Ubiquitination and selective autophagy
Open accessAbstract
Ubiquitination has long been recognised as a key determinator of protein fate by tagging proteins for proteasomal degradation. Most recently, the ability of conjugated ubiquitin chains to confer selectivity to autophagy was demonstrated. Although autophagy was first believed to be a bulk, non-selective 'self-eating' degradative process, the molecular mechanisms of selectivity are now starting to emerge. With the discovery of autophagy receptors - which bind both ubiquitinated substrates and autophagy specific light chain 3 (LC3) modifier on the inner sheath of autophagosomes - a new pathway of selective autophagy is being unravelled. In this review, we focus on the special role of ubiquitin signals and selective autophagy receptors in sorting a variety of autophagic cargos.
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Ubiquitination of the mitochondrial outer membrane protein is a prerequisite for autophagosome recruitment via adaptor proteins.
“Ubiquitination of the mitochondrial outer membrane protein is a prerequisite for autophagosome recruitment via adaptor proteins [22]”
From Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster (2019) · cites this paper as [22]
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- Authors
- Shaid, S., Brandts, C. H., Serve, H., & Dikic, I.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Brandts, C H
- ORCID
- Venue
- Cell Death & Differentiation
- Published
- 2012-06-22
- Volume
- 20
- Issue
- 1
- Pages
- 21-30
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC3524631
- OpenAlex
- W2048494900
- Cited by
- 800
- References
- 107
- Citations by year
- 2026: 55 · 2025: 66 · 2024: 88 · 2023: 75 · 2022: 54 · 2021: 67 · 2020: 55 · 2019: 57 · 2018: 44 · 2017: 37 · 2016: 51 · 2015: 55 · 2014: 50 · 2013: 38 · 2012: 7
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft ((EXC 115)., SFB,834)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- ubiquitination, selective autophagy, autophagy receptors, LC3, autophagosomes, ubiquitin chains, protein degradation, cargo sorting, proteasomal degradation
- MeSH terms
- Autophagy, Humans, Signal Transduction, Ubiquitin, Ubiquitination
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