Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm
Open accessAbstract
Although important progress has been made recently in the elucidation of the molecular mechanisms that regulate differentiation and morphogenesis of endoderm-derived tissues such as pancreas and liver, less is known about the preliminary steps of early regional specification. Recent evidence supports the proposal that the early endoderm contains a bipotential precursor cell type for pancreas and liver. We have also previously shown that the activity of the homeobox gene Prox1 controls hepatocyte migration during liver morphogenesis. Using detailed comparative analysis of whole embryos and reverse transcriptase polymerase chain reaction of dissected embryonic endoderm, we have now determined that in the early endoderm, Prox1 expression is restricted to regions giving rise to the mammalian pancreas and liver. This finding indicates that Prox1 is one of the earliest specific markers of this commonly fated region of the mammalian endoderm.
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Prox1 is only expressed by the liver and pancreas progenitors beginning at the 7-8 somite stage.
“For example, Prox1 is only expressed by the liver and pancreas progenitors beginning at the 7–8 somite stage [43].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [43]
The Results and discussion section says Prox1 is first detected in hepatic endoderm at the 7–8 somite stage, but section 1.1 places detectable dorsal pancreatic expression later, at 15–18 somites. Figure 1 also reports expression near the node and in the hindgut, contrary to “only” liver and pancreas progenitors. Page numbers are unavailable in our copy. (LLM, conf=0.90)
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Cites
Prox1 Function Is Required for the Development of the Murine Lymphatic System
Wigle, J. T., & Oliver, G. C. (1999) · Cell · doi:10.1016/s0092-8674(00)81511-1 · Cited by 1,581 · see citing works
Self-citationHNF-3β is essential for node and notochord formation in mouse development
Ang, S., & Rossant, J. (1994) · Cell · doi:10.1016/0092-8674(94)90522-3 · Cited by 981 · see citing works
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721 · see citing works
Rossi, J. M., Dunn, N. R., Hogan, B. L. M., & Zaret, K. S. (2001) · Genes & Development · doi:10.1101/gad.904601 · Cited by 646 · see citing works
Notochord repression of endodermal Sonic hedgehog permits pancreas development
Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628 · see citing works
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611 · see citing works
Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.Preprint
Gualdi, R., Bossard, P., Zheng, M., Hamada, Y., Coleman, J. R., & Zaret, K. S. (1996) · Genes & Development · doi:10.1101/gad.10.13.1670 · Cited by 590 · see citing works
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
Bellusci, S., Furuta, Y., Rush, M., Henderson, R., Winnier, G. E., & Hogan, B. L. M. (1997) · Development · doi:10.1242/dev.124.1.53 · Cited by 579 · see citing works
Martı́nez-Barberá, J. P., Clements, M., Thomas, P. Q., Rodríguez, T. A., Meloy, D., Kioussis, D., & Beddington, R. S. P. (2000) · Development · doi:10.1242/dev.127.11.2433 · Cited by 471 · see citing works
Prox1 function is crucial for mouse lens-fibre elongation
Wigle, J. T., Chowdhury, K., Gruß, P., & Oliver, G. C. (1999) · Nature Genetics · doi:10.1038/6844 · Cited by 432 · see citing works
Self-citationNotochord to endoderm signaling is required for pancreas development
Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405 · see citing works
Hepatocyte migration during liver development requires Prox1
Sosa-Pineda, B., Wigle, J. T., & Oliver, G. (2000) · Nature Genetics · doi:10.1038/76996 · Cited by 381 · see citing works
Self-citationEarly mouse endoderm is patterned by soluble factors from adjacent germ layers
Wells, J. M., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.8.1563 · Cited by 366 · see citing works
An experimental analysis of liver development.
Douarin, N. M. L. (1975) · PubMed · Cited by 268 · see citing works
Lawson, K. A., Meneses, J. J., & Pedersen, R. A. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90253-8 · Cited by 227 · see citing works
Cell fate and morphogenetic movement in the late mouse primitive streak
Wilson, V. A., & Beddington, R. S. P. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(95)00493-9 · Cited by 185 · see citing works
Keng, V. W., Yagi, H., Ikawa, M., Nagano, T., Myint, Z. W., Yamada, K., Tanaka, T., Sato, A., Muramatsu, I., Okabe, M., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3548 · Cited by 183 · see citing works
Rausa, F. M., Samadani, U., Ye, H., Lim, L., Fletcher, C., Jenkins, N. A., Copeland, N. G., & Costa, R. H. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8744 · Cited by 169 · see citing works
Essential developmental biology: a practical approach.
