Clearance of amyloid β-peptide from brain: transport or metabolism?

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

Jarrett, J. T., & Lansbury, P. T. (1993) · Cell · doi:10.1016/0092-8674(93)90635-4 · Cited by 2,178 · see citing works

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works

Amyloid, the presenilins and Alzheimer’s disease

Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370 · see citing works

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

Iwata, N., Tsubuki, S., Takaki, Y., Watanabe, K., Sekiguchi, M., Hosoki, E., Kawashima-Morishima, M., Lee, H.-J., Hama, E., Sekine-Aizawa, Y., et al. (2000) · Nature Medicine · doi:10.1038/72237 · Cited by 867 · see citing works

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

Selkoe, D. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01363-4 · Cited by 862 · see citing works

β-Amyloid-mediated vasoactivity and vascular endothelial damage

Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703 · see citing works

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

Zlokovic, B. V., Martel, C. L., Matsubara, E., McComb, J. G., Zheng, G., McCluskey, R. T., Frangione, B., & Ghiso, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4229 · Cited by 430 · see citing works

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406 · see citing works

The presenilins and Alzheimer's disease

Hutton, M. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.10.1639 · Cited by 368 · see citing works

α2‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein

Narita, M., Holtzman, D. M., Schwartz, A. L., & Bu, G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051904.x · Cited by 259 · see citing works

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

Mackic, J. B., Stins, M., McComb, J. G., Calero, M., Ghiso, J., Kim, K. S., Yan, S. D., Stern, D., Schmidt, A. M., Frangione, B., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2029 · Cited by 242 · see citing works

Amyloid β‐Peptide Induces Cell Monolayer Albumin Permeability, Impairs Glucose Transport, and Induces Apoptosis in Vascular Endothelial Cells

Blanc, E. M., Toborek, M. J., Mark, R. J., Hennig, B., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68051870.x · Cited by 174 · see citing works

Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin.

Hersh, L. B., & Morihara, K. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84580-5 · Cited by 97 · see citing works

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development

Chen, G.-F., Xu, T.-H., Yan, Y., Zhou, Y.-R., Jiang, Y., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.28 · Cited by 1,965 · see citing works

Clearance systems in the brain—implications for Alzheimer disease

Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678 · see citing works

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426 · see citing works

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413 · see citing works

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060 · see citing works

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

Bell, R. D., & Zlokovic, B. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0522-3 · Cited by 892 · see citing works

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.017 · Cited by 828 · see citing works

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36663 · Cited by 771 · see citing works

P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model

Cirrito, J. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25247 · Cited by 660 · see citing works

Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model

Harrison, I. F., Ismail, O., Machhada, A., Colgan, N. C., Ohene, Y., Nahavandi, P., Ahmed, Z., Fisher, A., Meftah, S., Murray, T. K., et al. (2020) · Brain · doi:10.1093/brain/awaa179 · Cited by 663 · see citing works

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

Deane, R., Bell, R. D., Sagare, A. P., & Zloković, B. V. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787601867 · Cited by 549 · see citing works

Cerebral Amyloid Angiopathy: A Systematic Review

Biffi, A., & Greenberg, S. M. (2011) · Journal of Clinical Neurology · doi:10.3988/jcn.2011.7.1.1 · Cited by 444 · see citing works

RAGE (Yin) Versus LRP (Yang) Balance Regulates Alzheimer Amyloid β-Peptide Clearance Through Transport Across the Blood–Brain Barrier

Deane, R., Wu, Z., & Zlokovic, B. V. (2004) · Stroke · doi:10.1161/01.str.0000143452.85382.d1 · Cited by 392 · see citing works

Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid β-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid β-Protein Precursor

Davis, J., Xu, F., Deane, R., Romanov, G., Previti, M. L., Zeigler, K., Zlokovic, B. V., & Van Nostrand, W. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312946200 · Cited by 373 · see citing works

