Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, Hideki, Hattori, Nobutaka, Kubo, Shin-ichiro, Mizuno, Yoshikuni, Asakawa, Shuichi, Minoshima, Shinsei, Shimizu, Nobuyoshi, Iwai, Kazuhiro +3 more·2000·Nature Genetics

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  6. S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
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  7. Molecular Insights into Parkinson's Disease
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  9. Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling
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  10. PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever
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  11. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
    Nucifora, Frederick C., Nucifora, Leslie G., Ng, Chee-Hoe, Arbez, Nicolas, Guo, Yajuan, Roby, Elaine, Shani, Vered, Engelender, Simone, Wei, Dong, Wang, Xiao-Fang et al. · 2016 · Nature Communications
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  14. Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies
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  15. Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival
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  19. Neddylation dysfunction in Alzheimer's disease
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  20. Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme
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  21. Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease?
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  26. Cell Death Pathways in Parkinson's Disease: Role of Mitochondria
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  27. Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice
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  28. Parkin Suppresses the Expression of Monoamine Oxidases
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  31. Mitochondrial Dynamics and Parkinson's Disease: Focus on Parkin
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  54. Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination
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