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Policy: NIH to balance sex in cell and animal studies
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“The species, strain, substrain, sex, weight, and age of animals are critical factors that can influence most experimental results [103–107].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [103]
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“Multiple longitudinal studies have evaluated whether an interaction exists between sex and AF-related risk of mortality, but the results have not been consistent (Supplementary Table S10).”
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Metadata
- Authors
- Clayton, J. A., & Collins, F. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Clayton, Janine A.
- Venue
- Nature
- Published
- 2014-05
- Volume
- 509
- Issue
- 7500
- Pages
- 282-283
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5101948
- OpenAlex
- W2027431314
- Cited by
- 1,816
- References
- 15
- Citations by year
- 2026: 105 · 2025: 120 · 2024: 142 · 2023: 142 · 2022: 163 · 2021: 162 · 2020: 169 · 2019: 134 · 2018: 141 · 2017: 146 · 2016: 177 · 2015: 151 · 2014: 63
- FWCI
- 178.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Social Sciences › Gender Studies › Diversity and Career in Medicine
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Keywords
- sex differences in research, NIH policy, preclinical research, sex-inclusive research, research funding policy, gender equity in science
- MeSH terms
- Animals, Animals, Laboratory, Cell Line, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Female, Financing, Organized, Humans, Male, Multiple Sclerosis, National Institutes of Health (U.S.), Neurons, Research Design, Sex Characteristics, Sex Ratio, United States, Peer Review, Research, Substance-Related Disorders, Animal Experimentation, Biomedical Research
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