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

He, X.-F., Liu, D.-X., Zhang, Q., Liang, F.-Y., Dai, G.-Y., Zeng, J.-S., Pei, Z., Xu, G.-Q., & Lan, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00144 · Cited by 371 · see citing works

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

Révész, T., Holton, J. L., Lashley, T., Plant, G. T., Frangione, B., Rostagno, A. A., & Ghiso, J. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0501-8 · Cited by 293 · see citing works

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

van Assema, D. M. E., Lubberink, M., Bauer, M., van der Flier, W. M., Schuit, R. C., Windhorst, A. D., Comans, E. F. I., Hoetjes, N. J., Tolboom, N., Langer, O., et al. (2012) · Brain · doi:10.1093/brain/awr298 · Cited by 318 · see citing works

Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?

Govindpani, K., McNamara, L. G., Smith, N. R., Vinnakota, C., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050651 · Cited by 271 · see citing works

Blood–brain-barriers in aging and in Alzheimer’s disease

Marques, F., Sousa, J. C., Sousa, N., & Palha, J. A. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-38 · Cited by 273 · see citing works

Amyloid β‐peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

Verdier, Y., Zarándi, M., & Penke, B. (2004) · Journal of Peptide Science · doi:10.1002/psc.573 · Cited by 261 · see citing works

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

Bell, R. D., Deane, R., Chow, N., Long, X., Sagare, A., Singh, I., Streb, J. W., Guo, H., Rubio, A., Van Nostrand, W., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1819 · Cited by 261 · see citing works

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain

Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., & Winkler, E. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07002.x · Cited by 261 · see citing works

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

Abuznait, A. H., Qosa, H., Busnena, B. A., Sayed, K. A. E., & Kaddoumi, A. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400024q · Cited by 261 · see citing works

Amyloid‐β efflux from the central nervous system into the plasma

Roberts, K. F., Elbert, D. L., Kasten, T. P., Patterson, B. W., Sigurdson, W. C., Connors, R., Ovod, V., Munsell, L. Y., Mawuenyega, K. G., Miller‐Thomas, M. M., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24270 · Cited by 250 · see citing works

Targeting Neuroinflammation to Treat Alzheimer’s Disease

Ardura-Fabregat, A., Boddeke, E., Boza‐Serrano, A., Brioschi, S., Castro‐Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, M. T., et al. (2017) · CNS Drugs · doi:10.1007/s40263-017-0483-3 · Cited by 236 · see citing works

MDR1‐P‐Glycoprotein (ABCB1) Mediates Transport of Alzheimer’s Amyloid‐β Peptides—Implications for the Mechanisms of Aβ Clearance at the Blood–Brain Barrier

Kuhnke, D., Jedlitschky, G., Grube, M., Krohn, M., Jucker, M., Mosyagin, I., Cascorbi, I., Walker, L. C., Kroemer, H. K., Warzok, R., et al. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00075.x · Cited by 226 · see citing works

Metabolism of amyloid-β peptide and Alzheimer's disease

Iwata, N., Higuchi, M., & Saido, T. C. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.03.010 · Cited by 216 · see citing works

The role of NPY in hypothalamic mediated food intake

Mercer, R. E., Chee, M. J. S., & Colmers, W. F. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.06.001 · Cited by 194 · see citing works

Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging

Silverberg, G. D., Messier, A. A., Miller, M. C., Machan, J. T., Majmudar, S. S., Stopa, E. G., Donahue, J. E., & Johanson, C. E. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181f46e25 · Cited by 191 · see citing works

Pathological role of hypoxia in Alzheimer's disease

Zhang, X., & Le, W. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.033 · Cited by 189 · see citing works

Passage of amyloid β protein antibody across the blood–brain barrier in a mouse model of Alzheimer’s disease

Banks, W. A., Terrell, B., Farr, S. A., Robinson, S. M., Nonaka, N., & Morley, J. E. (2002) · Peptides · doi:10.1016/s0196-9781(02)00261-9 · Cited by 184 · see citing works

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

Deane, R., Sagare, A. P., & Zloković, B. V. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705487 · Cited by 184 · see citing works

Can oral infection be a risk factor for Alzheimer's disease?

