Inflamed fat: what starts the fire?
Open accessAbstract
Obesity is associated with increased macrophage infiltration of adipose tissue, and these macrophages may be an important component of the chronic inflammatory response playing a crucial role in the development of insulin resistance. This prompts the question as to how macrophages infiltrate obese adipose tissue. In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications.
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Adipocytes promote macrophage recruitment, then adipocytes and immune cells secrete more adipokines such as leptin, chemerin, resistin, and more cytokines such as TNF-α, ILs, INF-γ, creating a circumstance of low-grade inflammation.
“Specifically, adipocytes promote macrophage recruitment (21), then adipocytes and immune cells secrete more adipokines such as leptin, chemerin, resistin, and more cytokines such as tumor necrosis factor-α (TNF-α), interleukins (ILs), interferon-γ (INF-γ) (22–25), creating a circumstance of low-grade inflammation.”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [21]
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- Authors
- Neels, J. G.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Neels, J. G.
- ORCID
- Neels, J. G.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-12-08
- Volume
- 116
- Issue
- 1
- Pages
- 33-35
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1323268
- OpenAlex
- W1999229158
- Cited by
- 463
- References
- 25
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 14 · 2021: 12 · 2020: 14 · 2019: 14 · 2018: 23 · 2017: 25 · 2016: 27 · 2015: 29 · 2014: 35 · 2013: 48 · 2012: 34
- FWCI
- 16.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Diego
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, macrophage infiltration, adipose tissue inflammation, CCR2, chemokine receptors, macrophage recruitment, insulin resistance, chronic inflammation
- MeSH terms
- Adipose Tissue, Animals, Humans, Inflammation, Insulin Resistance, Macrophages, Mice, Transgenic, Obesity, Mice, Knockout, Receptors, Chemokine, Mice, Receptors, CCR2
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