The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Immunobiology of mesenchymal stem cells
Open accessAbstract
Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively expanded in vitro. Although their true in situ properties and biological functions remain to be elucidated, these in vitro expanded cells have been shown to possess potential to differentiate into specific cell lineages. It is speculated that MSCs in situ have important roles in tissue cellular homeostasis by replacing dead or dysfunctional cells. Recent studies have demonstrated that in vitro expanded MSCs of various origins have great capacity to modulate immune responses and change the progression of different inflammatory diseases. As tissue injuries are often accompanied by inflammation, inflammatory factors may provide cues to mobilize MSCs to tissue sites with damage. Before carrying out tissue repair functions, MSCs first prepare the microenvironment by modulating inflammatory processes and releasing various growth factors in response to the inflammation status. In this review, we focus on the crosstalk between MSCs and immune responses and their potential clinical applications, especially in inflammatory diseases.
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Cites
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“differentiation potential into osteoblasts, chondrocytes and adipocytes.(12,13) However, not all pericytes have the unique properties of MSCs and not all MSCs are equivalent to”
BackgroundMesenchymal stem cells in health and disease
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Cited by
Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications
Wang, Y., Chen, X., Cao, W., & Shi, Y. (2014) · Nature Immunology · doi:10.1038/ni.3002 · Cited by 1,452
Self-citationImmunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases
Shi, Y., Wang, Y., Li, Q., Liu, K., Hou, J., Shao, C., & Wang, Y. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0023-5 · Cited by 1,223
Self-citationBiological functions of mesenchymal stem cells and clinical implications
Naji, A., Eitoku, M., Favier, B., Deschaseaux, F., Rouas-Freiss, N., & Suganuma, N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03125-1 · Cited by 624
Skin tissue regeneration for burn injury
Shpichka, A., Butnaru, D., Bezrukov, E. A., Sukhanov, R. B., Atala, A., Burdukovskii, V., Zhang, Y., & Timashev, P. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1203-3 · Cited by 417
Interactions between mesenchymal stem cells and the immune system
Li, N., & Hua, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2473-5 · Cited by 338
Metadata
- Authors
- Ma, S., Xie, N., Li, W., Yuan, B., Shi, Y., & Wang, Y.
- Venue
- Cell Death & Differentiation
- Published
- 2013-11-01
- Volume
- 21
- Issue
- 2
- Pages
- 216-225
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W1995286643
- Cited by
- 771
- References
- 144
- FWCI
- 26.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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