Olsen, I., & Singhrao, S. K. (2015) · Journal of Oral Microbiology · doi:10.3402/jom.v7.29143 · Cited by 182 · see citing works

Angiotensins in Alzheimer's disease – friend or foe?

Kehoe, P. G., Miners, J. S., & Love, S. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.006 · Cited by 166 · see citing works

miR128 up-regulation correlates with impaired amyloid β(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease

Tiribuzi, R., Crispoltoni, L., Porcellati, S., Di Lullo, M., Florenzano, F., Pirro, M., Bagaglia, F., Kawarai, T., Zampolini, M., Orlacchio, A., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.003 · Cited by 162 · see citing works

Human antibodies against amyloid β peptide: A potential treatment for Alzheimer's disease

Dodel, R. C., Hampel, H. J., Depboylu, C., Lin, S., Gao, F., Schock, S., Jäckel, S., Wei, X., Büerger, K., Höft, C., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10253 · Cited by 161 · see citing works

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

Qosa, H., Abuznait, A. H., Hill, R. A., & Kaddoumi, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120319 · Cited by 160 · see citing works

1α,25-Dihydroxyvitamin D 3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

Durk, M. R., Han, K., Chow, E. C. Y., Ahrens, R., Henderson, J. T., Fraser, P. E., & Pang, K. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2711-13.2014 · Cited by 154 · see citing works

Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia

Zambón, D., Quintana, M., Mata, P., Rodrigo Alonso, K., Benavent, J., Cruz-Sánchez, F., Gich, J., Pocovı́, M., Civeira, F., Capurro, S., et al. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.08.015 · Cited by 149 · see citing works

Stem cell therapy for Alzheimer's disease

Liu, X., Yang, L.-P., & Zhao, L. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.787 · Cited by 157 · see citing works

New Therapeutic Targets in the Neurovascular Pathway in Alzheimer's Disease

Zloković, B. V. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.011 · Cited by 149 · see citing works

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance

Feng, W., Zhang, Y., Wang, Z., Xu, H., Wu, T., Marshall, C., Gao, J., & Xiao, M. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00688-1 · Cited by 150 · see citing works

Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease

Moore, A. H., & O’Banion, M. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00162-x · Cited by 146 · see citing works

Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

Sagare, A. P., Deane, R., & Zloković, B. V. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.07.008 · Cited by 144 · see citing works

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

Pflanzner, T., Janko, M. C., André-Dohmen, B., Reuss, S., Weggen, S., Roebroek, A. J. M., Kuhlmann, C. R. W., & Pietrzik, C. U. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.025 · Cited by 141 · see citing works

Blood Platelets in the Progression of Alzheimer’s Disease

Gowert, N. S., Donner, L., Chatterjee, M., Eisele, Y. S., Towhid, S. T., Münzer, P., Walker, B., Ogorek, I., Borst, O., Grandoch, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090523 · Cited by 142 · see citing works

Circulating amyloid-β peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions

Mačkić, J. B., Bading, J. R., Ghiso, J. A., Walker, L. C., Wısnıewskı, T., Frangione, B., & Zloković, B. V. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(02)00198-2 · Cited by 141 · see citing works

Omega‐3 polyunsaturated fatty acids promote amyloid‐β clearance from the brain through mediating the function of the glymphatic system

Ren, H., Luo, C., Feng, Y., Yao, X., Shi, Z., Liang, F., Kang, J. X., Wan, J., Pei, Z., & Su, H. (2016) · The FASEB Journal · doi:10.1096/fj.201600896 · Cited by 136 · see citing works

Current therapeutic targets for the treatment of Alzheimer’s disease

Grill, J. D., & Cummings, J. L. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.29 · Cited by 121 · see citing works

The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer’s Disease: A Foreseeable Medical Challenge in Post-HAART Era

