The Need to Feed

Positional cloning of the mouse obese gene and its human homologue

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Ghrelin is a growth-hormone-releasing acylated peptide from stomach

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Central nervous system control of food intake

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

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Leptin and the regulation of body weight in mammals

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Predictive reward signal of dopamine neurons

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Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

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Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

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Ghrelin induces adiposity in rodents

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

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Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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Identification and expression cloning of a leptin receptor, OB-R.

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

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A role for ghrelin in the central regulation of feeding

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Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

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Narcolepsy in orexin Knockout Mice

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

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Getting formal with dopamine and reward

Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works

Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.

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Obesity and the regulation of energy balance

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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Gut hormone PYY3-36 physiologically inhibits food intake

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Abnormal splicing of the leptin receptor in diabetic mice

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Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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A role for glucagon-like peptide-1 in the central regulation of feeding

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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

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Mammalian sweet taste receptors

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Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

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Differential expression of orexin receptors 1 and 2 in the rat brain

Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659 · see citing works

The sleep switch: hypothalamic control of sleep and wakefulness

Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works

Leptin-regulated endocannabinoids are involved in maintaining food intake

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An amino-acid taste receptor

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Identification of targets of leptin action in rat hypothalamus.

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The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking

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T2Rs Function as Bitter Taste Receptors

Chandrashekar, J. V., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., Guo, W., Zuker, C. S., & Ryba, N. J. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80706-0 · Cited by 1,402 · see citing works

A Novel Family of Mammalian Taste Receptors

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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320 · see citing works

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289 · see citing works

Efferent connections of the parabrachial nucleus in the rat

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Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

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Changes in brain activity related to eating chocolate: From pleasure to aversion

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Signals That Regulate Food Intake and Energy Homeostasis

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Addiction, Dopamine, and the Molecular Mechanisms of Memory

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Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

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From Lesions to Leptin

Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160 · see citing works

A frameshift mutation in MC4R associated with dominantly inherited human obesity

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Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

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Mice lacking melanin-concentrating hormone are hypophagic and lean

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

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The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization

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Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

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Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

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Neural Economics and the Biological Substrates of Valuation

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Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat

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Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

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Brain Reward Circuitry

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Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

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Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

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Autonomic regulation of islet hormone secretion – Implications for health and disease

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The central autonomic nervous system: conscious visceral perception and autonomic pattern generation

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Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

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Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

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Addictive Drugs and Brain Stimulation Reward

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Genetics of body-weight regulation

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Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

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Leptin Regulation of Neuroendocrine Systems

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Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

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Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat

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Role of dopamine in the behavioural actions of nicotine related to addiction

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Receptors and transduction in taste

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Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.Preprint

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Localization of a "Feeding Center" in the Hypothalamus of the Rat

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Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

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Elevated plasma ghrelin levels in Prader–Willi syndrome

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Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

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Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

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Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

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Key enzyme in leptin-induced anorexia

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Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat

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Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective

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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons.

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Opioid modulation of taste hedonics within the ventral striatum

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