Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
Walczak, Henning, Miller, Robert E., Ariail, Kiley, Gliniak, Brian, Griffith, Thomas S., Kubin, Marek, Chin, Wilson, Jones, Jon, Woodward, Anne, Le, Tiep, Smith, Craig, Smolak, Pam, Goodwin, Raymond G., Rauch, Charles T., Schuh, JoAnn C.L., Lynch, David H.·1999·Nature Medicine
DOI 10.1038/5517
Cited by (1,003)
Items 801–900 of 1,003
- Breast Tumor Xenografts: Diffusion-weighted MR Imaging to Assess Early Therapy with Novel Apoptosis-Inducing Anti-DR5 AntibodyHyunki Kim, Desiree E. Morgan, Huadong Zeng, William E. Grizzle, Jason M. Warram, Cecil R. Stockard, Deli Wang, Kurt R. Zinn · 2008 · Radiology
- JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligandSimon R. Mucha, Antonia Rizzani, Alexander L. Gerbes, Peter Čamaj, Wolfgang Erwin Thasler, Christiane J. Bruns, S.T. Eichhorst, Eike Gallmeier, Frank Thomas Kolligs, Burkhard Göke et al. · 2008 · Gut
- Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cellsTakaaki Matsui · 2006 · Carcinogenesis
- Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenograftsIrina V. Balyasnikova, Sherise Desiree Ferguson, Yu Han, Fei‐Fei Liu, Maciej S. Lesniak · 2011 · Cancer Letters
- Role of the TRAIL/APO2-L death receptors in chlorambucil- and fludarabine-induced apoptosis in chronic lymphocytic leukemiaJames B. Johnston, Albert F. Kaboré, Jeanna Strutinsky, Xiaojie Hu, James T. Paul, Dianne M Kropp, Brenda Kuschak, Asher Begleiter, Spencer Bruce Gibson · 2003 · Oncogene
- Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell ApoptosisJean‐Philippe Herbeuval, Claude Lambert, Odile Sabido, Michèle Cottier A, P. Fournel, Michel Dy, Christian Genin · 2003 · JNCI Journal of the National Cancer Institute
- TRAIL-induced apoptosis of thyroid cancer cells: potential for therapeutic interventionManzoor Ahmad, Yufei Shi · 2000 · Oncogene
- Using extracellular biomarkers for monitoring efficacy of therapeutics in cancer patients: an updateSarah H. Beachy, Elizabeth A. Repasky · 2008 · Cancer Immunology Immunotherapy
- Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulationJenny N. H. G. Ho, Dominik Schmidt, Theresa Lowinus, Jeongmin Ryoo, Elaine-Pashupati Dopfer, Nicolás Gonzalo Núñez, Sara Costa-Pereira, Cristina Toffalori, Marco Punta, Viktor Fetsch et al. · 2022 · Blood
- Bone Marrow Stroma Confers Resistance to Apo2 Ligand/TRAIL in Multiple Myeloma in Part by Regulating c-FLIPLia Elena Perez, Nancy Parquet, Kenneth H. Shain, Ramadevi Nimmanapalli, Melissa Alsina, Claudio Anasetti, William S. Dalton · 2008 · The Journal of Immunology
- Nitrosative stress in cancer therapyDavid, G. Hirst · 2007 · Frontiers in bioscience
- Molecular Pathogenesis of CholangiocarcinomaGiammarco Fava, Ivano Lorenzini · 2011 · International Journal of Hepatology
- Modulation of CD4+ T-cell activation by CD95 co-stimulationMaren Paulsen, S. Valentin, Blurton-Jones Mathew, Sabine Adam‐Klages, Uwe Bertsch, Inna N. Lavrik, Peter H. Krammer, Dieter Kabelitz, Ottmar Janßen · 2010 · Cell Death and Differentiation
- CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cellsDavid Llobet‐Navàs, Núria Eritja, Mario Encinas, Núria Llecha, Andrée Yeramian, J Pallares, Anabel Sorolla, Francisco Javier Gonzalez-Tallada, Xavier Matías‐Guiu, Xavier Dolcet · 2007 · Oncogene
