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Cited by 1,004Tactile and Sensory InteractionsPain Mechanisms and TreatmentsIon Channels and Receptors

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Thermosensory activation of insular cortex

Craig, A. D., Chen, K., Bandy, D., Reiman, E. M.·2000·Nature Neuroscience
DOI 10.1038/72131
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Abstract

Temperature sensation is regarded as a submodality of touch, but evidence suggests involvement of insular cortex rather than parietal somatosensory cortices. Using positron emission tomography (PET), we found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans. This corresponds to the thermoreceptive- and nociceptive-specific lamina I spinothalamocortical pathway in monkeys, and can be considered an enteroceptive area within limbic sensory cortex. Because lesions at this site can produce the post-stroke central pain syndrome, this finding supports the proposal that central pain results from loss of the normal inhibition of pain by cold. Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices.

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Crossref · 10.1038/72131

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Citations

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Research works printed but not linked: 6

  1. Darian-Smith, I. in Handbook of Physiology, Section 1, The Nervous System, Vol. III, Sensory Processes (ed. Darian-Smith, I.) 879–913 (American Physiological Society, Bethesda, 1984).
  2. Craig, A. D. in Forebrain Areas Involved in Pain Processing. (eds. Besson, J.-M., Guilbaud, G. & Ollat, H.) 13–26 (John Libbey, Paris, 1995).
  3. Dostrovsky, J. O., Wells, F. E. B. & Tasker, R. R. in Processing and Inhibition of Nociceptive Information, International Congress Series 989 (eds. Inoka, R., Shigenaga, Y. & Tohyama, M.) 115–120 (Excerpta Medica, Amsterdam, 1992).
  4. Reiman, E. M. The application of positron emission tomography to the study of normal and pathological emotions. J. Clin. Psychiatry 58, 4–12 (1997).
  5. Volkow, N. D., Mullani, N., Gould, L. K., Adler, S. S. & Gatley, S. J. Sensitivity of measurements of regional brain activation with oxygen-15-water and PET to time of stimulation and period of image reconstruction. J. Nucl. Med. 32, 58–61 (1991).
  6. Talairach, J. & Tournoux, P. Co-Planar Stereotaxic Atlas of the Human Brain (Thieme, New York, 1988).

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Metadata

Authors
Craig, A. D., Chen, K., Bandy, D., & Reiman, E. M.
Affiliations
  • Barrow Neurological Institute (US)
  • Good Samaritan Regional Medical Center (US)
  • University of Arizona (US)
Corresponding author
Craig, A. D.
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2000-02
Volume
3
Issue
2
Pages
184-190
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/72131
OpenAlex
W1990876814
Cited by
1,004
References
41
Citations by year
2026: 15 · 2025: 34 · 2024: 38 · 2023: 36 · 2022: 31 · 2021: 44 · 2020: 48 · 2019: 34 · 2018: 40 · 2017: 40 · 2016: 44 · 2015: 53 · 2014: 46 · 2013: 43 · 2012: 46
FWCI
15.59
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
thermosensation, insula, nociception, central pain, stroke, anterior insula, orbitofrontal cortex, somatosensory cortex
MeSH terms
Adult, Brain Mapping, Cerebral Cortex, Cerebrovascular Circulation, Cold Temperature, Differential Threshold, Female, Hand, Humans, Male, Middle Aged, Pain Measurement, Physical Stimulation, Thermosensing, Tomography, Emission-Computed, Linear Models, Prosencephalon

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