Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

Walczak, Henning, Miller, Robert E., Ariail, Kiley, Gliniak, Brian, Griffith, Thomas S., Kubin, Marek, Chin, Wilson, Jones, Jon +8 more·1999·Nature Medicine

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  3. Transcription Factor NF-κB Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1
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  4. An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes
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  8. Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling
    Wafik S. El‐Deiry · 2001 · Cell Death and Differentiation
  9. Implication of TNF-Related Apoptosis-Inducing Ligand in Inflammatory Intestinal Epithelial Lesions
    Bernadette Bègue, Harald Wajant, Jean–Christophe Bambou, Laurent Dubuquoy, Daniela Siegmund, Jean‐François Beaulieu, Danielle Canioni, Dominique D. Berrebi, Nicole Brousse, Pierre Desreumaux et al. · 2006 · Gastroenterology
  10. Evidence that the death receptor DR4 is a DNA damage‐inducible, p53‐regulated gene
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  11. Crystal Structure of TRAIL-DR5 Complex Identifies a Critical Role of the Unique Frame Insertion in Conferring Recognition Specificity
    Sun‐Shin Cha, Byungje Sung, Young‐A Kim, Young-Lan Song, Hyun-Ju Kim, Sunshin Kim, Myung‐Shik Lee, Byung‐Ha Oh · 2000 · Journal of Biological Chemistry
  12. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
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  13. Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis
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  15. Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo
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  16. Tumor therapeutics by design: targeting and activation of death receptors
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  17. Baicalein Overcomes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance via Two Different Cell-Specific Pathways in Cancer Cells but not in Normal Cells
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  18. FLIP and the death effector domain family
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  19. TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies
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  20. Death Ligand TRAIL Induces No Apoptosis but Inhibits Activation of Human (Auto)antigen-Specific T Cells
    Jan D. Lünemann, Sonia Waiczies, Stefan Ehrlich, Uwe Wendling, Bibiane Seeger, Thomas Kamradt, Frauke Zipp · 2002 · The Journal of Immunology
  21. Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter.
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  22. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.
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  23. Curcumin sensitizes prostate cancer cells to tumor necrosis factor–related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-κB through suppression of IκBα phosphorylation
    Dorrah Deeb, Hao Jiang, Xiaohua Gao, Mikehl S. Hafner, Henry Wong, George Divine, Robert Chapman, Scott A. Dulchavsky, Subhash C. Gautam · 2004 · Molecular Cancer Therapeutics
  24. Is TRAIL the holy grail of cancer therapy?
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  25. A new dawn for the use of traditional Chinese medicine in cancer therapy
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  27. Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program.
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  28. p53-Independent Upregulation of KILLER/DR5 TRAIL Receptor Expression by Glucocorticoids and Interferon-γ
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  29. Identification of a New Murine Tumor Necrosis Factor Receptor Locus That Contains Two Novel Murine Receptors for Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)
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  30. Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis
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  32. The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology
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  35. Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors
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  38. Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments
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  39. Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
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  40. Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL‐R2 gene 1
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  41. TRAIL regulates normal erythroid maturation through an ERK-dependent pathway
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  42. Emerging non‐apoptotic functions of tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)/Apo2L
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  43. Local administration of dendritic cells inhibits established breast tumor growth: implications for apoptosis-inducing agents.
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  44. Mapatumumab, an Antibody Targeting TRAIL-R1, in Combination With Paclitaxel and Carboplatin in Patients With Advanced Solid Malignancies: Results of a Phase I and Pharmacokinetic Study
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  45. Mechanisms of Apoptosis Resistance to NK Cell-Mediated Cytotoxicity in Cancer
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  46. TRAIL receptor–mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality
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  47. Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1
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  48. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease
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  50. Expression of tumor necrosis factor–related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis
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  51. Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL
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  54. Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design
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  56. The TRAIL Decoy Receptor TRUNDD (DcR2, TRAIL-R4) Is Induced by Adenovirus-p53 Overexpression and Can Delay TRAIL-, p53-, and KILLER/DR5-Dependent Colon Cancer Apoptosis
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  57. A Tumor-Targeted and Conditionally Replicating Oncolytic Adenovirus Vector Expressing TRAIL for Treatment of Liver Metastases
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  58. Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells.
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  59. Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells.
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  60. Rel/NF-κB Transcription Factors Protect against Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Up-regulating the TRAIL Decoy Receptor DcR1
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  61. Death to the bad guys: Targeting cancer via Apo2L/TRAIL
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  62. Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells
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  63. Overexpression of Soluble TRAIL Induces Apoptosis in Human Lung Adenocarcinoma and Inhibits Growth of Tumor Xenografts in Nude Mice
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  69. TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2
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  70. Tunicamycin Sensitizes Human Melanoma Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis by Up-regulation of TRAIL-R2 via the Unfolded Protein Response
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  84. Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) Sequentially Upregulates Nitric Oxide and Prostanoid Production in Primary Human Endothelial Cells
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