- A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 ActivationJulia C. Hoffmann, Alexander Pappa, Peter H. Krammer, Inna N. Lavrik · 2009 · Molecular and Cellular Biology
- Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cellsSung‐Chul Lim, Hong‐Quan Duong, Jeong Eun Choi, Tae-Bum Lee, Ju‐Hee Kang, Seung Hyun Oh, Song Iy Han · 2011 · Carcinogenesis
- Butein Sensitizes Human Hepatoma Cells to TRAIL-Induced Apoptosis via Extracellular Signal-Regulated Kinase/Sp1–Dependent DR5 Upregulation and NF-κB InactivationDong‐Oh Moon, Mun-Ock Kim, Yung Hyun Choi, Gi‐Young Kim · 2010 · Molecular Cancer Therapeutics
- Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer TherapyJavier Naval, Diego de Miguel, Ana Gallego-Lleyda, Alberto Anel, Luis Martínez‐Lostao · 2019 · Cancers
- The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancerAmanda Dutton, Lawrence S. Young, Paul Gerard Murray · 2006 · Expert Opinion on Therapeutic Targets
- The role of TRAIL/TRAIL receptors in central nervous system pathologyOrhan Aktaş · 2007 · Frontiers in bioscience
- Interferon-γ Sensitizes Human Myeloid Leukemia Cells to Death Receptor-mediated Apoptosis by a Pleiotropic MechanismNieves Varela, Cristina Muñoz‐Pinedo, Carmen Ruiz‐Ruiz, Gema Robledo, Miriam Pedroso, Abelardo López‐Rivas · 2001 · Journal of Biological Chemistry
- Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosisChao Wu Xiao, B FENGYANG, Jin Hyang Song, Howard Schulman, L LI, Chunhai Hao · 2004 · Experimental Cell Research
- Inhibition of the NF-κB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cellsBahri Karaçay, Salih Şanlıoğlu, Thomas S. Griffith, Anthony David Sandler, Daniel J. Bonthius · 2004 · Cancer Gene Therapy
- Bid Mediates Apoptotic Synergy between Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and DNA DamageV. Courtney Broaddus, Tobias B. Dansen, Keith S. Abayasiriwardana, Shannon M. Wilson, Andrew J. Finch, Lamorna Brown Swigart, Abigail E. Hunt, Gérard I. Evan · 2004 · Journal of Biological Chemistry
- Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral InfectionKathrin Sutter, Jara J. Joedicke, Andreas Meryk, Mirko Trilling, Sandra Francois, Janine Duppach, Anke R.M. Kraft, Karl Sebastian Lang, Ulf Dittmer · 2012 · PLoS Pathogens
- TRAIL receptor mediates inflammatory cytokine release in an NF-κB-dependent mannerWanhu Tang, Weimin Wang, Yaxi Zhang, Shilian Liu, Yanxin Liu, Dexian Zheng · 2009 · Cell Research
- PEGylated TNF-Related Apoptosis-Inducing Ligand (TRAIL) Analogues: Pharmacokinetics and Antitumor EffectsTae Hyung Kim, Yu Seok Youn, Hai Hua Jiang, Seulki Lee, Xiaoyuan Shawn Chen, Kang Choon Lee · 2011 · Bioconjugate Chemistry
- Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cellsShunchao Yan, Xiujuan Qu, XU Chong-an, Zhitu Zhu, Lingyun Zhang, Ling Xu, Na Song, Yuee Teng, Yunpeng Liu · 2012 · Journal of Cancer Research and Clinical Oncology
- Nuclear drug delivery to target tumour cellsKylie M. Wagstaff, David A. Jans · 2009 · European Journal of Pharmacology
- Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC -independent mechanism in human malignant tumor cellsJun Hee Lim, Jung‐Won Park, Kyeong Sook Choi, Y. B. Park, Taeg Kyu Kwon · 2008 · Carcinogenesis
