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Policy: NIH to balance sex in cell and animal studies
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“The species, strain, substrain, sex, weight, and age of animals are critical factors that can influence most experimental results [103–107].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [103]
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“Multiple longitudinal studies have evaluated whether an interaction exists between sex and AF-related risk of mortality, but the results have not been consistent (Supplementary Table S10).”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [108]
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Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763
Policy: NIH plans to enhance reproducibility
Collins, F. S., & Tabak, L. A. (2014) · Nature · doi:10.1038/505612a · Cited by 1,247
Self-citationA call for transparent reporting to optimize the predictive value of preclinical research
Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature · doi:10.1038/nature11556 · Cited by 1,196
Strategies and Methods for Research on Sex Differences in Brain and Behavior
Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S. A., Sadée, W., Steiner, M. S., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1142 · Cited by 833
Female mice liberated for inclusion in neuroscience and biomedical research
Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.001 · Cited by 788
Males still dominate animal studies
Zucker, I., & Beery, A. K. (2010) · Nature · doi:10.1038/465690a · Cited by 487
Gender differences in drug responses
Franconi, F., Brunelleschi, S., Steardo, L., & Cuomo, V. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.11.001 · Cited by 475
The case for the inclusion of female subjects in basic science studies of pain
Mogil, J. S., & Chanda, M. L. (2005) · Pain · doi:10.1016/j.pain.2005.06.020 · Cited by 376
Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway
Du, L., Bayır, H., Lai, Y., Zhang, X., Kochanek, P. M., Watkins, S. C., Graham, S. H., & Clark, R. S. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405461200 · Cited by 355
The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice
Chen, X., McClusky, R., Chen, J., Beaven, S. W., Tontonoz, P., Arnold, A. P., & Reue, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002709 · Cited by 326
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Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0
Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000411 · Cited by 2,677
Sex and Gender Equity in Research: rationale for the SAGER guidelines and recommended use
Heidari, S., Babor, T. F., De Castro, P., Tort, S., & Curno, M. (2016) · Research Integrity and Peer Review · doi:10.1186/s41073-016-0007-6 · Cited by 2,184
Sex and gender: modifiers of health, disease, and medicine
Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001
Lonardo, A., Nascimbeni, F., Ballestri, S., Fairweather, D., Win, S., Than, T. A., Abdelmalek, M. F., & Suzuki, A. (2019) · Hepatology · doi:10.1002/hep.30626 · Cited by 1,095
Addressing bias in big data and AI for health care: A call for open science
Norori, N., Hu, Q., Aellen, F. M., Faraci, F. D., & Tzovara, A. (2021) · Patterns · doi:10.1016/j.patter.2021.100347 · Cited by 903
Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes
Regitz‐Zagrosek, V., Oertelt‐Prigione, S., Prescott, E., Franconi, F., Gerdts, E., Foryst‐Ludwig, A., Maas, A. H. E. M., Kautzky‐Willer, A., Knappe-Wegner, D., Kintscher, U., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv598 · Cited by 761
Qualitative sex differences in pain processing: emerging evidence of a biased literature
Mogil, J. S. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0310-6 · Cited by 691
Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626
“NIH Director Francis Collins and Associate Director for Research on Women’s Health Janine Clayton finally asked scientists to consider sex in preclinical research, to ensure that women get the same benefit of medical research as men [2].”
BackgroundEvrard, S., Lecce, L., Michelis, K. C., Nomura-Kitabayashi, A., Pandey, G. S., Purushothaman, K., d’Escamard, V., Li, J. R., Hadri, L., Fujitani, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms11853 · Cited by 628
Diversity in clinical and biomedical research: a promise yet to be fulfilled
Oh, S. S., Galanter, J., Thakur, N., Pino-Yanes, M., Barcelo, N. E., White, M. J., de Bruin, D. M., Greenblatt, R. M., Bibbins-Domingo, K., Wu, A. H. B., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001918 · Cited by 585
Halladay, A. K., Bishop, S. L., Constantino, J. N., Daniels, A. M., Koenig, K., Palmer, K., Messinger, D. S., Pelphrey, K. A., Sanders, S., Singer, A., et al. (2015) · Molecular Autism · doi:10.1186/s13229-015-0019-y · Cited by 639
Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019Preprint
du Sert, N. P., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/703355 · Cited by 557
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“…potential of the OT system to restore social dysfunction in sex-biased psychiatric disorders (Guastella et al., 2010a; Meyer-Lindenberg et al., 2011; Cochran et al., 2013), and recent initiatives from the NIH requiring the inclusion of both sexes in preclinical research (Clayton & Collins, 2014).”