Stern, C. D., & Holland, P. W. H. (1993) · IRL Press eBooks · Cited by 150 · see citing works
Molecular Genetics of Early Liver Development
Zaret, K. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001311 · Cited by 109 · see citing works
Essential Developmental Biology: A Practical Approach
Becker, D. L. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90123-6 · Cited by 99 · see citing works
The histogenetic capacity of tissues in the caudal end of the embryonic axis of the mouse
Tam, P. (1984) · Development · doi:10.1242/dev.82.1.253 · Cited by 77 · see citing works
Immunocytochemistry of embryonic material
Stern, C. D. (1993) · doi:10.1093/oso/9780199634231.003.0021 · Cited by 31 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
Harvey, N. L., Srinivasan, R. S., Dillard, M. E., Johnson, N. C., Witte, M. H., Boyd, K. L., Sleeman, M. W., & Oliver, G. C. (2005) · Nature Genetics · doi:10.1038/ng1642 · Cited by 580 · see citing works
Self-citationDevelopmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 465 · see citing works
Yoshitomi, H., & Zaret, K. (2004) · Development · doi:10.1242/dev.00960 · Cited by 268 · see citing works
Choi, I., Chung, H. K., Ramu, S., Lee, H. N., Kim, K. E., Lee, S., Yoo, J., Choi, D., Lee, Y. S., Aguilar, B., et al. (2010) · Blood · doi:10.1182/blood-2010-07-298562 · Cited by 244 · see citing works
Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors
Wandzioch, E., & Zaret, K. (2009) · Science · doi:10.1126/science.1174497 · Cited by 249 · see citing works
Molotkov, A., Molotkova, N., & Duester, G. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20256 · Cited by 211 · see citing works
Bmp and Fgf signaling are essential for liver specification in zebrafish
Shin, D., Shin, C. H., Tucker, J. A., Ober, E. A., Rentzsch, F., Poss, K. D., Hammerschmidt, M., Mullins, M. C., & Stainier, D. Y. R. (2007) · Development · doi:10.1242/dev.000281 · Cited by 207 · see citing works
The biliary tree—a reservoir of multipotent stem cells
Cardinale, V., Wang, Y.-F., Carpino, G., Mendel, G. L., Alpini, G., Gaudio, E., Reid, L., & Alvaro, D. (2012) · Nature Reviews Gastroenterology &Hepatology · doi:10.1038/nrgastro.2012.23 · Cited by 206 · see citing works
Transcriptional dynamics of endodermal organ formation
Sherwood, R. I., Chen, T. A., & Melton, D. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21810 · Cited by 191 · see citing works
Guler, G. D., Ning, Y., Ku, C., Phillips, T. C., McCarthy, E., Ellison, C. K., Bergamaschi, A., Collin, F., Lloyd, P., Scott, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18965-w · Cited by 177 · see citing works
Transcription factor PROX1: its role in development and cancer
Elsir, T., Smits, A., Lindström, M. S., & Nistér, M. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9390-8 · Cited by 154 · see citing works
Prox1 expression patterns in the developing and adult murine brain
Lavado, A., & Oliver, G. C. (2006) · Developmental Dynamics · doi:10.1002/dvdy.21024 · Cited by 146 · see citing works
Self-citationThe Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis
Tanaka, M., & Iwakiri, Y. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.09.002 · Cited by 146 · see citing works
The homeobox protein Prox1 is a negative modulator of ERRα/PGC-1α bioenergetic functionsPreprint
