Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, Hideki, Hattori, Nobutaka, Kubo, Shin-ichiro, Mizuno, Yoshikuni, Asakawa, Shuichi, Minoshima, Shinsei, Shimizu, Nobuyoshi, Iwai, Kazuhiro, Chiba, Tomoki, Tanaka, Keiji, Suzuki, Toshiaki·2000·Nature Genetics

Cited by (1,004)

Items 501–600 of 1,004

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    Wei Yang, Yuhua Chen, Hao Liu, Hongdang Qu · 2015 · International Journal of Molecular Medicine
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    Daisuke Ariyasu, Hiderou Yoshida, Yukihiro Hasegawa · 2017 · International Journal of Molecular Sciences
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  11. The Ubiquitin–Proteasome System in Retinal Health and Disease
    Laura Campello, Julián Esteve-Rudd, Nicolás Cuenca, José Martín‐Nieto · 2013 · Molecular Neurobiology
  12. Multifaceted deaths orchestrated by mitochondria in neurones
    Phillip Nagley, Gavin C. Higgins, Julie D. Atkin, Philip M. Beart · 2009 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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  14. Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease
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  15. The associations between Parkinson’s disease and cancer: the plot thickens
    Danielle D. Feng, Waijiao Cai, Xiqun Michael Chen · 2015 · Translational Neurodegeneration
  16. Parkin mediates the degradation‐independent ubiquitination of Hsp70
    Darren J. Moore, Andrew B. West, Dustin A. Dikeman, Valina Lynn Dawson, Ted M. Dawson · 2008 · Journal of Neurochemistry
  17. Functional modulation of parkin through physical interaction with SUMO‐1
    Ji Won Um, Kwang Chul Chung · 2006 · Journal of Neuroscience Research
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    Majoor‐Krakauer, D, Willems, PJ, Hofman, A · 2003 · Clinical Genetics
  19. Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease
    Steven Beasley, Ventzislava A. Hristova, Gary S. Shaw · 2007 · Proceedings of the National Academy of Sciences
  20. Cyclin-Dependent Kinase Activity Is Required for Apoptotic Death But Not Inclusion Formation in Cortical Neurons after Proteasomal Inhibition
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  21. Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression
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  22. Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
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  29. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1
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  44. The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila
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  45. Probing Mechanisms That Underlie Human Neurodegenerative Diseases in Drosophila
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  46. Integral UBL domain proteins: a family of proteasome interacting proteins
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  47. Parkin protects dopaminergic neurons from excessive Wnt/β-catenin signaling
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  48. Parkin reverses intracellular β‐amyloid accumulation and its negative effects on proteasome function
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  49. Genetic susceptibility to mycobacterial disease in humans
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    Steven H. Graham, Hao Liu · 2016 · Ageing Research Reviews
  53. Synaptic vesicle trafficking and Parkinson's disease
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  54. Structure of the C-terminal RING Finger from a RING-IBR-RING/TRIAD Motif Reveals a Novel Zinc-binding Domain Distinct from a RING
    Allan D. Capili, E.L. Edghill, Kenneth Kun-yu Wu, Katherine L. B. Borden · 2004 · Journal of Molecular Biology
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  56. Ubiquitin Ligase Parkin Promotes Mdm2–Arrestin Interaction but Inhibits Arrestin Ubiquitination
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  57. Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease
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  59. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates.
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  60. Caspase-1 and Caspase-8 Cleave and Inactivate Cellular Parkin
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  61. Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-β are Associated with Autophagic Defects in Alzheimer's Disease
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  63. Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells
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  64. Endoplasmic Reticulum Protein Quality Control in Neurodegenerative Disease: The Good, the Bad and the Therapy
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  65. Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice
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