BackgroundSex Differences in Traumatic Brain Injury: What We Know and What We Should Know
Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533
Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition
Haizlip, K. M., Harrison, B. C., & Leinwand, L. A. (2015) · Physiology · doi:10.1152/physiol.00024.2014 · Cited by 521
Sex-specific differences in hypertension and associated cardiovascular disease
Colafella, K. M. M., & Denton, K. M. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.189 · Cited by 505
Female rats are not more variable than male rats: a meta-analysis of neuroscience studies
Becker, J. B., Prendergast, B. J., & Liang, J. W. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0087-5 · Cited by 473
Sex-Specific Placental Responses in Fetal Development
Rosenfeld, C. S. (2015) · Endocrinology · doi:10.1210/en.2015-1227 · Cited by 485
Estradiol and cognitive function: Past, present and future
Luine, V. N. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.08.011 · Cited by 457
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Peltier, M. R., Verplaetse, T. L., Mineur, Y. S., Petrakis, I. L., Cosgrove, K., Picciotto, M. R., & McKee, S. A. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100149 · Cited by 440
Sex-Specific Differences in Lipid and Glucose Metabolism
Varlamov, O., Bethea, C. L., & Roberts, C. T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00241 · Cited by 429
Sorge, R. E., & Totsch, S. K. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23841 · Cited by 418
Gender Differences in Depression: Biological, Affective, Cognitive, and Sociocultural Factors
Hyde, J. S., & Mezulis, A. H. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000230 · Cited by 385
Reproducibility of animal research in light of biological variation
Voelkl, B., Altman, N., Forsman, A., Forstmeier, W., Gurevitch, J., Jarić, I., Karp, N. A., Kas, M. J., Schielzeth, H., de Casteele, T. V., et al. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0313-3 · Cited by 415
Why sex and gender matter in implementation research
Tannenbaum, C., Greaves, L., & Graham, I. D. (2016) · BMC Medical Research Methodology · doi:10.1186/s12874-016-0247-7 · Cited by 386
Studying both sexes: a guiding principle for biomedicine
Clayton, J. A. (2016) · The FASEB Journal · doi:10.1096/fj.15-279554 · Cited by 358
Self-citationStress, social behavior, and resilience: Insights from rodents
Beery, A. K., & Kaufer, D. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.004 · Cited by 394
Inclusion of females does not increase variability in rodent research studies
Beery, A. K. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.016 · Cited by 386
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Haupt, S., Caramia, F., Klein, S. L., Rubin, J. B., & Haupt, Y. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00348-y · Cited by 350
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Mollayeva, T., Mollayeva, S., & Colantonio, A. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0091-y · Cited by 336
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Aggarwal, N. R., Patel, H. N., Mehta, L. S., Sanghani, R. M., Lundberg, G. P., Lewis, S. J., Mendelson, M. A., Wood, M. J., Volgman, A. S., & Mieres, J. H. (2018) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.117.004437 · Cited by 341
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Woitowich, N. C., Beery, A. K., & Woodruff, T. K. (2020) · eLife · doi:10.7554/elife.56344 · Cited by 344
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Kozlowski, D., Larivière, V., Sugimoto, C. R., & Monroe‐White, T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113067119 · Cited by 374
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Tamargo, J. L., Rosano, G. M. C., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K. P., Savarese, G., et al. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw042 · Cited by 325
The gestational foundation of sex differences in development and vulnerability
DiPietro, J. A., & Voegtline, K. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.068 · Cited by 316
Mazure, C. M., & Jones, D. P. (2015) · BMC Women s Health · doi:10.1186/s12905-015-0251-9 · Cited by 339
Sex differences in stroke: Challenges and opportunities
Bushnell, C., Chaturvedi, S., Gage, K. R., Herson, P. S., Hurn, P. D., Jiménez, M. C., Kittner, S. J., Madsen, T. E., McCullough, L. D., McDermott, M., et al. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18793324 · Cited by 309
Sugimoto, C. R., Ahn, Y., Smith, E. M. R., Macaluso, B., & Larivière, V. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32995-7 · Cited by 323
Genetic Basis for Sex Differences in Obesity and Lipid Metabolism
Link, J. C., & Reue, K. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064827 · Cited by 306
A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism
Mauvais‐Jarvis, F., Arnold, A. P., & Reue, K. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.033 · Cited by 284
Sex bias exists in basic science and translational surgical research
Yoon, D. Y., Mansukhani, N. A., Stubbs, V. C., Helenowski, I. B., Woodruff, T. K., & Kibbe, M. R. (2014) · Surgery · doi:10.1016/j.surg.2014.07.001 · Cited by 270
Prevalence of sexual dimorphism in mammalian phenotypic traits
Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., Dickinson, M. E., Flenniken, A. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15475 · Cited by 257
Tractenberg, S. G., Levandowski, M. L., de Azeredo, L. A., Orso, R., Roithmann, L. G., Hoffmann, E. S., Brenhouse, H., & Grassi-Oliveira, R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.021 · Cited by 267
Steinberg, J. R., Turner, B. E., Weeks, B. T., Magnani, C. J., Wong, B. O., Rodríguez, F., Yee, L. M., & Cullen, M. R. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.13749 · Cited by 266
Sex differences in obesity, lipid metabolism, and inflammation—A role for the sex chromosomes?
