Cited by 1,004Tactile and Sensory InteractionsPain Mechanisms and TreatmentsIon Channels and Receptors

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Thermosensory activation of insular cortex

Craig, A. D., Chen, K., Bandy, D., Reiman, E. M.·2000·Nature Neuroscience

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Abstract

Temperature sensation is regarded as a submodality of touch, but evidence suggests involvement of insular cortex rather than parietal somatosensory cortices. Using positron emission tomography (PET), we found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans. This corresponds to the thermoreceptive- and nociceptive-specific lamina I spinothalamocortical pathway in monkeys, and can be considered an enteroceptive area within limbic sensory cortex. Because lesions at this site can produce the post-stroke central pain syndrome, this finding supports the proposal that central pain results from loss of the normal inhibition of pain by cold. Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices.

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Authors: Craig, A. D., Chen, K., Bandy, D., & Reiman, E. M.
Affiliations: Barrow Neurological Institute (US)
Good Samaritan Regional Medical Center (US)
University of Arizona (US)
Corresponding author: Craig, A. D.
ORCID: Chen, K.
Reiman, E. M.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2000-02
Volume: 3
Issue: 2
Pages: 184-190
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/72131
OpenAlex: W1990876814
Cited by: 1,004
References: 41
Citations by year: 2026: 15 · 2025: 34 · 2024: 38 · 2023: 36 · 2022: 31 · 2021: 44 · 2020: 48 · 2019: 34 · 2018: 40 · 2017: 40 · 2016: 44 · 2015: 53 · 2014: 46 · 2013: 43 · 2012: 46
FWCI: 15.59
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: thermosensation, insula, nociception, central pain, stroke, anterior insula, orbitofrontal cortex, somatosensory cortex
MeSH terms: Adult, Brain Mapping, Cerebral Cortex, Cerebrovascular Circulation, Cold Temperature, Differential Threshold, Female, Hand, Humans, Male, Middle Aged, Pain Measurement, Physical Stimulation, Thermosensing, Tomography, Emission-Computed, Linear Models, Prosencephalon

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