Role of p62/SQSTM1 in liver physiology and pathogenesis
Open accessAbstract
p62/sequestosome-1/A170/ZIP (hereafter referred to as p62) is a scaffold protein that has multiple functions, such as signal transduction, cell proliferation, cell survival, cell death, inflammation, tumourigenesis and oxidative stress response. While p62 is an autophagy substrate and is degraded by autophagy, p62 serves as an autophagy receptor for selective autophagic clearance of protein aggregates and organelles. Moreover, p62 functions as a signalling hub for various signalling pathways, including NF-κB, Nrf2 and mTOR. In this review, we discuss the pathophysiological role of p62 in the liver, including formation of hepatic inclusion bodies, cholestasis, obesity, insulin resistance, liver cell death and tumourigenesis.
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SQSTM1 mutations affect muscle, bone, and liver.
“SQSTM1 mutations affect muscle, bone, and liver [125,367,368]”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [368]
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“Conversely, tyrosine phosphorylation of both IRS-1 and its downstream target Akt in response to insulin injection was severely decreased in both muscle and fat tissues of p62 KO mice.(94) These results suggest that p62 may play a positive role in insulin sensitivity by enhancing the insulin signalling pathway, and p62…”
BackgroundInfluentialThe multifaceted role of mTORC1 in the control of lipid metabolism
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PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
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Accumulation of p62/ SQSTM 1 is associated with poor prognosis in patients with lung adenocarcinoma
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Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
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Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
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p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer
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Feedback on Fat: p62-mTORC1-Autophagy Connections
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Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation
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PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation
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p62 Links β-adrenergic input to mitochondrial function and thermogenesis
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The Role of Ubiquitin in Autophagy-Dependent Protein Aggregate Processing
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Research works printed but not linked: 1
- [98]Muller TD Lee SJ Jastroch M Kabra D Stemmer K Aichler M Abplanalp B Ananthakrishnan G Bhardwaj N Collins S Divanovic S Endele M Finan B Gao Y Habegger KM Hembree J Heppner KM Hofmann S Holland J Kuchler D Kutschke M Krishna R Lehti M Oelkrug R Ottaway N Perez-Tilve D Raver C Walch AK Schriever SC Speakman J Tseng YH Diaz-Meco M Pfluger PT Moscat J Tschop MH p62 Links beta-adrenergic input to mitochondrial function and thermogenesis The Journal of clinical investigation 2012 PMC3533288 23257354
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Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
“neural tissues manifest the detrimental effects of compromised autophagy [11], but to varying extents [365,366]: SQSTM1 mutations affect muscle, bone, and liver [125,367,368]; C9orf72 deficiency leads to lymphocytic inflammation, lymphadenopathy, and splenomegaly [149]; CHMP2B mutations induce oligodendroglial patholo…”
Background
- Authors
- Manley, S., Williams, J. A., & Ding, W.-X.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Ding, Wen-Xing
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 2013-05
- Volume
- 238
- Issue
- 5
- Pages
- 525-538
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- PMC
- PMC4096157
- OpenAlex
- W1983413606
- Cited by
- 135
- References
- 150
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 9 · 2020: 13 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 11 · 2014: 10 · 2013: 2
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA020518, R37AA020518)
- National Institute of Environmental Health Sciences (T32ES007079)
- National Center for Research Resources (P20RR021940)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- p62, liver physiology, liver disease pathogenesis, selective autophagy, autophagy receptors, protein aggregates, cholestasis, obesity, insulin resistance, hepatocyte death, NF-κB signaling, Nrf2 signaling, mTOR signaling, oxidative stress
- MeSH terms
- Sequestosome-1 Protein, Animals, Autophagy, Cell Transformation, Neoplastic, Inclusion Bodies, Humans, Inflammation, Insulin Resistance, Liver, Liver Neoplasms, Neoplasm Proteins, Signal Transduction, NF-kappa B, Oxidative Stress, Adaptor Proteins, Signal Transducing, Cell Proliferation, NF-E2-Related Factor 2, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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