Xu, J., & Ikezu, T. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9136-0 · Cited by 118 · see citing works

LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases

Guo, Q., Zhu, Q., Miao, T., Tao, J., Ju, X., Sun, Z., Li, H., Xu, G., Chen, H., & Han, L. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.031 · Cited by 119 · see citing works

β-Amyloid deposition in brain is enhanced in mouse models of arterial hypertension

Gentile, M. T., Poulet, R., Pardo, A. D., Cifelli, G., Maffei, A., Vecchione, C., Passarelli, F., Landolfi, A., Carullo, P., & Lembo, G. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.06.005 · Cited by 116 · see citing works

Selective Antihypertensive Dihydropyridines Lower Aβ Accumulation by Targeting both the Production and the Clearance of Aβ across the Blood-Brain Barrier

Paris, D., Bachmeier, C., Patel, N., Quadros, A., Volmar, C.-H., Laporte, V., Ganey, J., Beaulieu-Abdelahad, D., Ait-Ghezala, G., Crawford, F., et al. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00180 · Cited by 114 · see citing works

HDL from an Alzheimer's disease perspective

Button, E. B., Robert, J., Caffrey, T. M., Fan, J., Zhao, W., & Wellington, C. L. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000604 · Cited by 114 · see citing works

Ghrelin

Wu, J. T., & Kral, J. G. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000118561.54919.61 · Cited by 111 · see citing works

Lipids and Cognition

Morley, J. E., & Banks, W. A. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091576 · Cited by 108 · see citing works

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-β peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

Monro, O. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00317-7 · Cited by 107 · see citing works

Further understanding the connection between Alzheimer's disease and Down syndrome

Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12112 · Cited by 105 · see citing works

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

Qosa, H., Mohamed, L. A., Batarseh, Y. S., Alqahtani, S., Ibrahim, B. A., LeVine, H., Keller, J. N., & Kaddoumi, A. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.022 · Cited by 105 · see citing works

Intermittent Fasting Protects against Alzheimer’s Disease Possible through Restoring Aquaporin-4 Polarity

Zhang, J., Zhan, Z., Li, X., Xing, A., Jiang, C., Chen, Y., Shi, W., & An, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00395 · Cited by 104 · see citing works

Neurovascular Pathways and Alzheimer Amyloid β-peptide

Zlokovic, B. V., Deane, R., Sallstrom, J., Chow, N., & Miano, J. M. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00103.x · Cited by 104 · see citing works

Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease

Saido, T. C., & Iwata, N. (2006) · Neuroscience Research · doi:10.1016/j.neures.2005.12.015 · Cited by 101 · see citing works

Aluminum complexing enhances amyloid β protein penetration of blood–brain barrier

Banks, W. A., Niehoff, M. L., Drago, D., & Zatta, P. F. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.112 · Cited by 103 · see citing works

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

Iulita, M. F., Allard, S. T. M., Richter, L., Munter, L. M., Ducatenzeiler, A., Weise, C., Carmo, S. D., Klein, W. L., Multhaup, G., & Cuello, A. C. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-61 · Cited by 102 · see citing works

Rapid, Reversible Modulation of Blood–Brain BarrierP-Glycoprotein Transport Activity by Vascular Endothelial Growth Factor

Hawkins, B. T., Sykes, D. B., & Miller, D. S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5103-09.2010 · Cited by 102 · see citing works

The Blood–Brain Barrier in Alzheimer's Disease

Sharma, H. S., Castellani, R. J., Smith, M. A., & Sharma, A. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-386986-9.00003-x · Cited by 102 · see citing works

Links Between the Pathology of Alzheimer's Disease and Vascular Dementia

Sadowski, M., Pankiewicz, J., Scholtzova, H., Li, Y.-S., Quartermain, D., Duff, K., & Wisniewski, T. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023612.66691.e6 · Cited by 109 · see citing works

Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E

Fan, J., Donkin, J., & Wellington, C. (2009) · BioFactors · doi:10.1002/biof.37 · Cited by 97 · see citing works

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

Guo, Y.-X., He, L., Zhang, M., Wang, F., Liu, F., & Peng, W. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.041 · Cited by 96 · see citing works

The Blood-Brain Barrier in NeuroAIDS

Banks, W. A., Nuran Ercal, A., & Price, T. O. (2006) · Current HIV Research · doi:10.2174/157016206777709447 · Cited by 95 · see citing works

Is RAGE Still A Therapeutic Target For Alzheimer’s Disease?