Zore, T., Palafox, M., & Reue, K. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.04.003 · Cited by 239
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Clayton, J. A. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.08.012 · Cited by 274
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Nielsen, M. W., Bloch, C. W., & Schiebinger, L. L. (2018) · Nature Human Behaviour · doi:10.1038/s41562-018-0433-1 · Cited by 260
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Lee, S. K. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.4.034 · Cited by 275
Curley, J. P., & Champagne, F. A. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.11.001 · Cited by 279
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Finn, D. P., Haroutounian, S., Hohmann, A. G., Krane, E. J., Soliman, N., & Rice, A. S. C. (2021) · Pain · doi:10.1097/j.pain.0000000000002268 · Cited by 280
Fillingim, R. B. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00038-3 · Cited by 256
Genetic Background Limits Generalizability of Genotype-Phenotype Relationships
Sittig, L. J., Carbonetto, P. S., Engel, K. A., Krauss, K. S., Barrios-Camacho, C. M., & Palmer, A. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.013 · Cited by 255
Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats
Mapplebeck, J. C. S., Dalgarno, R., Tu, Y., Moriarty, O., Beggs, S., Kwok, C. H. T., Halievski, K., Assi, S., Mogil, J. S., Trang, T., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001265 · Cited by 245
Mapplebeck, J. C. S., Beggs, S., & Salter, M. W. (2015) · Pain · doi:10.1097/j.pain.0000000000000389 · Cited by 243
Rechlin, R. K., Splinter, T. F. L., Hodges, T. E., Albert, A. Y., & Galea, L. A. M. (2022) · Nature Communications · doi:10.1038/s41467-022-29903-3 · Cited by 218
Reporting and misreporting of sex differences in the biological sciences
Garcia-Sifuentes, Y., & Maney, D. L. (2021) · eLife · doi:10.7554/elife.70817 · Cited by 241
Sex inclusion in basic research drives discovery
Klein, S. L., Schiebinger, L., Stefanick, M. L., Cahill, L., Danska, J., de Vries, G. J., Kibbe, M. R., McCarthy, M. M., Mogil, J. S., Woodruff, T. K., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502843112 · Cited by 238
Uncovering sex differences of rodent microglia
Han, J., Fan, Y., Zhou, K., Blomgren, K., & Harris, R. A. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02124-z · Cited by 224
Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging
Mangold, C. A., Wronowski, B., Du, M., Masser, D. R., Hadad, N., Bixler, G. V., Brucklacher, R. M., Ford, M. M., Sonntag, W. E., & Freeman, W. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0920-8 · Cited by 203
The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease
Trexler, C. L., Harvey, P. A., Reckelhoff, J. F., & Leinwand, L. A. (2016) · Circulation Research · doi:10.1161/circresaha.116.307509 · Cited by 225
Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL/6J mice
Casimiro, I., Stull, N. D., Tersey, S. A., & Mirmira, R. G. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107795 · Cited by 215
Gender medicine and oncology: report and consensus of an ESMO workshop
Wagner, A. D., Oertelt‐Prigione, S., Adjei, A. A., Buclin, T., Cristina, V., Csajka, C., Coukos, G., Dafni, U., Dotto, G. P., Ducreux, M. P., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz414 · Cited by 215
The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System
Menazza, S., & Murphy, E. (2016) · Circulation Research · doi:10.1161/circresaha.115.305376 · Cited by 177
Streptozotocin as a tool for induction of rat models of diabetes: a practical guide
Ghasemi, A., & Jeddi, S. (2022) · EXCLI journal · doi:10.17179/excli2022-5720 · Cited by 273
Gender Differences in Binge Drinking: Prevalence, Predictors, and Consequences
Wilsnack, R. W., Wilsnack, S. C., Gmel, G. E., & Kantor, L. W. (2018) · Europe PMC (PubMed Central) · Cited by 210
Improving and Accelerating Drug Development for Nervous System Disorders
Pankevich, D. E., Altevogt, B. M., Dunlop, J., Gage, F. H., & Hyman, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.007 · Cited by 208
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203
Challenging the binary: Gender/sex and the bio‐logics of normalcy
DuBois, L. Z., & Shattuck‐Heidorn, H. (2021) · American Journal of Human Biology · doi:10.1002/ajhb.23623 · Cited by 228