- Engineered adenoviruses combine enhanced oncolysis with improved virus production by mesenchymal stromal carrier cellsKatharina Hammer, Adam Kazcorowski, Li Liu, Michael Behr, Peter Schemmer, Ingrid Herr, Dirk M. Nettelbeck · 2015 · International Journal of Cancer
- Immunoglobulin Fc Domain Fusion to TRAIL Significantly Prolongs Its Plasma Half-Life and Enhances Its Antitumor ActivityHaizhen Wang, Jennifer Sarah Davis, Xiangwei Wu · 2014 · Molecular Cancer Therapeutics
- Current treatment for Ewing’s sarcomaMihir M. Thacker, Harry Thomas Temple, Sean P. Scully · 2005 · Expert Review of Anticancer Therapy
- ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non–Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent MechanismsMarie D. Ralff, Christina Leah B. Kline, Ozan C. Küçükkase, Jessica Wagner, Bora Lim, David T. Dicker, Varun V. Prabhu, Wolfgang Oster, Wafik S. El‐Deiry · 2017 · Molecular Cancer Therapeutics
- The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1sSam Sheppard, Iona S. Schuster, Christopher E. Andoniou, Clément Cocita, Thomas Adejumo, Sam K. P. Kung, Joseph Chai-Yuen Sun, Mariapia A. Degli‐Esposti, Nadia Guerra · 2018 · Cell Reports
- α‐Fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase‐3‐like proteasesElena I. Dudich, Lidia Semenkova, Igor V. Dudich, Elena Gorbatova, Natasha Tochtamisheva, Edward Tatulov, M. A. Nikolaeva, Gennady Tikhonovich Sukhikh · 1999 · European Journal of Biochemistry
- A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Δ12, 14 prostaglandin J2 productionHiroo Hasegawa, Yasuaki Yamada, Kanki Komiyama, Masahiko Hayashi, Masami Ishibashi, Toshiaki Sunazuka, Takeshi Izuhara, Kazuyuki Sugahara, Kazuto Tsuruda, Masato Masuda et al. · 2007 · Blood
- Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis.Ali R. Jazirehi, Chuen‐Pei Ng, Xiao-Hu Gan, Gary John Schiller, Benjamin Bonavida · 2001 · PubMed
- Enhancement of Apo2L/TRAIL (tumor necrosis factor–related apoptosis-inducing ligand)–induced apoptosis in non–small cell lung cancer cell lines by chemotherapeutic agents without correlation to the expression level of cellular protease caspase-8 inhibitory proteinSteffen Frese, Thomas Brunner, Mathias Gugger, Aima N. Uduehi, Ralph Alexander Schmid · 2002 · Journal of Thoracic and Cardiovascular Surgery
- Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecanMarion Déjosez, U. Ramp, Csaba Mahotka, Andreas H. Krieg, Henning Walczak, Helmut Erich Gabbert, C D Gerharz · 2000 · Cell Death and Differentiation
- Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancerLuis Martínez‐Lostao, Isabel Marzo, Alberto Anel, Javier Naval · 2012 · Biochemical Pharmacology
- The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanismsDavid Llobet‐Navàs, Núria Eritja, Andrée Yeramian, J. Pallares, Anabel Sorolla, M. Domingo, Marı́a Santacana, Francisco Javier Gonzalez-Tallada, Xavier Matías‐Guiu, Xavier Dolcet · 2010 · European Journal of Cancer
- Emerging role of tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) as a key regulator of inflammatory responsesAdam Collison, Paul S. Foster, Joërg Mattes · 2009 · Clinical and Experimental Pharmacology and Physiology
- Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer CellsEwelina Szliszka, Wojciech Król · 2013 · Evidence-based Complementary and Alternative Medicine
