091439 · Cited by 70 · see citing works

Instantaneous room temperature bonding of a wide range of non-silicon substrates with poly(dimethylsiloxane) (PDMS) elastomer mediated by a mercaptosilane

Wu, W., Wu, J., Kim, J.-H., & Lee, N. Y. (2015) · Lab on a Chip · doi:10.1039/c5lc00285k · Cited by 68 · see citing works

A morphospace for synthetic organs and organoids: the possible and the actual

Ollé-Vila, A., Duran‐Nebreda, S., Pueyo, N. C., Montañez, R., & Solé, R. V. (2016) · Integrative Biology · doi:10.1039/c5ib00324e · Cited by 65 · see citing works

Microfluidic trends in drug screening and drug delivery

Feng, J., Neužil, J., Manz, A., Iliescu, C., & Neužil, P. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116821 · Cited by 66 · see citing works

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

Vivarès, A., Salle-Lefort, S., Arabeyre‐Fabre, C., Ngo, R., Pénarier, G., Bremond, M., Moliner, P., Gallas, J., Fabre, G., & Klieber, S. (2014) · Xenobiotica · doi:10.3109/00498254.2014.944612 · Cited by 64 · see citing works

Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions

Tralau, T., Oelgeschläger, M., Gürtler, R., Heinemeyer, G., Herzler, M., Hofer, T. F., Itter, H., Kühl, T., Lange, N., Lorenz, N., et al. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1510-0 · Cited by 64 · see citing works

In vitro Models and On-Chip Systems: Biomaterial Interaction Studies With Tissues Generated Using Lung Epithelial and Liver Metabolic Cell Lines

Nikolic, M. M., Geroski, T., & Filipović, N. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00120 · Cited by 62 · see citing works

Nanotechnology meets 3D in vitro models: Tissue engineered tumors and cancer therapies

da Rocha, E. L., Porto, L. M., & Rambo, C. R. (2013) · Materials Science and Engineering C · doi:10.1016/j.msec.2013.09.019 · Cited by 56 · see citing works

Current approaches and future role of high content imaging in safety sciences and drug discovery

van Vliet, E. (2014) · ALTEX · doi:10.14573/altex.1405271 · Cited by 56 · see citing works

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures

Zanetti, F., Sewer, A., Mathis, C., Iskandar, A. R., Kostadinova, R. M., Schlage, W. K., Leroy, P., Majeed, S., Guedj, E., Trivedi, K., et al. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00174 · Cited by 56 · see citing works

Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery

Berg, E. L., Hsu, Y.-C., & Lee, J. A. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.01.013 · Cited by 53 · see citing works

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow

Dawson, A., Dyer, C. E., Macfie, J., Davies, J., Karsai, L., Greenman, J., & Jacobsen, M. (2016) · Biomicrofluidics · doi:10.1063/1.4964813 · Cited by 53 · see citing works

Biofabricating murine and human myo‐substitutes for rapid volumetric muscle loss restoration

Costantini, M., Testa, S., Fornetti, E., Fuoco, C., Riera, C. S., Nie, M., Bernardini, S., Rainer, A., Baldi, J., Zoccali, C., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012778 · Cited by 51 · see citing works

In vitro modeling of endometriosis and endometriotic microenvironment – Challenges and recent advances

Gołąbek-Grenda, A., & Olejnik, A. M. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110375 · Cited by 48 · see citing works

Advances and challenges in organ-on-chip technology: toward mimicking human physiology and disease in vitro

Kumar, D., Nadda, R., & Repaka, R. (2024) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-024-03062-7 · Cited by 48 · see citing works

Viable cell culture in PDMS-based microfluidic devices

Tanyeri, M., & Tay, S. (2018) · Methods in cell biology · doi:10.1016/bs.mcb.2018.09.007 · Cited by 49 · see citing works

3D Miniaturization of Human Organs for Drug Discovery

Park, J., Wetzel, I., Dréau, D., & Cho, H. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700551 · Cited by 47 · see citing works

Heavy Metal Pollution and Male Fertility: An Overview on Adverse Biological Effects and Socio-Economic Implications

Ballini, A., Arrigoni, R., Crocetto, F., Risolo, R., Colapietro, R., Bellavita, R., Barone, B., Caputo, V. F., Luca, G., Grieco, P., et al. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220627141651 · Cited by 46 · see citing works

Bioengineering of a Full-Thickness Skin Equivalent in a 96-Well Insert Format for Substance Permeation Studies and Organ-On-A-Chip Applications

Schimek, K. M. S., Hsu, H.-H., Boehme, M., Kornet, J. J., Marx, U., Lauster, R., Pörtner, R., & Lindner, G. (2018) · Bioengineering · doi:10.3390/bioengineering5020043 · Cited by 46 · see citing works

Three-Dimensional Renal Organoids from Whole Kidney Cells: Generation, Optimization, and Potential Application in Nephrotoxicology In Vitro

Ding, B., Sun, G., Liu, S., Peng, E., Wan, M., Chen, L., Jackson, J. D., & Atala, A. (2020) · Cell Transplantation · doi:10.1177/0963689719897066 · Cited by 43 · see citing works

Three dimensional human small intestine models for ADME-Tox studies

Yu, J., Carrier, R. L., March, J. C., & Griffith, L. G. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.05.003 · Cited by 42 · see citing works

Advances in dynamic microphysiological organ-on-a-chip: Design principle and its biomedical application

Lee, S.-H., & Jun, B.-H. (2019) · Journal of Industrial & Engineering Chemistry · doi:10.1016/j.jiec.2018.11.041 · Cited by 30 · see citing works

A continuous perfusion microplate for cell culture

Goral, V. N., Zhou, C., Lai, F., & Yuen, P. K. (2012) · Lab on a Chip · doi:10.1039/c2lc41102d · Cited by 39 · see citing works

A Novel Modular Bioreactor to In Vitro Study the Hepatic Sinusoid

Illa, X., Vila, S., Yeste, J., Peralta, C., Gracia‐Sancho, J., & Villa, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111864 · Cited by 36 · see citing works

Biophysical properties of dermal building-blocks affect extra cellular matrix assembly in 3D endogenous macrotissue

Urciuolo, F., Garziano, A., Imparato, G., Panzetta, V., Fusco, S., Casale, C., & Netti, P. A. (2016) · Biofabrication · doi:10.1088/1758-5090/8/1/015010 · Cited by 36 · see citing works

Nanoelectronics Meets Biology: From New Nanoscale Devices for Live‐Cell Recording to 3D Innervated Tissues

Duan, X., & Lieber, C. M. (2013) · Chemistry - An Asian Journal · doi:10.1002/asia.201300630 · Cited by 33 · see citing works

Cellular therapy and bioartificial approaches to liver replacement

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Organs-on-chips and Its Applications

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