Deane, R. J. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.51 · Cited by 94 · see citing works

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

Pérez‐González, R., Pascual, C., Antequera, D., Bolós, M., Redondo, M., Pérez, D. I., Pérez‐Grijalba, V., Krzyzanowska, A., Sarasa, M., Gil, C., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.011 · Cited by 91 · see citing works

Efflux of human and mouse amyloid β proteins 1–40 and 1–42 from brain: impairment in a mouse model of alzheimer's disease

Banks, W. A., Robinson, S. M., Verma, S., & Morley, J. E. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00474-3 · Cited by 90 · see citing works

Brain Clearance of Alzheimer's Amyloid-β40 in the Squirrel Monkey: A SPECT Study in a Primate Model of Cerebral Amyloid Angiopathy

Bading, J., Yamada, S., Mackic, J., Kirkman, L., Miller, C., Calero, M., Ghiso, J., Frangione, B., & Zlokovic, B. (2002) · Journal of drug targeting (Print) · doi:10.1080/10611860290031831 · Cited by 89 · see citing works

Neural stem cell therapy for neurovascular injury in Alzheimer's disease

Boese, A. C., Hamblin, M. H., & Lee, J. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113112 · Cited by 88 · see citing works

The blood–brain barrier as a regulatory interface in the gut–brain axes

Banks, W. A. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.07.004 · Cited by 84 · see citing works

Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment

Khan, N. U., Jiang, N., Ju, X., Miao, T., Chen, H., & Han, L. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.015 · Cited by 83 · see citing works

Mechanism of Nucleated Conformational Conversion of Aβ42

Fu, Z., Aucoin, D., Davis, J., Nostrand, W. E. V., & Smith, S. O. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00467 · Cited by 83 · see citing works

1α,25‐Dihydroxyvitamin D3‐liganded vitamin D receptor increases expression and transport activity of P‐glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

Durk, M. R., Chan, G. N. Y., Campos, C. R., Peart, J. C., Chow, E. C. Y., Lee, E., Cannon, R. E., Bendayan, R., Miller, D. S., & Pang, K. S. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12041 · Cited by 83 · see citing works

Cerebrospinal fluid physiology: visualization of cerebrospinal fluid dynamics using the magnetic resonance imaging Time-Spatial Inversion Pulse method

Yamada, S. (2014) · Croatian Medical Journal · doi:10.3325/cmj.2014.55.337 · Cited by 81 · see citing works

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease

Sagare, A. P., Deane, R., Zetterberg, H., Wallin, A., Blennow, K., & Zloković, B. V. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101248 · Cited by 80 · see citing works

Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease

van Beek, A. H. E. A., Lagró, J., Olde-Rikkert, M. G. M., Zhang, R., & Claassen, J. A. H. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.016 · Cited by 77 · see citing works

Association of Plasma Aß Peptides with Blood Pressure in the Elderly

Lambert, J., Dallongeville, J., Ellis, K. A., Schraen‐Maschke, S., Lui, J. K., Laws, S. M., Dumont, J., Richard, F., Cottel, D., Berr, C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018536 · Cited by 78 · see citing works

Modulation of the Blood–Brain Barrier for Drug Delivery to Brain

Han, L. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122024 · Cited by 74 · see citing works

Intranasal delivery of therapeutic proteins for neurological diseases

Malerba, F., Paoletti, F., Capsoni, S., & Cattaneo, A. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.588204 · Cited by 73 · see citing works