Sex- and Gender-Based Pharmacological Response to Drugs
Mauvais‐Jarvis, F., Berthold, H. K., Campesi, I., Carrero, J. J., Dhakal, S., Franconi, F., Gouni‐Berthold, I., Heiman, M. L., Kautzky‐Willer, A., Klein, S. L., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000206 · Cited by 203
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Sadler, K. E., Mogil, J. S., & Stucky, C. L. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00536-7 · Cited by 199
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Hamson, D. K., Roes, M., & Galea, L. A. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150031 · Cited by 216
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Shansky, R. M., & Woolley, C. S. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1390-16.2016 · Cited by 191
Sex differences in mitochondrial (dys)function: Implications for neuroprotection
Demarest, T. G., & McCarthy, M. M. (2015) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9583-7 · Cited by 192
Modulation of autoimmune rheumatic diseases by oestrogen and progesterone
Hughes, G. C., & Choubey, D. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.144 · Cited by 191
Neuroanatomy of developmental dyslexia: Pitfalls and promise
Ramus, F., Altarelli, I., Jednoróg, K., Zhao, J., & di Covella, L. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.001 · Cited by 210
Perils and pitfalls of reporting sex differences
Maney, D. L. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0119 · Cited by 201
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Bangasser, D. A., Eck, S. R., & Sanchez, E. O. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0137-2 · Cited by 192
Is Man the Measure of All Things? A Social Cognitive Account of Androcentrism
Bailey, A. H., LaFrance, M., & Dovidio, J. F. (2018) · Personality and Social Psychology Review · doi:10.1177/1088868318782848 · Cited by 223
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Scully, E. P. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0383-2 · Cited by 184
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Bjelobaba, I. M., Begović-Kuprešanin, V., Peković, S., & Lavrnja, I. C. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24224 · Cited by 197
Why estrogens matter for behavior and brain health
Galea, L. A. M., Frick, K. M., Hampson, E., Sohrabji, F., & Choleris, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.024 · Cited by 195
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Legato, M. J., Johnson, P. A., & Manson, J. E. (2016) · JAMA · doi:10.1001/jama.2016.13995 · Cited by 178
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Hudry, B., de Goeij, E., Mineo, A., Gaspar, P., Hadjieconomou, D., Studd, C., Mokochinski, J. B., Kramer, H., Plaçais, P.-Y., Préat, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.029 · Cited by 164
Kahn, S., & Ginther, D. K. (2017) · National Bureau of Economic Research · doi:10.3386/w23525 · Cited by 197
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Metadata
- Authors
- Clayton, J. A., & Collins, F. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Clayton, Janine A.
- Venue
- Nature
- Published
- 2014-05
- Volume
- 509
- Issue
- 7500
- Pages
- 282-283
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5101948
- OpenAlex
- W2027431314
- Cited by
- 1,816
- References
- 15
- Citations by year
- 2026: 105 · 2025: 120 · 2024: 142 · 2023: 142 · 2022: 163 · 2021: 162 · 2020: 169 · 2019: 134 · 2018: 141 · 2017: 146 · 2016: 177 · 2015: 151 · 2014: 63
- FWCI
- 178.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Social Sciences › Gender Studies › Diversity and Career in Medicine
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Keywords
- sex differences in research, NIH policy, preclinical research, sex-inclusive research, research funding policy, gender equity in science
- MeSH terms
- Animals, Animals, Laboratory, Cell Line, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Female, Financing, Organized, Humans, Male, Multiple Sclerosis, National Institutes of Health (U.S.), Neurons, Research Design, Sex Characteristics, Sex Ratio, United States, Peer Review, Research, Substance-Related Disorders, Animal Experimentation, Biomedical Research
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