- TRAIL-induced apoptosis and expression of death receptor TRAIL-R1 and TRAIL-R2 in bladder cancer cells.Ewelina Szliszka, Bogdan Mazur, Grzegorz Zydowicz, Zenon Paweł Czuba, Wojciech Król · 2010 · Folia Histochemica et Cytobiologica
- Clusterin mediates TRAIL resistance in prostate tumor cellsDavid Andrew Sallman, Xianghong Chen, Bin Zhong, Danielle L. Gilvary, Junmin Zhou, Sheng Wei, Julie Y. Djeu · 2007 · Molecular Cancer Therapeutics
- Effective Combination Therapy for Malignant Glioma with TRAIL-Secreting Mesenchymal Stem Cells and Lipoxygenase Inhibitor MK886Seong Muk Kim, Ji Sun Woo, Chang Hyun Jeong, Chung Heon Ryu, Jung Yeon Lim, Sin‐Soo Jeun · 2012 · Cancer Research
- NFκB-dependent Down-regulation of Tumor Necrosis Factor Receptor-associated Proteins Contributes to Interleukin-1-mediated Enhancement of Ultraviolet B-induced ApoptosisBirgit Pöppelmann, Kerstin Klimmek, Elwira A. Strozyk, Reinhard Voß, Thomas Schwarz, Dagmar Kulms · 2005 · Journal of Biological Chemistry
- Mutation analysis of the apoptotic “death‐receptors” and the adaptors TRADD and FADD/MORT‐1 in osteosarcoma tumor samples and osteosarcoma cell linesMarkus J. Dechant, Jörg Fellenberg, C.G. Scheuerpflug, V. Ewerbeck, Klaus‐Michael Debatin · 2004 · International Journal of Cancer
- Caspase Regulation in Non–Small Cell Lung Cancer and its Potential for Therapeutic ExploitationDean Anthony Fennell · 2005 · Clinical Cancer Research
- Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells.George Kulik, James P. Carson, Tomáš Vomastek, K Overman, Barry D. Gooch, Srinivasa Murty Srinivasula, Emad S. Alnemri, Gabriel Núñez, Michael J. Weber · 2001 · PubMed
- Role of NF-κB Activity in Apoptotic Response of Keratinocytes Mediated by Interferon-γ, Tumor Necrosis Factor-α, and Tumor-Necrosis-Factor-Related Apoptosis-Inducing LigandJian‐Zhong Qin, Patricia E. Bacon, Vijaya Chaturvedi, Brian J. Nickoloff · 2001 · Journal of Investigative Dermatology
- Actinomycin D and Gemcitabine Synergistically Sensitize Androgen-Independent Prostate Cancer Cells to Apo2L/TRAIL-Mediated ApoptosisAmnon Zisman, Chuen‐Pei Ng, Allan J. Pantuck, Benjamin Bonavida, Arie S. Belldegrun · 2001 · Journal of Immunotherapy
- Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53.Khondoker M. Akram, Nicola J Lomas, Nicholas Robert Forsyth, M A Spiteri · 2014 · Europe PMC (PubMed Central)
- Targeted polymeric nanoparticles for cancer gene therapyJayoung Kim, David R. Wilson, Camila Gadens Zamboni, Jordan J. Green · 2015 · Journal of drug targeting
- Luteolin enhances TNF-related apoptosis-inducing ligand’s anticancer activity in a lung cancer xenograft mouse modelJiaqi Yan, Qiong Wang, Xuelian Zheng, Hong Sun, Yuqiong Zhou, Daoxia Li, Yong Lin, Xia Wang · 2011 · Biochemical and Biophysical Research Communications
- Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agentsTania Sánchez‐Pérez, Gustavo Ortiz-Ferrón, Abelardo López‐Rivas · 2009 · Cell Death and Differentiation
- Triptolide and TRAIL Combination Enhances Apoptosis in CholangiocarcinomaKimberly A. Clawson, Daniel Borja–Cacho, Mara B. Antonoff, Ashok Kumar Saluja, Selwyn Maurice Vickers · 2010 · Journal of Surgical Research
- TNF-? induces changes in LDH isotype profile following triggering of apoptosis in PBL of non-Hodgkin?s lymphomasVladimir Jurišić, V. Bumbaširević, Gordana M. Konjević, B. Djuričič, I Spužić · 2004 · Annals of Hematology