An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease

Hurwitz, S. N., Sun, L. J., Cole, K. Y., Ford, C. R., Olcese, J., & Meckes, D. G. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.05.022 · Cited by 72 · see citing works

The role of inflammatory processes in Alzheimer’s disease

Broussard, G. J., Mytar, J. O., Li, R., & Klapstein, G. J. (2012) · Inflammopharmacology · doi:10.1007/s10787-012-0130-z · Cited by 68 · see citing works

Delivery of peptides to the brain: Emphasis on therapeutic development

Banks, W. A. (2008) · Biopolymers · doi:10.1002/bip.20980 · Cited by 68 · see citing works

Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels

Roşu, G. C., Cătălin, B., Bălşeanu, T. A., Mogoantă, L., Mărgăritescu, C., Kumar‐Singh, S., & Pirici, D. N. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02044-8 · Cited by 65 · see citing works

Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis

Zhu, D., Su, Y., Fu, B. M., & Xu, H. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0896-0 · Cited by 64 · see citing works

Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease

Janota, C. S., Lemere, C. A., & Brito, M. A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9319-7 · Cited by 65 · see citing works

Vascular disorder in Alzheimer’s disease: role in pathogenesis of dementia and therapeutic targets

Zloković, B. V. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00150-3 · Cited by 62 · see citing works

High-throughput screening for identification of blood-brain barrier integrity enhancers: a drug repurposing opportunity to rectify vascular amyloid toxicity

Qosa, H., Mohamed, L. A., Rihani, S. B. A., Batarseh, Y. S., Duong, Q.-V., Keller, J., & Kaddoumi, A. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-151179 · Cited by 48 · see citing works

Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease

Nuutinen, T., Suuronen, T., Kauppinen, A., & Salminen, A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.041 · Cited by 63 · see citing works

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

Mohamed, L. A., Keller, J. N., & Kaddoumi, A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.013 · Cited by 63 · see citing works

Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia

Yan, F., Zheng, Y., & Zhao, F. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0435-6 · Cited by 62 · see citing works

Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer’s disease

Hong-xin, F., Zhang, Y., Liu, T., Zhang, X., & Wu, S. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1399788 · Cited by 61 · see citing works

Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism

Lukiw, W. J., Pappolla, M., Pelaez, R. P., & Bazan, N. G. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4010-6 · Cited by 59 · see citing works

Cerebrospinal Fluid Dynamics and the Pathophysiology of Hydrocephalus: New Concepts

Yamada, S., & Kelly, E. J. (2016) · Seminars in Ultrasound CT and MRI · doi:10.1053/j.sult.2016.01.001 · Cited by 59 · see citing works

P4–069: Modeling amyloid β–peptide transport across the blood–brain barrier in TR–BBB cells

Yamada, K., Yabuki, C., Tachikawa, M., Ohtsuki, S., Strickland, D. K., Bu, G., Terasaki, T., Hashimoto, T., & Iwatsubo, T. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1807

Possible Reverse Transport of β-Amyloid Peptide Across the Blood-Brain Barrier

Pluta, R., Misicka, A., Barcikowska, M., Spisacka, S., Lipkowski, A., & Januszewski, S. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6346-7_15 · Cited by 34 · see citing works

Amyloid β‐Peptide Induces Cell Monolayer Albumin Permeability, Impairs Glucose Transport, and Induces Apoptosis in Vascular Endothelial Cells

Blanc, E. M., Toborek, M. J., Mark, R. J., Hennig, B., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68051870.x · Cited by 174 · see citing works

Vascular Transport of Alzheimer’s Amyloid β Peptides and Apolipoproteins

Zloković, B. V., Ghiso, J. A., & Frangione, B. (2000) · Springer eBooks · doi:10.1007/978-94-017-1007-7_20 · Cited by 1 · see citing works

The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease

Su, Q., Guo, J.-H., Zhang, Y.-L., Wang, J., & Zhang, Z.-N. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335829 · Cited by 91 · see citing works