Charest-Marcotte, A., Dufour, C. R., Wilson, B. J., Tremblay, A., Eichner, L. J., Arlow, D. H., Mootha, V. K., & Giguère, V. (2010) · Genes & Development · doi:10.1101/gad.1871610 · Cited by 142 · see citing works
Paskeh, M. D. A., Mirzaei, S., Ashrafizadeh, M., Zarrabi, A., & Sethi, G. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s336858 · Cited by 135 · see citing works
Understanding the marvels behind liver regeneration
Rmilah, A. A. A., Zhou, W., Nelson, E., Li, L., Amiot, B. P., & Nyberg, S. L. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.340 · Cited by 133 · see citing works
Wang, J., Kilic, G., Sayitoğlu, M., Burke, Z. D., Oliver, G. C., & Sosa‐Pineda, B. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.07.021 · Cited by 133 · see citing works
Self-citationA novel perivascular cell population in the zebrafish brain
Galanternik, M. V., Castranova, D., Gore, A. V., Blewett, N. H., Jung, H. M., Stratman, A. N., Kirby, M., Iben, J., Miller, M. F., Kawakami, K., et al. (2017) · eLife · doi:10.7554/elife.24369 · Cited by 123 · see citing works
Differentiation of mouse and human embryonic stem cells into hepatic lineages
Shiraki, N., Umeda, K., Sakashita, N., Takeya, M., Kume, K., & Kume, S. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01201.x · Cited by 112 · see citing works
Gastrointestinal lymphatics in health and disease
Alexander, J. S., Ganta, V. C., Jordan, P., & Witte, M. H. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.09.003 · Cited by 109 · see citing works
Zhang, Y., Yang, Y., Jiang, M. Z., Huang, S. X. L., Zhang, W., Alam, D. A., Danopoulos, S., Mori, M., Chen, Y., Balasubramanian, R., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.009 · Cited by 98 · see citing works
Lymphatic vessels: new targets for the treatment of inflammatory diseases
Dieterich, L. C., Seidel, C. D., & Detmar, M. J. (2013) · Angiogenesis · doi:10.1007/s10456-013-9406-1 · Cited by 96 · see citing works
System for tamoxifen‐inducible expression of cre‐recombinase from the Foxa2 locus in mice
Park, E. J., Sun, X., Nichol, P. F., Saijoh, Y., Martin, J. F., & Moon, A. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21415 · Cited by 94 · see citing works
Genes controlling pancreas ontogeny.
Bonal, C., & Herrera, P. (2008) · International Journal of Developmental Biology · doi:10.1387/ijdb.072444cb · Cited by 100 · see citing works
Qin, J., Gao, D., Jiang, Q.-F., Zhou, Q., Kong, Y., Wang, Y., & Xie, Y. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0009 · Cited by 89 · see citing works
Miettinen, M., & Wang, Z.-F. (2011) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318236c312 · Cited by 87 · see citing works
Liu, Y., Ye, X., Zhang, J.-B., Ouyang, H., Shen, Z., Wu, Y., Wang, W., Wu, J., Tao, S., Yang, X., et al. (2015) · Oncogene · doi:10.1038/onc.2015.7 · Cited by 93 · see citing works
Fritzsch, B., Dillard, M. E., Lavado, A., Harvey, N. L., & Jahan, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009377 · Cited by 83 · see citing works
Cellular and Molecular Basis of Liver Development
Shin, D., & Monga, S. P. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120022 · Cited by 95 · see citing works
Pattern and process during sea urchin gut morphogenesis: The regulatory landscape
Annunziata, R., Perillo, M., Andrikou, C., Cole, A. G., Martı́nez, P., & Arnone, M. I. (2013) · genesis · doi:10.1002/dvg.22738 · Cited by 78 · see citing works
Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development