- Potential Application of Temozolomide in Mesenchymal Stem Cell-Based TRAIL Gene Therapy Against Malignant GliomaSeong Muk Kim, Ji Sun Woo, Chang Hyun Jeong, Chung Heon Ryu, Jae-Deog Jang, Sin‐Soo Jeun · 2014 · Stem Cells Translational Medicine
- Surface modification of TPGS-b-(PCL-ran-PGA) nanoparticles with polyethyleneimine as a co-delivery system of TRAIL and endostatin for cervical cancer gene therapyYi Zheng, Hongbo Chen, Xiaowei Zeng, Zhigang Liu, Xiaojun Xiao, Yongqiang Zhu, Dayong Gu, Lin Mei · 2013 · Nanoscale Research Letters
- Decursin enhances TRAIL‐induced apoptosis through oxidative stress mediated‐ endoplasmic reticulum stress signalling in non‐small cell lung cancersJae Kwang Kim, Miyong Yun, Eun‐Ok Kim, Deok‐Beom Jung, Gunho Won, Bonglee Kim, Ji Hoon Jung, Sung‐Hoon Kim · 2015 · British Journal of Pharmacology
- A randomized, double-blind, placebo-controlled phase II study to assess the efficacy and safety of mapatumumab with sorafenib in patients with advanced hepatocellular carcinomaTudor–Eliade Ciuleanu, Igor S. Bazin, Dan Lungulescu, Lucian Miron, Igor Bondarenko, Andrzej Deptała, Maribel Rodriguez‐Torres, Bruce J. Giantonio, N. L. Fox, Paul Stephen Wissel et al. · 2016 · Annals of Oncology
- TRAIL–NP hybrids for cancer therapy: a reviewHanène Belkahla, Guillaume Herlem, Fabien Picaud, Tijani Gharbi, Miryana Hémadi, Souad Ammar, Olivier Micheau · 2017 · Nanoscale
- Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavageU. Ramp, E Caliskan, Csaba Mahotka, Andreas H. Krieg, Sebastian Heikaus, Helmut Erich Gabbert, C D Gerharz · 2003 · British Journal of Cancer
- The Role of Death Receptor Ligands in Shaping Tumor MicroenvironmentTheresa L. Whiteside · 2006 · Immunological Investigations
- Clinical potential of inhibitors of survival pathways and activators of apoptotic pathways in treatment of cervical cancer: changing the apoptotic balanceBrigitte M.T. Hougardy, John H. Maduro, Ate GJ van der Zee, Pax H.B. Willemse, Steven de Jong, Elisabeth G.E. de Vries · 2005 · The Lancet Oncology
- cFLIPL Inhibits Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated NF-κB Activation at the Death-inducing Signaling Complex in Human KeratinocytesTina Wachter, Martin Ronald Sprick, Dominikus Hausmann, Andreas Kerstan, Kirsty McPherson, Giorgio Stassi, Eva‐B. Bröcker, Henning Walczak, Martin Leverkus · 2004 · Journal of Biological Chemistry
- 15-Deoxy-Δ12,14-prostaglandin J2 induces death receptor 5 expression through mRNA stabilization independently of PPARγ and potentiates TRAIL-induced apoptosisSusumu Nakata, Tatsushi Yoshida, Takumi Shiraishi, Mano Horinaka, Junji Kouhara, Miki Wakada, Toshiyuki Sakai · 2006 · Molecular Cancer Therapeutics
- Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cellsQin He, Xiuquan Luo, Ying Kao Huang, M. Saeed Sheikh · 2002 · Oncogene
- Steering anti-cancer drugs away from the TRAILShigekazu Nagata · 2000 · Nature Medicine
- Understanding tumor-stroma interplays for targeted therapies by armed mesenchymal stromal progenitors: the Mesenkillers.Giulia Grisendi, Rita Bussolari, Elena Veronesi, Maria Serena Piccinno, Jorge Sans Burns, Giorgio De Santis, Pietro Loschi, Marco Pignatti, Fabrizio Di Benedetto, Roberto Ballarin et al. · 2011 · Europe PMC (PubMed Central)
