The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease
Open accessAbstract
Mechanisms controlling vascular smooth muscle cell (VSMC) plasticity and renewal still remain to be elucidated completely. A class of small RNAs called microRNAs (miRs) regulate gene expression at the post-transcriptional level. Here, we show a critical role of the miR-143/145 cluster in SMC differentiation and vascular pathogenesis, also through the generation of a mouse model of miR-143 and -145 knockout (KO). We determined that the expression of miR-143 and -145 is decreased in acute and chronic vascular stress (transverse aortic constriction and in aortas of the ApoE KO mouse). In human aortic aneurysms, the expression of miR-143 and -145 was significantly decreased compared with control aortas. In addition, overexpression of miR-143 and -145 decreased neointimal formation in a rat model of acute vascular injury. An in-depth analysis of the miR-143/145 KO mouse model showed that this miR cluster is expressed mostly in the SMC compartment, both during development and postnatally, in vessels and SMC-containing organs. Loss of miR-143 and miR-145 expression induces structural modifications of the aorta, because of an incomplete differentiation of VSMCs. In conclusion, our results show that the miR-143/145 gene cluster has a critical role during SMC differentiation and strongly suggest its involvement in the reversion of the VSMC differentiation phenotype that occurs during vascular disease.
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1 retracted
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Cited by
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Metadata
- Authors
- Elia, L., Quintavalle, M., Zhang, J., Contu, R., Cossu, L., Latronico, M. V. G., Peterson, K. L., Indolfi, C., Catalucci, D., Chen, J., Courtneidge, S. A., & Condorelli, G.
- Venue
- Cell Death & Differentiation
- Published
- 2009-10-09
- Volume
- 16
- Issue
- 12
- Pages
- 1590-1598
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W2094940134
- Cited by
- 560
- References
- 29
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Elia, L., Quintavalle, M., Zhang, J., Contu, R., Cossu, L., Latronico, M. V. G., Peterson, K. L., Indolfi, C., Catalucci, D., Chen, J., Courtneidge, S. A., & Condorelli, G. (2009). The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death & Differentiation. https://doi.org/10.1038/cdd.2009.153
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