Poulain, M., & Ober, E. A. (2011) · Development · doi:10.1242/dev.055921 · Cited by 77 · see citing works
Schneider, M., Büchler, P., Giese, N. A., Giese, T., Wilting, J., Büchler, M. W., & Friess, H. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.4.883 · Cited by 77 · see citing works
Rodríguez-Seguel, E. D. P., Mah, N., Naumann, H., Pongrac, I. M., Cerdá‐Esteban, N., Fontaine, J., Wang, Y., Chen, W., Andrade-Navarro, M. A., & Spagnoli, F. M. (2013) · Genes & Development · doi:10.1101/gad.220244.113 · Cited by 71 · see citing works
Mechanisms of embryonic stomach development
McCracken, K. W., & Wells, J. M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.02.004 · Cited by 73 · see citing works
Song, K. H., Li, T., & Chiang, J. Y. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513420200 · Cited by 71 · see citing works
Kivelä, R., Salmela, I., Nguyen, Y. H., Petrova, T. V., Koistinen, H. A., Wiener, Z., & Alitalo, K. K. (2016) · Nature Communications · doi:10.1038/ncomms13124 · Cited by 71 · see citing works
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
Armour, S. M., Remsberg, J. R., Damle, M., Sidoli, S., Ho, W. Y., Li, Z., Garcia, B. A., & Lazar, M. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00772-5 · Cited by 69 · see citing works
Guney, M. A., & Gannon, M. (2009) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20156 · Cited by 70 · see citing works
Liu, Y., Gao, W., Teh, H.-L., Tan, J., & Chan, W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7243-7255.2003 · Cited by 67 · see citing works
Hirose, Y., Itoh, T., & Miyajima, A. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.06.018 · Cited by 63 · see citing works
C/EBPalpha and C/EBPbeta are early markers of liver development
Westmacott, A., Burke, Z. D., Oliver, G. C., Slack, J. M. W., & Tosh, D. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.062146aw · Cited by 63 · see citing works
Self-citationSteffensen, K. R., Holter, E., Båvner, A., Nilsson, M., Pelto‐Huikko, M., Tomarev, S. I., & Treuter, E. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400147 · Cited by 62 · see citing works
Immunohistochemical Endothelial Markers
Ordóǹez, N. G. (2012) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e3182691c2a · Cited by 61 · see citing works
Prox-1 Promotes Invasion of Kaposiform Hemangioendotheliomas
Dadras, S. S., Skrzypek, A., Nguyen, L., Shin, J. W., Schulz, M. M. P., Arbiser, J. L., Mihm, M. C., & Detmar, M. J. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.176 · Cited by 60 · see citing works
Hepatic Stem Cells and Hepatoblasts: Identification, Isolation, and Ex Vivo Maintenance
Wauthier, E., Schmelzer, E., Turner, W. S., Zhang, L., LeCluyse, E. L., Ruiz, J., Turner, R., Furth, M. E., KUBOTA, H. Y., Lozoya, O. A., et al. (2008) · Methods in cell biology · doi:10.1016/s0091-679x(08)00008-3 · Cited by 58 · see citing works
Altered regulation of Prox1-gene-expression in liver tumors
Dudás, J., Mansuroglu, T., Moriconi, F., Haller, F., Wilting, J., Lorf, T., FÜZESI, L., & Ramadori, G. P. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-92 · Cited by 57 · see citing works
Hou, J., Charters, A. M., Lee, S. C., Zhao, Y., Wu, M. K., Jones, S. J., Marra, M. A., & Hoodless, P. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-92 · Cited by 56 · see citing works
“For example, Prox1 is only expressed by the liver and pancreas progenitors beginning at the 7–8 somite stage [43].”