- Anti-DR5 monoclonal antibody-mediated DTIC-loaded nanoparticles combining chemotherapy and immunotherapy for malignant melanoma: target formulation development and in vitro anticancer activityShen Gao, Ding Ding, Shen Gao · 2011 · International Journal of Nanomedicine
- Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: relationship to Bcl-2 family and caspase activationAhmed Hamaï, Catherine Richon, Franck Meslin, Florence Faure, Audrey Kauffmann, Yann Lécluse, Abdelali Jalil, Lionel Larue, M.-F. Avril, Salem Chouaı̈b et al. · 2006 · Oncogene
- Effective gene–virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5Xin‐Yuan Liu, Song-Bo Qiu, Wei-Gou Zou, Zi-Fei Pei, Jin-Fa Gu, Chun-Xia Luo, Hong-Mei Ruan, Yu Chen, Yi-Peng Qi, Cheng Qian · 2005 · Molecular Therapy
- Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosisHongqin Zhuang, Weiwei Jiang, Wei Cheng, Kui Qian, Wei Dong, Lin Cao, Qilai Huang, Shufeng Li, Fei Dou, Jen‐Fu Chiu et al. · 2009 · Lung Cancer
- HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cellsDae-Hee Lee, Ki Sa Sung, David L. Bartlett, Yong Tae Kwon, Yong Jun Lee · 2014 · Cellular Signalling
- Genetic determinants for chemo- and radiotherapy resistance in bladder cancerAndrea Mari, David D’Andrea, Mohammad M. Abufaraj, Beat Foerster, Shoji Kimura, Shahrokh François Shariat · 2017 · Translational Andrology and Urology
- The secretable form of trimeric TRAIL, a potent inducer of apoptosisMihyang Kim, Timothy R. Billiar, Dai‐Wu Seol · 2004 · Biochemical and Biophysical Research Communications
- BCR–ABL-mediated upregulation of PRAME is responsible for knocking down TRAIL in CML patientsDaniel Diniz De Carvalho, Renata Binato, Welbert Oliveira Pereira, Janine Marie Gisele Leroy, M D Colassanti, Rodrigo Proto‐Siqueira, Ana Elisa B. Bueno-da-Silva, Marco Antonio Zago, Maria Aparecida Zanichelli, Eliana S. F. W. Abdelhay et al. · 2010 · Oncogene
- A “Stealth Effect”: Adenocarcinoma Cells Engineered to Express TRAIL Elude Tumor-Specific and Allogeneic T Cell ReactionsMirella Giovarelli, Piero Musiani, Gianni Garotta, Reinhard Ebner, Emma Di Carlo, Yun‐Soo Kim, Paola Cappello, Laura Maria Rigamonti, Paola Bernabei, Francesco Novelli et al. · 1999 · The Journal of Immunology
- Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancersAmmad Ahmad Farooqı, Humaira Naureen, Rabbia Zahid, Lara Youssef, Rükset Attar, Baojun Xu · 2021 · Pharmacological Research
- LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signalsNina D. Rintala‐Maki, Leslie C. Sutherland · 2004 · APOPTOSIS
- Inhibition of MKK7–JNK by the TOR Signaling Pathway Regulator-Like Protein Contributes to Resistance of HCC Cells to TRAIL-Induced ApoptosisIn Sung Song, Soo Young Jun, Hee–Jun Na, Hyun–Taek Kim, So Young Jung, Ga‐Hee Ha, Young–Ho Park, Liang Zhe Long, Dae‐Yeul Yu, Jin‐Man Kim et al. · 2012 · Gastroenterology
- The pro‐metastatic role of bone marrow‐derived cells: a focus on MSCs and regulatory T cellsBong Ihn Koh, Yibin Kang · 2012 · EMBO Reports
- Role of Intracellular Glutathione in Cell Sensitivity to the Apoptosis Induced by Tumor Necrosis Factor α–Related Apoptosis-Inducing Ligand/Anticancer Drug CombinationsOlivier Meurette, Luz Lefeuvre‐Orfila, Amélie Rébillard, Dominique Lagadic‐Gossmann, Marie‐Thérèse Dimanche‐Boitrel · 2005 · Clinical Cancer Research
