Adiponectin and Hypertension
Abstract
Adipose tissue secretes a variety of bioactive molecules, also known as adipocytokines or adipokines. Obesity, in particular, visceral fat accumulation, is implicated in the dysregulated secretion of adipocytokines, which can contribute to the development of metabolic syndrome and cardiovascular diseases. Adiponectin is an adipocytokine that is exclusively secreted from adipose tissue, but its plasma levels are reduced in obese subjects, especially those with visceral fat accumulation. Adiponectin has a variety of protective properties against obesity-linked complications, such as hypertension, metabolic dysfunction, atherosclerosis, and ischemic heart disease. Adiponectin exerts the beneficial effects on vascular disorders by directly affecting components of vascular tissue. This review will discuss clinical and experimental findings that examine the role of adiponectin in regulation of hypertension and vascular function.
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Plasma adiponectin concentration is decreased in patients with obesity, especially those with excess visceral fat, and this downregulation is associated with insulin resistance, impaired glucose metabolism, decreased fatty acid metabolism, and ectopic fat accumulation.
“Plasma adiponectin concentration is decreased in patients with obesity, especially those with excess visceral fat, and this downregulation is associated with insulin resistance, impaired glucose metabolism, decreased fatty acid metabolism and ectopic fat accumulation114,115.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [114]
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- Authors
- Ohashi, K., Ouchi, N., & Matsuzawa, Y.
- Affiliations
- Nagoya University (JP)
- Sumitomo Hospital (JP)
- ORCID
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-01
- Volume
- 24
- Issue
- 3
- Pages
- 263-269
- ISSN
- 0895-7061 (ISSN-L)
- 1941-7225
- OpenAlex
- W1968290606
- Cited by
- 127
- References
- 82
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 13 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 22 · 2012: 15
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adiponectin, hypertension, adipokines, adipose tissue, visceral fat, obesity, metabolic syndrome, cardiovascular disease, atherosclerosis, ischemic heart disease, vascular function
- MeSH terms
- Animals, Endothelium, Vascular, Humans, Hypertension, Macrophages, Nitric Oxide, Renin-Angiotensin System, Biomarkers, Cyclooxygenase 2, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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