BackgroundLaerm, A., Helmbold, P., Goldberg, M., Dammann, R., Holzhausen, H.-J., & Ballhausen, W. G. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.07.033 · Cited by 55 · see citing works
Multiple roles for Med12 in vertebrate endoderm development
Shin, C. H., Chung, W., Hong, S., Ober, E. A., Verkade, H. M., Field, H. A., Huisken, J., & Stainier, D. Y. R. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.02.031 · Cited by 55 · see citing works
Min, N., Park, H., Hong, T., An, G., Song, G., & Lim, W. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130202 · Cited by 53 · see citing works
Dudás, J., Papoutsi, M., Hecht, M., Elmaouhoub, A., Saile, B., Christ, B., Tomarev, S. I., von Kaisenberg, C. S., Schweigerer, L., Ramadori, G. P., et al. (2004) · Anatomy and Embryology · doi:10.1007/s00429-004-0403-4 · Cited by 53 · see citing works
Mu, T., Xu, L., Zhong, Y., Liu, X., Zhao, Z., Huang, C., Lan, X., Lufei, C., Zhou, Y., Su, Y., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01364-8 · Cited by 52 · see citing works
Στεργιόπουλος, Α., Elkouris, M., & Politis, P. K. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00454 · Cited by 49 · see citing works
Kamiya, A., Kakinuma, S., Onodera, M., Miyajima, A., & Nakauchi, H. (2008) · Hepatology · doi:10.1002/hep.22303 · Cited by 51 · see citing works
Seth, A., Ye, J., Yu, N., Guez, F., Bedford, D. C., Neale, G. A., Cordi, S., Brindle, P. K., Lemaigre, F. P., Kaestner, K. H., et al. (2014) · Development · doi:10.1242/dev.099481 · Cited by 50 · see citing works
Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth
Nissim, S., Sherwood, R. I., Wucherpfennig, J. I., Saunders, D. C., Harris, J. M., Esain, V., Carroll, K. J., Frechette, G. M., Kim, A. J., Hwang, K. L., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.01.006 · Cited by 49 · see citing works
Westmoreland, J. J., Kilic, G., Sartain, C. V., Sırma, S., Blain, J., Rehg, J. E., Harvey, N. L., & Sosa‐Pineda, B. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.12.007 · Cited by 48 · see citing works
Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2
Jacquemin, P., Pierreux, C. E., Fierens, S., van Eyll, J. M., Lemaigre, F. P., & Rousseau, G. G. (2003) · Gene Expression Patterns · doi:10.1016/s1567-133x(03)00110-8 · Cited by 48 · see citing works
Delás, M., Kalaitzis, C. M., Fawzi, T., Demuth, M., Zhang, I., Stuart, H., Costantini, E., Ivanovitch, K., Tanaka, E. M., & Briscoe, J. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.11.016 · Cited by 31 · see citing works
Ras Pathways on Prox1 and Lymphangiogenesis: Insights for Therapeutics
Bui, K., & Hong, Y. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.597374 · Cited by 45 · see citing works
Comparative epigenome analysis using Infinium DNA methylation BeadChips
Ding, W., Kaur, D., Horvath, S., & Zhou, W. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac617 · Cited by 48 · see citing works
Transcriptional activation of the Prox1 gene by HIF‐1α and HIF‐2α in response to hypoxia
Zhou, B., Si, W., Su, Z., Deng, W., Tu, X., & Wang, Q. K. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.053 · Cited by 44 · see citing works
Dudás, J., Elmaouhoub, A., Mansuroglu, T., Batusic, D. S., Tron, K., Saile, B., Papoutsi, M., Pieler, T., Wilting, J., & Ramadori, G. P. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0191-4 · Cited by 45 · see citing works
Pierreux, C. E., Vanhorenbeeck, V., Jacquemin, P., Lemaigre, F. P., & Rousseau, G. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409038200 · Cited by 43 · see citing works
PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma
Saukkonen, K., Hagström, J., Mustonen, H. K., Juuti, A., Nordling, S., Kallio, P., Alitalo, K. K., Seppänen, H. E., & Haglund, C. H. (2016) · BMC Cancer · doi:10.1186/s12885-016-2497-5 · Cited by 43 · see citing works
Li, Z., Korzh, V. P., & Gong, Z. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-117 · Cited by 40 · see citing works
FGF signaling is required for anterior but not posterior specification of the murine liver bud
Wang, J., Rhee, S., Palaria, A., & Tremblay, K. D. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24215 · Cited by 40 · see citing works
