Cited by 127Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

Adiponectin and Hypertension

Ohashi, K., Ouchi, N., Matsuzawa, Y.·2011·American Journal of Hypertension

Abstract

Adipose tissue secretes a variety of bioactive molecules, also known as adipocytokines or adipokines. Obesity, in particular, visceral fat accumulation, is implicated in the dysregulated secretion of adipocytokines, which can contribute to the development of metabolic syndrome and cardiovascular diseases. Adiponectin is an adipocytokine that is exclusively secreted from adipose tissue, but its plasma levels are reduced in obese subjects, especially those with visceral fat accumulation. Adiponectin has a variety of protective properties against obesity-linked complications, such as hypertension, metabolic dysfunction, atherosclerosis, and ischemic heart disease. Adiponectin exerts the beneficial effects on vascular disorders by directly affecting components of vascular tissue. This review will discuss clinical and experimental findings that examine the role of adiponectin in regulation of hypertension and vascular function.

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Crossref · 10.1038/ajh.2010.216

Cites

82 of 82 references verified0 citation errors · 0 not checkable

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  • Plasma adiponectin concentration is decreased in patients with obesity, especially those with excess visceral fat, and this downregulation is associated with insulin resistance, impaired glucose metabolism, decreased fatty acid metabolism, and ectopic fat accumulation.

    “Plasma adiponectin concentration is decreased in patients with obesity, especially those with excess visceral fat, and this downregulation is associated with insulin resistance, impaired glucose metabolism, decreased fatty acid metabolism and ectopic fat accumulation114,115.”

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Research works printed but not linked: 2

  1. 2003, 125, 1796
  2. Furukawa, 2004, Journal of Clinical Investigation, 114, 1752, 10.1172/JCI200421625 · DOI · Paper page

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Authors
Ohashi, K., Ouchi, N., & Matsuzawa, Y.
Affiliations
  • Nagoya University (JP)
  • Sumitomo Hospital (JP)
Venue
American Journal of Hypertension
Published
2011-03-01
Volume
24
Issue
3
Pages
263-269
ISSN
  • 0895-7061 (ISSN-L)
  • 1941-7225
OpenAlex
W1968290606
Cited by
127
References
82
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 13 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 22 · 2012: 15
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adiponectin, hypertension, adipokines, adipose tissue, visceral fat, obesity, metabolic syndrome, cardiovascular disease, atherosclerosis, ischemic heart disease, vascular function
MeSH terms
Animals, Endothelium, Vascular, Humans, Hypertension, Macrophages, Nitric Oxide, Renin-Angiotensin System, Biomarkers, Cyclooxygenase 2, Adiponectin

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