- Exceptionally Potent Anti-Tumor Bystander Activity of an scFv:sTRAIL Fusion Protein with Specificity for EGP2 Toward Target Antigen-Negative Tumor CellsEdwin Bremer, Douwe Freerk Samplonius, Bart‐Jan Kroesen, Linda van Genne, Lou de Leij, Wijnand Helfrich · 2004 · Neoplasia
- Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPsDarren Finlay, Mitchell Vamos, Marcos González‐López, Robert Ardecky, Santhi Reddy, Hongbin Yuan, Ying Su, Trina R. Cooley, Curt T. Hauser, Kate Welsh et al. · 2013 · Molecular Cancer Therapeutics
- Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand PathwayWei Xin Liu, Chao Xu, Hongyan Zhao, Pengpeng Xia, Ruilong Song, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Yan Yuan, Zongping Liu · 2015 · PLoS ONE
- High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancerDiego de Miguel, Ana Gallego-Lleyda, José María Ayuso, María Dolores Pejenaute‐Ochoa, Vidal Jarauta, Isabel Marzo, Luis José Fernández, Ignacio Ochoa, Blanca Conde, Alberto Anel et al. · 2016 · Cancer Letters
- A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastomaEonju Oh, JinWoo Hong, Oh‐Joon Kwon, Chae‐Ok Yun · 2018 · Scientific Reports
- Molecular Mode of Action of TRAIL Receptor Agonists—Common Principles and Their Translational ExploitationHarald Wajant · 2019 · Cancers
- Multi-functional gene ASY/Nogo/RTN-X/RTN4: Apoptosis, tumor suppression, and inhibition of neuronal regenerationAkihiro Watari, Masuo Yutsudo · 2003 · APOPTOSIS
- Caspases Target Only Two Architectural Components within the Core Structure of the Nuclear Pore ComplexMonika Patre, Anja Tabbert, Daniela Hermann, Henning Walczak, Hans‐Richard Rackwitz, Volker C. Cordes, Elisa Ferrando‐May · 2005 · Journal of Biological Chemistry
- Expression of the apoptosis-inducing ligands FasL and TRAIL in malignant and benign human breast tumorsChristina Herrnring, Toralf Reimer, Udo Jeschke, Josef Makovitzky, K. Krüger, Bernhard Gerber, Dieter Kabelitz, K Friese · 2000 · Histochemistry and Cell Biology
- High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival.Johnathan M. Lancaster, Robyn A. Sayer, Carrie Blanchette, Brian Calingaert, Regina S. Whitaker, Joellen Schildkraut, Jeffrey R. Marks, Andrew Berchuck · 2003 · PubMed
- Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in ChondrosarcomaSubbiah, Vivek, Chawla, Sant P., Conley, Anthony P., Wilky, Breelyn A., Tolcher, Anthony, Lakhani, Nehal J., Berz, David, Andrianov, Vasily, Crago, William, Holcomb, Monica et al. · 2023 · Clinical Cancer Research
- Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumorsSunil Sharma, Elisabeth G.E. de Vries, Jeffrey R. Infante, Corina N.A.M. Oldenhuis, Jourik A. Gietema, Lin Yang, Sanela Bilic, Katie Parker, Michael Goldbrunner, Jeffrey W. Scott et al. · 2013 · Investigational New Drugs
- Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancerIrene Zinonos, Agatha Labrinidis, Michelle Lee, Vasilios Liapis, Shelley J. Hay, Vladimir Ponomarev, Peter Diamond, Andrew C.W. Zannettino, David M. Findlay, Andreas Evdokiou · 2009 · Molecular Cancer Therapeutics
- miR-20a-directed regulation of BID is associated with the TRAIL sensitivity in colorectal cancerGuanli Huang, Xiangjian Chen, Yefeng Cai, Xiaobo Wang, Chungen Xing · 2016 · Oncology Reports