Wang, Y., Luo, M., Wang, F., Tong, Y., Li, L., Shu, Y., Qiao, K., Zhang, L., Yan, G., Liu, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34747-y · Cited by 40 · see citing works
Liu, Y., Zhang, Y., Wang, S., Dong, Q., Shen, Z., Wang, W., Tao, S., Gu, C., Liu, J., Xie, Y., et al. (2017) · Hepatology · doi:10.1002/hep.29337 · Cited by 40 · see citing works
PROX1 is a transcriptional regulator of MMP14
Gramolelli, S., Cheng, J., Martínez‐Corral, I., Vähä-Koskela, M. J. V., Elbasani, E., Kaivanto, E., Rantanen, V., Tuohinto, K., Hautaniemi, S., Bower, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27739-w · Cited by 40 · see citing works
A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development
Marino, D., Dabouras, V., Brändli, A. W., & Detmar, M. J. (2010) · Journal of Vascular Research · doi:10.1159/000320620 · Cited by 39 · see citing works
The identification of different endothelial cell populations within the mouse proepicardium
Cossette, S. M., & Misra, R. P. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22724 · Cited by 37 · see citing works
Genetic and Molecular Insights Into the Role of PROX1 in Glucose Metabolism
Lecompte, S., Pasquetti, G., Hermant, X., Grenier‐Boley, B., González‐Gross, M., Henauw, S. D., Molnár, D., Stehle, P., Béghin, L., Moreno, L. A., et al. (2012) · Diabetes · doi:10.2337/db12-0864 · Cited by 37 · see citing works
Ritz-Laser, B., Mamin, A., Brun, T., Avril, I., Schwitzgebel, V., & Philippé, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0051 · Cited by 36 · see citing works
Qin, J., Zhai, J., Hong, R., Shan, S., Kong, Y., Wen, Y., Wang, Y., Liu, J., & Xie, Y. (2009) · Journal of General Virology · doi:10.1099/vir.0.006007-0 · Cited by 35 · see citing works
Ji, R., Eshita, Y., & Kato, S. (2007) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2007.00532.x · Cited by 28 · see citing works
Kinetics of albumin- and alpha-fetoprotein-production during rat liver development
Elmaouhoub, A., Dudás, J., & Ramadori, G. P. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0338-y · Cited by 27 · see citing works
PROX1 Gene is Differentially Expressed in Oral Cancer and Reduces Cellular Proliferation
Rodrigues, M. F. S. D., Rodini, C. O., Xavier, F. C. D. A., Paiva, K. B. S., Severino, P., Moysés, R. A., López, R. M., Cicco, R. D., Rocha, L. A., de Carvalho, M. B., et al. (2014) · Medicine · doi:10.1097/md.0000000000000192 · Cited by 27 · see citing works
Olmeda, D., Cerezo‐Wallis, D., Castellano‐Sanz, E., Garcı́a-Silva, S., Peinado, H., & Soengas, M. S. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113833 · Cited by 26 · see citing works
Liver‐specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice
Goto, T., Elbahrawy, A., Furuyama, K., Horiguchi, M., Hosokawa, S., Aoyama, Y., Tsuboi, K., Sakikubo, M., Hirata, K., Masui, T., et al. (2017) · FEBS Letters · doi:10.1002/1873-3468.12570 · Cited by 25 · see citing works
Molecular characterization of a toxicological tipping point during human stem cell differentiation
Saili, K. S., Antonijevic, T., Zurlinden, T. J., Shah, I., Deisenroth, C., & Knudsen, T. B. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.10.001 · Cited by 25 · see citing works
Flaht‐Zabost, A., Jankowska-Steifer, E. A., Radomska-Leśniewska, D. M., Madej, M., Gula, G., Kujawa, M., & Ratajska, A. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23827 · Cited by 25 · see citing works
Horra, A., Salazar, J., Ferré, R., Vallvé, J.-C., Guardiola, M., Rosales, R., Masana, L., & Ribalta, J. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.02.026 · Cited by 25 · see citing works
Kahan, B. W., Magliocca, J., Merriam, F., Treff, N., Budde, M. L., Nelson, J., Browning, V., Ziehr, B., & Odorico, J. (2010) · Stem Cell Research · doi:10.1016/j.scr.2010.10.003 · Cited by 27 · see citing works
Palaria, A., Angelo, J. R., Guertin, T. M., Mager, J., & Tremblay, K. D. (2018) · Hepatology · doi:10.1002/hep.29769 · Cited by 24 · see citing works
Facucho-Oliveira, J., Bento, M. C., & Belo, J. A. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113394jf · Cited by 23 · see citing works
Neurturin-GFRα2 signaling controls liver bud migration along the ductus venosus in the chick embryo
Tatsumi, N., Miki, R., Katsu, K., & Yokouchi, Y. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.519 · Cited by 21 · see citing works
Directed hepatic differentiation from embryonic stem cells
Chen, X., & Zeng, F. (2011) · Protein & Cell · doi:10.1007/s13238-011-1023-4 · Cited by 21 · see citing works
Decreased Expression of Prox1 Is Associated With Postoperative Recurrence in Crohn’s Disease
Shen, W., Li, Y. Z., Cao, L., Cai, X., Ge, Y., & Zhu, W. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy091 · Cited by 20 · see citing works
Jackson, J. T., Nutt, S. L., & McCormack, M. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1197490 · Cited by 20 · see citing works
A BAC transgenic Hes1-EGFP reporter reveals novel expression domains in mouse embryos
Klinck, R., Füchtbauer, E., Ahnfelt‐Rønne, J., Serup, P., Jensen, J. N., & Jørgensen, M. C. (2011) · Gene Expression Patterns · doi:10.1016/j.gep.2011.06.004 · Cited by 17 · see citing works
Intestinal precursors avoid being misinduced to liver cells by activating Cdx-Wnt inhibition cascade
Yang, Y., Li, Y., Fu, J., Li, Y., Li, S., Ni, R., Yang, Q., & Luo, L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205110119 · Cited by 17 · see citing works
Gene regulation by homeobox transcription factor Prox1 in murine hepatoblasts
Papoutsi, M., Dudás, J., Becker, J., Tripodi, M., Opitz, L., Ramadori, G. P., & Wilting, J. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0477-4 · Cited by 18 · see citing works
Xu, C., & Zaret, K. S. (2012) · Nucleus · doi:10.4161/nucl.19321 · Cited by 17 · see citing works
Magnesium and Liver Metabolism Through the Lifespan
Bravo, M., Simón, J., González‐Recio, I., Martínez‐Cruz, L. A., Goikoetxea‐Usandizaga, N., & Martínez‐Chantar, M. L. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.05.009 · Cited by 17 · see citing works
Min, N., Park, H., Hong, T., Song, J., Song, G., & Lim, W. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164839 · Cited by 17 · see citing works
Zhu, S., Shan, C., Wu, Z.-F., & Xu, S. (2013) · PubMed · Cited by 17 · see citing works
Imaging leukocyte migration through afferent lymphatics*
Collado‐Díaz, V., Medina-Sanchez, J. D., Gkountidi, A., & Halin, C. (2021) · Immunological Reviews · doi:10.1111/imr.13030 · Cited by 16 · see citing works
3-D reconstruction and multiple marker analysis of mouse proepicardial endothelial cell population
Niderla‐Bielińska, J., Gula, G., Flaht‐Zabost, A., Jankowska-Steifer, E. A., Czarnowska, E., Radomska-Leśniewska, D. M., Ciszek, B., & Ratajska, A. (2015) · Microvascular Research · doi:10.1016/j.mvr.2015.08.007 · Cited by 15 · see citing works
Cellular and Molecular Basis of Liver Development
Shin, D., & Monga, S. P. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00508.x · Cited by 15 · see citing works
- Authors
- Burke, Z., & Oliver, G.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Oliver, Guillermo
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 118
- Issue
- 1-2
- Pages
- 147-155
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2082073317
- Cited by
- 177
- References
- 23
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 11 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Lebanese Syrian Associated Charities (CA 21765)
- National Institutes of Health (CA21765))
- National Eye Institute (R01EY012162, EY 12162)
- National Cancer Institute (CA21765, P30CA021765)
- National Institute of General Medical Sciences (GM58462, R01GM058462)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- Prox1, homeobox genes, foregut endoderm, liver development, pancreatic development, regional specification, hepatocyte migration, embryonic endoderm, developmental markers
- MeSH terms
- Prospero-Related Homeobox 1 Protein, Animals, beta-Galactosidase, Cell Movement, Cell Separation, DNA-Binding Proteins, Endoderm, Flow Cytometry, Immunohistochemistry, Liver, Notochord, Nuclear Proteins, Pancreas, Time Factors, Transcription Factors, Trans-Activators, Protein Serine-Threonine Kinases, In Situ Hybridization, Receptors, Growth Factor, Homeodomain Proteins, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Hepatocytes, Tumor Suppressor Proteins, Activin Receptors, Type I, Mice, Hepatocyte Nuclear Factor 3-beta, Hepatocyte Nuclear Factor 6, Bone Morphogenetic Protein Receptors, Type I, Hedgehog Proteins
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